ermtr

erythromycin resistance methylase

Validation StatusCandidate

Overview

Validation Method: PCR and DNA sequencing
Drug Classes: erythromycin, clindamycin, macrolides
Organisms: Streptococcus dysgalactiae subsp. equisimilis, Streptococcus pyogenes
Geographic Location: Hong Kong, Ontario, Canada|Finland|Houston, Texas
Papers: 2
Databases: Reslit

Papers2

Clinical and molecular epidemiology of erythromycin-resistant beta-hemolytic lancefield group G streptococci causing bacteremia.

PMID 14605159 · 2003

The study identifies ermTR, ermB, and mef genes as mediators of erythromycin resistance in beta-hemolytic group G streptococci, highlighting the role of horizontal gene transfer in the spread of resistance.

Gene Information

Gene Name: ermtr
Allele: ermTR
Encodes: erythromycin resistance methylase
Source Database: Reslit
Confers Resistance To: erythromycinclindamycin
Organisms Tested In: • Streptococcus dysgalactiae subsp. equisimilis
Geographic Location: Hong Kong
Validation Method: PCR and DNA sequencing
Sequence Accession: AY355403|AY355404|AY355405|AY355406|AY355407|AY355408|AY355409|AY355410

Genetic diversity among type emm28 group A Streptococcus strains causing invasive infections and pharyngitis.

PMID 16081955 · 2005

The study identified the presence of macrolide resistance genes mefA, ermB, and ermTR in less than 2% of the emm28 group A Streptococcus strains analyzed.

Gene Information

Gene Name: ermtr
Allele: ermTR
Encodes: ribosomal methylase
Source Database: Reslit
Confers Resistance To: macrolides
Organisms Tested In: • Streptococcus pyogenes
Geographic Location: Ontario, Canada|Finland|Houston, Texas
Validation Method: PCR detection of gene presence

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