fabY

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β-acetoacetyl-acyl carrier protein synthase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

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UniProt

Protein entries specific to fabY

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Validation StatusCandidate

Overview

Mechanism: enhances lipopolysaccharide production, thereby increasing the surface binding of colistin and bacterial susceptibility
Validation Method: deletion of fabY in either the pvrA mutant or wild-type strain increases bacterial susceptibility to colistin
Drug Classes: colistin
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

The fatty acid synthesis gene fabY affects lipopolysaccharide synthesis and colistin susceptibility in Pseudomonas aeruginosa.

PMID 40662729 · 2025

Mutation of the fatty acid synthesis gene fabY increases Pseudomonas aeruginosa susceptibility to colistin by enhancing lipopolysaccharide production and promoting colistin binding.

Gene Information

Gene Name: fabY
Allele: fabY
Encodes: β-acetoacetyl-acyl carrier protein synthase
Source Database: Reslit
Mechanism: enhances lipopolysaccharide production, thereby increasing the surface binding of colistin and bacterial susceptibility
Confers Resistance To: colistin
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: deletion of fabY in either the pvrA mutant or wild-type strain increases bacterial susceptibility to colistin

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fabY

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fabY

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