Browse AMR Genes

Explore antimicrobial resistance genes from the literature

ResLit

erm(36)

23S rRNA adenine N 6-methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to erm(36)

AMR Rules

Browse AMR rules for erm(36)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: heterologous expression experiments
Drug Classes: Erythromycin, Macrolide, QUINUPRISTIN, PRISTINAMYCIN IA, CLINDAMYCIN, LINCOMYCIN, ERYTHROMYCIN, VIRGINIAMYCIN S, Lincosamide, Streptogramin b
Organisms: Micrococcus luteus, Corynebacterium glutamicum, Escherichia coli
Geographic Location: China
Alleles: 2
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(36)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	5	Erythromycin, Macrolide +8	Micrococcus luteus +2

Papers2

Plasmid-borne macrolide resistance in Micrococcus luteus

PMID 12177341 · 2002

The study identifies a plasmid-borne macrolide resistance gene, erm(36), in Micrococcus luteus strain MAW843, which confers resistance to erythromycin, other macrolides, and lincomycin. The gene was localized to a 1.8 kb region of plasmid pMEC2 and showed similarity to 23S rRNA methyltransferases in high-G+C Gram-positive bacteria.

Gene Information

Gene Name: erm(36)
Allele: Erm(36)
Encodes: 23S rRNA adenine N 6-methyltransferase
Source Database: Reslit
Confers Resistance To: ErythromycinMacrolide
Organisms Tested In: • Micrococcus luteus
• Corynebacterium glutamicum
Validation Method: heterologous expression experiments
Sequence Accession: AF462611

Plasmid-borne macrolide resistance in Micrococcus luteus.

PMID 12177341 · 2002

Gene Information

Gene Name: erm(36)
Allele: Erm(36)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(36)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Micrococcus luteus
Sequence Accession: AF462611.1
Protein Accession: AAL68827.1
Notes: 23S rRNA methylase; Inducible MLSb phenotype

Plasmid-borne macrolide resistance in Micrococcus luteus.

PMID 12177341 · 2002

Gene Information

Gene Name: erm(36)
Allele: Erm(36)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(36)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Micrococcus luteus
Sequence Accession: AF462611.1
Protein Accession: AAL68827.1
Notes: 23S rRNA methylase; Inducible MLSb phenotype

Plasmid-borne macrolide resistance in Micrococcus luteus.

PMID 12177341 · 2002

Gene Information

Gene Name: erm(36)
Allele: Erm(36)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(36), Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: Target modification, antibiotic target alteration
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Micrococcus luteus
Sequence Accession: AF462611.1
Protein Accession: AAL68827.1
Notes: 23S rRNA methylase; Inducible MLSb phenotype, ARO:3000605

Plasmid-borne macrolide resistance in Micrococcus luteus.

PMID 12177341 · 2002

Gene Information

Gene Name: erm(36)
Allele: erm(36)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Micrococcus luteus
Sequence Accession: AF462611
Notes: 23S rRNA methylase; Inducible MLSb phenotype

Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.

PMID 34093457 · 2021

The study identified several antibiotic resistance genes (ARGs) in chicken manure, mushroom residues, and heat-treated chicken manure, highlighting the impact of different organic manures on the soil resistome. Key findings include the enrichment of specific ARGs such as aadE, aadD, qacE1, qacH, lnuA, vatE, and tetL in soils treated with various manures, indicating the potential for ARG transfer through manure application.

Gene Information

Gene Name: erm(36)
Allele: Erm(36)
Encodes: erythromycin ribosome methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Escherichia coli
Geographic Location: China
Validation Method: qPCR analysis