erm(55)

23S rRNA methylase

Validation StatusConfirmed2+ DBs

Overview

Validation Method: whole-genome sequencing and PCR-based screening
Drug Classes: Macrolide, CLARITHROMYCIN, Azithromycin
Organisms: Mycobacterium chelonae, Mycobacterium iranicum, Mycobacterium obuense, Mycobacteroides chelonae, Escherichia coli
Geographic Location: Europe, United States|Canada|Portugal|California, USA
Papers: 2
Databases: Reference Gene CatalogReslit

Papers2

Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm(55).

PMID 37347171 · 2023

The study identifies a novel 23S rRNA methylase gene, erm(55), which confers inducible macrolide resistance in Mycobacterium chelonae. This gene was found on a conjugative plasmid and in chromosomal variants, and it was also detected in other Mycobacterium species.

Gene Information

Gene Name: erm(55)
Allele: Erm(55)
Encodes: 23S rRNA methylase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium chelonae
• Mycobacterium iranicum
• Mycobacterium obuense
Geographic Location: United States|Canada|Portugal|California, USA
Validation Method: whole-genome sequencing and PCR-based screening
Sequence Accession: OQ656455|OQ656456|OQ656457|CP118918.1

Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm(55).

PMID 37347171 · 2023

Gene Information

Gene Name: erm(55)
Allele: Erm(55)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55)
Source Database: Reference Gene Catalog
Confers Resistance To: CLARITHROMYCIN
Organisms Tested In: • Mycobacteroides chelonae
Sequence Accession: OQ656455.1
Protein Accession: WHP53453.1

Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm(55).

PMID 37347171 · 2023

Gene Information

Gene Name: erm(55)
Allele: Erm(55)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55)
Source Database: Reference Gene Catalog
Confers Resistance To: CLARITHROMYCIN
Organisms Tested In: • Mycobacteroides chelonae
Sequence Accession: OQ656456.1
Protein Accession: WHP53454.1

Emergence of Inducible Macrolide Resistance in Mycobacterium chelonae Due to Broad-Host-Range Plasmid and Chromosomal Variants of the Novel 23S rRNA Methylase Gene, erm(55).

PMID 37347171 · 2023

Gene Information

Gene Name: erm(55)
Allele: Erm(55)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(55)
Source Database: Reference Gene Catalog
Confers Resistance To: CLARITHROMYCIN
Organisms Tested In: • Mycobacteroides chelonae
Sequence Accession: OQ656457.1
Protein Accession: WHP53456.1

Macrolide resistance due to erm(55).

PMID 39817789 · 2025

The study confirms that the erm(55) gene, when expressed in a macrolide-susceptible strain of E. coli, confers resistance to azithromycin and clarithromycin. Three variants of erm(55) (P, T, and C) were shown to confer varying degrees of macrolide resistance.

Gene Information

Gene Name: erm(55)
Allele: Erm(55)
Encodes: ribosomal methyltransferase
Source Database: Reslit
Confers Resistance To: Azithromycin
Organisms Tested In: • Escherichia coli
• Mycobacterium chelonae
Geographic Location: Europe
Validation Method: plasmid expression in E. coli M6394Δ9 and MIC testing
Sequence Accession: OQ656455.1|OQ656456.1|OQ656457.1

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erm(55)

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