erm(tr)

ribosomal RNA adenine methylase

Validation StatusSupported

Overview

Mechanism: modification of the 23S rRNA target
Validation Method: colony blot hybridization and PCR followed by restriction analysis
Drug Classes: Macrolide, Lincosamide, Streptogramin b, Erythromycin, Clindamycin
Organisms: Streptococcus pyogenes, Streptococcus pneumoniae, Helcococcus kunzii, Helcococcus kunzii ATCC 51366 T, Staphylococcus epidermidis, Streptococcus agalactiae, Streptococcus canis, Salmonella enteritidis, Streptococcus spp.
Geographic Location: Calgary, Canada|Calgary, Alberta, Canada, Central Greece, Egypt, Europe, France|Switzerland +5 more
Papers: 11
Databases: Reslit

Papers11

Resistance determinants and clonal diversity in group A streptococci collected during a period of increasing macrolide resistance.

PMID 12019095 · 2002

The study identified erm(B), erm(TR), and mef(A) as key resistance determinants in group A streptococci, with erm(B) being the most prevalent contributor to increased macrolide resistance.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: ribosomal RNA adenine methylase
Source Database: Reslit
Mechanism: modification of the 23S rRNA target
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Streptococcus pyogenes
Geographic Location: Italy
Validation Method: colony blot hybridization and PCR followed by restriction analysis

New genetic element carrying the erythromycin resistance determinant erm(TR) in Streptococcus pneumoniae.

PMID 18070957 · 2008

The study identifies a new genetic element carrying the erythromycin resistance determinant erm(TR) in a clinical isolate of Streptococcus pneumoniae, demonstrating that the wild-type erm(TR) gene confers erythromycin resistance.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: erythromycin resistance methylase
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Streptococcus pneumoniae
Geographic Location: Italy
Validation Method: PCR and sequencing
Sequence Accession: EF469826

Macrolide and tetracycline resistance and emm type distribution of Streptococcus pyogenes isolates recovered from Turkish patients.

PMID 20624096 · 2010

The study identified erm(TR) as the primary macrolide resistance gene and tet(O) as the most common tetracycline resistance gene in Streptococcus pyogenes isolates from Turkey.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: ribosomal methylase
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Streptococcus pyogenes
Geographic Location: Turkey
Validation Method: real-time PCR

In vitro antimicrobial susceptibility of Helcococcus kunzii and molecular analysis of macrolide and tetracycline resistance.

PMID 26194694 · 2015

The study identified erm(TR) as a cause of high-level erythromycin resistance and tet(M) as a cause of tetracycline resistance in Helcococcus kunzii.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: methyltransferase
Source Database: Reslit
Mechanism: target modification
Confers Resistance To: Erythromycin
Organisms Tested In: • Helcococcus kunzii
• Helcococcus kunzii ATCC 51366 T
Geographic Location: France|Switzerland
Validation Method: PCR and sequencing

Epidemiological and Inducible Resistance in Coagulase Negative Staphylococci.

PMID 26573051 · 2015

The study identified erm(A), erm(B), erm(C), and erm(TR) genes in erythromycin-resistant Coagulase Negative Staphylococci (CNS) isolates, indicating inducible clindamycin resistance. The majority of the isolates exhibited unique genomic patterns, suggesting limited transmission of resistant strains.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: erythromycin ribosome methylase
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Staphylococcus epidermidis
Geographic Location: Sanandaj
Validation Method: multiplex PCR

Increasing macrolide resistance among Streptococcus agalactiae causing invasive disease in non-pregnant adults was driven by a single capsular-transformed lineage, Portugal, 2009 to 2015.

PMID 29845930 · 2018

The study identifies a significant increase in macrolide resistance among Streptococcus agalactiae isolates causing invasive disease in non-pregnant adults in Portugal, primarily linked to the expansion of a specific capsular-transformed lineage (CC1) harboring resistance genes such as erm(B), erm(TR), erm(T), mef(E), tet(M), tet(O), and tet(L).

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: erythromycin ribosome methylase
Source Database: Reslit
Confers Resistance To: ErythromycinClindamycin
Organisms Tested In: • Streptococcus agalactiae
Geographic Location: Portugal
Validation Method: PCR detection of resistance genes
Sequence Accession: SRR5575010|SRR5575009

emm Types and clusters and macrolide resistance of pediatric group A streptococcal isolates in Central Greece during 2011-2017.

PMID 32379802 · 2020

The study identified macrolide resistance genes erm(B), erm(TR), and mef(A) in Streptococcus pyogenes isolates from Central Greece, with erm(B) and erm(TR) being the primary drivers of resistance.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: methylase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Streptococcus pyogenes
Geographic Location: Central Greece
Validation Method: PCR and sequencing

Tetracycline, Macrolide and Lincosamide Resistance in Streptococcus canis Strains from Companion Animals and Its Genetic Determinants.

PMID 36009903 · 2022

The study identified tetracycline resistance genes tet(O), tet(M), and tet(T), and MLS resistance genes erm(B) and erm(TR) in Streptococcus canis strains from companion animals.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: rRNA methylase
Source Database: Reslit
Confers Resistance To: ErythromycinClindamycin
Organisms Tested In: • Streptococcus canis
Geographic Location: Poland
Validation Method: PCR and MIC testing
Sequence Accession: OM973245

Ecological prevalence, genetic diversity, and multidrug resistance of Salmonella enteritidis recovered from broiler and layer chicken farms.

PMID 38215504 · 2024

The study identified various AMR genes in Salmonella enteritidis isolates from broiler and layer chicken farms, including blaCTX-M, blaDHA-1, qnrA, qnrB, qnrS, gyrA, erm(B), erm(C), msr(A), tet(A), and tet(B). These genes conferred resistance to multiple antibiotics such as beta-lactams, quinolones, macrolides, and tetracyclines.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: Ribosomal methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Salmonella enteritidis
Geographic Location: Egypt
Validation Method: PCR screening

ICESp1109, a Novel Hybrid Integrative Conjugative Element of Macrolide-Resistant Streptococcus pyogenes Serotype M77 Collected Between 2003 and 2017 in Poland.

PMID 39393813 · 2025

The study identifies the tet(O) and erm(TR) genes as responsible for tetracycline and macrolide resistance, respectively, in Streptococcus pyogenes M77/ST63 strains. A novel hybrid integrative conjugative element, ICE Sp1109, was discovered, combining features of ICE Sp2906 and ICE Sp1108.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: 23S rRNA methyltransferase
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Streptococcus pyogenes
Geographic Location: Europe
Validation Method: whole genome sequencing
Sequence Accession: CP155734|CP155735|CP155736|CP155737|CP155738|CP155739|CP155740|CP155741

Metagenomic analysis after selective culture enrichment of hospital and community wastewater enhances antimicrobial resistance gene detection.

PMID 40741762 · 2025

The study identifies various beta-lactamase genes such as bla CTX-M, bla KPC, bla NDM, and bla VIM, along with other resistance genes like erm(TR), lsa, efrA, efrB, and optrA, which were detected through selective culture enrichment of wastewater samples.

Gene Information

Gene Name: erm(tr)
Allele: erm(TR)
Encodes: methyltransferase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Streptococcus spp.
Geographic Location: Calgary, Canada|Calgary, Alberta, Canada
Validation Method: metagenomic sequencing

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