Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
rRNA methylase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| Erm(S) | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | Macrolides, Lincosamides, Streptogramin b, Clindamycin, Erythromycin, Tylosin, Ostreogrycin, Quinupristin, Pristinamycin ia, Lincomycin +1 more | environmental bacteria, Streptomyces, Streptomyces fradiae, Escherichia coli | Europe, Global | 1988, 2011, 2020, 2021, 2023 | V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013 | AAA26742.1 |
| ErmS | Card Database | 1 | Tylosin, Macrolide antibiotic, Lincosamide antibiotic, Streptogramin b antibiotic, Ostreogrycin, Streptogramin antibiotic, Erythromycin, Clindamycin | Streptomyces fradiae | - | - | M19269.1 | AAA26742.1 |
Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria.
Research Article
The paper discusses the characterization of environmental macrolide-lincosamide-streptogramin (MLS) and tetracycline resistance genes, highlighting the diversity and distribution of these genes in environmental bacteria. It identifies several MLS resistance genes such as erm(H), erm(I), erm(N), and others, as well as tetracycline resistance genes like tetA(P), tet(V), and tet(X).
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
Research Article
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.
Research Article
Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.
Research Article
Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.
Research Article
Plausible Minimal Substrate for Erm Protein.
Research Article
The study identifies the minimal RNA substrate required for methylation by Erm proteins, highlighting the importance of specific nucleotide sequences and structural motifs in the 23S rRNA for resistance to macrolides, lincosamides, and streptogramin B.
Potential Target Site for Inhibitors in MLS(B) Antibiotic Resistance.
Research Article
The study identifies specific mutations in the ermS gene that affect erythromycin resistance, highlighting the role of amino acid residues S64, Q65, and F67 in the resistance mechanism.
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