Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
macrolide-lincosamide-streptogramin B resistance
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| ErmG | Card DatabaseReslit | 15 | Erythromycin, Clindamycin +5 | Bacteroides spp. +17 | human colon, Asia|Europe|North America|Australia/New Zealand, Minnesota, Brazil, USA|Japan|Taiwan|NASA's-JPL SAF, Japan |
| 1987, 2001, 2003, 2014, 2017, 2021, 2022, 2023, 2024, 2025 |
| X58717|Y08615|Z21523|M15332|X58285 |
| AAC37034.1 |
| Erm(G) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 13 | STREPTOGRAMIN, ERYTHROMYCIN +13 | Bacteroides ovatus +17 | Global, Northern China, Minnesota, United Kingdom|High-risk countries, Belgium|Germany|Hungary|Slovenia|Turkey | 1987, 2003, 2018, 2020, 2022, 2023, 2024, 2026 | AJ557257.1 | CAD89787.1 |
| erm(G) | ResFinder Database | 1 | QUINUPRISTIN, PRISTINAMYCIN IA +4 | Lysinibacillus sphaericus, Bacteroides thetaiotaomicron | - | 1987 | M15332, L42817 | - |
Evidence for extensive resistance gene transfer among Bacteroides spp. and among Bacteroides and other genera in the human colon.
The study shows extensive horizontal gene transfer of tetracycline resistance gene tetQ and erythromycin resistance genes ermF, ermG, and ermB among Bacteroides species and between Bacteroides and other genera in the human colon.
A newly discovered Bacteroides conjugative transposon, CTnGERM1, contains genes also found in gram-positive bacteria.
A newly discovered Bacteroides conjugative transposon, CTnGERM1, contains genes also found in gram-positive bacteria.
The study identifies CTnGERM1, a conjugative transposon containing the erythromycin resistance gene ermG and the macrolide efflux gene mefA, which were found to confer resistance in Bacteroides and Streptococcus pyogenes.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
A multiple antibiotic-resistant enterobacter cloacae strain isolated from a bioethanol fermentation facility.
The study identifies the presence of the ampC gene encoding a beta-lactamase and the ermG gene encoding a ribosomal methyltransferase in the multiple antibiotic-resistant Enterobacter cloacae strain F3S3, which confers resistance to penicillin and erythromycin respectively.
Enrichment allows identification of diverse, rare elements in metagenomic resistome-virulome sequencing.
The study identified a low-abundance portion of the resistome that contained important and prevalent genes, such as ermG, which confers resistance to macrolides, lincosamides, and streptogramins. The use of bait-capture and enrichment significantly increased the detection of these low-abundance genes.
Molecular epidemiology and antimicrobial susceptibility of human Clostridium difficile isolates from a single institution in Northern China.
The study identified mutations in GyrA (F86Y) and GyrB (D426N, D426V, S416A) that confer quinolone resistance, and mutations in RpoB (H502N, R505K, E573A, G603D) that confer rifampin resistance. Additionally, the erm(B) and erm(G) genes were found to mediate resistance to macrolide-lincosamide-streptogramin B antibiotics.
Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus.
Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus.
The study identifies and characterizes ermG, a novel macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus, which encodes an rRNA transmethylase that confers resistance through methylation of 23S rRNA.
Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus.
Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus.
Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus.
Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus.
Cloning and analysis of ermG, a new macrolide-lincosamide-streptogramin B resistance element from Bacillus sphaericus., The erythromycin resistance gene from the Bacteroides conjugal transposon Tcr Emr 7853 is nearly identical to ermG from Bacillus sphaericus.
Antimicrobial Resistance in Clostridium and Brachyspira spp. and Other Anaerobes.
The paper describes the antimicrobial resistance mechanisms in Clostridium and Brachyspira spp. and other anaerobes, focusing on the genetic basis of resistance to various antibiotics, including tetracyclines, macrolides, lincosamides, chloramphenicol, and others. It highlights the role of specific genes such as tet, erm, and cat in conferring resistance.
Resistome Analysis in the Digestive Tract of Food-Producing Animals
The study identifies tetW and mefA as highly expressed tetracycline and macrolide resistance genes in the rumen of beef cattle, highlighting their significance in the resistome of food-producing animals.
A species-wide genetic atlas of antimicrobial resistance in Clostridioides difficile.
This study identifies multiple AMR genes and mutations in Clostridioides difficile, including ermB, tetM, mefH, and various mutations in gyrA, gyrB, rpoB, pbp1, and pbp3. These findings highlight the widespread nature of AMR in C. difficile and its potential role in the spread of the bacterium.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
The impacts of viral infection and subsequent antimicrobials on the microbiome-resistome of growing pigs.
The study identified ermG as a gene that increased in abundance in the feces of treated pigs compared to those that did not receive post-PRRS antimicrobials, indicating its role in macrolide, lincosamide, and streptogramin B resistance.
Exploring the Bacteriome and Resistome of Humans and Food-Producing Animals in Brazil.
The study identified various antimicrobial resistance genes (ARGs) in humans and food-producing animals in Brazil, including novel carbapenemase-encoding genes such as blaAIM-1, blaCAM-1, blaGIM-2, and blaHMB-1, which were not previously reported in Latin America. Other significant ARGs included aac(6')-Ib-cr, ermF, ermB, ermG, tetO, tetQ, tetW, qnrB10, qnrB19, qnrD1, and crpP.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Case Report: The effect of intravenous and oral antibiotics on the gut microbiome and breath volatile organic compounds over one year.
The study identified several resistance genes in Bacteroides coprophilus and Bacteroides dorei, including adeF, ermF, tetQ, ermG, and a carbapenem resistance gene, highlighting the impact of antimicrobial exposure on the gut microbiome's resistance profiles.
Prevalence and Persistence of Antibiotic Resistance Determinants in the Gut of Travelers Returning to the United Kingdom is Associated with Colonization by Pathogenic Escherichia coli.
The study identified various antibiotic resistance genes in the gut microbiota of travelers returning to the UK, highlighting the association with colonization by pathogenic E. coli. Key findings include the prevalence of genes conferring resistance to macrolides, tetracyclines, sulfonamides, and others.
Novel spore-forming species exhibiting intrinsic resistance to third- and fourth-generation cephalosporins and description of Tigheibacillus jepli gen. nov., sp. nov.
The study identifies Tigheibacillus jepli as a novel spore-forming species with intrinsic resistance to third- and fourth-generation cephalosporins, lacking known β-lactamases, suggesting resistance via variant penicillin-binding proteins. It also reports three vancomycin resistance-related ARG in T. jepli.
Detection of the antibiotic resistance genes content of intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients from European countries.
The study identified and compared the prevalence of antibiotic resistance genes in intestinal Bacteroides, Parabacteroides and Phocaeicola isolates from healthy and carbapenem-treated patients in European countries, highlighting differences in gene carriage between gut microbiota and clinical strains.
Alistipes Bacteremia in Older Patients with Digestive and Cancer Comorbidities, Japan, 2016-2023.
The study identified several antimicrobial resistance genes in Alistipes strains, including adeF, tet(Q), cfxA3, cfxA4, and ermG, which confer resistance to various antibiotics such as minocycline, cefuroxime, and clindamycin.
Dietary impact on the gut resistome: western diet independently increases the prevalence of antibiotic resistance genes within the gut microbiota.
The study shows that a western diet independently increases the prevalence of antibiotic resistance genes (ARGs) in the gut microbiota without antibiotic exposure. Specifically, ARGs such as ErmG, CfxA2, tetQ, lnuC, and mefA were found to be significantly enriched in the gut microbiota of mice fed a western diet.
Elucidation of population-based bacterial adaptation to antimicrobial treatment by single-cell sequencing analysis of the gut microbiome of a hospital patient.
The study identified 29 ARG subtypes across eight types in 13 known, five unknown, and 18 unclassified species, highlighting the complex and dynamic nature of antimicrobial resistance in the gut microbiome. Notably, the cfr(C) gene was detected in 11 bacterial species following antimicrobial treatment, with mutation patterns characterized in several species.
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