ermbc

23S rRNA methylase

Validation StatusCandidate

Overview

Validation Method: expression in E. coli and B. subtilis, comparison of amino acid differences
Drug Classes: Macrolide, Lincosamide, Streptogramin b
Organisms: Escherichia coli, Bacillus subtilis
Papers: 1
Databases: Reslit

Papers1

Evidence for natural gene transfer from gram-positive cocci to Escherichia coli.

PMID 2832378 · 1988

The study identifies the ermBC gene on plasmid pIP1527 as responsible for high-level MLS resistance in E. coli BM2570, showing it is similar to erm genes from Streptococcus sanguis and Enterococcus faecalis but expresses constitutively due to mutations in its regulatory region.

Gene Information

Gene Name: ermbc
Allele: ermBC
Encodes: 23S rRNA methylase
Source Database: Reslit
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Escherichia coli
• Bacillus subtilis
Validation Method: expression in E. coli and B. subtilis, comparison of amino acid differences

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ermbc

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