estT

serine-dependent macrolide esterase

Validation StatusConfirmed2+ DBs

Overview

Mechanism: antibiotic inactivation
Validation Method: transformation into E. coli DH5α and measurement of MIC increase
Drug Classes: Tildipirosin, Tilmicosin, TYLOSIN, Tylosin, Macrolide
Organisms: Sphingobacterium faecium WB1, Escherichia coli DH5α, Sphingobacterium faecium, Pasteurella multocida, Mannheimia haemolytica
Geographic Location: Australia, Canada, North America
Papers: 3
Databases: Card DatabaseReference Gene CatalogReslit

Papers3

A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.

PMID 36791107 · 2023

The study identifies and characterizes a novel macrolide esterase, EstT, which confers resistance to tildipirosin and tilmicosin by hydrolyzing the macrocyclic lactone ring of 16-atom-containing macrolides.

Gene Information

Gene Name: estT
Allele: EstT
Encodes: serine-dependent macrolide esterase
Source Database: Reslit
Confers Resistance To: TildipirosinTilmicosin
Organisms Tested In: • Sphingobacterium faecium WB1
• Escherichia coli DH5α
Geographic Location: Canada
Validation Method: transformation into E. coli DH5α and measurement of MIC increase
Sequence Accession: CP079805

A neglected and emerging antimicrobial resistance gene encodes for a serine-dependent macrolide esterase.

PMID 36791107 · 2023

Gene Information

Gene Name: estT
Allele: EstT
Encodes: macrolide hydrolase EstT
Source Database: Reference Gene Catalog
Confers Resistance To: TYLOSIN
Organisms Tested In: • Sphingobacterium faecium
Sequence Accession: CP094932.1

Identification and evolution of ICE-PmuST394: a novel integrative conjugative element in Pasteurella multocida ST394.

PMID 38380682 · 2024

The study identifies a novel integrative conjugative element, ICE-PmuST394, in Pasteurella multocida ST394, which contains two allelic variants of the beta-lactamase gene bla ROB (bla ROB-1 and bla ROB-13) and the macrolide esterase gene estT. These genes confer resistance to ampicillin, tilmicosin, and tylosin.

Gene Information

Gene Name: estT
Allele: EstT
Encodes: macrolide esterase
Source Database: Reslit
Confers Resistance To: TilmicosinTylosin
Organisms Tested In: • Pasteurella multocida
Geographic Location: Australia
Validation Method: genomic analysis
Sequence Accession: JARXZF000000000.1|JARXZE000000000.1|CP123618.1

Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.

PMID 39918326 · 2025

The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.

Gene Information

Gene Name: estT
Allele: EstT
Encodes: tylosin esterase
Source Database: Reslit
Confers Resistance To: Macrolide
Organisms Tested In: • Mannheimia haemolytica
• Pasteurella multocida
Geographic Location: North America
Validation Method: genomic analysis

PMID N/A

Gene Information

Gene Name: estT
Allele: EstT
Encodes: macrolide esterase
Source Database: Card Database
Mechanism: antibiotic inactivation
Organisms Tested In: • Sphingobacterium faecium
Sequence Accession: CP094932.1
Protein Accession: UXD71803.1
Notes: ARO:3007459

Browse AMR Genes

estT

Gene Information

Gene Information

Gene Information

Gene Information

Gene Information