erm(50)

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rRNA adenine N-6-methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to erm(50)

AMR Rules

Browse AMR rules for erm(50)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: whole-genome sequencing and transconjugation experiments
Drug Classes: Macrolides, Clindamycin, Quinupristin, Pristinamycin ia, Lincomycin, Erythromycin, Clarithromycin, Virginiamycin s
Organisms: Cutibacterium acnes, Cutibacterium granulosum
Geographic Location: Japan
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

The study identified a novel macrolide-clindamycin resistance gene, erm(50), and a tetracycline resistance gene, tet(W), on a transferable multidrug-resistant plasmid pTZC1 in Cutibacterium acnes.

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: rRNA adenine N-6-methyltransferase
Source Database: Reslit
Confers Resistance To: macrolidesclindamycin
Organisms Tested In: • Cutibacterium acnes
Geographic Location: Japan
Validation Method: whole-genome sequencing and transconjugation experiments
Sequence Accession: AP019664|LC473083

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50), Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: Target modification, antibiotic target alteration
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: erm(50)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface.

Research Article

PMID 36847559 · 2023

The study identifies the multidrug resistance plasmid pTZC1, which contains the macrolide-clindamycin resistance gene erm(50) and the tetracycline resistance gene tet(W), and demonstrates its transfer between Cutibacterium acnes and Cutibacterium granulosum strains.

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA methylase
Source Database: Reslit
Confers Resistance To: macrolidesclindamycin
Organisms Tested In: • Cutibacterium acnes
• Cutibacterium granulosum
Validation Method: PCR and sequencing
Sequence Accession: AP026712|AP026713|AP026710|AP026711

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erm(50)

View on PubMed

rRNA adenine N-6-methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to erm(50)

AMR Rules

Browse AMR rules for erm(50)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: whole-genome sequencing and transconjugation experiments
Drug Classes: Macrolides, Clindamycin, Quinupristin, Pristinamycin ia, Lincomycin, Erythromycin, Clarithromycin, Virginiamycin s
Organisms: Cutibacterium acnes, Cutibacterium granulosum
Geographic Location: Japan
Papers: 2
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Papers2

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

The study identified a novel macrolide-clindamycin resistance gene, erm(50), and a tetracycline resistance gene, tet(W), on a transferable multidrug-resistant plasmid pTZC1 in Cutibacterium acnes.

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: rRNA adenine N-6-methyltransferase
Source Database: Reslit
Confers Resistance To: macrolidesclindamycin
Organisms Tested In: • Cutibacterium acnes
Geographic Location: Japan
Validation Method: whole-genome sequencing and transconjugation experiments
Sequence Accession: AP019664|LC473083

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(50), Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: Target modification, antibiotic target alteration
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINCLARITHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083.1
Protein Accession: BBJ25230.1
Notes: ARO:3007032

Transferable Multidrug-Resistance Plasmid Carrying a Novel Macrolide-Clindamycin Resistance Gene, erm(50), in Cutibacterium acnes.

Research Article

PMID 31844016 · 2020

Gene Information

Gene Name: erm(50)
Allele: erm(50)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Cutibacterium acnes
Sequence Accession: LC473083

Multidrug Resistance Plasmid pTZC1 Could Be Pooled among Cutibacterium Strains on the Skin Surface.

Research Article

PMID 36847559 · 2023

Gene Information

Gene Name: erm(50)
Allele: Erm(50)
Encodes: 23S rRNA methylase
Source Database: Reslit
Confers Resistance To: macrolidesclindamycin
Organisms Tested In: • Cutibacterium acnes
• Cutibacterium granulosum
Validation Method: PCR and sequencing
Sequence Accession: AP026712|AP026713|AP026710|AP026711

Comments (0)

No comments yet. Be the first to comment!

erm(50)

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erm(50)

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