Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
enoyl-(acyl-carrier-protein) reductase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| D101G | - | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
| F203L | - | single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli | triclosanmultiple antibioticsisoniazid | Card DatabaseReference Gene CatalogReslit | Confirmed |
| F203C | - | single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli | triclosanmultiple antibioticsisoniazid | Card DatabaseReference Gene CatalogReslit | Confirmed |
| F203V | - | single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli | triclosanmultiple antibiotics | Card DatabaseReference Gene CatalogReslit | Confirmed |
| F203S | - | - | Escherichia coli | triclosan | Reslit | Candidate |
| A21T | - | - | Escherichia coli | triclosan | Reslit | Candidate |
| I192F | - | - | Escherichia coli | triclosan | Reslit | Candidate |
| T194S | - | - | Escherichia coli | triclosan | Reslit | Candidate |
| G93S | - | single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli, Salmonella Typhimurium | triclosanmultiple antibioticsisoniazid | Card DatabaseReference Gene CatalogReslit | Confirmed |
| M159T | - | single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli | triclosanmultiple antibiotics | Card DatabaseReference Gene CatalogReslit | Confirmed |
| G95S | - | - | Acinetobacter baumannii | triclosan | Reslit | Candidate |
| G93V | - | resistance to triclosan, single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli, Salmonella Typhimurium | triclosanmultiple antibioticsisoniazid | Card DatabaseReference Gene CatalogReslit | Confirmed |
| F204C | - | prevents the formation of the stable triclosan-NAD+-FabI complex | Staphylococcus aureus | triclosan | Reslit | Candidate |
| G23S | - | resistance to triclosan | Staphylococcus aureus | triclosan | Reslit | Candidate |
| L12P | - | - | Enterococcus faecalis | triclosan | Reslit | Candidate |
| Y147H | - | FabI(Y147H) was catalytically defective but retained its sensitivity to AFN-1252 | Staphylococcus aureus | triclosan | Reslit | Candidate |
| F204S | - | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
| F204L | - | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
| A24T | - | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
| D101Y | - | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
| I193F | - | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
| F203A | - | single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli | triclosanmultiple antibioticsisoniazid | Card DatabaseReference Gene CatalogReslit | Confirmed |
| S241F | - | - | - | triclosan | Reslit | Candidate |
| A95V | - | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
| K34E | - | - | Escherichia coli | triclosan | Reslit | Candidate |
| G93A | - | single resistance variant, enoyl-[acyl-carrier-protein] reductase FabI | Escherichia coli | multiple antibioticsisoniazidtriclosan | Card DatabaseReference Gene Catalog | Confirmed |
| - | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| N220I | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| - | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| - | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| H253P | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| - | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| A69T | - | Escherichia coli | triclosan | Reslit | Candidate | |
| G79A | - | Escherichia coli | triclosan | Reslit | Candidate | |
| G113V | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| G227C | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| A230T | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| V241I | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| - | - | Salmonella enterica | triclosan | Reslit | Candidate | |
| - | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| - | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| Y123H | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| S166N | - | Staphylococcus aureus | triclosan | Reslit | Candidate | |
| F252I | - | Staphylococcus aureus | triclosan | Reslit | Candidate |
A platform for detecting cross-resistance in antibacterial drug discovery.
Research Article
Experimental evolution in morbidostat reveals converging genomic trajectories on the path to triclosan resistance.
Research Article
Some mutations were found in combination with others.
fabI
Molecular Characterization of Reduced Susceptibility to Biocides in Clinical Isolates of Acinetobacter baumannii.
Research Article
The Gly95Ser mutation in fabI was found in one isolate and contributes to triclosan resistance.
The impact of DNA adenine methyltransferase knockout on the development of triclosan resistance and antibiotic cross-resistance in Escherichia coli.
Research Article
Defining and combating the mechanisms of triclosan resistance in clinical isolates of Staphylococcus aureus.
Research Article
The F204C mutation prevents the formation of the stable triclosan-NAD+-FabI complex.
Importance of sigma factor mutations in increased triclosan resistance in Salmonella Typhimurium.
Research Article
Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics.
Review
Resistant to triclosan.
Using Selection by Nonantibiotic Stressors to Sensitize Bacteria to Antibiotics.
Research Article
Resistance to AFN-1252 arises from missense mutations in Staphylococcus aureus enoyl-acyl carrier protein reductase (FabI).
Research Article
Mutations in fabI were identified as the cause of resistance to AFN-1252 and triclosan.
Staphylococcus aureus but not Listeria monocytogenes adapt to triclosan and adaptation correlates with increased fabI expression and agr deficiency.
Research Article
Mutations in fabI were found in USA300 strains but not in 8325-4 strains.
Distribution of triclosan-resistant genes in major pathogenic microorganisms revealed by metagenome and genome-wide analysis.
Research Article
Mutations in FabI confer triclosan resistance
Fatty Acid Supplementation Reverses the Small Colony Variant Phenotype in Triclosan-Adapted Staphylococcus aureus: Genetic, Proteomic and Phenotypic Analyses.
Research Article
Associations between sensitivity to antibiotics, disinfectants and heavy metals in natural, clinical and laboratory isolates of Escherichia coli.
Research Article
Triclosan Resistome from Metagenome Reveals Diverse Enoyl Acyl Carrier Protein Reductases and Selective Enrichment of Triclosan Resistance Genes.
Research Article
Escherichia coli fabI mutations conferring resistance to isoniazid and triclosan; CARD accession: CARD:3004045
fabI
Structure-activity studies of the inhibition of FabI, the enoyl reductase from Escherichia coli, by triclosan: kinetic analysis of mutant FabIs.
Research Article
fabI
Cerebral micro arteriovenous malformations (mAVMs). Review of 13 cases.
Research Article
fabI
Mutations upstream of fabI in triclosan resistant Staphylococcus aureus strains are associated with elevated fabI gene expression.
Research Article
Mutations in the upstream region of fabI were associated with increased gene expression and triclosan resistance.
Nonactive-Site Mutations in S. aureus FabI That Induce Triclosan Resistance.
Research Article
Mutations identified in non-active site regions of Sa FabI that confer triclosan resistance.
The prevalence and mechanism of triclosan resistance in Escherichia coli isolated from urine samples in Wenzhou, China.
Research Article
Mutations were detected in triclosan-resistant strains but also in susceptible strains.
Multiple adaptive routes of Salmonella enterica Typhimurium to biocide and antibiotic exposure.
Research Article