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fabG1

ethionamide resistant fabG1

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to fabG1

Browse AMR rules for fabG1

Validation StatusEstablished

Overview

Mechanism: antibiotic target alteration
Drug Classes: Isoniazid, Ethionamide, Isoniazid|Ethionamide, Ethionamide,Isoniazid, INH|Ethionamide, INH
Organisms: Mycobacterium tuberculosis H37Rv, Mycobacterium tuberculosis
Alleles: 3
Papers: 41
Databases: Card Database
Mutations: 28

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
I194T	-	-	Mycobacterium tuberculosis	Isoniazid	Reslit	Candidate
V232A	-	-	-	Isoniazid	Reslit	Candidate
L5F	-	-	-	Ethionamide	Reslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
Mtub_fabG1_ETO	Card Database	1	-	Mycobacterium tuberculosis H37Rv	-	-	NC_000962.3	NP_215999.1
Mtub_fabG1_INH	Card Database	1	-	Mycobacterium tuberculosis H37Rv	-	-	NC_000962.3	NP_215999.1
Mtub_fabG1_PTO	Card Database	1	-	Mycobacterium tuberculosis H37Rv	-	-	NC_000962.3	NP_215999.1