fadE24

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Membrane-bound fatty acid oxidoreductase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to fadE24

AMR Rules

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Validation StatusCandidate

Overview

Validation Method: sequencing and mutation analysis
Drug Classes: isoniazid
Organisms: Mycobacterium tuberculosis
Geographic Location: Southern India
Papers: 1
Databases: Reslit

Papers1

Mycobacterium tuberculosis Whole Genome Sequences From Southern India Suggest Novel Resistance Mechanisms and the Need for Region-Specific Diagnostics.

PMID 28498943 · 2017

The study identified novel resistance mechanisms in Mycobacterium tuberculosis strains from Southern India, including mutations in katG, fadE24, fabD, gidB, and rrs that contribute to isoniazid and streptomycin resistance.

Gene Information

Gene Name: fadE24
Allele: fadE24
Encodes: Membrane-bound fatty acid oxidoreductase
Source Database: Reslit
Confers Resistance To: isoniazid
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Southern India
Validation Method: sequencing and mutation analysis
Sequence Accession: PRJNA235851

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fadE24

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fadE24

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