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ResLit

ethR

transcription repressor

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to ethR

AMR Rules

Browse AMR rules for ethR

Validation StatusSupported

Overview

Validation Method: binding assays, EMSA, BLI, qRT-PCR, drug sensitivity assay
Drug Classes: Ethionamide
Organisms: Mycobacterium tuberculosis, Mycobacterium smegmatis, Mycobacterium tuberculosis variant bovis
Geographic Location: Brazil|Mato Grosso, South Africa
Alleles: 2
Papers: 8
Databases: Reslit
Mutations: 6

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
T182A	-	-	Mycobacterium tuberculosis	Ethionamide	Reslit	Candidate
H169H	-	-	Mycobacterium tuberculosis	Ethionamide	Reslit	Candidate
G106D	-	-	Mycobacterium tuberculosis	Ethionamide	Reslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
ethr	Reslit	1	Ethionamide	Mycobacterium tuberculosis +1	-	2017	-	-
ethR	Reslit	2	Ethionamide	Mycobacterium tuberculosis +1	South Africa, Brazil\|Mato Grosso	2021, 2022	SRR15649877\|SRR15649878\|SRR15649879\|SRR15649880\|SAMN21018175\|SAMN21018176\|SAMN21018177\|SAMN21018178\|JAIOHE000000000\|JAIOHF000000000\|JAIOHG000000000\|JAIOHH000000000\|ERR3445501\|ERR3445502\|ERR3445503\|ERR3445504\|SRR10997360\|SRR10997362\|SRR10997361\|SRR13046675\|SRR12511761\|SRR9850830	-

Papers8

Cyclic di-GMP regulates Mycobacterium tuberculosis resistance to ethionamide.

PMID 28725053 · 2017

Cyclic di-GMP binds to Ethr, enhancing its binding to the etha promoter and repressing etha transcription, thereby contributing to ethionamide resistance in mycobacteria.

Gene Information

Gene Name: ethR
Allele: ethr
Encodes: transcription repressor
Source Database: Reslit
Confers Resistance To: Ethionamide
Organisms Tested In: • Mycobacterium tuberculosis
• Mycobacterium smegmatis
Validation Method: binding assays, EMSA, BLI, qRT-PCR, drug sensitivity assay

Wastewater-Based Surveillance of Antibiotic Resistance Genes Associated with Tuberculosis Treatment Regimen in KwaZulu Natal, South Africa.

PMID 34827300 · 2021

The study identified several antibiotic resistance genes (ARGs) associated with tuberculosis treatment in wastewater samples from South Africa, including rrs (streptomycin resistance), pncA (pyrazinamide resistance), katG (isoniazid resistance), rpoB (rifampicin resistance), embB (ethambutol resistance), gyrA (ofloxacin resistance), gyrB (moxifloxacin resistance), atpE (bedaquiline resistance), ethR (ethionamide resistance), and eis (kanamycin/amikacin resistance).

Gene Information

Gene Name: ethR
Allele: ethR
Encodes: ethionamide resistance transcriptional regulator
Source Database: Reslit
Confers Resistance To: Ethionamide
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: South Africa
Validation Method: conventional PCR and ddPCR

Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.

PMID 36467663 · 2022

The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.

Gene Information

Gene Name: ethR
Allele: ethR
Encodes: ethionamide resistance
Source Database: Reslit
Confers Resistance To: Ethionamide
Organisms Tested In: • Mycobacterium tuberculosis variant bovis
Geographic Location: Brazil|Mato Grosso
Validation Method: genomic analysis
Sequence Accession: SRR15649877|SRR15649878|SRR15649879|SRR15649880|SAMN21018175|SAMN21018176|SAMN21018177|SAMN21018178|JAIOHE000000000|JAIOHF000000000|JAIOHG000000000|JAIOHH000000000|ERR3445501|ERR3445502|ERR3445503|ERR3445504|SRR10997360|SRR10997362|SRR10997361|SRR13046675|SRR12511761|SRR9850830