Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(44)v

23S rRNA methylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(44)v

Browse AMR rules for erm(44)v

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: cloning in S. aureus + MIC testing
Drug Classes: LINCOMYCIN, AZITHROMYCIN, CLINDAMYCIN, ERYTHROMYCIN, Macrolide, Lincosamide, Streptogramin b, Streptogramin, Erythromycin, Clindamycin
Organisms: Staphylococcus saprophyticus, Staphylococcus aureus, Staphylococcus carnosus, Staphylococcus pseudoxylosus, Staphylococcus xylosus
Geographic Location: Europe, North America|South America|Europe|Asia|Africa, Portugal|Spain|Denmark
Alleles: 3
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
erm(44)v	ResFinder Database	1	LINCOMYCIN, AZITHROMYCIN +2	Staphylococcus saprophyticus	-	2017	LN623525	-
Erm(44)v	Card Database

Papers4

1

A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.

PMID 27799208 · 2017

Gene Information

Gene Name: erm(44)v
Allele: erm(44)v
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: LINCOMYCINAZITHROMYCINCLINDAMYCINERYTHROMYCIN
Organisms Tested In: • Staphylococcus saprophyticus
Sequence Accession: LN623525
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

2

A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.

PMID 27799208 · 2017

A novel erm(44)v gene variant was identified in a human Staphylococcus saprophyticus isolate, which confers resistance to macrolides and lincosamides but not to streptogramin B when expressed in S. aureus.

Gene Information

Gene Name: erm(44)v
Allele: Erm(44)v
Encodes: 23S rRNA methylase
Source Database: Reslit
Mechanism: methylation of 23S rRNA at position A2058
Confers Resistance To: MacrolideLincosamide
Organisms Tested In: • Staphylococcus aureus
• Staphylococcus saprophyticus
Validation Method: cloning in S. aureus + MIC testing
Sequence Accession: LN623525

3

A Novel erm(44) Gene Variant from a Human Staphylococcus saprophyticus Isolate Confers Resistance to Macrolides and Lincosamides but Not Streptogramins.

PMID 27799208 · 2017

Gene Information

Gene Name: erm(44)v
Allele: Erm(44)v
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(44)v
Source Database: Reference Gene Catalog
Confers Resistance To: CLINDAMYCINERYTHROMYCIN
Organisms Tested In: • Staphylococcus saprophyticus
Sequence Accession: LN623525.1

4

Foodborne Origin and Local and Global Spread of Staphylococcus saprophyticus Causing Human Urinary Tract Infections.

PMID 33622483 · 2021

The study identified antimicrobial resistance genes qacA, dfrG, and qacC in Staphylococcus saprophyticus isolates, highlighting their role in resistance to quaternary ammonium compounds, trimethoprim, and biocides respectively.

Gene Information

Gene Name: erm(44)v
Allele: erm44v
Encodes: erythromycin ribosome methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideStreptogramin b
Organisms Tested In: • Staphylococcus saprophyticus
Geographic Location: Portugal|Spain|Denmark
Validation Method: SNP-based phylogenetic analysis and antimicrobial resistance profiling
Sequence Accession: PRJNA604222

5

Antimicrobial resistance determinants in silage.

PMID 35347213 · 2022

The study identified 16 antimicrobial resistance genes (ARGs) in silage samples, highlighting their potential to spread through the food chain and contribute to antimicrobial resistance.

Gene Information

Gene Name: erm(44)v
Allele: Erm(44)v
Encodes: macrolide 2'-O-phosphotransferase
Source Database: Reslit
Confers Resistance To: LincosamideMacrolideStreptogramin
Organisms Tested In: • Staphylococcus carnosus
• Staphylococcus pseudoxylosus
• Staphylococcus saprophyticus
Geographic Location: Europe
Validation Method: metagenomic analysis

6

Comparative genomics reveals the correlations of stress response genes and bacteriophages in developing antibiotic resistance of Staphylococcus saprophyticus.

PMID 38051037 · 2023

The study identifies several AMR genes in Staphylococcus saprophyticus, including mecA, blaZ, erm, erm(44)v, msr(A), and mph(C), which confer resistance to beta-lactams, macrolides, and lincosamides. The presence of these genes is associated with varying levels of resistance, and some genes, like mecA, are useful markers for predicting resistance to specific antibiotics.

Gene Information

Gene Name: erm(44)v
Allele: Erm(44)v
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase
Source Database: Reslit
Mechanism: Methylates the 23S rRNA, preventing binding of macrolides, lincosamides, and streptogramin B
Confers Resistance To: ErythromycinClindamycin
Organisms Tested In: • Staphylococcus saprophyticus
Geographic Location: North America|South America|Europe|Asia|Africa
Validation Method: Disk diffusion assays

7

Gene Information

Gene Name: erm(44)v
Allele: Erm(44)v
Encodes: Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Staphylococcus xylosus
Sequence Accession: HG796218.2
Protein Accession: CDL65151.1
Notes: ARO:3003971