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erm(R)

23S rRNA methyltransferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(R)

Browse AMR rules for erm(R)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Target modification
Validation Method: Disruption of the chromosomal ermR gene and phenotypic characterization
Drug Classes: Macrolide, QUINUPRISTIN, PRISTINAMYCIN IA, CLINDAMYCIN, LINCOMYCIN, ERYTHROMYCIN, VIRGINIAMYCIN S, Lincosamide, Streptogramin b
Organisms: Aeromicrobium erythreum, environmental bacteria, Arthrobacter, Arthrobacter sp.
Geographic Location: Europe, Global
Alleles: 3
Papers: 4
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
ErmR	Card DatabaseReslit	2	Macrolide	Aeromicrobium erythreum	-	1991	AY623658.2	AAU93796.1
Erm(R)

Papers4

1

Cloning vectors, mutagenesis, and gene disruption (ermR) for the erythromycin-producing bacterium Aeromicrobium erythreum.

PMID 1768148 · 1991

The study identified the ermR gene as the sole determinant of macrolide antibiotic resistance in Aeromicrobium erythreum through gene disruption and phenotypic analysis.

Gene Information

Gene Name: erm(R)
Allele: ErmR
Encodes: 23S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Aeromicrobium erythreum
Validation Method: Disruption of the chromosomal ermR gene and phenotypic characterization

2

Cloning vectors, mutagenesis, and gene disruption (ermR) for the erythromycin-producing bacterium Aeromicrobium erythreum.

PMID 1768148 · 1991

Gene Information

Gene Name: erm(R)
Allele: Erm(R)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(R)
Source Database: Reference Gene Catalog
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Aeromicrobium erythreum
Sequence Accession: AY623658.2
Protein Accession: AAU93796.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

3

Cloning vectors, mutagenesis, and gene disruption (ermR) for the erythromycin-producing bacterium Aeromicrobium erythreum.

PMID 1768148 · 1991

Gene Information

Gene Name: erm(R)
Allele: Erm(R)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(R)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Aeromicrobium erythreum
Sequence Accession: AY623658.2
Protein Accession: AAU93796.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

4

Cloning vectors, mutagenesis, and gene disruption (ermR) for the erythromycin-producing bacterium Aeromicrobium erythreum.

PMID 1768148 · 1991

Gene Information

Gene Name: erm(R)
Allele: Erm(R)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(R)
Source Database: Card Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Aeromicrobium erythreum
Sequence Accession: AY623658.2
Protein Accession: AAU93796.1
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

5

Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria.

PMID 21833302 · 2011

The paper discusses the characterization of environmental macrolide-lincosamide-streptogramin (MLS) and tetracycline resistance genes, highlighting the diversity and distribution of these genes in environmental bacteria. It identifies several MLS resistance genes such as erm(H), erm(I), erm(N), and others, as well as tetracycline resistance genes like tetA(P), tet(V), and tet(X).

Gene Information

Gene Name: erm(R)
Allele: Erm(R)
Encodes: rRNA methylase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • environmental bacteria
Geographic Location: Europe
Validation Method: experimental validation

6

Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges

PMID 22046172 · 2023

This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.

Gene Information

Gene Name: erm(R)
Allele: Erm(R)
Encodes: rRNA methylase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Arthrobacter
Geographic Location: Global
Validation Method: experimental characterization
Sequence Accession: V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013

7

An erythromycin-resistance gene from an erythromycin-producing strain of Arthrobacter sp.

PMID 4043733 · 1985

Gene Information

Gene Name: erm(R)
Allele: erm(R)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Arthrobacter sp.
Sequence Accession: M11276
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

8

Gene Information

Gene Name: erm(R)
Allele: ErmR
Encodes: Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Aeromicrobium erythreum
Sequence Accession: AY623658.2
Protein Accession: AAU93796.1
Notes: ARO:3000594