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aac(6')

Gene Family
NCBI Pathogen Isolates
Genomes carrying any aac(6') allele
NCBI Reference Gene Catalog
All known alleles and reference sequences
UniProt
Protein entries for the encoded enzyme
Alleles25
AllelePapersDrug ClassesOrganismsCountriesYearsStatus
AAC(6')-29a2 papersAMINOGLYCOSIDEPseudomonas aeruginosa-2001Not Validated
AAC(6')-29b2 papersAMINOGLYCOSIDEPseudomonas aeruginosa-2001Not Validated
AAC(6')-292 papersAMINOGLYCOSIDEEnterobacter hormaechei subsp. steigerwaltii--Not Validated
aac(6')-30/aac(6')-Ib'6 papersTOBRAMYCIN, AMINOGLYCOSIDE +7Pseudomonas aeruginosa-2004Not Validated
AAC(6')-303 papersAMINOGLYCOSIDE, kanamycin +3Enterobacter hormaechei +1Brazil2004Not Validated
AAC(6')-316 papersAMINOGLYCOSIDEAcinetobacter baumannii +2-2007Not Validated
AAC(6')-352 papersKANAMYCINBrevibacillus brevis Vm4--Not Validated
aac(6')98 papersAMINOGLYCOSIDEStreptomyces sp. NRRL F-4707 +33-2015, 2016Not Validated
AAC(6')-326 papersTOBRAMYCIN, AMINOGLYCOSIDEPseudomonas aeruginosa-2007Not Validated
AAC(6')-336 papersTOBRAMYCIN, AMIKACIN +1Pseudomonas aeruginosa-2009Not Validated
aac(6')-aph(2'')2 papersgentamicin, tobramycin +2Staphylococcus aureusJapan, Pennsylvania2001, 2004Not Validated
AAC(6')-I306 papersTOBRAMYCIN, AMINOGLYCOSIDE +4Salmonella enterica subsp. enterica serovar Agona-2004Not Validated
AAC(6')-Iaa6 papersTOBRAMYCIN, AMIKACIN +1Salmonella enterica subsp. enterica serovar Typhimurium str. LT2--Not Validated
AAC(6')-Iae7 papersTOBRAMYCIN, AMINOGLYCOSIDE +9Pseudomonas aeruginosa +2Japan2005Not Validated
AAC(6')-Iaf4 papersAMINOGLYCOSIDEPseudomonas aeruginosa-2009Not Validated
AAC(6')-Iai6 papersTOBRAMYCIN, AMINOGLYCOSIDE +4Pseudomonas aeruginosa--Not Validated
AAC(6')-Iaj6 papersTOBRAMYCIN, AMINOGLYCOSIDE +4Pseudomonas aeruginosa-2013Not Validated
AAC(6')-Ial2 papersAMINOGLYCOSIDESerratia marcescens--Not Validated
AAC(6')-Ic7 papersgentamicin, tobramycin +7Escherichia coli +1-1992Not Validated
AAC(6')-Isa6 papersTOBRAMYCIN, AMIKACIN +1Streptomyces noursei-2004Not Validated
AAC(6')-Iy4 papersAMINOGLYCOSIDESalmonella enterica subsp. enterica serovar Enteritidis-1999Not Validated
aac6'-aph2"1 papergentamicin, tobramycin +1Staphylococcus aureusFrance|French West Indies1999Not Validated
AacA162 papersAMINOGLYCOSIDEAcinetobacter baumannii 1656-2--Not Validated
AacA472 papersAMINOGLYCOSIDEChamaesiphon minutus PCC 6605-2013Not Validated
AacA562 papersTOBRAMYCIN, KANAMYCIN +1Pseudomonas aeruginosa-2023Not Validated
Papers20
1

Characterization of Class 1 integrons from Pseudomonas aeruginosa that contain the bla(VIM-2) carbapenem-hydrolyzing beta-lactamase gene and of two novel aminoglycoside resistance gene cassettes.

PMID: 11158753 · 2001
2

Integron carrying a novel metallo-beta-lactamase gene, blaIMP-16, and a fused form of aminoglycoside-resistant gene aac(6')-30/aac(6')-Ib': report from the SENTRY Antimicrobial Surveillance Program.

PMID: 15561846 · 2004
3

Characterization of an integron carrying blaIMP-1 and a new aminoglycoside resistance gene, aac(6')-31, and its dissemination among genetically unrelated clinical isolates in a Brazilian hospital.

PMID: 17470660 · 2007
4

Genome Sequence of Stenotrophomonas maltophilia Strain SmAs1, Isolated From the Asian Malaria Mosquito Anopheles stephensi.

PMID: 26966198 · 2016
5

Comparative genome analyses of Serratia marcescens FS14 reveals its high antagonistic potential.

PMID: 25856195 · 2015
6

Complete Genome Sequence of Serratia marcescens SmUNAM836, a Nonpigmented Multidrug-Resistant Strain Isolated from a Mexican Patient with Obstructive Pulmonary Disease.

PMID: 26798087 · 2016
7

Molecular epidemiology and mechanisms of carbapenem resistance in Pseudomonas aeruginosa isolates from Spanish hospitals.

PMID: 17938181 · 2007
8

Nosocomial spread of colistin-only-sensitive sequence type 235 Pseudomonas aeruginosa isolates producing the extended-spectrum beta-lactamases GES-1 and GES-5 in Spain.

PMID: 19738007 · 2009
9

Identification of Aminoglycoside-Modifying Enzymes by Susceptibility Testing: Epidemiology of Methicillin-Resistant Staphylococcus aureus in Japan.

PMID: 11526138 · 2001
10

Vancomycin-resistant Staphylococcus aureus isolate from a patient in Pennsylvania.

PMID: 14693550 · 2004
11

Characterization of a Salmonella enterica serovar Agona strain harbouring a class 1 integron containing novel OXA-type beta-lactamase (blaOXA-53) and 6'-N-aminoglycoside acetyltransferase genes [aac(6')-I30].

PMID: 15231768 · 2004
12

Multidrug-resistant Pseudomonas aeruginosa strain that caused an outbreak in a neurosurgery ward and its aac(6′)-Iae gene cassette encoding a novel aminoglycoside acetyltransferase.

PMID: 16127047 · 2005
13

AAC(6')-Iaf, a novel aminoglycoside 6'-N-acetyltransferase from multidrug-resistant Pseudomonas aeruginosa clinical isolates.

PMID: 19349516 · 2009
14

novel 6'-n-aminoglycoside acetyltransferase AAC(6')-Iaj from a clinical isolate of Pseudomonas aeruginosa.

PMID: 23070167 · 2013
15

Characterization of the chromosomal aac(6')-Ic gene from Serratia marcescens.

PMID: 1354954 · 1992
16

Overexpression and characterization of an aminoglycoside 6'-N-acetyltransferase with broad specificity from an epsilon-poly-L-lysine producer, Streptomyces albulus IFO14147.

PMID: 15625322 · 2004
17

Activation of the cryptic aac(6')-Iy aminoglycoside resistance gene of Salmonella by a chromosomal deletion generating a transcriptional fusion.

PMID: 10542165 · 1999
18

Emergence and spread in French hospitals of methicillin-resistant Staphylococcus aureus with increasing susceptibility to gentamicin and other antibiotics.

PMID: 10523533 · 1999
19

Improving the coverage of the cyanobacterial phylum using diversity-driven genome sequencing.

PMID: 23277585 · 2013
20

Extensive screening reveals previously undiscovered aminoglycoside resistance genes in human pathogens.

PMID: 37537271 · 2023
Overview
Drug Classes
AMINOGLYCOSIDETOBRAMYCINISEPAMICINAMIKACINSISOMICINNETILMICINNEOMYCINKANAMYCINGENTAMICINkanamycinneomycinnetilmicintobramycingentamicinamikacinDIBEKACINsisomicin
Organisms
  • Pseudomonas aeruginosa
  • Enterobacter hormaechei subsp. steigerwaltii
  • Enterobacter hormaechei
  • Escherichia coli
  • Acinetobacter baumannii
  • +44 more

25 known alleles

20 papers in ResLit