Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
macrolide-lincosamide-streptogramin B rRNA methylase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(43) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | Erythromycin, Clindamycin +11 |
| Switzerland|Turkey, South Africa|Nigeria, North America|Europe|International Space Station |
| 2012, 2021, 2022 |
| HE650138|HE775264|HE775265 |
| CCF55073.1 |
| erm(43) | ResFinder Database | 1 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Mammaliicoccus lentus | - | 2012 | HE650138 | - |
| erm43 | Reslit | 1 | Erythromycin | Microbacterium yannicii | France | 2013 | FN547412|CAJF01000001-CAJF01000067 | - |
New MLSB resistance gene erm(43) in Staphylococcus lentus.
The study identifies a new MLSB resistance gene, erm(43), in Staphylococcus lentus, which confers resistance to erythromycin, clindamycin, and pristinamycin IA through rRNA methylation.
New MLSB resistance gene erm(43) in Staphylococcus lentus.
New MLSB resistance gene erm(43) in Staphylococcus lentus.
New MLSB resistance gene erm(43) in Staphylococcus lentus.
New MLSB resistance gene erm(43) in Staphylococcus lentus.
Phenotypic and genotypic properties of Microbacterium yannicii, a recently described multidrug resistant bacterium isolated from a lung transplanted patient with cystic fibrosis in France.
The study identifies a new erm43 gene encoding a 23S rRNA N-6-methyltransferase responsible for erythromycin resistance in Microbacterium yannicii. Additionally, mutations in gyrA (S83A) and parC (S80A) contribute to fluoroquinolone resistance, while ampC, aph51, and dhps genes are associated with beta-lactam, aminoglycoside, and sulfamethoxazole-trimethoprim resistance, respectively.
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity.
The study identified several AMR genes in coagulase-negative staphylococci isolates from South Africa and Nigeria, highlighting environmentally driven heterogeneity. Notably, the tetM gene was found in South African isolates but not in Nigerian ones, while cadmium resistance genes were present in Nigerian isolates. Other genes like blaZ, FosB, mecA, FusF, dfrG, ErmA, ErmB, Erm(43), and mphC were also characterized.
Extensive Horizontal Gene Transfer within and between Species of Coagulase-Negative Staphylococcus.
The study identifies various antimicrobial resistance genes in CoNS species, including mecA, norA, vatB, vgaB, lsaB, erm(43), ermT, fusD, fusF, and salA, which confer resistance to beta-lactams, fluoroquinolones, lincosamides, macrolides, streptogramins, fusidic acid, and other antimicrobial agents. These genes are associated with horizontal gene transfer and recombination, highlighting the dynamic nature of CoNS evolution.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
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