fdh1 cb

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formate dehydrogenase

NCBI Pathogen Isolates

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NCBI Reference Gene Catalog

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UniProt

Protein entries specific to fdh1 cb

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Validation StatusCandidate

Overview

Mechanism: conversion of formate to CO2 while reducing NAD+ to NADH
Validation Method: disk diffusion assay and Etest
Drug Classes: fluoroquinolones, aminoglycosides
Organisms: Pseudomonas aeruginosa
Papers: 1
Databases: Reslit

Papers1

Dual Effect: High NADH Levels Contribute to Efflux-Mediated Antibiotic Resistance but Drive Lethality Mediated by Reactive Oxygen Species.

PMID 35038918 · 2022

Overexpression of FDH1 Cb in P. aeruginosa increased resistance to fluoroquinolones and aminoglycosides, likely through activation of efflux pumps. Overexpression of nox Sp increased sensitivity to antibiotics.

Gene Information

Gene Name: fdh1 cb
Allele: FDH1 Cb
Encodes: formate dehydrogenase
Source Database: Reslit
Mechanism: conversion of formate to CO2 while reducing NAD+ to NADH
Confers Resistance To: fluoroquinolonesaminoglycosides
Organisms Tested In: • Pseudomonas aeruginosa
Validation Method: disk diffusion assay and Etest

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fdh1 cb

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fdh1 cb

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