erm(39)
adenine rRNA methylase
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to erm(39)
AMR Rules
Browse AMR rules for erm(39)
Validation StatusCandidate
Overview
- Mechanism
- methylation of 23S rRNA at position A2058
- Validation Method
- genetic complementation and plasmid transfer
- Drug Classes
- macrolides, lincosamides
- Organisms
- Mycobacterium fortuitum, Mycobacterium smegmatis
- Papers
- 1
- Databases
- Reslit
Papers1
1
Molecular basis of intrinsic macrolide resistance in clinical isolates of Mycobacterium fortuitum.
The study identified erm(39) as the gene responsible for intrinsic macrolide resistance in Mycobacterium fortuitum, which confers resistance to macrolides and lincosamides through methylation of 23S rRNA.
Gene Information
- Gene Name
- erm(39)
- Allele
- Erm(39)
- Encodes
- adenine rRNA methylase
- Source Database
- Reslit
- Mechanism
- methylation of 23S rRNA at position A2058
- Confers Resistance To
- macrolideslincosamides
- Organisms Tested In
- • Mycobacterium fortuitum• Mycobacterium smegmatis
- Validation Method
- genetic complementation and plasmid transfer
- Sequence Accession
- AY487229
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