erm(C)
erythromycin ribosome methylase
Overview
- Drug Classes
- macrolides, lincosamides, streptogramin b, erythromycin, spiramycin, clindamycin
- Organisms
- Staphylococcus aureus, Streptococcus pyogenes, coagulase-negative staphylococci +1 more
- Papers
- 5
Antimicrobial Resistance Mechanisms and Molecular Detection Techniques
PMID 11585788 · 2023The paper discusses molecular detection methods for antimicrobial resistance, focusing on genes like mecA and blaZ, which confer resistance to beta-lactam antibiotics in staphylococci.
Gene Information
- Gene Name
- erm(C)
- Allele
- ErmC
- Encodes
- erythromycin ribosome methylase
- Validation Method
- PCR and sequencing
Confers Resistance To
Organisms Tested In
Isolation Details
Practical disk diffusion method for detection of inducible clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci.
PMID 14532213 · 2003The study identifies and characterizes the genes ermA, ermC, and msrA responsible for inducible and constitutive clindamycin resistance in Staphylococcus aureus and coagulase-negative staphylococci using PCR and disk diffusion testing.
Gene Information
- Gene Name
- erm(C)
- Allele
- ErmC
- Encodes
- ribosomal methylase
- Validation Method
- PCR and disk diffusion testing
Mechanism
methylation of 23S rRNA
Confers Resistance To
Organisms Tested In
Emergence and persistence of macrolide resistance in oropharyngeal flora and elimination of nasal carriage of Staphylococcus aureus after therapy with slow-release clarithromycin: a randomized, double-blind, placebo-controlled study.
PMID 15504839 · 2004The study found that treatment with slow-release clarithromycin led to increased macrolide resistance in oropharyngeal flora, with significant rises in ermB and ermC genes in streptococci and staphylococci, respectively.
Gene Information
- Gene Name
- erm(C)
- Allele
- ErmC
- Encodes
- target modification
- Validation Method
- PCR and MIC testing
Confers Resistance To
Organisms Tested In
Antibiotic susceptibility of bacteria isolated from pasteurized milk and characterization of macrolide-lincosamide-streptogramin resistance genes.
PMID 15726980 · 2005The study identified the ermC gene in 2 out of 25 Micrococcaceae strains resistant to erythromycin and/or spiramycin, indicating its role in macrolide-lincosamide-streptogramin resistance.
Gene Information
- Gene Name
- erm(C)
- Allele
- ErmC
- Encodes
- macrolide-lincosamide-streptogramin resistance
- Validation Method
- PCR and sequence analysis
Confers Resistance To
Organisms Tested In
Testing for induction of clindamycin resistance in erythromycin-resistant isolates of Staphylococcus aureus.
PMID 15814990 · 2005The study identifies ermA, ermC, and msrA as genes responsible for clindamycin resistance in erythromycin-resistant Staphylococcus aureus isolates, with distinct phenotypes observed in disk diffusion testing.
Gene Information
- Gene Name
- erm(C)
- Allele
- ErmC
- Encodes
- ribosomal RNA methylase
- Validation Method
- PCR and disk diffusion testing
Confers Resistance To
Organisms Tested In
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