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ResLit

fgd1

F420 recycling enzyme

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to fgd1

AMR Rules

Browse AMR rules for fgd1

Validation StatusSupported

Overview

Mechanism: non-synonymous mutation
Validation Method: mutation analysis and MIC testing
Drug Classes: Delamanid, Pretomanid, Delamanid|Pretomanid, Pa-824, Delamanid|Clofazimine
Organisms: Mycobacterium tuberculosis, Mycobacterium tuberculosis variant bovis
Geographic Location: Brazil|Mato Grosso, Iran, Viet Nam|Thailand
Papers: 11
Databases: Reslit
Mutations: 19

Mutations

Protein Change	Nucleotide Change	Mechanism	Organism	Resistance To	Database	Validation Status
V1Var	-	single resistance variant	Mycobacterium tuberculosis	Delamanid	Card Database	Established
K296E	-	-	Mycobacterium tuberculosis	Delamanid\|Pretomanid	Reslit	Candidate
V310D	-	-	Mycobacterium tuberculosis	Delamanid

Papers11

Systematic review of mutations associated with resistance to the new and repurposed Mycobacterium tuberculosis drugs bedaquiline, clofazimine, linezolid, delamanid and pretomanid.

PMID 32361756 · 2020

This study identifies numerous mutations in genes associated with resistance to bedaquiline, clofazimine, linezolid, delamanid, and pretomanid in Mycobacterium tuberculosis, highlighting the genetic basis of resistance to these drugs.

Gene Information

Gene Name: fgd1
Allele: fgd1
Encodes: F420 recycling enzyme
Source Database: Reslit
Confers Resistance To: DelamanidPretomanid
Organisms Tested In: • Mycobacterium tuberculosis
Validation Method: mutation analysis and MIC testing

Genomic analysis of Mycobacterium tuberculosis variant bovis strains isolated from bovine in the state of Mato Grosso, Brazil.

PMID 36467663 · 2022

The study identified multiple AMR genes and mutations in Mycobacterium tuberculosis variant bovis strains from Mato Grosso, Brazil, including resistance to pyrazinamide, isoniazid, rifampicin, streptomycin, ethambutol, ethionamide, fluoroquinolones, kanamycin, capreomycin, paraminosalicylic acid, cycloserine, bedaquiline, linezolid, and delamanid.

Gene Information

Gene Name: fgd1
Allele: fgd1
Encodes: delamanid resistance
Source Database: Reslit
Confers Resistance To: Delamanid
Organisms Tested In: • Mycobacterium tuberculosis variant bovis
Geographic Location: Brazil|Mato Grosso
Validation Method: genomic analysis
Sequence Accession: SRR15649877|SRR15649878|SRR15649879|SRR15649880|SAMN21018175|SAMN21018176|SAMN21018177|SAMN21018178|JAIOHE000000000|JAIOHF000000000|JAIOHG000000000|JAIOHH000000000|ERR3445501|ERR3445502|ERR3445503|ERR3445504|SRR10997360|SRR10997362|SRR10997361|SRR13046675|SRR12511761|SRR9850830

Identification of bacterial determinants of tuberculosis infection and treatment outcomes: a phenogenomic analysis of clinical strains.

PMID 38734030 · 2024

Mutations in Rv1339 and the L1.1.1.1 subclade were associated with treatment failure and cavitary disease. mmpL5 and fgd1 mutations were linked to reduced susceptibility to bedaquiline, clofazimine, and pretomanid.

Gene Information

Gene Name: fgd1
Allele: fgd1
Encodes: pretomanid resistance determinant
Source Database: Reslit
Mechanism: non-synonymous mutation
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Viet Nam|Thailand
Validation Method: genome-wide association study
Sequence Accession: PRJNA950969|PRJNA355614

Investigation of delamanid, bedaquiline, and linezolid resistance rates and related gene mutations in multidrug-resistant Mycobacterium tuberculosis in regional tuberculosis reference laboratories of Iran.

PMID 40817101 · 2025

This study identified multiple mutations in the fgd1, fbiA, fbiC, rplC, and rrl genes associated with delamanid and linezolid resistance in multidrug-resistant Mycobacterium tuberculosis isolates in Iran.

Gene Information

Gene Name: fgd1
Allele: fgd1
Encodes: glucose-6-phosphate dehydrogenase
Source Database: Reslit
Mechanism: mutation in fgd1 gene leads to resistance to delamanid
Confers Resistance To: Delamanid
Organisms Tested In: • Mycobacterium tuberculosis
Geographic Location: Iran
Validation Method: sequencing