erma1

erythromycin resistance

Validation StatusCandidate

Overview

Mechanism: ribosomal modification
Validation Method: genomic analysis
Drug Classes: Erythromycin, Macrolide, Lincosamide, Streptogramin b
Organisms: Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium
Geographic Location: United Kingdom
Papers: 2
Databases: Reslit

Papers2

Genome sequence of a recently emerged, highly transmissible, multi-antibiotic- and antiseptic-resistant variant of methicillin-resistant Staphylococcus aureus, sequence type 239 (TW).

PMID 19948800 · 2010

The study identifies several AMR genes and mutations in the MRSA strain TW20, including mecA for methicillin resistance, qacA for antiseptic resistance, Tn554 and ermA1 for streptomycin and erythromycin resistance, BlaZ for beta-lactam resistance, TetM for tetracycline resistance, and DfrG for trimethoprim resistance. Additionally, a point mutation in GyrA (Ser84Leu) confers quinolone resistance.

Gene Information

Gene Name: erma1
Allele: ermA1
Encodes: erythromycin resistance
Source Database: Reslit
Confers Resistance To: Erythromycin
Organisms Tested In: • Staphylococcus aureus
Geographic Location: United Kingdom
Validation Method: genomic analysis
Sequence Accession: FN433596|FN433597|FN433598

Molecular characteristics of oxazolidinone resistance in enterococci from a multicenter study in China.

PMID 31299904 · 2019

Gene Information

Gene Name: erma1
Allele: ermA1
Encodes: macrolide/lincosamide/streptogramin B resistance
Source Database: Reslit
Mechanism: ribosomal modification
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Enterococcus faecalis
• Enterococcus faecium
Validation Method: PCR and sequencing

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