Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(42)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(42) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 24 | CLINDAMYCIN, ERYTHROMYCIN +11 |
| United States, United States|France, North America, Alberta|North America, Egypt, China, Hong Kong SAR, Thailand, Brazilian Amazon, Taiwan, Saudi Arabia, Southeastern U.S., Europe, Shenzhen, China |
| 2011, 2012, 2016, 2020, 2021, 2022, 2023, 2024, 2025 |
| AB601890.1 |
| CBY77552.1 |
| erm(42) | ResFinder Database | 1 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Pasteurella multocida, Photobacterium damselae subsp. piscicida | - | 2011 | FR734406, AB601890 | - |
| erm42 | Reslit | 5 | Erythromycin, Clindamycin +5 | Mannheimia haemolytica +4 | Texas|Nebraska|Alberta|France|Alberta, Canada|Nebraska, Texas, USA|Nantes, France, California|Midwest|Germany|China, North America|Asia|Europe|Australia|South America, China, California | 2016, 2017, 2021, 2022, 2024 | LFXX00000000|LFXY00000000|LFYD00000000|LFYB00000000|LFXW00000000|LFXZ00000000|LFYC00000000|LFYA00000000|LFXV00000000|AOGP00000000|LFYE00000000|CP005383|NC_021082 | - |
| erm ( 42 ) | Reslit | 1 | Macrolide, Lincosamide +1 | Escherichia coli | Malaysia | 2024 | SRR29155955|SRR29155950|SRR29155917 | - |
A novel Erm monomethyltransferase in antibiotic-resistant isolates of Mannheimia haemolytica and Pasteurella multocida.
Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.
The study identifies three new resistance genes, erm(42), msr(E), and mph(E), responsible for macrolide, triamilide, and lincosamide resistance in Pasteurella multocida. These genes were experimentally validated through cloning and antimicrobial susceptibility testing.
Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.
Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.
Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.
Molecular basis of macrolide, triamilide, and lincosamide resistance in Pasteurella multocida from bovine respiratory disease.
Combinations of macrolide resistance determinants in field isolates of Mannheimia haemolytica and Pasteurella multocida.
The study identifies three macrolide resistance determinants, erm(42), msr(E), and mph(E), in field isolates of Mannheimia haemolytica and Pasteurella multocida. These genes confer resistance to macrolides, lincosamides, and streptogramin B, with erm(42) mediating resistance through 23S rRNA methylation, msr(E) through efflux, and mph(E) through phosphorylation.
Multiplex PCR to identify macrolide resistance determinants in Mannheimia haemolytica and Pasteurella multocida.
The study developed a multiplex PCR assay to detect and differentiate macrolide resistance genes erm(42), msr(E), and mph(E) in Mannheimia haemolytica and Pasteurella multocida. These genes confer resistance to macrolides, lincosamides, and streptogramin B through various mechanisms including methylation, efflux, and phosphorylation.
Comparative Genomic Analysis of Mannheimia haemolytica from Bovine Sources.
The study identified a bla ROB-1 gene in an integrative conjugative element (ICE) of M. haemolytica, which had a single nucleotide substitution leading to a non-functional gene and sensitivity to ampicillin.
Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes.
The study identifies multiple antibiotic resistance genes in Mannheimia haemolytica, particularly in genotype 2, subtype 2b isolates, which are associated with the lungs of cattle with respiratory disease and contain various combinations of resistance genes.
Whole-Genome Sequencing and Concordance Between Antimicrobial Susceptibility Genotypes and Phenotypes of Bacterial Isolates Associated with Bovine Respiratory Disease.
The study identified several antimicrobial resistance genes in bacterial isolates associated with bovine respiratory disease, including ermF, dfrA14, tetH, sul2, floR, aph3-Ia, ROB-1, and cat2. These genes conferred resistance to various antibiotics such as macrolides, tetracyclines, sulfonamides, phenicols, aminoglycosides, and beta-lactams.
Antimicrobial Resistance in Members of the Bacterial Bovine Respiratory Disease Complex Isolated from Lung Tissue of Cattle Mortalities Managed with or without the Use of Antimicrobials.
The study identified several AMR genes, including aadA31, bla ROB-1, floR, mph(E), msr(E), and tet(H), in bovine respiratory disease organisms, highlighting the impact of antimicrobial use on AMR development.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Virulence Determinants and Antimicrobial Profiles of Pasteurella multocida Isolated from Cattle and Humans in Egypt.
The study identified multiple antimicrobial resistance genes in Pasteurella multocida isolates from cattle and humans in Egypt, including erm(Q), erm(42), mph(E), msr(E), intl1, intl2, blaCTX-M, blaCTX-M-1, and blaTEM, which confer resistance to various antibiotics such as erythromycin, azithromycin, cefotaxime, and ampicillin.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Characterization of Carbapenem-Resistant Enterobacteriaceae Cultured From Retail Meat Products, Patients, and Porcine Excrement in China.
The study identified bla NDM-5, bla KPC-2, and mcr-1 as key resistance genes in carbapenem-resistant Enterobacteriaceae isolated from retail meat products, patients, and porcine excrement in China.
Genetic Characterization of a Conjugative Plasmid That Encodes Azithromycin Resistance in Enterobacteriaceae.
The study identifies a conjugative plasmid carrying three macrolide resistance genes: erm(B), a novel erm(42) gene, and mph(A), which confer resistance to azithromycin in Enterobacteriaceae.
Genetic Characterization of Four Groups of Chromosome-Borne Accessory Genetic Elements Carrying Drug Resistance Genes in Providencia.
This study characterizes four groups of chromosome-borne accessory genetic elements (AGEs) in Providencia, highlighting the diversity and complexity of multidrug resistance (MDR) regions within these elements. It identifies numerous drug resistance genes, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others, contributing to the understanding of AMR mechanisms in Providencia.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Genomic Analysis of Klebsiella pneumoniae ST258 Strain Coproducing KPC-2 and CTX-M-14 Isolated from Poultry in the Brazilian Amazon Region.
The study characterizes a multidrug-resistant Klebsiella pneumoniae ST258 strain (KP411) isolated from poultry in the Brazilian Amazon, which carries several AMR genes including blaKPC-2, blaCTX-M-14, and others, highlighting the potential of food-producing animals as reservoirs of MDR clones.
Antimicrobial Resistance and Mechanisms of Azithromycin Resistance in Nontyphoidal Salmonella Isolates in Taiwan, 2017 to 2018.
The study identifies mph(A), erm(42), erm(B), and ramAp as the primary mechanisms of azithromycin resistance in non-typhoidal Salmonella isolates from Taiwan.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Genomic analysis of azithromycin-resistant Salmonella from food animals at slaughter and processing, and retail meats, 2011-2021, United States.
Tulathromycin metaphylaxis increases nasopharyngeal isolation of multidrug resistant Mannheimia haemolytica in stocker heifers.
The study found that tulathromycin metaphylaxis increased the isolation of multidrug-resistant (MDR) Mannheimia haemolytica (MH) in stocker heifers. MDR MH isolates were associated with integrative conjugative elements (ICE) carrying antimicrobial resistance genes.
Antimicrobial Resistance Genes in Respiratory Bacteria from Weaned Dairy Heifers.
The study identified 26 AMR genes in respiratory bacteria from weaned dairy heifers, with high prevalence of tetracycline, aminoglycoside, sulfonamide, beta-lactam, phenicol, and macrolide resistance genes.
Azithromycin resistance in Escherichia coli and Salmonella from food-producing animals and meat in Europe.
The study identified several macrolide resistance genes, including mph(A), mph(B), mef(B), erm(B), mef(C)-mph(G), erm(C), erm(42), ere(A), and msr(E)-mph(E), associated with azithromycin resistance in E. coli and Salmonella from food-producing animals and meat in Europe. The study also highlighted the importance of the mph(A) operon structure and its regulatory region in determining azithromycin resistance.
Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.
Plasmid-Mediated Co-Occurrence of mcr-1.1 in Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli Isolated From the Indigenous Seminomadic Community in Malaysia.
The study identifies the presence of mcr-1.1, bla TEM, bla CTX-M−15, bla CTX-M−55, and other resistance genes in ESBL-producing E. coli isolates from the Jehai community in Malaysia, highlighting the co-occurrence of multiple antibiotic resistance mechanisms.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
A multi-isolate genomic approach identifies diverse Escherichia coli contamination and antimicrobial resistance carriage on retail foods.
The study identified various AMR genes in E. coli isolates from retail foods, including beta-lactamases (blaCMY-2, blaCTX-M-27, blaCTX-M-55) and the macrolide resistance gene erm(42).
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