Browse AMR Genes

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ResLit

fbiC

F420 biosynthesis enzyme

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to fbiC

AMR Rules

Browse AMR rules for fbiC

Validation StatusSupported

Overview

Mechanism: delamanid resistance
Validation Method: mutation analysis and MIC testing
Drug Classes: Delamanid, Pretomanid, DLM|PAS, Delamanid|Pretomanid, Pretomanid|Delamanid
Organisms: Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis, Mycobacterium bovis
Geographic Location: Brazil|Mato Grosso, Egypt|France|Algeria|South Africa, Iran
Papers: 15
Databases: Reslit
Mutations: 17

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
R536L	-	-	-	DLM\|PAS	Reslit	Candidate
V318I	G952A	-	Mycobacterium tuberculosis	Delamanid	Reslit	Supported
W678G	-	-	Mycobacterium tuberculosis	Delamanid\|Pretomanid

Papers15

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.

PMID 32361756 · 2020

This study identifies numerous mutations in genes associated with resistance to bedaquiline, clofazimine, linezolid, delamanid, and pretomanid in Mycobacterium tuberculosis, highlighting the genetic basis of resistance to these drugs.

Gene Information

Gene Name: fbiC
Allele: fbiC
Encodes: F420 biosynthesis enzyme
Source Database: Reslit
Confers Resistance To: DelamanidPretomanid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: mutation analysis and MIC testing

Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.

PMID 36467663 · 2022

The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.

Gene Information

Gene Name: fbiC
Allele: fbiC
Encodes: delamanid resistance
Source Database: Reslit
Confers Resistance To: Delamanid
Organisms Tested In: • Mycobacterium tuberculosis variant bovis
Geographic Location: Brazil|Mato Grosso
Validation Method: genomic analysis
Sequence Accession: SRR15649877|SRR15649878|SRR15649879|SRR15649880|SAMN21018175|SAMN21018176|SAMN21018177|SAMN21018178|JAIOHE000000000|JAIOHF000000000|JAIOHG000000000|JAIOHH000000000|ERR3445501|ERR3445502|ERR3445503|ERR3445504|SRR10997360|SRR10997362|SRR10997361|SRR13046675|SRR12511761|SRR9850830

Selection of Multi-Drug Targets against Drug-Resistant Mycobacterium tuberculosis XDR1219 Using the Hyperbolic Mapping of the Protein Interaction Network.

PMID 37762354 · 2023

The study identifies several drug targets (DTs) in Mycobacterium tuberculosis XDR1219 using hyperbolic mapping of the protein interaction network. Key DTs include rpsA, rpsL, embB, embA, fbiC, fbiB, rpoB, dnaK, rpoA, rpoC, rpoZ, ddl, alr, pbpB, rplD, rplC, rmlC, Isr2, tlyA, pknB, dprE1, fas, accD1, accE5, Rv0200, galE3, pks5, msl3, phoP, dacB2, pknI, echA19, ltp3, and Rv3520c, which are involved in various metabolic pathways and are targeted by different antibiotics.

Gene Information

Gene Name: fbiC
Allele: fbiC
Encodes: activator of prodrugs
Source Database: Reslit
Confers Resistance To: DelamanidPretomanid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: hyperbolic mapping of protein interaction network

Genetic diversities and drug resistance in Mycobacterium bovis isolates from zoonotic tuberculosis using whole genome sequencing.

PMID 39487429 · 2024

The study identified multiple AMR genes and mutations in Mycobacterium bovis isolates, including resistance to isoniazid, streptomycin, ethambutol, fluoroquinolones, pyrazinamide, d-cycloserine, rifampin, delamanid, and para-aminosalicylic acid.

Gene Information

Gene Name: fbiC
Allele: fbiC
Encodes: ferric-bacillibactin transporter
Source Database: Reslit
Mechanism: delamanid resistance
Confers Resistance To: Delamanid
Organisms Tested In: • Mycobacterium bovis
Geographic Location: Egypt|France|Algeria|South Africa
Validation Method: genomic sequencing and mutation analysis
Sequence Accession: SAMN37519983|SAMN37519961|SAMN37519964|SAMN38024412|SAMN37519969|PRJNA1019495

Investigation of delamanid, bedaquiline, and linezolid resistance rates and related gene mutations in multidrug-resistant Mycobacterium tuberculosis in regional tuberculosis reference laboratories of Iran.

PMID 40817101 · 2025

This study identified multiple mutations in the fgd1, fbiA, fbiC, rplC, and rrl genes associated with delamanid and linezolid resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Iran.

Gene Information

Gene Name: fbiC
Allele: fbiC
Encodes: flavin-containing monooxygenase
Source Database: Reslit
Mechanism: mutation in fbiC gene leads to resistance to delamanid
Confers Resistance To: Delamanid
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Iran
Validation Method: sequencing

In vitro exposure to clofazimine can select for delamanid and pretomanid resistance in Mycobacterium tuberculosis.

PMID 40980917 · 2025

Gene Information

Gene Name: fbiC
Allele: fbiC
Encodes: non-essential gene involved in activation of delamanid and pretomanid
Source Database: Reslit
Mechanism: inactivation leads to cross-resistance to delamanid and pretomanid
Confers Resistance To: DelamanidPretomanid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: in vitro selection experiments and antimicrobial susceptibility testing