Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(44)

23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(44)

Browse AMR rules for erm(44)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: cloning in Staphylococcus aureus and MIC testing
Drug Classes: QUINUPRISTIN, PRISTINAMYCIN IA, CLINDAMYCIN, LINCOMYCIN, ERYTHROMYCIN, VIRGINIAMYCIN S, PRISTINAMYCIN, Macrolide, Lincosamide, Streptogramin b, Erythromycin, Azithromycin
Organisms: Staphylococcus xylosus, Staphylococcus aureus, Bacteroides ovatus ELH-B2, Mycobacteroides abscessus complex, Mammaliicoccus sciuri
Geographic Location: Swiss Canton Tessin|various herds|Switzerland
Alleles: 2
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
erm(44)	ResFinder Database	1	QUINUPRISTIN, PRISTINAMYCIN IA +4	Staphylococcus xylosus	-	2014	HG796218	-
Erm(44)	Card Database

Papers4

1

The novel macrolide-Lincosamide-Streptogramin B resistance gene erm(44) is associated with a prophage in Staphylococcus xylosus.

PMID 25092709 · 2014

Gene Information

Gene Name: erm(44)
Allele: erm(44)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Staphylococcus xylosus
Sequence Accession: HG796218
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

2

The novel macrolide-Lincosamide-Streptogramin B resistance gene erm(44) is associated with a prophage in Staphylococcus xylosus.

PMID 25092709 · 2014

Gene Information

Gene Name: erm(44)
Allele: Erm(44)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Staphylococcus xylosus
Sequence Accession: HG796218.2
Protein Accession: CDL65151.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

3

The novel macrolide-Lincosamide-Streptogramin B resistance gene erm(44) is associated with a prophage in Staphylococcus xylosus.

PMID 25092709 · 2014

Gene Information

Gene Name: erm(44)
Allele: Erm(44)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)
Source Database: Card Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Staphylococcus xylosus
Sequence Accession: HG796218.2
Protein Accession: CDL65151.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

4

The novel macrolide-Lincosamide-Streptogramin B resistance gene erm(44) is associated with a prophage in Staphylococcus xylosus.

PMID 25092709 · 2014

The study identifies a novel macrolide-lincosamide-streptogramin B resistance gene, erm(44), associated with a prophage in Staphylococcus xylosus. The gene was experimentally validated to confer resistance to macrolide, lincosamide, and streptogramin B antibiotics.

Gene Information

Gene Name: erm(44)
Allele: Erm(44)
Encodes: erythromycin ribosome methylase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Staphylococcus xylosus
• Staphylococcus aureus
Validation Method: cloning in Staphylococcus aureus and MIC testing
Sequence Accession: HG796218|LK392593

5

The novel macrolide-Lincosamide-Streptogramin B resistance gene erm(44) is associated with a prophage in Staphylococcus xylosus.

PMID 25092709 · 2014

Gene Information

Gene Name: erm(44)
Allele: Erm(44)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Staphylococcus xylosus
Sequence Accession: HG796218.2
Protein Accession: CDL65151.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

6

Pilot Safety Evaluation of a Novel Strain of Bacteroides ovatus.

PMID 30459813 · 2018

The study identified several antibiotic resistance genes in Bacteroides ovatus ELH-B2, including those conferring resistance to tetracycline, erythromycin, aminoglycosides, macrolides, and other antibiotics. These genes were validated through minimum inhibitory concentration (MIC) tests.

Gene Information

Gene Name: erm(44)
Allele: Erm(44)
Encodes: Resistance to lincosamide and macrolide antibiotics
Source Database: Reslit
Mechanism: methylation
Confers Resistance To: LincosamideMacrolide
Organisms Tested In: • Bacteroides ovatus ELH-B2
Validation Method: minimum inhibitory concentration (MIC) test
Sequence Accession: NZ_CP012938

7

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: erm(44)
Allele: Erm(44)
Encodes: 23S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Mycobacteroides abscessus complex
Validation Method: frequently detected in all subspecies

8

Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.

PMID 37583512 · 2023

The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.

Gene Information

Gene Name: erm(44)
Allele: Erm(44)
Encodes: erythromycin ribosome methyltransferase
Source Database: Reslit
Confers Resistance To: ErythromycinAzithromycin
Organisms Tested In: • Staphylococcus xylosus
• Mammaliicoccus sciuri
Geographic Location: Swiss Canton Tessin|various herds|Switzerland
Validation Method: whole genome sequencing and phenotypic analysis
Sequence Accession: PRJNA936091|PRJNA859642