erm(A)
erythromycin resistance methylase
Overview
- Drug Classes
- erythromycin, clindamycin, azithromycin, spiramycin, macrolides, lincosamides, streptogramin b
- Organisms
- Streptococcus pyogenes, Enterococcus faecium, Staphylococcus aureus +2 more
- Alleles
- 3
- Papers
- 7
- Mutations
- 1
| Nucleotide Change | Protein Change | Type | Effect on Function | Resistance To | Year | Paper | Status |
|---|---|---|---|---|---|---|---|
| A2058G | - | - | - | azithromycin|clarithromycin | 2003 | Effects of an Efflux Mechanism and Ribosomal Mutations on Macrolide Susceptibility of Haemophilus influenzae Clinical Isolates. PMID: 12604536 | Not Validated |
| Allele | Papers | Drug Classes | Organisms | Countries | Years | Status |
|---|---|---|---|---|---|---|
| erm | 1 | erythromycin, clindamycin | Streptococcus pyogenes | San Francisco Bay area|Northern California | 1999 | Not Validated |
| ErmA | 4 | erythromycin, azithromycin +5 | Enterococcus faecium +4 | Spain, Europe|North America|Asia | 2000, 2003, 2005, 2023 | Not Validated |
| Erm(A) | 2 | macrolides, erythromycin | Streptococcus pyogenes +1 | Pennsylvania | 2002, 2004 | Not Validated |
Characterization of antimicrobial resistance in Streptococcus pyogenes isolates from the San Francisco Bay area of northern California.
PMID 10325315 · 1999The study identifies the presence of erm genes in erythromycin-resistant Streptococcus pyogenes isolates, which confer resistance to erythromycin and clindamycin through target site modification.
Gene Information
- Gene Name
- erm(A)
- Allele
- erm
- Encodes
- erythromycin resistance methylase
- Validation Method
- double-disk diffusion test
Mechanism
target site modification
Confers Resistance To
Organisms Tested In
Isolation Details
Macrolide Resistance Genes in Enterococcus spp.
PMID 10722498 · 2000The study identified the presence of ermB and ermA genes in various Enterococcus species, which confer resistance to macrolides, lincosamides, and streptogramins. Additionally, a novel gene, msrC, was discovered in Enterococcus faecium, which is proposed to encode a putative ABC transporter involved in macrolide resistance.
Gene Information
- Gene Name
- erm(A)
- Allele
- ErmA
- Encodes
- erythromycin ribosomal methylase
- Validation Method
- PCR amplification and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- erm(A)
- Allele
- ErmA
- Encodes
- erythromycin ribosome methylase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Antistreptococcal activity of telithromycin compared with seven other drugs in relation to macrolide resistance mechanisms in Russia.
PMID 12183254 · 2002Gene Information
- Gene Name
- erm(A)
- Allele
- Erm(A)
- Encodes
- ribosomal methylase
- Validation Method
- PCR and sequencing
Mechanism
ribosomal methylation
Confers Resistance To
Organisms Tested In
Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci.
PMID 14532213 · 2003The study identifies and characterizes the genes ermA, ermC, and msrA responsible for inducible and constitutive clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci using PCR and disk diffusion testing.
Gene Information
- Gene Name
- erm(A)
- Allele
- ErmA
- Encodes
- ribosomal methylase
- Validation Method
- PCR and disk diffusion testing
Mechanism
methylation of 23S rRNA
Confers Resistance To
Organisms Tested In
Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania.
PMID 14693550 · 2004The study reports the second VRSA isolate in the United States, which contains the vanA gene responsible for vancomycin resistance and other resistance genes such as mecA, erm(A), and aac(6')-aph(2").
Gene Information
- Gene Name
- erm(A)
- Allele
- Erm(A)
- Encodes
- erythromycin resistance determinant
- Validation Method
- PCR and DNA sequence analysis
Confers Resistance To
Organisms Tested In
Isolation Details
Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus.
PMID 15814990 · 2005The study identifies ermA, ermC, and msrA as genes responsible for clindamycin resistance in erythromycin-resistant Staphylococcus aureus isolates, with distinct phenotypes observed in disk diffusion testing.
Gene Information
- Gene Name
- erm(A)
- Allele
- ErmA
- Encodes
- ribosomal RNA methylase
- Validation Method
- PCR and disk diffusion testing
Confers Resistance To
Organisms Tested In
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