Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
rRNA methylase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(E) | Card DatabaseReference Gene CatalogReslit | 5 | Macrolide, Lincosamide +5 | Bacteroides +7 | Global, Canada | 1985, 1990, 2013, 2023 |
| CAB60001.1 |
| erm(E) | ResFinder Database | 1 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Saccharopolyspora erythraea NRRL 2338 | - | 1990 | X51891, M11200 | - |
| ErmE | Card DatabaseReslit | 9 | Erythromycin, MLS +3 | Escherichia coli +5 | Italy, Egypt|healthcare facilities 1|healthcare facilities 2|healthcare facility 1|healthcare facility 2 | 1985, 1987, 2020, 2025 | JAABOY000000000 | CAB60001.1 |
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methyltransferase from the erythromycin producer Saccharopolyspora erythraea.
A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methyltransferase from the erythromycin producer Saccharopolyspora erythraea.
A repeated decapeptide motif in the C-terminal domain of the ribosomal RNA methyltransferase from the erythromycin producer Saccharopolyspora erythraea., N-Methyl transferase of Streptomyces erythraeus that confers resistance to the macrolide-lincosamide-streptogramin B antibiotics: amino acid sequence and its homology to cognate R-factor enzymes from pathogenic bacilli and cocci.
Impact of manure fertilization on the abundance of antibiotic-resistant bacteria and frequency of detection of antibiotic resistance genes in soil and on vegetables at harvest.
The study identified several antibiotic resistance genes in soil and on vegetables, including genes conferring resistance to tetracycline, aminoglycosides, erythromycin, sulfamethoxazole, and beta-lactams. The presence of these genes was influenced by manure fertilization, with certain genes more frequently detected in manured soils.
Cloning and analysis of the promoter region of the erythromycin resistance gene (ermE) of Streptomyces erythraeus.
Expression of the macrolide-lincosamide-streptogramin-B-resistance methylase gene, ermE, from Streptomyces erythraeus in Escherichia coli results in N6-monomethylation and N6,N6-dimethylation of ribosomal RNA.
The ermE gene from Streptomyces erythraeus, when expressed in E. coli, confers high-level resistance to erythromycin and other MLS antibiotics by catalyzing N6-monomethylation and N6,N6-dimethylation of adenine residues in rRNA.
First detection of autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 from a patient with bloodstream infection in Italy, October 2019.
The study reports the first autochthonous extensively drug-resistant NDM-1 Pseudomonas aeruginosa ST235 strain in Italy, highlighting the presence of multiple beta-lactamase genes, aminoglycoside modifying enzymes, and multidrug efflux pumps contributing to its extensive drug resistance.
Plausible Minimal Substrate for Erm Protein.
The study identifies the minimal RNA substrate required for methylation by Erm proteins, highlighting the importance of specific nucleotide sequences and structural motifs in the 23S rRNA for resistance to macrolides, lincosamides, and streptogramin B.
Shared requirements for key residues in the antibiotic resistance enzymes ErmC and ErmE suggest a common mode of RNA recognition.
The study identifies key residues in ErmC and ErmE that are essential for their function in methylating A2058 of 23S rRNA, thereby conferring resistance to macrolides, lincosamides, and streptogramin B. Functional analyses reveal that specific amino acid residues, such as Tyr-104, Arg-134 in ErmC, and Tyr-134, Lys-164, and Arg-171 in ErmE, are critical for substrate recognition and methylation activity.
N-Methyl transferase of Streptomyces erythraeus that confers resistance to the macrolide-lincosamide-streptogramin B antibiotics: amino acid sequence and its homology to cognate R-factor enzymes from pathogenic bacilli and cocci.
The study identifies the ermE gene from Streptomyces erythraeus, which encodes a ribosomal RNA N6-amino adenine N-methyl transferase that confers resistance to macrolide, lincosamide, and streptogramin B antibiotics.
Two dynamic N-terminal regions are required for function in ribosomal RNA adenine dimethylase family members.
A cross-sectional molecular epidemiological study of biofilm-producing methicillin-resistant Staphylococcus aureus.
The study identified multiple antimicrobial resistance genes, including mecA, vanA, vanB, ermE, tetK, and icaA, in biofilm-producing methicillin-resistant Staphylococcus aureus isolates. These genes were associated with resistance to various antibiotics and biofilm formation.
Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.
The study characterizes several AMR genes, including blaIPM-4, blaOXA-1, blaOXA-10, aacA4, blaOXA-101, aadA11, aadA9, qacEΔ1, sat2-aadA1, and others, highlighting their role in conferring resistance to various antibiotics in different bacterial species.
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