Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(37)

23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(37)

Browse AMR rules for erm(37)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: genetic experiments and comparative genomics
Drug Classes: CLINDAMYCIN, AZITHROMYCIN, ERYTHROMYCIN, TELITHROMYCIN, CLARITHROMYCIN, Macrolide, Lincosamide, LINCOMYCIN
Organisms: Mycobacterium tuberculosis CCDC5180, Mycobacterium tuberculosis, Mycobacterium bovis, Mycobacterium pinnipedii, Mycobacterium tuberculosis H37Rv
Geographic Location: Italy
Alleles: 4
Papers: 5
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants4

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(37)	Card DatabaseReference Gene Catalog	3	CLINDAMYCIN, AZITHROMYCIN +3	Mycobacterium tuberculosis CCDC5180 +1	-	2004	CP002885.1

Papers5

1

Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.

PMID 14693532 · 2004

Gene Information

Gene Name: erm(37)
Allele: Erm(37)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: CLINDAMYCINAZITHROMYCINERYTHROMYCINTELITHROMYCINCLARITHROMYCIN
Organisms Tested In: • Mycobacterium tuberculosis CCDC5180
Sequence Accession: CP002885.1
Protein Accession: AHJ55183.1
Notes: ARO:3000392

2

Molecular basis of intrinsic macrolide resistance in the Mycobacterium tuberculosis complex.

PMID 14693532 · 2004

Gene Information

Gene Name: erm(37)
Allele: Erm(37)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(37)
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: CLINDAMYCINAZITHROMYCINERYTHROMYCINTELITHROMYCINCLARITHROMYCIN
Organisms Tested In: • Mycobacterium tuberculosis CCDC5180
Sequence Accession: CP002885.1
Protein Accession: AHJ55183.1
Notes: ARO:3000392

3

Antimicrobial Resistance Mechanisms in Mycobacterium tuberculosis

PMID 23179675 · 2023

The paper discusses the molecular mechanisms of drug resistance in Mycobacterium tuberculosis, focusing on genes like pncA, rspA, erm37, tlyA, eis, BlaC, mfpA, IniBAC, EfP, and Tap, which are involved in resistance to pyrazinamide, macrolides, lincosamides, capreomycin, viomycin, kanamycin, β-lactams, fluoroquinolones, isoniazid, ethambutol, and multiple antibiotics.

Gene Information

Gene Name: erm(37)
Allele: erm37
Encodes: ribosomal RNA methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamide
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium bovis
Validation Method: genetic experiments and comparative genomics

4

Discovery of natural-product-derived sequanamycins as potent oral anti-tuberculosis agents.

PMID 36827973 · 2023

The study identifies the erm37 gene as a determinant of macrolide resistance in Mycobacterium tuberculosis, and demonstrates that sequanamycins can overcome this resistance.

Gene Information

Gene Name: erm(37)
Allele: erm37
Encodes: methyltransferase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: expression in Mtb and measurement of MIC

5

Genomics insights into a Mycobacterium pinnipedii isolate causing tuberculosis in a captive South American sea lion (Otaria flavescens) from Italy.

PMID 38188565 · 2023

The study identified intrinsic resistance genes erm-37 and aac(2')-Ic in a Mycobacterium pinnipedii isolate from a sea lion, conferring resistance to macrolides and aminoglycosides, respectively.

Gene Information

Gene Name: erm(37)
Allele: erm-37
Encodes: macrolide resistance
Source Database: Reslit
Mechanism: intrinsic resistance
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium pinnipedii
Geographic Location: Italy
Validation Method: whole-genome sequencing analysis
Sequence Accession: PRJEB66335

6

Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence.

PMID 9634230 · 1998

Gene Information

Gene Name: erm(37)
Allele: erm(37)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: TELITHROMYCINLINCOMYCINCLINDAMYCINERYTHROMYCIN
Organisms Tested In: • Mycobacterium tuberculosis H37Rv
Sequence Accession: AL123456
Notes: 23S rRNA methylase; Natural in Mycobacterium tubercolosis

7

Gene Information

Gene Name: erm(37)
Allele: Erm(37)
Encodes: Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Mycobacterium tuberculosis H37Rv
Sequence Accession: AL123456.1
Protein Accession: CCP44758.1
Notes: ARO:3000392