Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(40)

rRNA methylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(40)

Browse AMR rules for erm(40)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: PCR and sequencing
Drug Classes: Macrolide, CLINDAMYCIN, CLARITHROMYCIN, ERYTHROMYCIN, TELITHROMYCIN, LINCOMYCIN
Organisms: Mycobacterium mageritense, Mycolicibacterium mageritense
Alleles: 2
Papers: 1
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(40)	Card DatabaseReference Gene CatalogReslit	3	Macrolide, CLINDAMYCIN +2	Mycobacterium mageritense +1	-	2006	AY154657\|AY487229\|AY570506\|DQ144638\|DQ144639\|DQ144640\|AY570506\|DQ144641\|DQ144642\|DQ447745\|DQ144643\|DQ435604\|DQ435605

Papers1

1

Intrinsic macrolide resistance in rapidly growing mycobacteria.

PMID 17005837 · 2006

This study identifies erm genes in various rapidly growing mycobacteria species, demonstrating their role in intrinsic macrolide resistance.

Gene Information

Gene Name: erm(40)
Allele: Erm(40)
Encodes: rRNA methylase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium mageritense
Validation Method: PCR and sequencing
Sequence Accession: AY154657|AY487229|AY570506|DQ144638|DQ144639|DQ144640|AY570506|DQ144641|DQ144642|DQ447745|DQ144643|DQ435604|DQ435605

2

Intrinsic macrolide resistance in rapidly growing mycobacteria.

PMID 17005837 · 2006

Gene Information

Gene Name: erm(40)
Allele: Erm(40)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(40)
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: CLINDAMYCINCLARITHROMYCINERYTHROMYCIN
Organisms Tested In: • Mycolicibacterium mageritense
Sequence Accession: AY570506.1
Protein Accession: AAS76623.1
Notes: ARO:3004606

3

Intrinsic macrolide resistance in rapidly growing mycobacteria.

PMID 17005837 · 2006

Gene Information

Gene Name: erm(40)
Allele: Erm(40)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(40)
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: CLINDAMYCINCLARITHROMYCINERYTHROMYCIN
Organisms Tested In: • Mycolicibacterium mageritense
Sequence Accession: AY570506.1
Protein Accession: AAS76623.1
Notes: ARO:3004606

4

Intrinsic macrolide resistance in rapidly growing mycobacteria.

PMID 17005837 · 2006

Gene Information

Gene Name: erm(40)
Allele: erm(40)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: TELITHROMYCINLINCOMYCINCLINDAMYCINERYTHROMYCIN
Organisms Tested In: • Mycolicibacterium mageritense
Sequence Accession: AY570506
Notes: 23S rRNA methylase; Natural in different Mycobacterium sp.

5

Intrinsic macrolide resistance in rapidly growing mycobacteria.

PMID 17005837 · 2006

Gene Information

Gene Name: erm(40)
Allele: erm(40)
Encodes: Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Mycolicibacterium mageritense
Sequence Accession: AY570506.1
Protein Accession: AAS76623.1
Notes: ARO:3004606