ermfu

ribosomal methylase

Validation StatusCandidate

Overview

Mechanism: target-site modification of the 50S ribosomal subunit
Validation Method: cloning in R. anatipestifer + MIC testing
Drug Classes: Erythromycin, Clindamycin, Macrolide, Lincosamide, Streptogramin b
Organisms: Riemerella anatipestifer
Geographic Location: China
Papers: 2
Databases: Reslit

Papers2

ErmF and ereD are responsible for erythromycin resistance in Riemerella anatipestifer.

PMID 26107936 · 2015

The study identifies ermF, ermFU, and ereD as the primary genes responsible for erythromycin resistance in Riemerella anatipestifer, demonstrating their role through cloning and MIC testing.

Gene Information

Gene Name: ermfu
Allele: ermFU
Encodes: ribosomal methylase
Source Database: Reslit
Mechanism: target-site modification of the 50S ribosomal subunit
Confers Resistance To: ErythromycinClindamycin
Organisms Tested In: • Riemerella anatipestifer
Geographic Location: China
Validation Method: cloning in R. anatipestifer + MIC testing
Sequence Accession: KP265714|KP265715|KP265716|KP265717|KP265718|KP265719|KP265720|KP265721|KP265722|KR857248|KR857249|KR857250|KR857251|KR857252|KR857253|KR857254|KR857255|KR857256|KR857257|KR857258|KR857259|KR857260|KR857261|KR857262|KR857263|KR857264|KR857265|KR857266|KR857267|KR857268|KR857269

Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.

PMID 40020410 · 2025

This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.

Gene Information

Gene Name: ermfu
Allele: ermFU
Encodes: ribosomal methyltransferase
Source Database: Reslit
Mechanism: modifies the ribosome, conferring resistance to macrolides, lincosamides, and streptogramin B
Confers Resistance To: MacrolideLincosamideStreptogramin b
Organisms Tested In: • Riemerella anatipestifer
Geographic Location: China
Validation Method: experimental validation

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