Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(47)

23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(47)

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(47)

Browse AMR rules for erm(47)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: whole genome sequencing
Drug Classes: STREPTOGRAMIN, QUINUPRISTIN, PRISTINAMYCIN IA, CLINDAMYCIN, LINCOMYCIN, AZITHROMYCIN, ERYTHROMYCIN, VIRGINIAMYCIN S, Macrolide, Lincosamide, Streptogramin b, Erythromycin
Organisms: Helcococcus kunzii, Pseudomonas spp., Streptococcus suis, Erysipelothrix rhusiopathiae
Geographic Location: China, Italy, Poland
Alleles: 3
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(47)	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	5	STREPTOGRAMIN, QUINUPRISTIN +10	Helcococcus kunzii +2

Papers4

1

Novel chromosome-encoded erm(47) determinant responsible for constitutive MLSB resistance in Helcococcus kunzii.

PMID 27494920 · 2016

Gene Information

Gene Name: erm(47)
Allele: Erm(47)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(47)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: STREPTOGRAMINQUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINAZITHROMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Helcococcus kunzii
Sequence Accession: KU612222.1
Protein Accession: ANZ79476.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

2

Novel chromosome-encoded erm(47) determinant responsible for constitutive MLSB resistance in Helcococcus kunzii.

PMID 27494920 · 2016

Gene Information

Gene Name: erm(47)
Allele: Erm(47)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(47)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: STREPTOGRAMINQUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINAZITHROMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Helcococcus kunzii
Sequence Accession: KU612222.1
Protein Accession: ANZ79476.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

3

Novel chromosome-encoded erm(47) determinant responsible for constitutive MLSB resistance in Helcococcus kunzii.

PMID 27494920 · 2016

Gene Information

Gene Name: erm(47)
Allele: Erm(47)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(47), Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: Target modification, antibiotic target alteration
Confers Resistance To: STREPTOGRAMINQUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINAZITHROMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Helcococcus kunzii
Sequence Accession: KU612222.1
Protein Accession: ANZ79476.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary, ARO:3003908

4

Novel chromosome-encoded erm(47) determinant responsible for constitutive MLSB resistance in Helcococcus kunzii.

PMID 27494920 · 2016

Gene Information

Gene Name: erm(47)
Allele: erm(47)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Helcococcus kunzii
Sequence Accession: KU612222
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

5

Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.

PMID 32655503 · 2020

The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.

Gene Information

Gene Name: erm(47)
Allele: Erm(47)
Encodes: erythromycin ribosome methyltransferase
Source Database: Reslit
Mechanism: methylates ribosomes
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Pseudomonas spp.
Geographic Location: China
Validation Method: whole genome sequencing
Sequence Accession: PRJNA523883|PRJNA523885|PRJNA593738

6

New Sequence Types and Antimicrobial Drug-Resistant Strains of Streptococcus suis in Diseased Pigs, Italy, 2017-2019.

PMID 34932464 · 2022

The study identified several AMR genes in Streptococcus suis isolates from diseased pigs in Italy, including ermb, tet(O), aac6-aph2, ant6-ia, aph3-iiia, spw, tet(40), tet(W), tet(O/W/32/O), tet(W/N/N), erm(47), lnuB, lsaE, and optrA, which confer resistance to various antibiotics such as erythromycin, tetracycline, gentamicin, lincomycin, and linezolid.

Gene Information

Gene Name: erm(47)
Allele: Erm(47)
Encodes: erythromycin ribosome methylase
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Streptococcus suis
Geographic Location: Italy
Validation Method: whole-genome sequencing and antimicrobial susceptibility testing
Sequence Accession: SAMN18490763|SAMN18490764|SAMN18490765|SAMN18490766|SAMN18490767|SAMN18490768|SAMN18490769|SAMN18490770|SAMN18490771|SAMN18490772|SAMN18490773|SAMN18490774|SAMN18490775|SAMN18490776|SAMN18490777|SAMN18490778|SAMN18490779|SAMN18490780|SAMN18490781|SAMN18490782|SAMN18490783|SAMN18490784|SAMN18490785|SAMN18490786|SAMN18490787|SAMN18490788|SAMN18490789|SAMN18490790

7

Integrative and Conjugative Elements and Prophage DNA as Carriers of Resistance Genes in Erysipelothrix rhusiopathiae Strains from Domestic Geese in Poland.

PMID 38731857 · 2024

The study identifies the presence of resistance genes erm47 and ermB in Erysipelothrix rhusiopathiae strains from domestic geese in Poland, along with other resistance genes such as tetM, lnuB, lsaE, ant(6)-Ia, and spw. It also highlights the role of integrative and conjugative elements (ICEs) and prophage DNA in the spread of these resistance genes.

Gene Information

Gene Name: erm(47)
Allele: erm47
Encodes: methyltransferase
Source Database: Reslit
Mechanism: constitutive resistance to MLSB
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Erysipelothrix rhusiopathiae
Geographic Location: Poland
Validation Method: genome analysis
Sequence Accession: NC_002148|KM576795.1|NG_054944.1|LM997412.1