Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(46)
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(46) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 13 | STREPTOGRAMIN B, QUINUPRISTIN +12 |
| United States, United States|Kentucky, Europe|North America, US, China |
| 2015, 2019, 2020, 2021, 2022, 2023, 2024 |
| KM679362.1 |
| AJF36617.1 |
| erm(46) | Card DatabaseResFinder Database | 2 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Prescottella equi | - | 2015 | KM679362 | AJF36617.1 |
The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.
The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.
The new macrolide-lincosamide-streptogramin B resistance gene erm(45) is located within a genomic island in Staphylococcus fleurettii.
Novel transferable erm(46) determinant responsible for emerging macrolide resistance in Rhodococcus equi.
Effect of Macrolide and Rifampin Resistance on Fitness of Rhodococcus equi during Intramacrophage Replication and In Vivo.
The study identifies erm(46) as a gene conferring macrolide resistance and a double rpoB mutation at amino acid position 531 as a mutation conferring rifampin resistance in Rhodococcus equi.
Clonal Confinement of a Highly Mobile Resistance Element Driven by Combination Therapy in Rhodococcus equi.
The study identifies the erm(46) gene as a novel macrolide resistance determinant in Rhodococcus equi, which is part of a highly mobile transposable element, Tn RErm46, carried on a conjugative plasmid pRErm46. Additionally, a rpoB S531F mutation was found to confer rifampin resistance.
A Common Practice of Widespread Antimicrobial Use in Horse Production Promotes Multi-Drug Resistance.
The study shows that the use of macrolides and rifampin (MaR) in foals promotes multi-drug resistance by increasing the abundance and diversity of antimicrobial resistance genes in the fecal microbiome, particularly for macrolides, aminoglycosides, glycopeptides, phenicols, tetracycline, and bacitracin.
Horizontal Spread of Rhodococcus equi Macrolide Resistance Plasmid pRErm46 across Environmental Actinobacteria.
The study identifies the erm(46) gene on the plasmid pRErm46 as responsible for macrolide, lincosamide, and streptogramin B resistance in Rhodococcus equi and demonstrates its horizontal transfer to various environmental Actinobacteria.
Antimicrobial Resistance Spectrum Conferred by pRErm46 of Emerging Macrolide (Multidrug)-Resistant Rhodococcus equi.
The study characterizes the antimicrobial resistance spectrum conferred by the pRErm46 plasmid in multidrug-resistant Rhodococcus equi, identifying genes erm(46), sul1, aadA9, and tetRA(33) that confer resistance to macrolides, lincosamides, streptogramin B, sulfonamides, streptomycin, spectinomycin, and tetracycline. Additionally, rpoB mutations (Ser531Phe, Ser531Leu, Ser531Tyr) were found to confer resistance to rifampin.
Assessment of listing and categorisation of animal diseases within the framework of the Animal Health Law (Regulation (EU) No 2016/429): antimicrobial-resistant Rhodococcus equi in horses.
The paper discusses the antimicrobial resistance of Rhodococcus equi in horses, highlighting the resistance mechanisms including the erm(46) gene for macrolide resistance and mutations in the rpoB gene for rifampicin resistance.
Novel Quantitative PCR for Rhodococcus equi and Macrolide Resistance Detection in Equine Respiratory Samples.
The study presents a novel multiplex qPCR assay for the rapid detection of Rhodococcus equi and its macrolide resistance genes, erm(46) and erm(51), in equine respiratory samples.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Exploring the Accessory Genome of Multidrug-Resistant Rhodococcus equi Clone 2287.
The study identifies the aac(3)IV apramycin resistance cassette, the erm(46) macrolide resistance gene, and the rpoB S531F rifampin resistance mutation in the MDR R. equi clone 2287, highlighting their roles in antimicrobial resistance.
Population genetic analysis of clinical Mycobacterium abscessus complex strains in China.
The study identifies several AMR genes and mutations in M. abscessus complex strains in China, including mtrA, RbpA, bla MAB, erm(41), and erm(46) for resistance to various antibiotics, as well as mutations in rrs, rrl, and gyrA contributing to aminoglycoside, macrolide, and fluoroquinolone resistance.
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