Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(45)

23S rRNA methylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(45)

Browse AMR rules for erm(45)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: cloning in Staphylococcus aureus + MIC testing
Drug Classes: Erythromycin, Clindamycin, QUINUPRISTIN, PRISTINAMYCIN, PRISTINAMYCIN IA, CLINDAMYCIN, LINCOMYCIN, ERYTHROMYCIN, VIRGINIAMYCIN S, Macrolide, Lincosamide, Streptogramin b
Organisms: Staphylococcus fleurettii, Staphylococcus aureus, Mammaliicoccus fleurettii, Stenotrophomonas maltophilia, Mycobacteroides abscessus complex, Streptococcus equi subsp. equi, Staphylococcus epidermidis, Staphylococcus saprophyticus, Staphylococcus haemolyticus, Staphylococcus sciuri, Staphylococcus hominis, Staphylococcus arlettae, Staphylococcus pasteuri, Staphylococcus hyicus, Staphylococcus simulans
Geographic Location: China, Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy
Alleles: 3
Papers: 5
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(45)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	7	Erythromycin, Clindamycin +10

Papers5

1

The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.

PMID 25779586 · 2015

The study identifies a novel macrolide-lincosamide-streptogramin B resistance gene, erm(45), located within a genomic island in Staphylococcus fleurettii. The gene was shown to confer inducible resistance to erythromycin, clindamycin, and pristinamycin IA when cloned into Staphylococcus aureus.

Gene Information

Gene Name: erm(45)
Allele: Erm(45)
Encodes: 23S rRNA methylase
Source Database: Reslit
Confers Resistance To: ErythromycinClindamycin
Organisms Tested In: • Staphylococcus fleurettii
• Staphylococcus aureus
Validation Method: cloning in Staphylococcus aureus + MIC testing
Sequence Accession: LN680996

2

The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.

PMID 25779586 · 2015

Gene Information

Gene Name: erm(45)
Allele: Erm(45)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(45)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Mammaliicoccus fleurettii
Sequence Accession: LN680996.1
Protein Accession: CEJ95855.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

3

The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.

PMID 25779586 · 2015

Gene Information

Gene Name: erm(45)
Allele: Erm(45)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(45)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Mammaliicoccus fleurettii
Sequence Accession: LN680996.1
Protein Accession: CEJ95855.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

4

The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.

PMID 25779586 · 2015

Gene Information

Gene Name: erm(45)
Allele: Erm(45)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(45)
Source Database: Card Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Mammaliicoccus fleurettii
Sequence Accession: LN680996.1
Protein Accession: CEJ95855.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

5

The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.

PMID 25779586 · 2015

Gene Information

Gene Name: erm(45)
Allele: erm(45)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Mammaliicoccus fleurettii
Sequence Accession: LN680996
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

6

Characterization of Novel Broad-Host-Range Bacteriophage DLP3 Specific to Stenotrophomonas maltophilia as a Potential Therapeutic Agent.

PMID 32670234 · 2020

The study characterizes the novel bacteriophage DLP3, which exhibits broad host range and encodes an erythromycin resistance protein, leading to lysogenic conversion of the host strain D1571.

Gene Information

Gene Name: erm(45)
Allele: Erm(45)
Encodes: methyltransferase
Source Database: Reslit
Mechanism: methylation of the erythromycin target-site on the ribosome
Confers Resistance To: Erythromycin
Organisms Tested In: • Stenotrophomonas maltophilia
Validation Method: minimum inhibitory concentration (MIC) assays
Sequence Accession: MT110073

7

The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.

PMID 36261788 · 2022

The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.

Gene Information

Gene Name: erm(45)
Allele: Erm(45)
Encodes: 23S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Mycobacteroides abscessus complex
Validation Method: frequently detected in all subspecies

8

Complete genome sequencing and comparative genomic analysis of three donkey Streptococcus equi subsp. equi isolates.

PMID 38029076 · 2023

The study identified multiple antibiotic resistance genes in three donkey-derived Streptococcus equi subsp. equi isolates, including genes conferring resistance to beta-lactams, tetracyclines, macrolides, fluoroquinolones, and others. Notably, the HT1112 isolate showed resistance to six antimicrobials, while HTP133 and HTP232 showed resistance to fewer drugs. Additionally, the study highlighted the role of biofilm formation in antimicrobial resistance.

Gene Information

Gene Name: erm(45)
Allele: Erm(45)
Encodes: 23S rRNA methyltransferase
Source Database: Reslit
Mechanism: macrolide, lincosamide, streptogramin resistance
Confers Resistance To: ErythromycinClindamycin
Organisms Tested In: • Streptococcus equi subsp. equi
Geographic Location: China
Validation Method: antimicrobial susceptibility testing
Sequence Accession: CP133957|CP133955|CP133956

9

Antimicrobial Resistance in Coagulase-Negative Staphylococci: Resistome, Mobiloome, and Relatedness

PMID 39287832 · 2023

The study identifies multiple AMR genes and mutations in CoNS isolates from various hosts, highlighting the spread of multidrug resistance and the role of mobile genetic elements in the dissemination of resistance traits.

Gene Information

Gene Name: erm(45)
Allele: erm45
Encodes: erythromycin ribosome methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Staphylococcus aureus
• Staphylococcus epidermidis
• Staphylococcus saprophyticus
• Staphylococcus haemolyticus
• Staphylococcus sciuri
• Staphylococcus hominis
• Staphylococcus arlettae
• Staphylococcus pasteuri
• Staphylococcus hyicus
• Staphylococcus simulans
Geographic Location: Spain|Portugal|Germany|UK|Switzerland|Thailand|Italy
Validation Method: PCR and sequencing
Sequence Accession: JQ246438.1|AM159501.1|FM207105|KR230047.1|NC_029025|NC_018281|NC_007054|NC_022914|NC_020490|NC_019915|NC_019914|NC_028862|NC_018284|NC_007056|NC_007055

10

Gene Information

Gene Name: erm(45)
Allele: erm(45)
Encodes: Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Mammaliicoccus fleurettii
Sequence Accession: LN680996.1
Protein Accession: CEJ95855.1
Notes: ARO:3004595