Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(32)

23S rRNA (guanine(748)-N(1))-methyltransferase Erm(32)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(32)

Browse AMR rules for erm(32)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: characterization of the gene and its resistance phenotype
Drug Classes: STREPTOGRAMIN, TYLOSIN, SPIRAMYCIN, OLEANDOMYCIN, LINCOSAMIDE, Macrolide
Organisms: Streptomyces fradiae, Klebsiella pneumoniae
Geographic Location: Europe|North America|Asia|Middle East|Africa|India
Alleles: 2
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(32)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	6	STREPTOGRAMIN, TYLOSIN +4	Streptomyces fradiae +1	Europe\|North America\|Asia\|Middle East\|Africa\|India

Papers2

1

Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism.

PMID 10348045 · 1999

Gene Information

Gene Name: erm(32)
Allele: Erm(32)
Encodes: 23S rRNA (guanine(748)-N(1))-methyltransferase Erm(32)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: STREPTOGRAMINTYLOSINSPIRAMYCINOLEANDOMYCINLINCOSAMIDE
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: AJ009971.2
Protein Accession: CAB37345.2
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

2

Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism.

PMID 10348045 · 1999

Gene Information

Gene Name: erm(32)
Allele: erm(32)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: SPIRAMYCINOLEANDOMYCINTYLOSIN
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: AJ009971
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

3

Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism.

PMID 10348045 · 1999

Gene Information

Gene Name: erm(32)
Allele: Erm(32)
Encodes: 23S rRNA (guanine(748)-N(1))-methyltransferase Erm(32)
Source Database: Card Database
Mechanism: Target modification
Confers Resistance To: STREPTOGRAMINTYLOSINSPIRAMYCINOLEANDOMYCINLINCOSAMIDE
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: AJ009971.2
Protein Accession: CAB37345.2
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

4

Molecular analysis of tlrB, an antibiotic-resistance gene from tylosin-producing Streptomyces fradiae, and discovery of a novel resistance mechanism.

PMID 10348045 · 1999

Gene Information

Gene Name: erm(32)
Allele: Erm(32)
Encodes: 23S rRNA (guanine(748)-N(1))-methyltransferase Erm(32)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: STREPTOGRAMINTYLOSINSPIRAMYCINOLEANDOMYCINLINCOSAMIDE
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: AJ009971.2
Protein Accession: CAB37345.2
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

5

Characterization of a new metallo-beta-lactamase gene, bla(NDM-1), and a novel erythromycin esterase gene carried on a unique genetic structure in Klebsiella pneumoniae sequence type 14 from India

PMID 40390585 · 2009

The paper discusses the global and regional prevalence of multidrug-resistant organisms (MDROs), focusing on carbapenem-resistant Enterobacteriaceae (CRE), and highlights the urgent need for comprehensive strategies to combat antimicrobial resistance (AMR).

Gene Information

Gene Name: erm(32)
Allele: Erm(32)
Encodes: erythromycin esterase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: Europe|North America|Asia|Middle East|Africa|India
Validation Method: characterization of the gene and its resistance phenotype

6

Gene Information

Gene Name: erm(32)
Allele: Erm(32)
Encodes: 23S rRNA (guanine(748)-N(1))-methyltransferase Erm(32)
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: STREPTOGRAMINLINCOSAMIDE
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: AF055922.1
Protein Accession: AAD12162.1
Notes: ARO:3001299

7

Gene Information

Gene Name: erm(32)
Allele: Erm(32)
Encodes: 23S rRNA (guanine(748)-N(1))-methyltransferase Erm(32)
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: STREPTOGRAMINLINCOSAMIDE
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: AF055922.1
Protein Accession: AAD12162.1
Notes: ARO:3001299

8

Gene Information

Gene Name: erm(32)
Allele: erm(32)
Encodes: Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: AJ009971.2
Protein Accession: CAB37345.2
Notes: ARO:3004592