Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm(S)

rRNA methylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm(S)

Browse AMR rules for erm(S)

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic target alteration
Validation Method: experimental validation
Drug Classes: Macrolide, Lincosamide, Streptogramin b, CLINDAMYCIN, ERYTHROMYCIN, TYLOSIN, OSTREOGRYCIN, QUINUPRISTIN, PRISTINAMYCIN IA, LINCOMYCIN, VIRGINIAMYCIN S, Erythromycin
Organisms: environmental bacteria, Streptomyces, Streptomyces fradiae, Escherichia coli
Geographic Location: Europe, Global
Alleles: 3
Papers: 5
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Erm(S)	Card DatabaseReference Gene CatalogReslit	4	Macrolide, Lincosamide +5	environmental bacteria +2	Europe, Global	1988, 2011, 2023

Papers5

1

Environmental macrolide-lincosamide-streptogramin and tetracycline resistant bacteria.

PMID 21833302 · 2011

The paper discusses the characterization of environmental macrolide-lincosamide-streptogramin (MLS) and tetracycline resistance genes, highlighting the diversity and distribution of these genes in environmental bacteria. It identifies several MLS resistance genes such as erm(H), erm(I), erm(N), and others, as well as tetracycline resistance genes like tetA(P), tet(V), and tet(X).

Gene Information

Gene Name: erm(S)
Allele: Erm(S)
Encodes: rRNA methylase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • environmental bacteria
Geographic Location: Europe
Validation Method: experimental validation

2

Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges

PMID 22046172 · 2023

This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.

Gene Information

Gene Name: erm(S)
Allele: Erm(S)
Encodes: rRNA methylase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Streptomyces
Geographic Location: Global
Validation Method: experimental characterization
Sequence Accession: V00622|X53796|X07848|M11587|P20074|K00544|X02529|AY355285|NC_002013|U15027|M35190|S48276|M93113|M55620|M58472|AF047479|AJ009818|AF036933|AF462019|AF878850|M64556|M22614|AF071555|AJ549214|X59968|U09991|Z12001|U85507|AJ579365|HM537013

3

Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.

PMID 3127381 · 1988

Gene Information

Gene Name: erm(S)
Allele: Erm(S)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(S)
Source Database: Card Database
Mechanism: antibiotic target alteration
Confers Resistance To: CLINDAMYCINERYTHROMYCINTYLOSINOSTREOGRYCIN
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: M19269.1
Protein Accession: AAA26742.1
Notes: ARO:3001304

4

Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.

PMID 3127381 · 1988

Gene Information

Gene Name: erm(S)
Allele: Erm(S)
Encodes: 23S rRNA (adenine(2058)-N(6))-methyltransferase Erm(S)
Source Database: Reference Gene Catalog
Mechanism: antibiotic target alteration
Confers Resistance To: CLINDAMYCINERYTHROMYCINTYLOSINOSTREOGRYCIN
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: M19269.1
Protein Accession: AAA26742.1
Notes: ARO:3001304

5

Translational attenuation control of ermSF, an inducible resistance determinant encoding rRNA N-methyltransferase from Streptomyces fradiae.

PMID 3127381 · 1988

Gene Information

Gene Name: erm(S)
Allele: erm(S)
Source Database: ResFinder Database
Mechanism: Target modification
Confers Resistance To: QUINUPRISTINPRISTINAMYCIN IACLINDAMYCINLINCOMYCINERYTHROMYCINVIRGINIAMYCIN S
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: M19269
Notes: 23S rRNA methylase; Azithromycin, Spiramycin resistance in Staphylococcus sp. and Streptococcus sp.; If inducible phenotype, patterns of spiramycin, lincomycin and clindamycin resistance may vary

6

Plausible Minimal Substrate for Erm Protein.

PMID 32571809 · 2020

The study identifies the minimal RNA substrate required for methylation by Erm proteins, highlighting the importance of specific nucleotide sequences and structural motifs in the 23S rRNA for resistance to macrolides, lincosamides, and streptogramin B.

Gene Information

Gene Name: erm(S)
Allele: ErmS
Encodes: methyltransferase
Source Database: Reslit
Mechanism: methylates a specific adenine residue (A2058) on 23S rRNA
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Escherichia coli
Validation Method: substrate activity assays

7

Potential Target Site for Inhibitors in MLS(B) Antibiotic Resistance.

PMID 33807634 · 2021

The study identifies specific mutations in the ermS gene that affect erythromycin resistance, highlighting the role of amino acid residues S64, Q65, and F67 in the resistance mechanism.

Gene Information

Gene Name: erm(S)
Allele: ErmS
Encodes: rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Escherichia coli
Validation Method: expression in E. coli and antibiotic susceptibility assay

8

Gene Information

Gene Name: erm(S)
Allele: ErmS
Encodes: Erm 23S ribosomal RNA methyltransferase
Source Database: Card Database
Mechanism: antibiotic target alteration
Organisms Tested In: • Streptomyces fradiae
Sequence Accession: M19269.1
Protein Accession: AAA26742.1
Notes: ARO:3001304