erm (41)

erythromycin ribosome methyltransferase

Validation StatusSupported

Overview

Mechanism: macrolide ribosome methylation
Validation Method: genotyping and MIC assays
Drug Classes: Macrolide
Organisms: Mycobacterium abscessus subsp. abscessus, Mycobacterium abscessus subsp. bolletii, Mycobacterium abscessus subsp. massiliense, Mycobacterium abscessus
Geographic Location: Brazil|Portugal, France, Japan
Papers: 5
Databases: Reslit

Papers5

The Contribution of Efflux Pumps in Mycobacterium abscessus Complex Resistance to Clarithromycin.

PMID 31540480 · 2019

Efflux pumps contribute significantly to clarithromycin resistance in Mycobacterium abscessus complex, alongside the erm (41) gene. Overexpression of MAB_3142 and MAB_1409 efflux pump genes was observed in multiple strains, enhancing resistance.

Gene Information

Gene Name: erm (41)
Allele: erm (41)
Encodes: erythromycin ribosome methyltransferase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium abscessus subsp. abscessus
• Mycobacterium abscessus subsp. bolletii
Geographic Location: Brazil|Portugal
Validation Method: genotyping and MIC assays

Impact on Macrolide Resistance of Genetic Diversity of Mycobacterium abscessus Species.

PMID 36416559 · 2022

Gene Information

Gene Name: erm (41)
Allele: erm (41)
Encodes: erythromycin ribosome methylase (Erm)
Source Database: Reslit
Mechanism: macrolide ribosome methylation
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium abscessus subsp. abscessus
• Mycobacterium abscessus subsp. massiliense
• Mycobacterium abscessus subsp. bolletii
Validation Method: sequencing and antimicrobial susceptibility testing

MGIT-seq for the Identification of Nontuberculous Mycobacteria and Drug Resistance: a Prospective Study.

PMID 36946719 · 2023

The study demonstrated the effectiveness of MGIT-seq for identifying nontuberculous mycobacteria (NTM) and predicting drug resistance, particularly for macrolides and amikacin. Key findings include the identification of specific mutations in rrl, erm (41), and rrs genes associated with resistance.

Gene Information

Gene Name: erm (41)
Allele: erm (41)
Encodes: erythromycin ribosome methyltransferase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium abscessus
Geographic Location: Japan
Validation Method: sequencing and drug susceptibility testing
Sequence Accession: NCBI SRA PRJDB12894

Extrapulmonary Mycobacterium abscessus Infections, France, 2012-2020(1).

PMID 39447147 · 2024

The study identifies the erm (41) gene as a cause of inducible macrolide resistance in Mycobacterium abscessus isolates.

Gene Information

Gene Name: erm (41)
Allele: erm (41)
Encodes: macrolide resistance
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium abscessus
Geographic Location: France
Validation Method: molecular detection of mutations associated with antimicrobial resistance by targeting rrl for macrolides and rrs for aminoglycosides

Evaluation of mlstverse system for accurate subspecies identification and drug resistance prediction in Mycobacterium abscessus species.

PMID 40742165 · 2025

The mlstverse system accurately identifies Mycobacterium abscessus subspecies and predicts drug resistance to clarithromycin and amikacin based on genetic analysis.

Gene Information

Gene Name: erm (41)
Allele: erm (41)
Encodes: macrolide resistance
Source Database: Reslit
Mechanism: mutation
Organisms Tested In: • Mycobacterium abscessus subsp. abscessus
• Mycobacterium abscessus subsp. massiliense
Geographic Location: Japan
Validation Method: genetic prediction and phenotypic DST

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erm (41)

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