Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
methyltransferase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| V80I | - | - | Mycobacterium abscessus | macrolides | Reslit | Candidate |
| T28C | - | - | Mycobacterium abscessus | macrolides | Reslit | Candidate |
| W28R | - | - | Mycobacterium abscessus, Mycobacterium massiliense, Mycobacterium bolletii | clarithromycin | Reslit | Candidate |
| R7* | - | - | Mycobacterium abscessus | macrolides | Reslit | Candidate |
| R67* | - | nonfunctional erythromycin ribosome methylase (Erm) | Mycobacterium abscessus | macrolides | Reslit | Candidate |
| - | - | Mycobacterium abscessus | clarithromycin | Reslit | Candidate | |
| - | - | Mycobacterium abscessus | clarithromycin | Reslit | Candidate | |
| - | - | Mycobacterium abscessus | macrolides | Reslit | Supported | |
| - | non-functional | Mycobacterium abscessus, M. abscessus, M. chelonae | clarithromycinmacrolides | Reslit | Supported | |
| L9P | - | Mycobacterium abscessus | macrolides | Reslit | Supported | |
| W10R | loss of methylase activity | Mycobacterium abscessus | macrolides | Reslit | Supported |
Genomic Analysis of Global Mycobacterium abscessus Isolates Reveals Ongoing Evolution of Drug Resistance-Associated Genes.
Research Article
The V80I mutation arose exclusively in the 28T background.
Molecular Epidemiological Characteristics of Mycobacterium abscessus Complex Derived from Non-Cystic Fibrosis Patients in Japan and Taiwan.
Research Article
The T28C mutation in erm(41) leads to macrolide susceptibility.
New Real-Time PCR Assays for Detection of Inducible and Acquired Clarithromycin Resistance in the Mycobacterium abscessus Group.
Research Article
T28C substitution in erm(41) leads to loss of inducible resistance.
Successful antibiotic treatment of pulmonary disease caused by Mycobacterium abscessus subsp. abscessus with C-to-T mutation at position 19 in erm(41) gene: case report.
Research Article
The C19→T mutation leads to a non-functional erm(41) gene, resulting in clarithromycin susceptibility.
Impact on Macrolide Resistance of Genetic Diversity of Mycobacterium abscessus Species.
Research Article
Nonsense mutation leading to nonfunctional Erm
MGIT-seq for the Identification of Nontuberculous Mycobacteria and Drug Resistance: a Prospective Study.
Research Article
Whole-genome sequencing to identify transmission of Mycobacterium abscessus between patients with cystic fibrosis: a retrospective cohort study.
Research Article
Mutation found in cluster 2
Subspecies distribution and drug-resistance characteristics of Mycobacterium abscessus complex clinical isolates in South China.
Research Article
Evaluation of the In Vitro Activity of Bedaquiline, Delamanid, and Clofazimine Against Mycobacterium abscessus Complex and Their Antibiofilm Potential.
Research Article
Drug susceptibility profiles and factors associated with non-tuberculous mycobacteria species circulating among patients diagnosed with pulmonary tuberculosis in Tanzania.
Research Article
Three MABC isolates had a T28 mutation in the erm(41) gene, resulting in macrolide resistance.
Clinical emergence of inducible macrolide resistance mediated by acquired erm(41) C28T mutation in Mycobacterium abscessus.
Research Article
The C28T mutation in erm(41) leads to inducible macrolide resistance.
Infection model of THP-1 cells, growth dynamics, and antimicrobial susceptibility of clinical Mycobacterium abscessus isolates from cystic fibrosis patients: Results from a multicentre study.
Research Article
Whole-genome recombination and dynamic accessory genomes drive the phenotypic diversity of Mycobacterium abscessus subspecies.
Research Article
Strains with T28C mutation showed macrolide susceptibility, while wild-type erm41 gene showed inducible resistance.
Evaluation of mlstverse system for accurate subspecies identification and drug resistance prediction in Mycobacterium abscessus species.
Research Article
Time-to-Detection of Inducible Macrolide Resistance in Mycobacterium abscessus Subspecies and Its Association with the Erm(41) Sequevar.
Research Article
The T28C mutation in the erm(41) gene renders the enzyme non-functional and does not result in inducible macrolide resistance.
Vancomycin and Clarithromycin Show Synergy against Mycobacterium abscessus In Vitro.
Research Article
The C28 erm(41) sequevar is nonfunctional and hence susceptible to clarithromycin.
Dissecting erm(41)-Mediated Macrolide-Inducible Resistance in Mycobacterium abscessus.
Research Article
T28C polymorphism is associated with loss of methylase activity and abrogation of inducible resistance
Whole-Genome Sequencing for Predicting Clarithromycin Resistance in Mycobacterium abscessus.
Research Article
Analysis of drug-susceptibility patterns and gene sequences associated with clarithromycin and amikacin resistance in serial Mycobacterium abscessus isolates from clinical specimens from Northeast Thailand.
Research Article
Subspecies Distribution and Antimicrobial Susceptibility Testing of Mycobacterium abscessus Clinical Isolates in Madrid, Spain: a Retrospective Multicenter Study.
Research Article