Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
adenine rRNA methylase
Overview
A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae.
The study identifies a novel inducible macrolide resistance gene, erm(41), in Mycobacterium abscessus, which confers resistance to macrolides, ketolides, and lincosamides. The gene is absent in Mycobacterium chelonae and is nonfunctional in some susceptible isolates.
A novel gene, erm(41), confers inducible macrolide resistance to clinical isolates of Mycobacterium abscessus but is absent from Mycobacterium chelonae.
A Hierarchical In Silico Approach to Identify Potential Therapeutic Candidates in Mycobacterium abscessus ATCC 19977
The study identifies the erm(41) gene as a novel horizontally acquired gene that confers resistance to macrolide-based chemotherapy in Mycobacterium abscessus.
The First Korean Case of Nontuberculous Mycobacterial Lung Disease Caused by Mycobacterium abscessus Subspecies bolletii in a Patient with Bronchiectasis.
The study identifies the first Korean case of lung disease caused by Mycobacterium abscessus subsp. bolletii, which exhibits resistance to clarithromycin due to the presence of the erm(41) gene with a T28 sequevar.
Utility of sequencing the erm(41) gene in isolates of Mycobacterium abscessus subsp. abscessus with low and intermediate clarithromycin MICs.
Successful antibiotic treatment of pulmonary disease caused by Mycobacterium abscessus subsp. abscessus with C-to-T mutation at position 19 in erm(41) gene: case report.
A case of pulmonary disease caused by Mycobacterium abscessus subsp. abscessus with a C-to-T mutation at position 19 in the erm(41) gene was successfully treated with a macrolide-containing regimen. This mutation resulted in a non-functional erm(41) allele, leading to clarithromycin susceptibility.
Mycobacterium abscessus, an Emerging and Worrisome Pathogen among Cystic Fibrosis Patients.
The paper discusses various AMR genes and mutations in Mycobacterium abscessus, including erm(41) for macrolide resistance, aac(2')-Ib for aminoglycoside resistance, blaMab for beta-lactam resistance, mabTetX for tetracycline resistance, rrs and rpsL for aminoglycoside resistance, mmpL3 for capuramycin resistance, and whiB7 for regulating resistance to aminoglycosides and macrolides.
Dissecting erm(41)-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessus.
GenSeizer: a Multiplex PCR-Based Targeted Gene Sequencing Platform for Rapid and Accurate Identification of Major Mycobacterium Species.
The GenSeizer platform was developed to identify 10 major Mycobacterium species and detect resistance genotypes, including erm(41) and rrl, which are associated with macrolide resistance in M. abscessus.
A real-time PCR assay for rapid identification of inducible and acquired clarithromycin resistance in Mycobacterium abscessus.
The study developed a real-time PCR assay for detecting inducible and acquired clarithromycin resistance in Mycobacterium abscessus. It identified the erm(41) gene and mutations in the rrl gene as critical for resistance mechanisms.
A novel DNA chromatography method to discriminate Mycobacterium abscessus subspecies and macrolide susceptibility.
The study identifies the erm(41) T28C sequevar as a marker for macrolide susceptibility in Mycobacterium abscessus subspecies, developing a DNA chromatography method for rapid and accurate discrimination of subspecies and macrolide resistance.
Mycobacterium abscessus complex: A Review of Recent Developments in an Emerging Pathogen.
The paper reviews the molecular mechanisms of resistance in Mycobacterium abscessus complex (MABC), highlighting the roles of erm(41), rrs, Bla_Mab, and MabTetX genes in conferring resistance to macrolides, aminoglycosides, beta-lactams, and tetracyclines respectively.
Nationwide surveillance of antimicrobial susceptibility of 509 rapidly growing mycobacteria strains isolated from clinical specimens in Japan.
The study identified various AMR genes and mutations in rapidly growing mycobacteria, including erm(41), rrl, rrs, and gyrA, which are associated with resistance to macrolides, aminoglycosides, and fluoroquinolones. The T28C mutation in erm(41) was linked to loss of macrolide resistance, while mutations in rrl and gyrA were associated with acquired resistance to macrolides and fluoroquinolones, respectively.
RNA Sequencing Elucidates Drug-Specific Mechanisms of Antibiotic Tolerance and Resistance in Mycobacterium abscessus.
The study identifies several genes involved in antibiotic resistance in Mycobacterium abscessus, including erm(41) for macrolide resistance, WhiB7 for general resistance to ribosome-targeting antibiotics, sigH for tigecycline resistance, cydA for clofazimine tolerance, and various aminoglycoside-modifying enzymes like aac(2'), aph(3'), and eis2.
Detection of Mixed Populations of Clarithromycin-Susceptible and -Resistant Mycobacterium abscessus Strains.
The study developed two droplet digital PCR assays to detect full-length and truncated erm(41) genes and clarify the resistance mechanisms of Mycobacterium abscessus to clarithromycin, identifying mutations in the 23S rRNA gene at positions 2058 and 2059.
Drug susceptibility profiles and factors associated with non-tuberculous mycobacteria species circulating among patients diagnosed with pulmonary tuberculosis in Tanzania.
The study identified Mycobacterium avium complex (MAC) as the most prevalent NTM species and found that three Mycobacterium abscessus complex (MABC) isolates had a T28 mutation in the erm(41) gene, leading to macrolide resistance.
Molecular Epidemiological Characteristics of Mycobacterium abscessus Complex Derived from Non-Cystic Fibrosis Patients in Japan and Taiwan.
The study identified the erm(41) T28C mutation as a significant factor in macrolide susceptibility in Mycobacterium abscessus complex isolates from non-CF patients in Japan and Taiwan.
Mycobacterioses Induced by Mycobacterium abscessus: Case Studies Indicating the Importance of Molecular Analysis for the Identification of Antibiotic Resistance.
The study identifies the erm(41) gene as a key determinant of inducible macrolide resistance in Mycobacterium abscessus, with specific mutations affecting resistance profiles.
New RAPMYCOI Sensititre(TM) Antimicrobial Susceptibility Test for Atypical Rapidly Growing Mycobacteria (RGM).
The study identified the presence of the erm(41) gene associated with inducible macrolide resistance in M. abscessus subsp. abscessus and the MUT2 mutation in the rrl gene linked to constitutive resistance in M. abscessus subsp. massiliense.
Open-Label Trial of Amikacin Liposome Inhalation Suspension in Mycobacterium abscessus Lung Disease.
Molecular Identification of Strains within the Mycobacterium abscessus Complex and Determination of Resistance to Macrolides and Aminoglycosides.
The study identified erm(41)T28 gene mutations associated with macrolide resistance in Mycobacterium abscessus subsp. abscessus. Additionally, rrl and rrs gene mutations were found to confer resistance to macrolides and aminoglycosides respectively.
Prevalence and antimicrobial susceptibility pattern of Mycobacterium abscessus complex isolates in Chongqing, Southwest China.
The study identifies erm(41) and rrl gene mutations as markers for predicting macrolide susceptibility in Mycobacterium abscessus complex isolates, highlighting their role in acquired and inducible resistance mechanisms.
Cyclophostin and Cyclipostins analogues counteract macrolide-induced resistance mediated by erm(41) in Mycobacterium abscessus.
The study identifies erm(41) as a target for CyC analogues, which can counteract macrolide resistance in Mycobacterium abscessus by inhibiting the Erm(41) methyltransferase.
Population genetic analysis of clinical Mycobacterium abscessus complex strains in China.
The study identifies several AMR genes and mutations in M. abscessus complex strains in China, including mtrA, RbpA, bla MAB, erm(41), and erm(46) for resistance to various antibiotics, as well as mutations in rrs, rrl, and gyrA contributing to aminoglycoside, macrolide, and fluoroquinolone resistance.
Antimicrobial resistance of rapidly growing mycobacteria isolated from companion animals in Taiwan.
The study identified the presence of erm(41) and erm genes in Mycobacterium abscessus complex and Mycobacterium fortuitum complex isolates, respectively, which confer inducible macrolide resistance. The detection of these genes was strongly correlated with clarithromycin resistance.
Evaluation of the In Vitro Activity of Bedaquiline, Delamanid, and Clofazimine Against Mycobacterium abscessus Complex and Their Antibiofilm Potential.
The study identified mutations in the erm(41), rrl, and rrs genes associated with macrolide and aminoglycoside resistance in Mycobacterium abscessus complex isolates. Bedaquiline showed potent activity against all isolates, while delamanid and clofazimine had limited efficacy.
Global trends in the proportion of macrolide-resistant Mycobacterium Species: A systematic review and meta-analysis.
This study highlights the increasing global prevalence of macrolide resistance in Mycobacterium species, with significant variations observed across different countries, continents, and species.
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