Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ere(D)

erythromycin esterase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to ere(D)

Browse AMR rules for ere(D)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: inactivation of erythromycin
Validation Method: cloning in R. anatipestifer + MIC testing
Drug Classes: Erythromycin, ERYTHROMYCIN, AZITHROMYCIN, Macrolide, Lincosamide, Streptogramin b
Organisms: Riemerella anatipestifer, Elizabethkingia anophelis, Empedobacter falsenii
Geographic Location: China, Europe
Alleles: 2
Papers: 5
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
ereD	Reslit	3	Erythromycin, Macrolide +2	Riemerella anatipestifer	China	2015, 2018, 2025	KP265714\|KP265715\|KP265716\|KP265717\|KP265718\|KP265719\|KP265720\|KP265721\|KP265722\|KR857248\|KR857249\|KR857250\|KR857251\|KR857252\|KR857253\|KR857254\|KR857255\|KR857256\|KR857257\|KR857258\|KR857259\|KR857260\|KR857261\|KR857262\|KR857263\|KR857264\|KR857265\|KR857266\|KR857267\|KR857268\|KR857269

Papers5

1

ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.

PMID 26107936 · 2015

The study identifies ermF, ermFU, and ereD as the primary genes responsible for erythromycin resistance in Riemerella anatipestifer, demonstrating their role through cloning and MIC testing.

Gene Information

Gene Name: ere(D)
Allele: ereD
Encodes: erythromycin esterase
Source Database: Reslit
Mechanism: inactivation of erythromycin
Confers Resistance To: Erythromycin
Organisms Tested In: • Riemerella anatipestifer
Geographic Location: China
Validation Method: cloning in R. anatipestifer + MIC testing
Sequence Accession: KP265714|KP265715|KP265716|KP265717|KP265718|KP265719|KP265720|KP265721|KP265722|KR857248|KR857249|KR857250|KR857251|KR857252|KR857253|KR857254|KR857255|KR857256|KR857257|KR857258|KR857259|KR857260|KR857261|KR857262|KR857263|KR857264|KR857265|KR857266|KR857267|KR857268|KR857269

2

ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.

PMID 26107936 · 2015

Gene Information

Gene Name: ere(D)
Allele: ere(D)
Encodes: EreD family erythromycin esterase
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: ERYTHROMYCINAZITHROMYCIN
Organisms Tested In: • Riemerella anatipestifer
Sequence Accession: KP265721.1
Protein Accession: AKO71461.1
Notes: Macrolide esterase

3

ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.

PMID 26107936 · 2015

Gene Information

Gene Name: ere(D)
Allele: ere(D)
Encodes: EreD family erythromycin esterase
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: ERYTHROMYCINAZITHROMYCIN
Organisms Tested In: • Riemerella anatipestifer
Sequence Accession: KP265721.1
Protein Accession: AKO71461.1
Notes: Macrolide esterase

4

ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.

PMID 26107936 · 2015

Gene Information

Gene Name: ere(D)
Allele: ere(D)
Encodes: EreD family erythromycin esterase, macrolide esterase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: ERYTHROMYCINAZITHROMYCIN
Organisms Tested In: • Riemerella anatipestifer
Sequence Accession: KP265721.1
Protein Accession: AKO71461.1
Notes: Macrolide esterase, ARO:3004608

5

ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.

PMID 26107936 · 2015

Gene Information

Gene Name: ere(D)
Allele: ere(D)
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: ERYTHROMYCIN
Organisms Tested In: • Riemerella anatipestifer
Sequence Accession: KP265721
Notes: Macrolide esterase

6

Look and Outlook on Enzyme-Mediated Macrolide Resistance.

PMID 30177927 · 2018

The review discusses the mechanisms of macrolide resistance, focusing on macrolide phosphotransferases (MPHs) and macrolide esterases (Eres). It highlights the role of MPHs in conferring resistance by phosphorylating macrolides, thereby reducing their efficacy.

Gene Information

Gene Name: ere(D)
Allele: ereD
Encodes: erythromycin esterase
Source Database: Reslit
Mechanism: hydrolysis of the ester bond in macrolides
Confers Resistance To: Erythromycin
Organisms Tested In: • Riemerella anatipestifer
Validation Method: sequence analysis and detection in clinical isolates

7

Isolation of Elizabethkingia anophelis From COVID-19 Swab Kits.

PMID 35058914 · 2021

The study identified multiple beta-lactamase genes (bla B, bla CME, bla GOB, and bla OXA), as well as the anti-macrolide gene ere(D), the sulfa-resistant gene sul2, and the anti-tetracycline gene tet(X) in Elizabethkingia anophelis isolates, indicating multidrug resistance.

Gene Information

Gene Name: ere(D)
Allele: ere(D)
Encodes: macrolide esterase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Elizabethkingia anophelis
Geographic Location: China
Validation Method: genomic analysis
Sequence Accession: PRJNA764017|PRJNA763973

8

Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.

PMID 40020410 · 2025

This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.

Gene Information

Gene Name: ere(D)
Allele: ereD
Encodes: ribosomal methyltransferase
Source Database: Reslit
Mechanism: modifies the ribosome, conferring resistance to macrolides, lincosamides, and streptogramin B
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Riemerella anatipestifer
Geographic Location: China
Validation Method: experimental validation

9

Characterization of antimicrobial resistant Empedobacter from fresh meat and meat preparations.

PMID 41080801 · 2025

The study identifies bla EBR-1, tet(X2), and ere(D) as key antimicrobial resistance genes in Empedobacter isolates from fresh meat, highlighting their potential role in the spread of resistance.

Gene Information

Gene Name: ere(D)
Allele: ere(D)
Encodes: erythromycin esterase
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Empedobacter falsenii
Geographic Location: Europe
Validation Method: whole genome sequencing
Sequence Accession: PRJNA1210498