Browse AMR Genes

Explore antimicrobial resistance genes from the literature

erm41

erythromycin resistance methylase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to erm41

Browse AMR rules for erm41

Validation StatusSupported

Overview

Validation Method: transcriptional response to erythromycin exposure
Drug Classes: Macrolide, Lincosamide, Clarithromycin
Organisms: Mycobacterium abscessus, Mycobacterium abscessus subsp. abscessus, Mycobacterium abscessus subsp. bolletii, Mycobacterium massiliense, Mycobacterium bolletii, M. abscessus, M. chelonae
Papers: 25
Databases: Reslit
Mutations: 12

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
W28R	-	-	Mycobacterium massiliense, Mycobacterium abscessus, Mycobacterium bolletii	Clarithromycin	Reslit	Candidate
T28C	-	-	Mycobacterium abscessus	Macrolide	Reslit	Candidate
V80I	-	-	Mycobacterium abscessus	Macrolide

Papers25

1

Functional characterization of the Mycobacterium abscessus genome coupled with condition specific transcriptomics reveals conserved molecular strategies for host adaptation and persistence.

PMID 27495169 · 2016

The study characterizes the functional genome of Mycobacterium abscessus and identifies genes involved in antibiotic resistance, including erm41, MAB_2640c, and MMPL13b, which are differentially expressed in response to antibiotic exposure.

Gene Information

Gene Name: erm41
Allele: erm41
Encodes: erythromycin resistance methylase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium abscessus
Validation Method: transcriptional response to erythromycin exposure
Sequence Accession: GSE78787|GSE72996

2

Repositioning rifamycins for Mycobacterium abscessus lung disease.

PMID 31195849 · 2019

The paper discusses the intrinsic resistance of Mycobacterium abscessus to rifamycins, highlighting the role of the erm41 gene encoding an rRNA methylase that confers inducible resistance to macrolides. It explores the potential of repositioning rifamycins, particularly rifabutin, for treating M. abscessus lung disease.

Gene Information

Gene Name: erm41
Allele: erm41
Encodes: rRNA methylase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium abscessus subsp. abscessus
• Mycobacterium abscessus subsp. bolletii
Validation Method: experimental data generated in this study

3

Hierarchy and interconnected networks in the WhiB7 mediated transcriptional response to antibiotic stress in Mycobacterium abscessus.

PMID 38055757 · 2023

The study identifies several genes regulated by WhiB7 that contribute to antibiotic resistance in Mycobacterium abscessus, including erm41, hflX, MAB_2780c, MAB_4532c, MAB_1409c, and MAB_3543c.

Gene Information

Gene Name: erm41
Allele: erm41
Encodes: ribosome-associated protein
Source Database: Reslit
Confers Resistance To: MacrolideLincosamide
Organisms Tested In: • Mycobacterium abscessus
Validation Method: functional analysis

4

Lsr2, a pleiotropic regulator at the core of the infectious strategy of Mycobacterium abscessus.

PMID 38353553 · 2024

Lsr2 regulates genes involved in antimicrobial resistance, including eis2, MAB_1409c, MAB_2355c, and erm41, which contribute to resistance against aminoglycosides and macrolides in Mycobacterium abscessus.

Gene Information

Gene Name: erm41
Allele: erm41
Encodes: macrolide ribosome methyltransferase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mycobacterium abscessus
Validation Method: RNA-seq and RT-qPCR