fabF

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fatty acid synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to fabF

AMR Rules

Browse AMR rules for fabF

Validation StatusCandidate

Overview

Mechanism: mutation
Validation Method: whole-genome sequencing and MIC testing
Drug Classes: daptomycin
Organisms: Enterococcus faecium
Geographic Location: New York metropolitan area, Portugal
Papers: 2
Databases: Reslit

Papers2

Genetic Basis of Emerging Vancomycin, Linezolid, and Daptomycin Heteroresistance in a Case of Persistent Enterococcus faecium Bacteremia.

PMID 29339387 · 2018

The study identifies a novel mutation in fabF associated with daptomycin resistance and confirms the role of vanA in vancomycin resistance in Enterococcus faecium. Additionally, a G2576U mutation in 23S rRNA was linked to linezolid resistance.

Gene Information

Gene Name: fabF
Allele: fabF
Encodes: fatty acid synthase
Source Database: Reslit
Mechanism: mutation
Confers Resistance To: daptomycin
Organisms Tested In: • Enterococcus faecium
Geographic Location: New York metropolitan area
Validation Method: whole-genome sequencing and MIC testing
Sequence Accession: PRJNA407447

Genetic basis of emerging vancomycin, linezolid, and daptomycin heteroresistance in a case of persistent Enterococcus faecium bacteremia.

PMID 39229839 · 2018

The study identifies vanA and vanM operons as key determinants of glycopeptide resistance in Enterococcus faecium, along with rRNA and fabF mutations associated with linezolid and daptomycin resistance, respectively.