Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
chloramphenicol/florfenicol efflux MFS transporter FloR
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| FloR | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 490 | CHLORAMPHENICOL, FLORFENICOL +14 | Vibrio cholerae +184 | Asia|United States, France|Germany, Canada|France|Belgium|Scotland, Asia, Italy, Czech Republic, Laos, Belgium, France|Belgium|Scotland|Canada, India|Mexico|Egypt|Morocco|Peru|Kenya|Senegal|Mali|South Africa|Vietnam|Nepal|Indonesia|Bolivia|Equatorial Guinea|Uganda|Cameroon|Guatemala|Philippines|Burkina-Faso, Taiwan, Canada, Atlantic Canada, Australia|United Kingdom, Japan|United States, Mozambique, Singapore|Colombia|Guyana|Brazil|Manaos, South Africa, Mexico, Korea, Ireland, Global, Haiti, Hungary, Japan, Germany, Europe, Nigeria, Iran, USA|Brazil|United States, Eastern China, China, Austria, Japan|Thailand|Canada|France|Spain|South Korea|United Kingdom|Croatia|Vietnam|global, Texas|Nebraska|Alberta|France|Alberta, Canada|Nebraska, Texas, USA|Nantes, France, United States, India, Europe|Portugal, North America, North America|US|Germany|Switzerland|Japan|China|Hong Kong|United Kingdom, Egypt, Germany|France|Netherlands|Belgium, Saudi Arabia, New York|Washington, France, Brazil, Kenya, Australia, USA|Australia|Canada|Japan|France|Madagascar|China|Thailand|Germany, Europe|seafood, Guangxi, China, Vietnam, Pakistan|China, United Kingdom, Singapore, Chile, Thailand|Japan, South Korea, Argentina, St. Louis, MO, USA, South America|South Korea, Malawi, Denmark|France|Poland|Italy|Hungary|Germany|Estonia|United States, Tanzania|Thailand|human|swine, Ecuador, UK, Southeastern Brazil, Taiwan|Germany|Netherlands|United Kingdom|United States, South China, Texas, USA, Alberta|North America, Bangladesh, Southern China, northern Xinjiang, China|China, Black Sea, Madagascar|Cambodia|Senegal, Spain, Philippines, Shanghai, China, Europe|Italy, USA|United States|China|Sri Lanka|Germany|Greece, South Africa|various water sources, Poland, USA|Peru|Egypt|Cambodia|Kenya, Shanxi Province, China, Embu Town|Kangaru Market, Europe|Poland, Jakarta, Yellow Sea, Armenia|Georgia, Sweden, Northeast China, Finland|Malaysia|Poland|Lithuania|United States|Canada|China|Japan|Norway|Brazil|Netherlands|Hong Kong|Germany|Switzerland|Portugal|Australia|UK|Vietnam|Spain|Dominican Republic|India|Thailand, Peru, Guizhou, China, North America|Asia|Europe|Australia|South America, Europe|Spain|Hungary|Germany|France|Belgium|Poland|United Kingdom|Denmark, Ontario, Canada|North America, California, Europe|Denmark|France|Germany|United Kingdom, India|Malaysia|South China, Europe|China|Egypt|Vietnam|Colombia, Malaysia, East Coast Peninsular Malaysia, Cambodia, England|Wales, Ghana, New York State, Russia|Moscow, North Carolina|USA, Quebec|Ontario|France|Switzerland, Victoria, Australia, Greece, Denmark, Zhanjiang, China, Hong Kong, Mecklenburg-Western Pomerania, China|Bangladesh|USA|England|India, Senegal, Europe|North America|Netherlands|Denmark|Pennsylvania|United States|France, Kuwait, North-Western Mexico, Guangxi Province, New South Wales, Australia, Georgia, USA|Georgia, Algeria, Germany|Colombia|Vietnam|Japan|Nicaragua|United States|Canada|Brazil|Thailand|Lebanon|Poland|France|Italy|Spain|Portugal|Mexico|China|South Korea|India, Spain|Peru, South America, Zhejiang Province, China, Southeast Nigeria, Henan|Hubei|Hunan|Anhui|Jiangxi|Shaanxi|Shanxi, North Sea|Baltic Sea, Germany|Central Germany, South America|Chile, Khon Kaen province, Thailand, Turkiye, Zhejiang, China|China, Thailand, Colombia, Shandong|Hebei|Jiangsu|Guangxi|Fujian|Henan|Guangdong, Yangzhou, China, Portugal|Antarctic|South Shetland Islands|North Adriatic Sea|Bohai Sea|Adriatic Sea|Pacific Ocean|Baltic Sea, Ontario, Canada, Shanxi Province, Midwestern U.S.|Nebraska, Anhui, China, Belgium|The Netherlands|Europe, Shandong Province, China, north-central Nigeria, Northwest, China|Northwest China, Global|Guinea|Austria|Vietnam|China|Spain|Canada|Hong Kong|Malaysia|Germany|South Africa|Vancouver|Vienna, West Texas, USA, Shenzhen, China|China, Moscow, Russia, Hunan Province|China, China|Bolivia|United States|Canada|New Zealand, Tennessee, USA|East Tennessee, Germany|Australia|Taiwan|USA|Canada|Denmark, Southeastern U.S., Shandong Province, North Carolina, Peruvian Amazon, Switzerland, Bangkok, Thailand, Hebei Province|China|Hebei Province, China, China|India|Portugal|Iraq|Nigeria|Brazil|Tunisia, Turkey, Canada|France|Germany|North America|Europe, Guangdong Province, China, Guangdong, China, France|Ecuador|Vietnam|India|Madagascar|Nigeria, Fiji, Tunisia, Indonesia|Australia, Pakistan|China|United States|United Kingdom|Canada|Australia|Spain|Denmark|UAE|Ethiopia|India|South Asia, Europe|Canada, Shenzhen|Dapeng, Uruguay, Latin America, Europe|Africa|North America|South America|Asia|Oceania, Kentucky|USA, Armenia, Republic of Korea, China|Anhui|Hainan|Sichuan, Central Zone of Mexico|Mexico, Guangzhou, China, Shanghai|Minhang District, Costa Rica, Inner Mongolia|Inner Mongolia, China, China|Lebanon|United States|Poland|France, North Carolina, USA, Shandong Province|adjacent regions in China, Xinjiang, China, North America|Canada, Germany|Spain|UK|Vietnam, China|North America|Asia|Europe|Africa|Other, Northern Nigeria|Nigeria, Shenzhen, China, China|United Kingdom|Argentina|Europe|Americas|Asia|Africa|Australasia|Vietnam|Switzerland|Thailand|Mexico, Asia|China, Southern Togo|Togo, United Arab Emirates | 1999, 2000, 2001, 2002, 2003, 2004, 2005, 2006, 2007, 2008, 2009, 2010, 2011, 2012, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025, 2026 | AY822603.1 | AAV84883.1 |
| floR | Card DatabaseResFinder Database | 2 | CHLORAMPHENICOL, FLORFENICOL +1 | Salmonella enterica subsp. enterica serovar Typhimurium str. DT104 +1 | - | 1999 | AF071555, AF118107 | AAG16656.1 |
| flo | Reslit | 7 | phenicols, florfenicol +2 | Escherichia coli +1 | United States, Oklahoma, Pakistan|China, Egypt | 2000, 2002, 2012, 2018, 2022, 2024 | AF252855 | - |
| floR-T1 | Reslit | 1 | florfenicol, phenicols | Pseudomonas aeruginosa | China | 2021 | CP053390 | - |
| floR-T2 | Reslit | 1 | florfenicol, phenicols | Pseudomonas aeruginosa | China | 2021 | CP053390 | - |
Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104.
Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104.
Molecular characterization of an antibiotic resistance gene cluster of Salmonella typhimurium DT104., A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104.
A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104.
A new chloramphenicol and florfenicol resistance gene flanked by two integron structures in Salmonella typhimurium DT104.
Changes in antimicrobial resistance in Salmonella enterica serovar typhimurium.
The study identifies the chloramphenicol resistance gene floR and the tetracycline resistance gene tet(G) in Salmonella enterica serovar Typhimurium DT104, suggesting their origin in aquatic bacteria and horizontal transfer.
Plasmid-mediated florfenicol resistance encoded by the floR gene in Escherichia coli isolated from cattle.
The study identified the floR gene as responsible for plasmid-mediated florfenicol resistance in Escherichia coli isolates from cattle.
Plasmid-mediated florfenicol resistance encoded by the floR gene in Escherichia coli isolated from cattle.
Plasmid-mediated florfenicol resistance encoded by the floR gene in Escherichia coli isolated from cattle.
Characterization of chloramphenicol and florfenicol resistance in Escherichia coli associated with bovine diarrhea.
The study identifies the flo gene as a mediator of nonenzymatic cross-resistance to both chloramphenicol and florfenicol in bovine E. coli isolates, along with the cmlA gene for chloramphenicol resistance.
Characterization of chloramphenicol and florfenicol resistance in Escherichia coli associated with bovine diarrhea.
Nonenzymatic chloramphenicol resistance mediated by IncC plasmid R55 is encoded by a floR gene variant.
Complete nucleotide sequence of a 43-kilobase genomic island associated with the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104 and its identification in phage type DT120 and serovar Agona.
The study characterizes the multidrug resistance region of Salmonella enterica serovar Typhimurium DT104, identifying genes such as aadA2, floR, qacE delta1, sulI delta1, and tet(G) that confer resistance to various antibiotics.
Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.
The study identifies the antibiotic resistance genes in Vibrio cholerae O139 and O1 SXT constins, including floR, strA, strB, sulII, and dfr18, which confer resistance to chloramphenicol, streptomycin, sulfamethoxazole, and trimethoprim, respectively.
Molecular analysis of antibiotic resistance gene clusters in vibrio cholerae O139 and O1 SXT constins.
Characterization of chloramphenicol resistance in beta-hemolytic Escherichia coli associated with diarrhea in neonatal swine.
The study identified the cmlA, flo, and cat-2 genes as mediators of chloramphenicol resistance in beta-hemolytic Escherichia coli isolates from neonatal swine. cmlA and flo encode efflux pumps, while cat-2 encodes a chloramphenicol acetyltransferase.
Genomic and functional analyses of SXT, an integrating antibiotic resistance gene transfer element derived from Vibrio cholerae.
The study identified the floR gene as a florfenicol resistance gene in the SXT element, which is involved in the export of florfenicol. Deletion of floR resulted in decreased resistance, and complementation restored the resistance phenotype.
Antibiotic Resistance Genes and Salmonella Genomic Island 1 in Salmonella enterica Serovar Typhimurium Isolated in Italy.
The study identifies antibiotic resistance genes and the presence of Salmonella Genomic Island 1 (SGI1) in multidrug-resistant Salmonella enterica serovar Typhimurium isolates from Italy. Key resistance genes include aadA2, pse-1, floR, tetA, and tetR, which contribute to resistance against various antibiotics.
Characterization of multidrug-resistant Escherichia coli isolates associated with nosocomial infections in dogs.
The study identified the cephamycinase gene bla CMY2 and the florfenicol resistance gene flo as significant contributors to multidrug resistance in Escherichia coli isolates from dogs. Additionally, the gene cassettes aadA5 and dfrA17 were found to confer resistance to spectinomycin and trimethoprim, respectively.
Evolution of antibiotic resistance in Salmonella enterica serovar typhimurium strains isolated in the Czech Republic between 1984 and 2002.
The study identifies the aadA21 gene, a novel variant of the aadA gene, and other resistance genes such as blaPSE-1, floR, sul1, and tetG in Salmonella enterica serovar Typhimurium strains from the Czech Republic between 1984 and 2002.
Molecular analysis of florfenicol-resistant Escherichia coli isolates from pigs.
Antibiotic Resistance Conferred by a Class I Integron and SXT Constin in Vibrio cholerae O1 Strains Isolated in Laos.
The study identifies the presence of a class I integron with the aadA1 gene cassette and an SXT constin in Vibrio cholerae O1 strains from Laos, which confer resistance to multiple antibiotics including streptomycin, chloramphenicol, tetracycline, and sulfamethoxazole.
Salmonella genomic island 1 multidrug resistance gene clusters in Salmonella enterica serovar Agona isolated in Belgium in 1992 to 2002.
The study identifies various multidrug resistance gene clusters in Salmonella enterica serovar Agona, including SGI1-A, SGI1-G, and several deletion variants. Key genes include floR, aadA2, pse-1, dfrA10, and orf513, which confer resistance to multiple antibiotics.
Characterization of florfenicol resistance among calf pathogenic Escherichia coli.
Characterization of florfenicol resistance among calf pathogenic Escherichia coli.
AcrAB-TolC Directs Efflux-Mediated Multidrug Resistance in Salmonella enterica Serovar Typhimurium DT104.
The study identifies AcrAB-TolC as a critical efflux system responsible for multidrug resistance in Salmonella enterica serovar Typhimurium DT104, along with the roles of floR and tet(G) in resistance to chloramphenicol-florfenicol and tetracyclines, respectively.
Mechanism of resistance to several antimicrobial agents in Salmonella Clinical isolates causing traveler's diarrhea.
The study identified several AMR genes and mutations in Salmonella isolates causing traveler's diarrhea, including blaTEM, blaOXA-1, tetA, tetB, tetG, dfrA1, dfrA12, dfrA14, dfrA17, floR, cmlA, and a mutation in the gyrA gene. These genes and mutations contribute to resistance against ampicillin, tetracycline, trimethoprim, chloramphenicol, and quinolones.
Plasmid-borne florfenicol resistance in Pasteurella multocida.
Structural and functional study of the phenicol-specific efflux pump FloR belonging to the major facilitator superfamily.
The study identifies FloR as a phenicol-specific efflux pump belonging to the major facilitator superfamily, which confers resistance to chloramphenicol, florfenicol, and thiamphenicol.
Influence of anti-FloR antibody on florfenicol accumulation in florfenicol-resistant Escherichia coli and enzyme-linked immunosorbent assay for detection of florfenicol-resistant E. coli isolates.
The study characterizes the floR gene, which confers resistance to florfenicol in Escherichia coli through an active efflux mechanism. An anti-FloR antibody was developed to detect the FloR protein, enhancing florfenicol accumulation and susceptibility in resistant strains.
Plasmid-mediated florfenicol resistance in Pasteurella trehalosi.
Detection of multidrug-resistant Salmonella enterica serovar typhimurium phage types DT102, DT104, and U302 by multiplex PCR.
The study identifies multiple AMR genes associated with multidrug-resistant Salmonella enterica serovar Typhimurium phage types DT104, DT102, and U302, including pse, floR, str, sulI, tetG, and spvC.
Variant Salmonella genomic island 1-L antibiotic resistance gene cluster in Salmonella enterica serovar Newport.
Efflux-mediated resistance to florfenicol and/or chloramphenicol in Bordetella bronchiseptica: identification of a novel chloramphenicol exporter.
Impact of feed supplementation with antimicrobial agents on growth performance of broiler chickens, Clostridium perfringens and enterococcus counts, and antibiotic resistance phenotypes and distribution of antimicrobial resistance determinants in Escherichia coli isolates.
The study identified several AMR genes in E. coli isolates from broiler chickens, including blaTEM, blaSHV, aadA, tet(A), tet(B), sulI, sulII, and floR, which conferred resistance to various antibiotics such as amoxicillin, tetracycline, sulfonamides, and chloramphenicol.
Transferable, multiple antibiotic and mercury resistance in Atlantic Canadian isolates of Aeromonas salmonicida subsp. salmonicida is associated with carriage of an IncA/C plasmid similar to the Salmonella enterica plasmid pSN254.
The study identifies multiple antibiotic and mercury resistance genes carried by an IncA/C plasmid in Atlantic Canadian isolates of Aeromonas salmonicida subsp. salmonicida, including aadA7, floR, tetA, sulII, strA, strB, blaCMY-2, and a mercury resistance operon.
Complete sequence of the floR-carrying multiresistance plasmid pAB5S9 from freshwater Aeromonas bestiarum.
SGI2, a Relative of Salmonella Genomic Island SGI1 with an Independent Origin
The study identifies SGI2, a genomic island in Salmonella enterica serovar Emek, which contains the cmlA9 and floR genes conferring resistance to chloramphenicol, florfenicol, and tetracycline. SGI2 has an independent origin from SGI1, with the integron located in a different position and showing sequence differences in the backbone.
Molecular analysis of florfenicol-resistant Pasteurella multocida isolates in Germany.
IncA/C plasmid-mediated florfenicol resistance in the catfish pathogen Edwardsiella ictaluri.
Aquaculture and florfenicol resistance in Salmonella enterica serovar Typhimurium DT104.
The study discusses the origin of the florfenicol resistance gene in Salmonella enterica serovar Typhimurium DT104, suggesting it originated from aquaculture environments through horizontal gene transfer from fish pathogens like Vibrio damsela and Pasteurella piscicida.
Antimicrobial susceptibility and mechanisms of resistance in Shigella and Salmonella isolates from children under five years of age with diarrhea in rural Mozambique.
The study identified multiple AMR genes in Shigella and Salmonella isolates, including bla-oxa-1-like, bla-tem-like, dfrA1, dfrA14-like, tetB, tetA, floR, cmlA, and cat, which confer resistance to ampicillin, trimethoprim-sulfamethoxazole, tetracycline, and chloramphenicol.
blaCMY-2-positive IncA/C plasmids from Escherichia coli and Salmonella enterica are a distinct component of a larger lineage of plasmids.
High prevalence of multidrug-tolerant bacteria and associated antimicrobial resistance genes isolated from ornamental fish and their carriage water.
The study identified a high prevalence of multidrug-tolerant bacteria and various antimicrobial resistance genes in ornamental fish and their carriage water, highlighting the potential risk of resistance gene spread through the aquatic environment.
Antibiotic susceptibility profiles of some Vibrio strains isolated from wastewater final effluents in a rural community of the Eastern Cape Province of South Africa.
The study identified several antibiotic resistance genes in Vibrio strains isolated from wastewater effluents, including dfrA1, dfr18, floR, sul2, strB, and tetA, which confer resistance to trimethoprim, chloramphenicol, sulfamethoxazole, streptomycin, and tetracycline.
Efflux-mediated antibiotic resistance in Acinetobacter spp.
The study characterizes several efflux pumps in Acinetobacter spp., including AdeABC, AdeIJK, AdeFGH, CraA, AmvA, AbeM, AbeS, AdeXYZ, AdeDE, TetA, TetB, CmlA, FloR, and QacE, which contribute to multidrug resistance by expelling antibiotics and other compounds.
Salmonella Typhimurium ST213 is associated with two types of IncA/C plasmids carrying multiple resistance determinants.
The study identifies bla CMY-2, dfrA12, orfF, aadA2, floR, and mer as resistance genes carried by IncA/C plasmids in Salmonella Typhimurium ST213, contributing to multidrug resistance.
Antimicrobial resistance, virulence-associated genes, and pulsed-field gel electrophoresis profiles of Salmonella enterica subsp. enterica serovar Typhimurium isolated from piglets with diarrhea in Korea.
The study identified multiple antimicrobial resistance genes in Salmonella enterica subsp. enterica serovar Typhimurium isolates from piglets with diarrhea in Korea, including bla PSE, bla TEM, cat1, cat2, floR, strA, strB, aadA, sulI, sulII, tetA, tetC, and tetG.
Characterization of multidrug-resistant Escherichia coli isolates from animals presenting at a university veterinary hospital.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from animals, including bla TEM, bla CTX-M-2, bla CMY-2, strA-strB, aadA, aphA1, aadB, cat, floR, sul1, sul2, tet(A), and tet(B). These genes confer resistance to various antibiotics such as beta-lactams, aminoglycosides, chloramphenicol, sulfonamides, and tetracyclines.
Antimicrobial Resistance in Bacteria: Mechanisms and Current Challenges
This paper characterizes several beta-lactamases, including TEM-1, SHV-1, CTX-M-15, and NDM-1, which confer resistance to various beta-lactam antibiotics. It also identifies erm(B) and mef(A) as mechanisms of macrolide, lincosamide, and streptogramin B resistance. Additionally, aadA1 and aac(6')-Ib are noted for aminoglycoside resistance, while catA1 and floR contribute to chloramphenicol resistance. The vanA gene is associated with glycopeptide resistance, and mcr-1 is linked to polymyxin resistance.
Drug-resistance mechanisms in Vibrio cholerae O1 outbreak strain, Haiti, 2010.
The study identified resistance genes strA, strB, sul2, dfrA1, and floR in the Haiti V. cholerae O1 outbreak strain, along with mutations in gyrA (Ser83Ile) and parC (Ser85Leu) contributing to quinolone resistance.
Comparison of the prevalences and antimicrobial resistances of Escherichia coli isolates from different retail meats in the United States, 2002 to 2008.
The study identified several AMR genes and mutations in E. coli isolates from retail meats, including bla CMY, cmlA, flo, catI, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Transcriptome mapping of pAR060302, a blaCMY-2-positive broad-host-range IncA/C plasmid.
The study characterizes the transcriptome of pAR060302, a blaCMY-2-positive IncA/C plasmid, highlighting the transcription of resistance genes such as blaCMY-2, aadA, aacA, and floR, which confer resistance to extended-spectrum cephalosporins, aminoglycosides, and phenicols, respectively.
Stability, entrapment and variant formation of Salmonella genomic island 1.
The study identifies and characterizes several AMR genes within the Salmonella genomic island 1 (SGI1), including aadA2, blaPSE-1, floR, qacEΔ1sulΔ1, qacEΔ1sul1, and tet(G). These genes confer resistance to various antibiotics such as streptomycin, spectinomycin, ampicillin, chloramphenicol, florfenicol, sulfonamides, and tetracycline.
Novel conjugative transferable multiple drug resistance plasmid pAQU1 from Photobacterium damselae subsp. damselae isolated from marine aquaculture environment.
The study identifies several AMR genes on the plasmid pAQU1, including bla CARB-9 -like, floR, mef (A)-like, sul2, tet (M), and tet (B), which confer resistance to various antibiotics such as carbenicillin, chloramphenicol, florfenicol, erythromycin, sulfonamide, and tetracycline.
Identification of acquired antimicrobial resistance genes.
The study presents ResFinder, a web-based tool for identifying acquired antimicrobial resistance genes in whole-genome data. It successfully identifies resistance genes with high accuracy and agrees with phenotypic testing. The tool detects various resistance genes across different bacterial species, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, and others.
Development and Evaluation of a Microarray-Based Serogenotyping Assay for Salmonella
The study presents a microarray-based serogenotyping assay for Salmonella, demonstrating high correlation between genotypic and phenotypic characteristics. Several AMR genes were identified and validated, showing strong association with AMR phenotypes.
DNA sequence analysis of plasmids from multidrug resistant Salmonella enterica serotype Heidelberg isolates.
The study identified multiple antimicrobial resistance genes in plasmids from multidrug-resistant Salmonella enterica serotype Heidelberg isolates, including bla CMY, aadA, aadB, aphA, strA, strB, sul1, sul2, tetA, floR, cmlA, dfrA1, dfrA12, and aacC.
Cholera outbreaks in Nigeria are associated with multidrug resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae.
The study identifies multidrug-resistant atypical El Tor and non-O1/non-O139 Vibrio cholerae strains in Nigeria, highlighting the presence of resistance genes such as floR, sul2, dfrA1, and strAB, along with quinolone resistance mutations in gyrA (Ser83Ile) and parC (Ser85Leu).
Molecular clonality and antimicrobial resistance in Salmonella enterica serovars Enteritidis and Infantis from broilers in three Northern regions of Iran.
The study identified multiple antimicrobial resistance genes, including aadA1, floR, dfrA14, sulI, and tetA, in Salmonella enterica serovars Enteritidis and Infantis from broilers in Iran. These genes were associated with resistance to streptomycin, florfenicol, trimethoprim, sulfamethoxazole, and tetracycline, respectively. Additionally, a single mutation in the gyrA gene was found to confer resistance to nalidixic acid and ciprofloxacin.
DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates.
The study developed a DNA microarray for genotyping antibiotic resistance determinants in Acinetobacter baumannii clinical isolates, identifying numerous resistance genes and mutations associated with carbapenem, aminoglycoside, fluoroquinolone, and other antibiotic resistances.
Acquired genetic mechanisms of a multiresistant bacterium isolated from a treatment plant receiving wastewater from antibiotic production.
Comparative genomic analysis and virulence differences in closely related salmonella enterica serotype heidelberg isolates from humans, retail meats, and animals.
The study identified several AMR genes and mutations in Salmonella enterica serotype Heidelberg isolates, including bla, aac(6')-Ib, tet(M), qnrS1, and erm(B). Mutations in genes such as SEEHRA37_03221, SEEHRA37_24108, and others were associated with resistance traits.
Characterization of multidrug-resistant Salmonella enterica serovars Indiana and Enteritidis from chickens in Eastern China.
The study identified multiple AMR genes including blaTEM, floR, tetA, strA, and aac(6')-Ib-cr in multidrug-resistant Salmonella enterica serovars Indiana and Enteritidis from chickens in Eastern China.
IncA/C plasmid-mediated spread of CMY-2 in multidrug-resistant Escherichia coli from food animals in China.
The study identifies the spread of CMY-2, CMY-41, and CMY-64 beta-lactamase genes in multidrug-resistant E. coli from food animals in China, highlighting the role of IncA/C plasmids in their transfer and the coexistence of other resistance genes such as qnrS1, floR, aac-(6′)-Ib-cr, oqxA, and rmtB.
Antimicrobial resistance of Escherichia coli isolates from canine urinary tract infections.
The study identified bla TEM-1, tet(B), tet(A), cmlA, floR, and aacC2 as key antimicrobial resistance genes in E. coli isolates from canine urinary tract infections, along with mutations in gyrA and parC conferring fluoroquinolone resistance.
Bacteriophages Isolated from Chicken Meat and the Horizontal Transfer of Antimicrobial Resistance Genes.
The study identified several antimicrobial resistance genes, including tet(A), aphA1, blaTEM, and floR, which were transduced by phages isolated from chicken meat, highlighting the role of bacteriophages in the horizontal transfer of antimicrobial resistance.
Characterisation of a mobilisable plasmid conferring florfenicol and chloramphenicol resistance in Actinobacillus pleuropneumoniae.
The study characterizes a 7.7 kb mobilizable plasmid (pM3446F) from Actinobacillus pleuropneumoniae that confers resistance to florfenicol and chloramphenicol through the floR gene, which encodes an efflux pump. The plasmid was successfully transferred to other Pasteurellaceae species.
Insight into the mobilome of Aeromonas strains.
The study characterizes various antibiotic resistance genes (ARG) in Aeromonas strains, highlighting the presence of beta-lactamases, aminoglycoside-modifying enzymes, tetracycline resistance genes, and others. These genes are often located on plasmids and contribute to multidrug resistance.
Persistence of Multi-Drug Resistance Plasmids in Sterile Water under Very Low Concentrations of Tetracycline.
The study shows that multi-drug resistance plasmids pAQU1 and IncFIB can persist in bacterial populations under very low selective pressure, including in non-culturable states. The plasmids retain their resistance genes, such as tet(M), tet(B), floR, mph(A)-like, mef(A)-like, and sul2, which confer resistance to tetracycline, florfenicol, macrolides, and sulfonamides.
Comparative Genomic Analysis of Mannheimia haemolytica from Bovine Sources.
The study identified a bla ROB-1 gene in an integrative conjugative element (ICE) of M. haemolytica, which had a single nucleotide substitution leading to a non-functional gene and sensitivity to ampicillin.
Variations in SXT elements in epidemic Vibrio cholerae O1 El Tor strains in China.
The study identifies various antibiotic resistance genes within SXT elements in epidemic Vibrio cholerae O1 El Tor strains in China, highlighting their role in multidrug resistance.
Co-spread of metal and antibiotic resistance within ST3-IncHI2 plasmids from E. coli isolates of food-producing animals.
The study identifies multiple antibiotic resistance genes, including oqxAB, bla CTX-M, aac(6')-Ib-cr, floR, qnrS1, rmtB, fosA3, pcoA, and silE, on ST3-IncHI2 plasmids from E. coli isolates of food-producing animals, highlighting the co-spreading of metal and antibiotic resistance.
Whole-Genome Sequencing for Detecting Antimicrobial Resistance in Nontyphoidal Salmonella.
The study identified 65 unique resistance genes in nontyphoidal Salmonella, including bla CTX-M1 and bla SHV2a, which were first reported in retail meat isolates in the United States. The research highlights the effectiveness of whole-genome sequencing in detecting antimicrobial resistance genes and correlating them with phenotypic resistance.
Draft Genome Sequence of Salmonella enterica subsp. enterica Serovar Bardo Strain CRJJGF_00099 (Phylum Gammaproteobacteria).
The study reports the identification of several AMR genes in a multidrug-resistant Salmonella enterica subsp. enterica serovar Bardo strain, including strA, strB, cmy-94, floR, sulII, tet(A), and aac6-Iy.
Carbapenem Resistance in Clonally Distinct Clinical Strains of Vibrio fluvialis Isolated from Diarrheal Samples.
The study identifies the bla NDM-1 gene as a major cause of carbapenem resistance in Vibrio fluvialis isolates from Kolkata, India. Several additional resistance genes, including aadA1, aadB, aac(6')-Ib-cr, sul1, sul3, floR, bla OXA-1, bla OXA-7, bla OXA-9, bla TEM-9, bla CTX-M-3, strA, and tetB, were also characterized.
Architecture of Class 1, 2, and 3 Integrons from Gram Negative Bacteria Recovered among Fruits and Vegetables.
The study identified several AMR genes in Gram-negative bacteria from fresh produce, including mcr-1, qnrA1, blaGES-11, mphA, and oqxAB, highlighting the presence of mobile genetic elements and clinically relevant resistance genes.
Genomic signatures of Mannheimia haemolytica that associate with the lungs of cattle with respiratory disease, an integrative conjugative element, and antibiotic resistance genes.
The study identifies multiple antibiotic resistance genes in Mannheimia haemolytica, particularly in genotype 2, subtype 2b isolates, which are associated with the lungs of cattle with respiratory disease and contain various combinations of resistance genes.
Clonal spread of mcr-1 in PMQR-carrying ST34 Salmonella isolates from animals in China.
The study identifies the mcr-1 gene as a plasmid-mediated colistin resistance gene in PMQR-carrying ST34 Salmonella isolates from animals in China, along with other resistance genes such as aac(6')-Ib-cr, oqxAB, and floR.
Whole-Genome Analysis of Antimicrobial-Resistant and Extraintestinal Pathogenic Escherichia coli in River Water.
The study identified numerous antimicrobial resistance genes in Escherichia coli isolates from river water, highlighting the presence of multidrug-resistant and extraintestinal pathogenic strains. Key resistance genes included blaTEM-1, aac(3)-IId, qnrB7, and others.
Antimicrobial usage and resistance in beef production.
The review discusses the impact of antimicrobial usage in beef production on the emergence and spread of antimicrobial resistance (AMR) in bovine pathogens. It highlights the role of antimicrobial use in promoting AMR, particularly in respiratory and liver abscess pathogens, and emphasizes the need for judicious use to mitigate risks to both animal and human health.
mcr-1-Harboring Salmonella enterica Serovar Typhimurium Sequence Type 34 in Pigs, China.
The study identifies the mcr-1 gene in Salmonella isolates from pigs in China, highlighting its association with colistin resistance. Additionally, the study reports the presence of floR and oqxAB genes, which confer resistance to florfenicol and olaquindox/ciprofloxacin, respectively.
Epidemiological, molecular characterization and antibiotic resistance of Salmonella enterica serovars isolated from chicken farms in Egypt.
The study identified various AMR genes in Salmonella enterica serovars isolated from chicken farms in Egypt, including blaTEM, aadA2, floR, cat1, sul1, sul3, tetC, tetA, and intI, which confer resistance to ampicillin, streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, and multiple antibiotics.
Carbapenem-resistance and pathogenicity of bovine Acinetobacter indicus-like isolates.
The study identifies carbapenem-resistant Acinetobacter indicus-like isolates from cattle carrying the blaOXA-23 gene, along with various other AMR genes such as aac(3)-IIa, strA/B, aph(3')-Ic, sul2, floR, tet(A), tet(Y), aadA1, aadB, sul1, and tet(X).
Prevalence, serotyping and antimicrobials resistance mechanism of Salmonella enterica isolated from clinical and environmental samples in Saudi Arabia.
The study identified several AMR genes and mutations in Salmonella enterica isolates from Saudi Arabia, including carb-like, dfrA1, floR, tetA, and mutations in gyrA and parC genes associated with resistance to beta-lactams, trimethoprim-sulfamethoxazole, chloramphenicol, tetracycline, and fluoroquinolones.
Whole-Genome Sequencing of Drug-Resistant Salmonella enterica Isolates from Dairy Cattle and Humans in New York and Washington States Reveals Source and Geographic Associations.
The study identified several AMR genes and mutations in Salmonella enterica isolates from dairy cattle and humans in New York and Washington States, highlighting the role of geographic and source-specific factors in AMR dissemination.
Multidrug Resistance Salmonella Genomic Island 1 in a Morganella morganii subsp. morganii Human Clinical Isolate from France.
The study reports the first identification of Salmonella genomic island 1 (SGI1) in a multidrug-resistant clinical isolate of Morganella morganii subsp. morganii, carrying resistance genes dfrA15, floR, tetA(G), blaCARB-2, and sul1, conferring resistance to trimethoprim, chloramphenicol, tetracycline, ticarcillin, and sulfonamides, respectively.
p518, a small floR plasmid from a South American isolate of Actinobacillus pleuropneumoniae.
The study identifies a 3.9 kb plasmid, p518, carrying the floR gene, which confers resistance to florfenicol and chloramphenicol in Actinobacillus pleuropneumoniae. The plasmid lacks mobilization genes and is not transferable by conjugation or natural transformation.
Antimicrobial resistance of Klebsiella pneumoniae stool isolates circulating in Kenya.
The study identified 46 AMR genes or gene families in 90 Klebsiella pneumoniae isolates from Kenya, highlighting the prevalence of multidrug resistance and the diversity of resistance mechanisms.
Characterization of the Complete Nucleotide Sequences of IncA/C2 Plasmids Carrying In809-Like Integrons from Enterobacteriaceae Isolates of Wildlife Origin.
The study characterized IncA/C2 plasmids carrying In809-like integrons from Enterobacteriaceae isolates of wildlife origin, identifying several AMR genes including blaIMP-4, blaIMP-26, blaIMP-38, sul2, floR, aac(3)-IId, qnrA1, arr-3, dfrA12, aphA1, aadA16, aadA2, blaOXA-1, blaTEM-1, and blaDHA-1.
An In Vitro Chicken Gut Model Demonstrates Transfer of a Multidrug Resistance Plasmid from Salmonella to Commensal Escherichia coli.
The study demonstrates the transfer of a multidrug resistance plasmid, pIFM3844, from Salmonella to commensal E. coli, highlighting the role of the bla CTX-M1 gene in conferring resistance to cefotaxime.
Comparative Sequence Analysis of Multidrug-Resistant IncA/C Plasmids from Salmonella enterica.
The study identified multiple antimicrobial resistance genes on IncA/C plasmids from various Salmonella serovars, including bla_cmy-2, bla_tem-1, strA, strB, aadB, aph(3')-Ia, tetA, floR, cmlA, sul1, sul2, dfra12, quacE, sugE, merA, merB, merC, merD, and merE, which contribute to multidrug resistance.
Resistance to Antibiotics, Biocides, Preservatives and Metals in Bacteria Isolated from Seafoods: Co-Selection of Strains Resistant or Tolerant to Different Classes of Compounds.
The study identified multiple antibiotic resistance genes, including sul1, sul2, floR, aadA1, aac(6')-Ib, blaTEM, blaCTX-M, blaPSE, blaNDM-1, qacEΔ1, pcoA/copA, chrB, and pcoR, in bacterial isolates from seafood. These genes conferred resistance to sulfonamides, phenicols, aminoglycosides, beta-lactams, and heavy metals.
Characterization of the Actinobacillus pleuropneumoniae SXT-related integrative and conjugative element ICEApl2 and analysis of the encoded FloR protein: hydrophobic residues in transmembrane domains contribute dynamically to florfenicol and chloramphenicol efflux.
The study characterizes the floR gene in the SXT-related ICEApl2 of Actinobacillus pleuropneumoniae, demonstrating that specific hydrophobic residues in the transmembrane domains of the FloR protein influence efflux of florfenicol and chloramphenicol. The FloR protein from ICEApl2 does not confer resistance to these antibiotics in A. pleuropneumoniae but does in E. coli.
pirAB(vp)-Bearing Vibrio parahaemolyticus and Vibrio campbellii Pathogens Isolated from the Same AHPND-Affected Pond Possess Highly Similar Pathogenic Plasmids.
The study identifies antibiotic resistance genes in Vibrio parahaemolyticus and Vibrio campbellii strains isolated from an AHPND-affected pond, highlighting the presence of tetracycline, sulfonamide, streptomycin, and florfenicol resistance mechanisms.
New eight genes identified at the clinical multidrug-resistant Acinetobacter baumannii DMS06669 strain in a Vietnam hospital.
The study identified 18 antibiotic resistance genes in the multidrug-resistant Acinetobacter baumannii DMS06669 strain, including eight novel genes not previously reported in A. baumannii. These genes conferred resistance to various antibiotic classes, including aminoglycosides, beta-lactams, phenicols, sulfonamides, tetracyclines, macrolides, lincosamides, streptogramin B, and rifampicins.
Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene ( acrR ) on phenicol resistance.
The study identifies several phenicol resistance genes (catA1, catA2, flo, flo-R) and highlights the role of acrR mutations in increasing phenicol resistance through overexpression of the AcrAB efflux pump.
Genetic characterization of phenicol-resistant Escherichia coli and role of wild-type repressor/regulator gene ( acrR ) on phenicol resistance.
The study identifies several phenicol resistance genes (catA1, catA2, flo, flo-R) and highlights the role of acrR mutations in increasing phenicol resistance through overexpression of the AcrAB efflux pump.
Prediction of Phenotypic Antimicrobial Resistance Profiles From Whole Genome Sequences of Non-typhoidal Salmonella enterica.
The study identified various AMR genes and mutations in non-typhoidal Salmonella enterica, including blaTEM-1, strA-strB, sul2, tet(A), qnrS1, aadA2, aadA17, floR, cmlA1, aac(3)-Id, aac(3)-IIa, dfrA12, dfrA1, dfrA14, blaCTX-M-9, blaCTX-M-55, blaSHV-12, blaPSE-1/blaCARB-2, and blaCMY-2, along with mutations in gyrA and parC associated with ciprofloxacin resistance.
Characterization of antimicrobial resistance genes in Haemophilus parasuis isolated from pigs in China.
The study identified multiple antimicrobial resistance genes in Haemophilus parasuis isolates from pigs in China, including blaTEM-1, blaROB-1, ermB, ermA, flor, catl, tetB, tetC, rmtB, rmtD, aadA1, aac(3′)-IIc, sul1, and sul2. Additionally, mutations in the gyrA and parC genes were associated with fluoroquinolone resistance.
Distribution and Genetic Characteristics of SXT/R391 Integrative Conjugative Elements in Shewanella spp. From China.
The study identified the SXT/R391 integrative conjugative element ICE Sup CHN110003 in Shewanella upenei strains, which carries antibiotic resistance genes floR, strA, strB, and sul2, conferring resistance to chloramphenicol, streptomycin, and sulfamethoxazole.
Characterization of a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul.
The study characterizes a novel multidrug resistance plasmid pSGB23 isolated from Salmonella enterica subspecies enterica serovar Saintpaul, carrying 11 antibiotic resistance genes responsible for resistance to 9 classes of antibiotics and quaternary ammonium compounds.
Current Status of the Use of Antibiotics and the Antimicrobial Resistance in the Chilean Salmon Farms.
The study identifies several AMR genes, including floR, tet(A), tet(B), tet(H), tet(l), tet(34), tet(35), aac(6')-Ib-cr, and intI1, associated with resistance to florfenicol, oxytetracycline, quinolones, and kanamycin in Chilean salmon farming environments.
Evolution and Comparative Genomics of F33:A-:B- Plasmids Carrying bla(CTX-M-55) or bla(CTX-M-65) in Escherichia coli and Klebsiella pneumoniae Isolated from Animals, Food Products, and Humans in China.
The study characterizes F33:A−:B− plasmids carrying various AMR genes such as bla(CTX-M-55), bla(CTX-M-65), fosA3, rmtB, and others in E. coli and K. pneumoniae isolates from diverse sources in China.
Extended antibiotic treatment in salmon farms select multiresistant gut bacteria with a high prevalence of antibiotic resistance genes.
The study identifies several AMR genes, including floR, fexA, and various tetracycline resistance genes (tetA, tetB, tetE, tetH, tetL, tetM, tet34, tet35), associated with resistance to florfenicol and oxytetracycline in gut bacteria from salmon farms. These genes were found in multiple bacterial species, highlighting the widespread nature of AMR in aquatic environments.
Acquisition of resistance to carbapenem and macrolide-mediated quorum sensing inhibition by Pseudomonas aeruginosa via ICE(Tn4371) 6385.
The study identifies a novel integrative and conjugative element (ICE) carrying blaNDM-1, msr(E), and floR, which confers resistance to carbapenems, macrolides, and florfenicol in Pseudomonas aeruginosa.
Interplay Between the Phenotype and Genotype, and Efflux Pumps in Drug-Resistant Strains of Riemerella anatipestifer.
The study identified multiple AMR genes and mutations in Riemerella anatipestifer, including aac(6')-Ib, aadA1, aadA2, aadA5, aac(3')-IIc, aac(3')-IV, aph(3')-VII, aph(2')-Ib, bla TEM, bla OXA, tet(A), tet(B), sul1, sul2, sul3, cat2, cmlA, floR, emrF, qnrS, and qnrD. Additionally, mutations in gyrA and parC were found to confer fluoroquinolone resistance.
Using Machine Learning To Predict Antimicrobial MICs and Associated Genomic Features for Nontyphoidal Salmonella.
The study presents a machine learning model capable of predicting antimicrobial MICs for nontyphoidal Salmonella using whole-genome sequence data, identifying key genomic features associated with resistance.
Genotypic and phenotypic characterization of Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants isolated in Thailand and Japan.
The study identified several antimicrobial resistance genes in Salmonella enterica subsp. enterica serovar Typhimurium monophasic variants, including blaTEM, aadA, strA, strB, tet(A), tet(B), tet(G), sul1, sul2, sul3, and floR, which confer resistance to ampicillin, streptomycin, oxytetracycline, sulfisoxazole, and chloramphenicol.
Spread of the florfenicol resistance floR gene among clinical Klebsiella pneumoniae isolates in China.
The study identifies the floR gene as a key factor in florfenicol resistance among clinical Klebsiella pneumoniae isolates in China, highlighting its presence on a conjugative plasmid and potential for horizontal transfer.
Interrelationship between tetracycline resistance determinants, phylogenetic group affiliation and carriage of class 1 integrons in commensal Escherichia coli isolates from cattle farms.
The study identified tetracycline resistance genes tet(A) and tet(B) as the most common in commensal E. coli isolates from cattle farms, along with gene cassettes such as aadA1, dfrA1, dfrA12, sul1, cat1, and floR associated with class 1 integrons.
Genome sequence analysis of an extensively drug-resistant Acinetobacter baumannii indigo-pigmented strain depicts evidence of increase genome plasticity.
The study identifies multiple antibiotic resistance genes in the extensively drug-resistant Acinetobacter baumannii strain Ab33405, including beta-lactamases, aminoglycoside modifying enzymes, and efflux pumps, highlighting the genetic basis of its multidrug resistance.
Population Structure, Antibiotic Resistance, and Uropathogenicity of Klebsiella variicola.
The study identifies several antibiotic resistance genes in Klebsiella variicola, including blaLEN, oqxAB, blaKPC-2, blaNDM-1, blaNDM-9, blaOXA-48, aac(6')-Ib, aadA16, sul1, sul2, qnrB6, arr-3, and floR. These genes confer resistance to various antibiotics such as ampicillin, ciprofloxacin, meropenem, gentamicin, kanamycin, sulfamethoxazole, rifampin, and chloramphenicol.
Dose-dependent impact of oxytetracycline on the veal calf microbiome and resistome.
The study identified tetM, mel, and floR as antibiotic resistance genes that showed increased abundance in the high-dose oxytetracycline group compared to the control group.
Oral administration of antibiotics increased the potential mobility of bacterial resistance genes in the gut of the fish Piaractus mesopotamicus.
The study found that oral administration of florfenicol increased the abundance and diversity of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in the gut of Piaractus mesopotamicus. Several ARGs, including floR, mexQ, macB, and others, were identified as being associated with multidrug resistance and efflux pump mechanisms.
Genomic analysis of Klebsiella pneumoniae isolates from Malawi reveals acquisition of multiple ESBL determinants across diverse lineages.
The study identified multiple ESBL genes, including bla CTX-M-15, several bla SHV, bla TEM-63, and bla OXA-10, along with other AMR genes across diverse lineages of K. pneumoniae isolates from Malawi. No carbapenem resistance genes were detected, but plasmids similar to carbapenem resistance-associated plasmid pNDM-mar were found.
Cross-Border Transmission of Salmonella Choleraesuis var. Kunzendorf in European Pigs and Wild Boar: Infection, Genetics, and Evolution.
The study identified multiple antimicrobial resistance genes in Salmonella Choleraesuis isolates, including aadA1, catA1, cmlA1, floR, mph(B), strA, strB, sul1, sul2, sul3, tet(A), tet(B), dfrA1, aph(3')-Ia, lnu(B), and blaTEM-1. These genes conferred resistance to various antibiotics such as streptomycin, chloramphenicol, florfenicol, erythromycin, sulfamethoxazole, tetracycline, trimethoprim, gentamicin, lincomycin, and ampicillin.
Characterisation of antibiotic resistance of Salmonella isolated from dog treats in Japan.
The study identified the presence of antibiotic-resistant Salmonella in dog treats in Japan, including the blaTEM gene, aadA1, aadA2, tetB, floR, catA1, dfrA12, and intI1 genes, indicating multidrug resistance.
Diversity, Virulence, and Antimicrobial Resistance in Isolates From the Newly Emerging Klebsiella pneumoniae ST101 Lineage.
The study characterizes the antimicrobial resistance genes and mutations in the emerging Klebsiella pneumoniae ST101 lineage, highlighting the presence of multiple resistance mechanisms including carbapenemases, extended-spectrum beta-lactamases, and various other resistance genes.
Genomic Investigation of the Emergence of Invasive Multidrug-Resistant Salmonella enterica Serovar Dublin in Humans and Animals in Canada.
The study identifies multiple AMR genes and mutations in multidrug-resistant Salmonella enterica serovar Dublin isolates from Canada, highlighting the role of IS 26 in plasmid hybridization and the emergence of MDR strains.
Genotypic antimicrobial resistance assays for use on E. coli isolates and stool specimens.
The study developed and validated 85 PCR assays to detect 79 AMR genes and mutations associated with resistance across 10 antimicrobial classes, focusing on E. coli. The assays showed high concordance with sequencing and phenotypic susceptibility testing, demonstrating their potential for AMR surveillance in E. coli isolates and direct stool specimens.
Diverse Commensal Escherichia coli Clones and Plasmids Disseminate Antimicrobial Resistance Genes in Domestic Animals and Children in a Semirural Community in Ecuador.
The study identified various antimicrobial resistance (AMR) genes in commensal Escherichia coli isolates from children and domestic animals in a semirural community in Ecuador. These genes included blaTEM-1B, dfrA8, qnrB19, strA, strB, tetA, tetB, sul1, sul2, and others, contributing to resistance against multiple antibiotics such as ampicillin, trimethoprim, tetracycline, and sulfamethoxazole. The research highlights the role of plasmids in disseminating these AMR genes and emphasizes the complexity of AMR transmission in such environments.
Determining antimicrobial susceptibility in Salmonella enterica serovar Typhimurium through whole genome sequencing: a comparison against multiple phenotypic susceptibility testing methods.
The study identified various AMR genes and mutations in Salmonella enterica serovar Typhimurium, including aadA, strAB, blaTEM, blaCARB, floR, cmlA1, catA1, qnrB19, sul1, sul2, sul3, dfrA1, dfrA12, dfrA14, tetA, tetB, tetC, tetG, and mutations in gyrA. These genes and mutations were validated through whole genome sequencing and phenotypic ASTs.
Dissemination of Multidrug-Resistant Commensal Escherichia coli in Feedlot Lambs in Southeastern Brazil.
The study identified multiple multidrug-resistant commensal E. coli isolates in feedlot lambs in Brazil, carrying various AMR genes including bla CTX-M-2, bla CTX-M-8, bla CTX-M-14, bla CTX-M-15, bla CMY-2, aac(3)-IIa, ant(2")-Ia, qnrB, tetA, tetB, sul1, sul2, floR, and cmlA. These genes confer resistance to beta-lactams, aminoglycosides, quinolones, tetracyclines, sulfonamides, and phenicols.
Genomic Features of High-Priority Salmonella enterica Serovars Circulating in the Food Production Chain, Brazil, 2000-2016.
The study identified several AMR genes in Salmonella enterica isolates from Brazil, including qnrE1, qnrB19, qnrS1, blaCTX-M-2, blaCTX-M-8, blaCMY-2, aadA1, aadA2, aac(3)-IVa, aac(3)-IIa, aac(6')-Ib, floR, sul1, sul2, tet(A), tet(B), strA, strB, drfA1, inu(F), qacEdelta1, and fosA7. These genes conferred resistance to various antibiotics such as fluoroquinolones, beta-lactams, aminoglycosides, sulfonamides, tetracyclines, chloramphenicol, trimethoprim, macrolides, quaternary ammonium compounds, and fosfomycin.
Emergence of Multidrug-Resistant Salmonella enterica Serovar Goldcoast Strains in Taiwan and International Spread of the ST358 Clone.
The study identifies multiple multidrug-resistant Salmonella enterica serovar Goldcoast strains in Taiwan, highlighting the emergence of an ST358 clone carrying various resistance genes, including blaCTX-M-55, mcr-1, and others, contributing to the rapid increase in infections.
Genomic Sequence Analysis of the Multidrug-Resistance Region of Avian Salmonella enterica serovar Indiana Strain MHYL.
The study identified several AMR genes, including blaTEM, strA, tetA, floR, and aac(6')-Ib-cr, in the multidrug-resistant Salmonella enterica serovar Indiana strain MHYL. These genes were localized in two distinct MDR regions, RR1 and RR2, and were associated with resistance to multiple antibiotics.
Molecular Characterization of a Multidrug-Resistant Klebsiella pneumoniae Strain R46 Isolated from a Rabbit.
The study identified a novel chromosome-encoded florfenicol resistance gene, mdfA2, and the floR gene in the multidrug-resistant Klebsiella pneumoniae strain R46. Both genes conferred resistance to florfenicol and chloramphenicol.
Inter-host Transmission of Carbapenemase-Producing Escherichia coli among Humans and Backyard Animals.
The study identified blaNDM genes as the primary cause of carbapenem resistance in Escherichia coli isolates from humans, pigs, chickens, and flies in rural China, highlighting the transmission of these resistance genes between humans and backyard animals.
Florfenicol Resistance in Enterobacteriaceae and Whole-Genome Sequence Analysis of Florfenicol-Resistant Leclercia adecarboxylata Strain R25.
The study identifies the floR gene as a major contributor to florfenicol resistance in Enterobacteriaceae, particularly in Leclercia adecarboxylata strain R25. Other resistance genes such as mdfA, aac(6')-Ib-cr, aadA16, qnrB6, sul1, dfrA27, arr-3, and qacEΔ1 were also characterized.
Characteristics of a Colistin-Resistant Escherichia coli ST695 Harboring the Chromosomally-Encoded mcr-1 Gene.
The study identifies the chromosomally-encoded mcr-1 gene in a colistin-resistant E. coli ST695 strain, along with various other resistance genes such as bla NDM-1, aadA1, aadA2, aph(3')-Ia, aph(3')-VI, rmtB, cmlA1, floR, tet(A), tet(M), dfrA12, oqxA, oqxB, qnrS1, mph(A), bla TEM-105, and bla TEM-1B, contributing to its multidrug-resistant phenotype.
Complex Class 1 Integron in a Clinical Escherichia coli Strain From Vietnam Carrying Both mcr-1 and bla (NDM-1).
The study identifies a multidrug-resistant E. coli strain carrying both mcr-1 and bla NDM-1, highlighting the co-existence of colistin and carbapenem resistance genes in Vietnam.
Emerging Variants of the Integrative and Conjugant Element ICEMh1 in Livestock Pathogens: Structural Insights, Potential Host Range, and Implications for Bacterial Fitness and Antimicrobial Therapy.
The study identified multiple antimicrobial resistance genes within the ICE Mh1 PM22, including aminoglycoside, sulfonamide, macrolide, and tetracycline resistance genes. These genes contribute to multidrug resistance in livestock pathogens.
Impacts of florfenicol on the microbiota landscape and resistome as revealed by metagenomic analysis.
Florfenicol treatment significantly altered the microbiome and resistome in catfish tanks, promoting the proliferation of florfenicol-resistant genes and inducing mutation-driven resistance.
Characterization of a Novel Conjugative Plasmid in Edwardsiella piscicida Strain MS-18-199.
The study characterizes a novel conjugative plasmid, pEPMS-18199, in Edwardsiella piscicida strain MS-18-199, which carries multiple antimicrobial resistance (AMR) genes including floR, tetA, tetR, sul2, strA, strB, arsA, and arsD, conferring resistance to phenicol, tetracycline, sulfonamide, and aminoglycoside antibiotics, as well as arsenic.
In Vitro Susceptibility and Florfenicol Resistance in Citrobacter Isolates and Whole-Genome Analysis of Multidrug-Resistant Citrobacter freundii.
The study identified the florfenicol resistance gene floR in Citrobacter isolates, which conferred resistance to florfenicol and chloramphenicol. The gene was found in a multidrug-resistant C. freundii strain and was part of a truncated transposon-like structure on a plasmid.
Use of whole genome sequencing of commensal Escherichia coli in pigs for antimicrobial resistance surveillance, United Kingdom, 2018.
The study analyzed 515 E. coli isolates from pigs using whole genome sequencing to identify AMR genes and mutations. Key findings include the prevalence of blaTEM-1b, tet(A), and tetA(B) genes, along with various mutations in gyrA, parC, and parE that confer resistance to fluoroquinolones. The study highlights the effectiveness of WGS in predicting AMR phenotypes with high concordance to MIC results.
Multidrug-Resistant and Clinically Relevant Gram-Negative Bacteria Are Present in German Surface Waters.
The study identifies several AMR genes in multidrug-resistant Gram-negative bacteria isolated from German surface waters, highlighting the presence of clinically relevant resistance mechanisms such as bla CTX-M-1, bla CTX-M-15, mcr-1, and others.
Genomic Characterization of New Variant of Hydrogen Sulfide (H(2)S)-Producing Escherichia coli with Multidrug Resistance Properties Carrying the mcr-1 Gene in China †
The study reports the first detection of a hydrogen sulfide (H2S)-producing Escherichia coli variant isolated from a human in China, with multidrug resistance properties, including colistin resistance mediated by the mcr-1 gene, along with other resistance genes such as aadA1, aadA2, dfrA12, blaTEM-1B, oqxA, oqxB, floR, cmlA1, sul3, and tet(A).
Antimicrobial Resistance in Members of the Bacterial Bovine Respiratory Disease Complex Isolated from Lung Tissue of Cattle Mortalities Managed with or without the Use of Antimicrobials.
The study identified several AMR genes, including aadA31, bla ROB-1, floR, mph(E), msr(E), and tet(H), in bovine respiratory disease organisms, highlighting the impact of antimicrobial use on AMR development.
Oral colonisation by antimicrobial-resistant Gram-negative bacteria among long-term care facility residents: prevalence, risk factors, and molecular epidemiology.
The study identified several AMR genes in Gram-negative bacteria isolated from LTCF residents, including bla CTX-M-27, bla CTX-M-14, bla TEM-1B, bla IMP-1, and others, which confer resistance to various antibiotics such as β-lactams, aminoglycosides, and fluoroquinolones.
Two New SGI1-LK Variants Found in Proteus mirabilis and Evolution of the SGI1-HKL Group of Salmonella Genomic Islands.
The study identifies two new SGI1-LK variants, SGI1-LK1 and SGI1-LK2, in Proteus mirabilis isolates, highlighting the evolutionary dynamics of the SGI1-HKL group of Salmonella genomic islands.
Dominant resistance and negative epistasis can limit the co-selection of de novo resistance mutations and antibiotic resistance genes.
The study identifies negative epistasis between the tetracycline efflux pump TetA and mutations in the nuo genes, which affects aminoglycoside resistance. It also characterizes the roles of various antibiotic resistance genes (ARGs) such as blaTEM-219, floR, qnrS1, and tetA in resistance to different antibiotics.
Molecular Detection of Multidrug Resistant Salmonella Species Isolated from Broiler Farm in Bangladesh.
The study identified multidrug-resistant Salmonella enterica serovar Typhimurium isolates from broiler farms in Bangladesh, carrying resistance genes tetA, floR, blaTEM-1, aadA1, and class 1 integron gene intl1.
Isolation of Drug-Resistant Gallibacterium anatis from Calves with Unresponsive Bronchopneumonia, Belgium.
The study identified 24 different antimicrobial-resistance determinants in Gallibacterium anatis isolates from calves with unresponsive bronchopneumonia, including novel resistance genes such as aadA23, blaCARB-8, tet(Y), and qnrD1.
Metadata Analysis of mcr-1-Bearing Plasmids Inspired by the Sequencing Evidence for Horizontal Transfer of Antibiotic Resistance Genes Between Polluted River and Wild Birds.
The study identifies the mcr-1 gene as a key factor in colistin resistance in E. coli strains isolated from polluted rivers and wild birds. It also characterizes several other AMR genes including aadA1, aadA2, aph(3′)-Ia, aph(3″)-Ib, aph(4)-Ia, aph(6)-Id, tet(B), tet(D), tet(A), bla CTX–M–14, bla TEM–1, qnrS2, oqxA, oqxB, cmlA1, floR, vgaC, sul1, sul2, sul3, dfrA12, and glpT (E448K).
Prevalence, Antimicrobial Resistance, Virulence Genes and Genetic Diversity of Salmonella Isolated from Retail Duck Meat in Southern China.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from retail duck meat in Southern China, including blaTEM, blaCTX-M, strA, aadA1, qnrS, aac(6')-Ib, qnrB, and floR, which confer resistance to various antibiotics such as ampicillin, cefotaxime, streptomycin, ciprofloxacin, ofloxacin, and florfenicol.
Systematic Evaluation of Whole Genome Sequence-Based Predictions of Salmonella Serotype and Antimicrobial Resistance.
The study evaluated the performance of various bioinformatics tools for predicting antimicrobial resistance (AMR) and serotypes of Salmonella enterica using whole-genome sequencing (WGS). It identified several AMR genes and mutations associated with resistance to various antibiotics.
Antimicrobial resistance of Escherichia coli isolated from retail foods in northern Xinjiang, China.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from retail foods in northern Xinjiang, China, including tetA, tetB, blaOXA, blaTEM, floR, sul1, sul2, aadAla, aadB, strA, and strB. These genes conferred resistance to tetracycline, beta-lactams, chloramphenicol, sulfonamides, and streptomycin.
Highly Transferable pAQU-Related Plasmids Encoding Multidrug Resistance Are Widespread in the Human and Fish Pathogen Photobacterium damselae subsp. damselae in Aquaculture Areas in the Black Sea.
The study identifies multiple multidrug resistance plasmids in Photobacterium damselae subsp. damselae, including novel versions of pAQU-group plasmids carrying resistance genes such as tetB, floR, sul2, qnrVC, dfrA, and strAB.
Klebsiella pneumoniae carriage in low-income countries: antimicrobial resistance, genomic diversity and risk factors.
The study identified various AMR genes and mutations in Klebsiella pneumoniae isolates from pregnant women in low-income countries, highlighting the prevalence of multidrug-resistant strains and the role of environmental factors in their carriage.
Phenotypic and Genotypic Characterization of Veterinary Vibrio cincinnatiensis Isolates.
The study identified several AMR genes in veterinary Vibrio cincinnatiensis isolates, including qnrVC6, sul2, dfrA1, aadA1, aph(3")-Ib, aph(6)-Id, and tetB, which confer resistance to various antibiotics such as ciprofloxacin, sulfamethoxazole, trimethoprim, gentamicin, and tetracycline.
Prevalence of Cefotaxime-Resistant Escherichia coli Isolates from Healthy Cattle and Sheep in Northern Spain: Phenotypic and Genome-Based Characterization of Antimicrobial Susceptibility.
The study identified various AMR genes in cefotaxime-resistant E. coli isolates from cattle and sheep in the Basque Country, including bla CTX-M-14, bla CMY-2, and others, highlighting the prevalence of ESBL and AmpC-producing strains.
Integrating whole-genome sequencing within the National Antimicrobial Resistance Surveillance Program in the Philippines.
The study identifies various carbapenemase genes such as blaNDM-1, blaNDM-7, blaCTX-M-15, and blaOXA-181, along with other AMR genes like rmtC, sul1, aac(6')-Ib-cr, mph(A), qnrB1, and others, which contribute to resistance against multiple antibiotics in Klebsiella pneumoniae, Escherichia coli, Acinetobacter baumannii, and Pseudomonas aeruginosa in the Philippines.
Comparative analysis of multidrug resistance plasmids and genetic background of CTX-M-producing Escherichia coli recovered from captive wild animals.
The study identifies multiple AMR genes and mutations in MDR E. coli strains from captive wild animals, highlighting the presence of CTX-M-8 and CTX-M-65 beta-lactamases, along with various other resistance mechanisms such as aminoglycoside, tetracycline, and fluoroquinolone resistance genes, as well as mutations in quinolone resistance-determining regions.
Genomic analysis of Escherichia coli strains isolated from diseased chicken in the Czech Republic.
The study identified multiple AMR genes and mutations in E. coli isolates from diseased chickens in the Czech Republic, highlighting the presence of multidrug-resistant strains with resistance to β-lactams, quinolones, sulfonamides, and tetracyclines.
Genomic analyses of multidrug-resistant Salmonella Indiana, Typhimurium, and Enteritidis isolates using MinION and MiSeq sequencing technologies.
The study identified various AMR genes in multidrug-resistant Salmonella isolates, including beta-lactamases (blaCTX-M-14, blaCTX-M-27, blaCTX-M-55, blaOXA-1, blaCMY-2, blaOXA, blaCMY), phenicol resistance genes (catB3, cmlA1, floR, catA1, catA2, oqxA, oqxB), aminoglycoside resistance genes (aac(6')-Ib-cr5, aac(6')-Ib-cr, oqxA2, qepA1, qnrS1), sulfonamide and trimethoprim resistance genes (sul1, sul2, sul3, dfrA12, dfrA7), and tetracycline resistance genes (tet(A), tet(B), tet(M)).
High-resolution characterisation of ESBL/pAmpC-producing Escherichia coli isolated from the broiler production pyramid.
The study identified multiple AMR genes, including bla CTX-M-55, bla CMY-2, bla CTX-M-1, bla SHV-12, sul2, aac(3)-Ia, aadA, strA, strB, tet(A), tet(B), dfrA14, floR, cmlA1, catA1, catB3, qnrS1, qnrS2, qnrB19, mph(A), mph(B), arr-3, and aac(6')Ib-cr, in ESBL/pAmpC-producing E. coli isolates from broiler production.
Antibiotic Resistance Patterns of Pseudomonas spp. Isolated From Raw Milk Revealed by Whole Genome Sequencing.
The study identified various AMR genes and mutations in Pseudomonas spp. isolated from raw milk, highlighting the prevalence of multidrug-resistant strains and the presence of resistance determinants such as beta-lactamases, aminoglycoside-modifying enzymes, and efflux pumps.
Tracking Recombination Events That Occur in Conjugative Virulence Plasmid p15WZ-82_Vir during the Transmission Process.
The study characterizes the recombination events in the conjugative virulence plasmid p15WZ-82_Vir during transmission, identifying multiple antibiotic resistance genes and their roles in the formation of mosaic plasmids that carry both virulence and resistance traits.
Occurrence and Antimicrobial Resistance Traits of Escherichia coli from Wild Birds and Rodents in Singapore.
Identification of Antimicrobial Resistance Determinants in Aeromonas veronii Strain MS-17-88 Recovered From Channel Catfish (Ictalurus punctatus).
The study identified multiple antimicrobial resistance genes in Aeromonas veronii strain MS-17-88, including beta-lactamase genes (imiS, ampS), phenicol resistance genes (floR, catB2, catB7, vat(F)), colistin resistance genes (mcr-3, mcr-7.1), tetracycline resistance genes (tet(34), tet(35), tet(E)), and a trimethoprim resistance gene (dfrA3).
Antibiotic Susceptibility Testing (AST) Reports: A Basis for Environmental/Epidemiological Surveillance and Infection Control Amongst Environmental Vibrio cholerae.
The study identified various antibiotic resistance genes in Vibrio cholerae isolates, including blaTEM, NDM-1, AmpC, and ESBL, indicating multidrug resistance in environmental V. cholerae.
Antimicrobial Resistance and Biofilm Formation Capacity of Salmonella enterica Serovar Enteritidis Strains Isolated from Poultry and Humans in Poland.
The study identified floR as the most common resistance gene in poultry strains and blaTEM in human strains. adrA, csgD, and sdiA were prevalent in both groups, with adrA being present in 100% of poultry strains.
Tracking Antimicrobial Resistance Determinants in Diarrheal Pathogens: A Cross-Institutional Pilot Study.
The study identified 55 different antimicrobial resistance determinants in diarrheal pathogens, highlighting the presence of genes conferring resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, macrolides, tetracyclines, phenicols, sulfonamides, and others. Notably, carbapenemase genes like bla OXA-48 and bla NDM were detected in certain isolates, indicating emerging resistance concerns.
The European Union Summary Report on Antimicrobial Resistance in zoonotic and indicator bacteria from humans, animals and food in 2017/2018.
The report highlights the prevalence of antimicrobial resistance in zoonotic and indicator bacteria, focusing on Salmonella, Campylobacter, and E. coli. It notes high resistance levels to ampicillin, sulfonamides, and tetracyclines in Salmonella and E. coli isolates, along with rising resistance to fluoroquinolones in certain serovars. Carbapenemase-producing E. coli and Salmonella were rarely detected.
Comparative Genomic Analysis of 450 Strains of Salmonella enterica Isolated from Diseased Animals.
The study identified 60 antimicrobial resistance genes (ARGs), 4 disinfectant resistance genes (DRGs), and 33 heavy metal resistance genes (HMRGs) in 450 Salmonella strains isolated from diseased animals. These genes contributed to resistance against multiple antimicrobial classes, including aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and phenicols.
Concordance of disk diffusion, broth microdilution, and whole-genome sequencing for determination of in vitro antimicrobial susceptibility of Mannheimia haemolytica.
The study identified several AMR genes and mutations in Mannheimia haemolytica isolates, including floR, bla-OXA2, bla-ROB1, tetH/R, erm42, msrE, mphE, and fluoroquinolone resistance mutations in gyrA and parC.
Analysis of Resistance to Florfenicol and the Related Mechanism of Dissemination in Different Animal-Derived Bacteria.
The study identified floR and cfr genes as the primary mechanisms of florfenicol resistance in animal-derived bacteria, with floR being the most prevalent.
Emergence of NDM-5-Producing Carbapenem-Resistant Klebsiella pneumoniae and SIM-Producing Hypervirulent Klebsiella pneumoniae Isolated from Aseptic Body Fluid in a Large Tertiary Hospital, 2017-2018: Genetic Traits of blaNDM-Like and blaSIM-Like Genes as Determined by NGS.
The study identified NDM-5-producing CRKP and SIM-producing hvKP strains, highlighting the emergence of novel resistance mechanisms and the effectiveness of tigecycline-carbapenem combinations in treating these infections.
Detection and Profiling of Antibiotic Resistance among Culturable Bacterial Isolates in Vended Food and Soil Samples.
The study identified several antibiotic resistance genes including Bla TEM, StrB, DfrA, TetA, and FloR in bacterial isolates from vended food and soil samples in Embu Town and Kangaru Market, Kenya.
Genome Characterization of mcr-1-Positive Escherichia coli Isolated From Pigs With Postweaning Diarrhea in China.
The study identifies multiple antimicrobial resistance genes, including mcr-1.1 and mcr-3.1, in multidrug-resistant E. coli isolates from pigs with postweaning diarrhea in China.
Can domestic pigeon be a potential carrier of zoonotic Salmonella?
The study identified several antimicrobial resistance genes in Salmonella enterica serovar Typhimurium isolated from domestic pigeons, including strB, tet(A), floR, sul1, and blaTEM-1, which confer resistance to aminoglycosides, tetracyclines, florfenicol, sulfonamides, and beta-lactams, respectively.
A Multidrug-resistant Monophasic Salmonella Typhimurium Co-harboring mcr-1, fosA3, bla (CTX-M-14) in a Transferable IncHI2 Plasmid from a Healthy Catering Worker in China.
Class 1 integron-borne cassettes harboring blaCARB-2 gene in multidrug-resistant and virulent Salmonella Typhimurium ST19 strains recovered from clinical human stool samples, United States.
The study identifies the presence of the blaCARB-2 gene along with other resistance genes such as aac(6')-Iaa, aadA2b, sul1, tetG, floR, and qacEΔ1 in multidrug-resistant Salmonella Typhimurium ST19 strains.
Characteristics and Epidemiology of Extended-Spectrum β-Lactamase-Producing Multidrug-Resistant Klebsiella pneumoniae From Red Kangaroo, China.
The study identified multiple AMR genes in a multidrug-resistant Klebsiella pneumoniae isolate from a Red Kangaroo, including beta-lactamases (bla DHA–3, bla SHV–1, bla CTX–M–14, bla TEM–191, bla TEM–1, bla CTX–M–3), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aac(3)-IIa, aac(6′)-Ib-cr, aadA16, arr-3), quinolone resistance genes (qnrS1, qnrB2), macrolide resistance gene (mphA), sulfonamide resistance genes (sul3, sul1), dihydrofolate reductase (dfrA3, dfrA27), chloramphenicol resistance gene (floR), tetracycline resistance genes (tetG, tetR), and multidrug efflux pump (qacEΔ1).
Whole-Genome Sequence Analysis of an Extensively Drug-Resistant Salmonella enterica Serovar Agona Isolate from an Australian Silver Gull (Chroicocephalus novaehollandiae) Reveals the Acquisition of Multidrug Resistance Plasmids.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Agona isolate from a silver gull, including bla CTX-M-55, dfrA14, sul3, qnrS1, tet(A), bla TEM-1, and others, indicating the acquisition of multidrug resistance plasmids.
Genetic diversity and characteristics of high-level tigecycline resistance Tet(X) in Acinetobacter species.
Four tet(X) variants (tet(X3), tet(X4), tet(X5.2), and tet(X5.3)) were identified in Acinetobacter species, showing high-level resistance to tigecycline, tetracycline, eravacycline, and omadacycline. These genes were found in multiple Acinetobacter species and were associated with IS CR2 elements, facilitating their spread.
Genome-based characterization of Escherichia coli causing bloodstream infection through next-generation sequencing.
The study identified various AMR genes in E. coli isolates from bloodstream infections, including genes conferring resistance to beta-lactams, macrolides, aminoglycosides, chloramphenicol, and trimethoprim. Additionally, mutations in quinolone resistance-determining regions of gyrA, parC, and parE were associated with ciprofloxacin resistance.
A Novel Mobile Element ICERspD18B in Rheinheimera sp. D18 Contributes to Antibiotic and Arsenic Resistance.
The study characterizes the novel integrative and conjugative element ICE Rsp D18B in Rheinheimera sp. D18, which contains six antibiotic resistance genes (floR, sul2, strB, aph(3'')-Ib, and others) and an arsenic tolerance operon (arsRHCB), contributing to resistance against antibiotics and arsenic compounds.
Extended-Spectrum β-Lactamases in Human Isolates of Multidrug-Resistant Non-typhoidal Salmonella enterica.
The study identified several β-lactamase genes, including bla CTX-M-5, bla OXA-1, bla CTX-M-15, bla CTX-M-3, and bla TEM-1, which contribute to extended-spectrum β-lactamase (ESBL) production in multidrug-resistant non-typhoidal Salmonella enterica isolates. Additionally, a mutation in the gyrA gene (D87N) was linked to quinolone resistance.
Colistin Dependence in Extensively Drug-Resistant Acinetobacter baumannii Strain Is Associated with ISAjo2 and ISAba13 Insertions and Multiple Cellular Responses.
The study identifies the disruption of lpxA, mlaD, and pldA genes by IS Ajo2 and IS Aba13 insertions in colistin-dependent A. baumannii, leading to lipid A deficiency and colistin dependence.
Molecular characterisation of extended-spectrum ß-lactamase producing Escherichia coli in wild birds and cattle, Ibadan, Nigeria.
The study identified various AMR genes in ESBL-producing E. coli from wild birds and cattle in Nigeria, including bla CTX-M1/15, bla CTX-M9, strB, sul2, tetA, and others. These genes were associated with resistance to multiple antibiotics, highlighting the potential for inter-species transmission of AMR bacteria.
Antibiotic resistance plasmid composition and architecture in Escherichia coli isolates from meat.
The study characterizes various AMR genes in plasmids from meat-derived E. coli isolates, highlighting the diversity and clustering of resistance genes such as bla CTX-M-1, aadA5, sul2, and others, along with their association with specific plasmid incompatibility groups.
Characterization of Enterococci- and ESBL-Producing Escherichia coli Isolated from Milk of Bovides with Mastitis in Egypt.
The study identified several AMR genes in Enterococcus and ESBL-producing E. coli isolates from bovine mastitis cases in Egypt, including erm(B), tetL, aac-aphD, vanA, and vanB.
Genomic Analysis of Antimicrobial Resistance and Resistance Plasmids in Salmonella Serovars from Poultry in Nigeria.
The study identified various antimicrobial resistance genes in Salmonella isolates from Nigerian poultry, including aac(6')-Ia, aac(6')-Ib, aadA7, aph(3")-Ia, aph(3")-Ib, aph(6')-Id, aph(6')-Ic, aac(3)-Ia, aac(3)-IIa, aac(3)-IVa, aac(6')-IIa, aac(3)-Id, sul1, sul2, sul3, tet(A), tet(M), qnrS1, qnrB19, blaTEM, dfrA14, dfrA15, dfrA17, catA1, cmlA1, and floR. Mutations in gyrA (Ser83Phe, Asp87Tyr) and parC (Thr57Ser, Ser80Ile) were also associated with resistance to nalidixic acid and ciprofloxacin.
Characterization of Extended-Spectrum Beta-Lactamase-Producing Escherichia coli Isolates from Jurong Lake, Singapore with Whole-Genome-Sequencing.
The study identified several extended-spectrum beta-lactamase (ESBL) genes, including bla CTX-M-15, bla CTX-M-8, bla CTX-M-27, bla CTX-M-14, and bla CTX-M-55, along with mcr-1.1 and mcr-3.1 for colistin resistance. Additionally, various other resistance genes such as qnrS1, mdf(A), mph(A), and others were found in the isolates, indicating multidrug resistance.
Endophytic Lifestyle of Global Clones of Extended-Spectrum β-Lactamase-Producing Priority Pathogens in Fresh Vegetables: a Trojan Horse Strategy Favoring Human Colonization?
The study identifies multiple AMR genes in endophytic ESBL-producing Enterobacterales isolated from fresh vegetables, highlighting their potential role in the spread of antibiotic resistance.
Prevalence and antimicrobial resistance of Salmonella isolates from goose farms in Northeast China.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from goose farms in Northeast China, including blaTEM-1, cmlA, aac(6')-Ib-cr, sul1, sul2, sul3, mcr-1.1, tetB, qnrB, and floR, which confer resistance to various antibiotics such as amoxicillin, chloramphenicol, gentamicin, kanamycin, tetracycline, florfenicol, and colistin.
Emergence of fosA3 and bla (CTX-M-) (14) in Multidrug-Resistant Citrobacter freundii Isolates From Flowers and the Retail Environment in China.
The study identifies fosA3 and bla CTX-M-14 in multidrug-resistant Citrobacter freundii isolates from flowers and retail environments in China, highlighting the role of untypable plasmids in the spread of these resistance genes.
Plasmid-Borne and Chromosomal ESBL/AmpC Genes in Escherichia coli and Klebsiella pneumoniae in Global Food Products.
The study identified several beta-lactamase genes, including bla CTX-M-1, bla CTX-M-15, bla CTX-M-55, bla CTX-M-65, bla SHV-12, bla SHV-28, bla SHV-81, bla TEM-1B, bla TEM-52C, bla CARB-2, bla OXA-1, bla DHA-1, and bla CMY-2, along with other AMR genes such as aac(3)-IIa, aac(6')-Ib-cr, aph(3')-Ia, aph(3')-Ib, aph(6)-Id, aadA1, aadA2, aph(4)-Ia, oqxA, oqxB, qnrB1, qnrS1, floR, sul2, sul1, tet(A), dfrA14, dfrA1, dfrA17, dfrA8, dfrA12, dfrA16, dfrA15, catB3, cmlA1, arr-2, and qnrB19, which confer resistance to various antibiotics in Escherichia coli and Klebsiella pneumoniae isolated from food products.
Market Chickens as a Source of Antibiotic-Resistant Escherichia coli in a Peri-Urban Community in Lima, Peru.
The study identified several AMR genes in E. coli isolates from market chickens and humans, including blaCTX-M-55, blaKPC-3, mcr-1, and floR, highlighting the potential transmission of resistance genes from poultry to humans.
Analysis of antibiotic resistance phenotypes and genes of Escherichia coli from healthy swine in Guizhou, China.
The study identified multiple antibiotic resistance genes in Escherichia coli isolates from healthy swine in Guizhou, China, highlighting the prevalence of multidrug resistance, particularly for tetracycline, doxycycline, and sulfisoxazole. Key genes included blaTEM, blaCTX-M-9G, aac(3')-IV, aadA1, aadA2, floR, qnrS, oqxA, and mcr-1.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Emergence of High Level Carbapenem and Extensively Drug Resistant Escherichia coli ST746 Producing NDM-5 in Influent of Wastewater Treatment Plant, Seoul, South Korea.
The study reports the emergence of a high-level carbapenem-resistant and extensively drug-resistant (XDR) Escherichia coli strain N7 producing NDM-5, highlighting the presence of multiple resistance genes on plasmids and chromosomes.
Genomic Diversity and Virulence Potential of ESBL- and AmpC-β-Lactamase-Producing Escherichia coli Strains From Healthy Food Animals Across Europe.
The study identifies various ESBL and AmpC beta-lactamase genes, including bla SHV-12, bla CTX-M-1, bla CTX-M-2, bla CTX-M-14, bla CTX-M-15, bla TEM-52, and bla CMY-2, along with the mcr-1 gene conferring colistin resistance in E. coli isolates from food animals in Europe.
Comparative Characteristics and Zoonotic Potential of Avian Pathogenic Escherichia coli (APEC) Isolates from Chicken and Duck in South Korea.
The study identified several antimicrobial resistance genes in APEC isolates from chickens and ducks in South Korea, including mcr-1, blaTEM, blaCTX-M group I, blaCTX-M group IV, mphA, cat, floR, cmlA, strA-B, aadA, sul1, sul2, tetA, and tetB. These genes conferred resistance to various antibiotics such as colistin, ampicillin, azithromycin, chloramphenicol, streptomycin, sulfisoxazole, and tetracycline. The study also highlighted the zoonotic potential of certain APEC isolates, particularly those belonging to phylogenetic group B2.
On-Farm Anaerobic Digestion of Dairy Manure Reduces the Abundance of Antibiotic Resistance-Associated Gene Targets and the Potential for Plasmid Transfer.
The study found that anaerobic digestion of dairy manure significantly reduced the abundance of antibiotic resistance genes, including various ESBL genes such as bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, and bla PER-1, as well as other resistance genes like aac(6')-Ib-cr, aph(3')-Ib, aph(6)-Id, bla OXA-1, catB4, dfrA1, floR, lnu(G), sul2, aadA2, mph(E), msr(E), tet(C), tet(E), and tet(X).
Epidemiology of antimicrobial resistance (AMR) on California dairies: descriptive and cluster analyses of AMR phenotype of fecal commensal bacteria isolated from adult cows.
The study found high levels of antimicrobial resistance in commensal E. coli and Enterococcus/Streptococcus spp. isolated from fecal samples of dairy cows in California, with significant regional and seasonal variations. High resistance was observed to florfenicol, tildipirosin, tilmicosin, and tiamulin, while low resistance was noted for drugs like ampicillin and penicillin.
Diversity of Plasmids and Genes Encoding Resistance to Extended-Spectrum β-Lactamase in Escherichia coli from Different Animal Sources.
The study identified various AMR genes and mutations in E. coli isolates from different animal sources, highlighting the presence of ESBL genes such as bla CTX-M-15, bla TEM-1B, and bla CMY-28, as well as mutations in parC and gyrA that confer resistance to fluoroquinolones.
The Spatiotemporal Dynamics and Microevolution Events That Favored the Success of the Highly Clonal Multidrug-Resistant Monophasic Salmonella Typhimurium Circulating in Europe.
The study identifies various AMR genes in the highly clonal multidrug-resistant monophasic Salmonella Typhimurium ST34, including beta-lactamases, sulfonamide resistance genes, tetracycline resistance genes, phenicol resistance genes, and polymyxin resistance genes.
Molecular Analysis of Antimicrobial Resistance among Enterobacteriaceae Isolated from Diarrhoeic Calves in Egypt.
The study identified multiple antimicrobial resistance genes, including blaTEM, floR, dfrA1, dfrA17, aadA1, aadA2, aadA5, catB3, sat1, and blaPse1, in Enterobacteriaceae isolates from diarrhoeic calves in Egypt. These genes confer resistance to various antibiotics such as ampicillin, tetracycline, chloramphenicol, and others.
Genomic Analysis of Delftia tsuruhatensis Strain TR1180 Isolated From A Patient From China With In4-Like Integron-Associated Antimicrobial Resistance.
The study identified multiple antimicrobial resistance genes in Delftia tsuruhatensis TR1180, including blaOXA-118, oqxB, dfrA16, aac(6')-Ib3, aadA2, sul1, floR, and tet(G), which correspond to the strain's resistance to beta-lactams, fluoroquinolones, sulfonamides, aminoglycosides, and tetracyclines.
Identification of floR Variants Associated With a Novel Tn4371-Like Integrative and Conjugative Element in Clinical Pseudomonas aeruginosa Isolates.
The study identifies two novel floR variants, floR-T1 and floR-T2, in clinical Pseudomonas aeruginosa isolates. Both variants confer resistance to florfenicol and chloramphenicol and are located on a novel Tn4371-like integrative and conjugative element (ICE).
Identification of floR Variants Associated With a Novel Tn4371-Like Integrative and Conjugative Element in Clinical Pseudomonas aeruginosa Isolates.
The study identifies two novel floR variants, floR-T1 and floR-T2, in clinical Pseudomonas aeruginosa isolates. Both variants confer resistance to florfenicol and chloramphenicol and are located on a novel Tn4371-like integrative and conjugative element (ICE).
Identification of floR Variants Associated With a Novel Tn4371-Like Integrative and Conjugative Element in Clinical Pseudomonas aeruginosa Isolates.
The study identifies two novel floR variants, floR-T1 and floR-T2, in clinical Pseudomonas aeruginosa isolates. Both variants confer resistance to florfenicol and chloramphenicol and are located on a novel Tn4371-like integrative and conjugative element (ICE).
Outbreak of NDM-1-producing Klebsiella pneumoniae in the intensive care unit during the COVID-19 pandemic: Another nightmare.
The study reports an outbreak of NDM-1-producing Klebsiella pneumoniae in an ICU during the COVID-19 pandemic, highlighting the presence of multiple AMR genes including blaNDM-1, blaTEM-1, blaCTX-M-15, blaOXA-1, blaCMY-4, and others, along with mutations in ParC and GyrA contributing to quinolone resistance.
Foodborne Pathogenic Vibrios: Antimicrobial Resistance.
The paper discusses the presence of various antibiotic resistance genes in Vibrio species, including strB, sul2, tetA, blaTEM, qnrA, ermB, floR, aac(3)-IIa, blaNDM-1, blaCMY, blaP1, catB3, and others, which confer resistance to antibiotics such as streptomycin, sulfamethoxazole, tetracycline, ampicillin, fluoroquinolones, erythromycin, florfenicol, gentamicin, carbapenems, chloramphenicol, and trimethoprim.
Prevalence and mechanisms of antibiotic resistance in Escherichia coli isolated from mastitic dairy cattle in Canada.
The study identified several AMR genes in E. coli isolates from bovine mastitis, including beta-lactamases (blaTEM-1, blaCARB-3, blaCMY-59), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aadA2), and multidrug efflux pump genes (acrA, acrB, acrD, tolC, baeR, emrA, emrB).
Antimicrobial Resistance of Non-Typhoid Salmonella in Meat and Meat Products.
The study highlights the prevalence of antimicrobial resistance in non-typhoid Salmonella isolates from meat and meat products, emphasizing the resistance patterns to antibiotics such as tetracycline, sulfonamides, ampicillin, and streptomycin. It identifies Enteritidis and Typhimurium as the most common serovars with significant resistance levels.
Genetic Features of Plasmid- and Chromosome-Mediated mcr-1 in Escherichia coli Isolates From Animal Organs With Lesions.
The study characterizes the mcr-1 gene and various other resistance genes in Escherichia coli isolates from animal organs with lesions, highlighting their multidrug resistance profiles and the genetic features of plasmids carrying these genes.
Genomic Characterization of Multidrug-Resistant Salmonella Serovars Derby and Rissen From the Pig Value Chain in Vietnam.
The study identified multiple antimicrobial resistance genes in Salmonella serovars Derby and Rissen from Vietnam, highlighting the presence of multidrug-resistant strains along the pig value chain.
Discerning the Antimicrobial Resistance, Virulence, and Phylogenetic Relatedness of Salmonella Isolates Across the Human, Poultry, and Food Materials Sources in Malaysia.
The study identified several AMR genes in Salmonella Enteritidis isolates from Malaysia, including aac(6')-ly, blaCMY-2, blaTEM-1, blaTEM-33, blaTEM-4, dfrA14, dfrA15, floR, qnrS1, qnrD1, sul1, sul2, strA, strB, tetA, and tetC. These genes conferred resistance to various antibiotics such as gentamicin, ampicillin, chloramphenicol, ciprofloxacin, sulfamethazine/trimethoprim, and tetracycline.
Antimicrobial resistance and genomic characterization of Salmonella Dublin isolates in cattle from the United States.
The study characterized multidrug-resistant Salmonella Dublin isolates from cattle in the United States, identifying key AMR genes such as sul2, tetA, aph(6)-Id, aph(3''-Ib, floR, and blaCMY-2, along with quinolone resistance mutations in gyrA.
Antimicrobial Resistance Patterns and Risk Factors Associated with Salmonella spp. Isolates from Poultry Farms in the East Coast of Peninsular Malaysia: A Cross-Sectional Study.
The study identified multiple antimicrobial resistance genes in Salmonella spp. isolates from poultry farms in Malaysia, including blaTEM, tet(A), tet(B), catA1, cat2, floR, sul1, and sul2, which confer resistance to beta-lactams, tetracyclines, chloramphenicol, and sulfonamides.
Genotypic and Phenotypic Characterization of Antimicrobial Resistance Profiles in Non-typhoidal Salmonella enterica Strains Isolated From Cambodian Informal Markets.
The study identified 17 unique AMR genes in 53% of the 81 S. enterica isolates, including genes encoding resistance to tetracycline, beta-lactam, sulfonamide, quinolone, aminoglycoside, phenicol, and trimethoprim.
IS1294 Reorganizes Plasmids in a Multidrug-Resistant Escherichia coli Strain.
The study identifies and characterizes various AMR genes, including blaCTX-M-55, rmtB, oqxAB, blaTEM-1b, floR, tet(A), strA, strB, sul1, sul2, aac(3)-IId, aadA2, dfrA12, and aph(3′)-IIa, in a multidrug-resistant E. coli strain. These genes contribute to resistance against multiple antibiotics such as beta-lactams, aminoglycosides, fluoroquinolones, tetracyclines, sulfonamides, and trimethoprim.
Characterization of a pESI-like plasmid and analysis of multidrug-resistant Salmonella enterica Infantis isolates in England and Wales.
The study characterizes a pESI-like plasmid harboring multiple resistance genes, including bla CTX-M-65, in multidrug-resistant Salmonella enterica Infantis isolates from England and Wales. The plasmid was associated with resistance to beta-lactams, aminoglycosides, chloramphenicol, tetracyclines, trimethoprim, sulfonamides, fosfomycin, and heavy metals.
Genomic Characterization of Endemic and Ecdemic Non-typhoidal Salmonella enterica Lineages Circulating Among Animals and Animal Products in South Africa.
The study identified streptomycin and tetracycline resistance-conferring genes in South African Salmonella enterica lineages, highlighting the presence of antimicrobial resistance in animal and animal product isolates.
Genetic Comparison of ESBL-Producing Escherichia coli from Workers and Pigs at Vietnamese Pig Farms.
The study identified several ESBL genes, colistin resistance genes, and other AMR genes in ESBL-producing E. coli from pigs and pig farm workers in Vietnam. Key findings include the prevalence of bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27, along with mcr-1 and mcr-3 for colistin resistance, and various other resistance genes for aminoglycosides, quinolones, tetracyclines, chloramphenicol, macrolides, and sulfonamides.
Identification of Three Novel PmGRI1 Genomic Resistance Islands and One Multidrug Resistant Hybrid Structure of Tn7-like Transposon and PmGRI1 in Proteus mirabilis.
The study identifies three novel variants of PmGRI1 and a hybrid structure combining Tn7-like transposon and PmGRI1 in Proteus mirabilis, highlighting their role in carrying multiple antibiotic resistance genes.
Multidrug Resistance Dynamics in Salmonella in Food Animals in the United States: An Analysis of Genomes from Public Databases.
The study analyzed 22,102 Salmonella genomes from public databases to track antimicrobial resistance (AMR) trends in food animals in the United States. It found that the prevalence of multidrug resistance (MDR) decreased in bovines and swine but increased in poultry. Key AMR genes identified include bla CMY-2, bla CTX-M-65, floR, tetA, sul2, aadA2, aac(3)-VIa, qnrB19, qnrB2, bla SHV-12, bla TEM-1, bla CARB-2, aph(3")-Ib, aph(6)-Id, aph(3')-Ia, ant(3")-Ia, aph(4)-Ia, and aac(3)-IVa. A significant mutation, gyrA D87Y, was associated with quinolone resistance in poultry.
Phylogenetic and antimicrobial drug resistance analysis of Vibrio cholerae O1 isolates from Ghana.
The study identified multiple antimicrobial resistance genes in Vibrio cholerae O1 isolates from Ghana, including strA, strB, catB5, floR, sul2, and dfrA1, which confer resistance to streptomycin, chloramphenicol, florfenicol, sulfonamides, and trimethoprim/sulfamethoxazole. Additionally, mutations in gyrA (S83I) and parC (S85L) were found to contribute to fluoroquinolone resistance.
Monitoring the Microevolution of Salmonella enterica in Healthy Dairy Cattle Populations at the Individual Farm Level Using Whole-Genome Sequencing.
The study identified several AMR genes, including bla CMY-2, floR, sul2, and tetA, in Salmonella enterica isolates from dairy cattle. These genes confer resistance to various antibiotics such as cephalosporins, florfenicol, sulfamethoxazole-trimethoprim, and tetracycline.
Whole-Genomic Analysis of NDM-5-Producing Enterobacteriaceae Recovered from an Urban River in China.
The study identified multiple antimicrobial resistance genes, including bla NDM-5, bla OXA-10, and bla TEM-1B, in NDM-5-producing Enterobacteriaceae isolates from an urban river in China. These genes conferred resistance to various antibiotics such as carbapenems, cephalosporins, quinolones, and aminoglycosides.
Co-occurrence of Klebsiella variicola and Klebsiella pneumoniae Both Carrying bla (KPC) from a Respiratory Intensive Care Unit Patient.
The study identified Klebsiella variicola and Klebsiella pneumoniae strains carrying multiple resistance genes, including bla KPC-2, bla TEM-1A, bla LEN17, aadA16, arr-3, qnrB4, oqxA/B, dfrA27, sul1, tetD, fosA, qacEΔ1, bla CTX-M-3, bla TEM-1B, bla CTX-M-65, bla SHV-27, aac(6')-IIa, rmtB, aph(3')-Ia, aadA16, qnrS1, aac(6')-Ib-cr, qnrB91, oqxA/B, mph(A), tet(A), fosA, dfrA27, and two copies of qacEΔ1-sul1.
CRISPR Element Patterns vs. Pathoadaptability of Clinical Pseudomonas aeruginosa Isolates from a Medical Center in Moscow, Russia.
The study identified multiple antibiotic resistance genes in clinical Pseudomonas aeruginosa isolates, including blaVIM-2, blaOXA-396, blaOXA-488, floR, tetG, sul1, dfrA5, dfrB2, dfrB5, aph(3)-Ib, blaPAO, catB7, and fosA, which confer resistance to various antibiotics such as beta-lactams, chloramphenicol, tetracycline, sulfonamides, trimethoprim, aminoglycosides, and fosfomycin.
Impact of Antibiotic Therapies on Resistance Genes Dynamic and Composition of the Animal Gut Microbiota.
The study examined the impact of antibiotic therapies on the dynamics and composition of resistance genes in the animal gut microbiota, identifying several AMR genes such as blaTEM, tetA, strA, strB, intI1, tetM, mel, floR, mcr-2, oqx B, tetC, tetG, tetO, tetW, tetX, ermB, ermF, sul1, sul2, and others, which were experimentally validated in Escherichia coli.
Identification of CTX-M Type ESBL E. coli from Sheep and Their Abattoir Environment Using Whole-Genome Sequencing.
The study identified various CTX-M-type beta-lactamase genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-32, bla CTX-M-55, and bla CTX-M-65, as well as other beta-lactamase genes such as bla TEM-1, bla CARB-2, and bla CMY-2 in ESBL E. coli isolates from sheep and their abattoir environment. Additional AMR genes related to aminoglycosides, macrolides, phenicols, quinolones, sulfonamides, tetracyclines, and trimethoprim were also detected.
Phage Cocktail Development against Aeromonas salmonicida subsp. salmonicida Strains Is Compromised by a Prophage.
The study identifies antibiotic resistance genes such as sul1, sul2, floR, tetA, and cat in Aeromonas salmonicida subsp. salmonicida strains, highlighting their role in resistance to sulfonamides, chloramphenicol, and tetracycline. It also shows that the presence of Prophage 3 reduces the effectiveness of phage cocktails against these strains.
Genomic Characterization of Extensively Drug-Resistant NDM-Producing Acinetobacter baumannii Clinical Isolates With the Emergence of Novel bla (ADC-257).
The study identified several AMR genes, including novel bla ADC-257, and mutations in gyrA and parC associated with fluoroquinolone resistance in extensively drug-resistant NDM-producing Acinetobacter baumannii isolates.
Genomic diversity of antimicrobial resistance in non-typhoidal Salmonella in Victoria, Australia.
The study identified various AMR genes and mutations in non-typhoidal Salmonella, including bla TEM-1, bla TEM-135, strAB, sul1, sul2, tet(A), tet(B), floR, bla CMY-2, bla CTX-M-55, and bla CTX-M-65, along with mutations in gyrA and parC contributing to ciprofloxacin resistance.
Letter to the Editor: Importation of the First Bovine ST361 New Delhi Metallo-5 Positive Escherichia coli in Greece.
The study reports the first bovine ST361 NDM-5 positive Escherichia coli in Greece, highlighting the importation of multidrug-resistant strains and the need for continued surveillance.
The Integrative and Conjugative Element ICECspPOL2 Contributes to the Outbreak of Multi-Antibiotic-Resistant Bacteria for Chryseobacterium Spp. and Elizabethkingia Spp.
The study identifies the integrative and conjugative element ICE Csp POL2 in the multi-antibiotic-resistant strain Chryseobacterium sp. POL2, which carries several antibiotic resistance genes including those conferring resistance to carbapenems, chloramphenicol, florfenicol, macrolides, tetracycline, and aminoglycosides. The element was found to transfer horizontally to Elizabethkingia species, contributing to the spread of multiple antibiotic resistance genes.
Outbreak of Multidrug-Resistant Salmonella Heidelberg Infections Linked to Dairy Calf Exposure, United States, 2015-2018.
The study identifies a multidrug-resistant (MDR) Salmonella Heidelberg outbreak linked to dairy calf exposure, highlighting the presence of plasmid-borne resistance genes such as aadA1, aph(3')-Ia, bla CMY-2, floR, fosA7, qnrB19, strA, strB, sull, sul2, tet(A), tet(B), tet(O), and a novel gene dfrA34.
Recurring outbreaks by the same Escherichia coli ST10 clone in a broiler unit during 18 months.
The study identifies multiple antimicrobial resistance genes, including blaTEM-1B, tetA, dfrA1/sul2, and floR, in E. coli ST10 isolates causing recurrent outbreaks in a broiler unit over 18 months.
Antimicrobial Resistance of Escherichia coli From Aquaculture Farms and Their Environment in Zhanjiang, China.
The study identified multiple antimicrobial resistance (AMR) genes in Escherichia coli isolates from aquaculture farms in Zhanjiang, China, including blaTEM, blaCIT, floR, OptrA, cmlA, aphA1, Sul2, oqxA, qnrS, and mcr1. These genes conferred resistance to various antibiotics such as beta-lactams, chloramphenicol, florfenicol, aminoglycosides, sulfonamides, quinolones, and colistin.
Anti-microbial resistance of Salmonella isolates from raw meat-based dog food in Japan.
High-resolution genomic surveillance elucidates a multilayered hierarchical transfer of resistance between WWTP- and human/animal-associated bacteria.
The study identifies multiple plasmid-borne AMR genes, including blaTEM-1, aph(3')-I, floR, and tetA, which confer resistance to ampicillin, kanamycin, chloramphenicol, and tetracycline, respectively. These genes are primarily located on conjugative plasmids and show potential for horizontal transfer between WWTP- and human/animal-associated bacteria.
S. algae as a reservoir and a vehicle of potential antimicrobial resistance
The study identified multiple antimicrobial resistance genes in S. algae strains, including genes conferring resistance to beta-lactams, aminoglycosides, quinolones, phenicols, macrolides, sulfonamides, tetracyclines, and lincosamides.
Genome Informatics and Machine Learning-Based Identification of Antimicrobial Resistance-Encoding Features and Virulence Attributes in Escherichia coli Genomes Representing Globally Prevalent Lineages, Including High-Risk Clonal Complexes.
The study identified 247 AMR genes across 19 STs of E. coli, including beta-lactamases (ampC, blaTEM-4), quinolone resistance (qnrS1), sulfonamide resistance (sul1, sul2), and efflux pumps (emrE, floR).
A Genomic and Bioinformatics View of the Classification and Evolution of Morganella Species and Their Chromosomal Accessory Genetic Elements Harboring Antimicrobial Resistance Genes.
The study identified 88 acquired antimicrobial resistance genes (ARGs) in 166 Morganella isolates, with a focus on tetracycline, aminoglycoside, sulfonamide, trimethoprim, and beta-lactam resistance genes. Key ARGs included blaKPC-2, blaNDM-1, aacA4, aadA5, dfrA17, catB3, arr-3, blaOXA-1, aacA4cr, mph(A), rmtB, sul2, floR, qnrS1, tetA, and ermB.
Genomic Analysis of ESBL-Producing E. coli in Wildlife from North-Eastern Germany.
The study identified ESBL-producing E. coli in wild boar and wild ruminants with a low prevalence. The most prevalent ESBL type was CTX-M-1. The study also found resistance genes for aminoglycosides, phenicol, sulfonamides, and tetracyclines.
Detection of Carbapenem Resistance of Proteus mirabilis Strains Isolated from Foxes, Raccoons and Minks in China.
The study identified several AMR genes in Proteus mirabilis isolates from foxes, raccoons, and minks in China, including blaTEM, blaOXA-1, aac(6′)Ib-cr, floR, sul1, blaNDM, and blaOXA-24. These genes conferred resistance to various antibiotics, with a high prevalence of multidrug-resistant isolates.
Comparison of Reference-Based Assembly and De Novo Assembly for Bacterial Plasmid Reconstruction and AMR Gene Localization in Salmonella enterica Serovar Schwarzengrund Isolates.
The study identified various AMR genes in Salmonella enterica serovar Schwarzengrund isolates, including aadA2, AAC(3)-IV, AAC(6')-Iy, APH(4)-Ia, cmlA1, dfrA12, floR, sul1, sul2, sul3, TEM-1, and tet(A). These genes were located on both the chromosome and plasmids, highlighting the importance of plasmid-mediated AMR gene transmission.
Population genomics of the food-borne pathogen Vibrio fluvialis reveals lineage associated pathogenicity-related genetic elements.
The study identified 21 antimicrobial resistance genes in Vibrio fluvialis, with 19 of them predominantly present in VflPop2. The tetracycline resistance gene tet(35) was found in 95% of VflPop2 strains, highlighting its significance in the population. Additionally, the plasmid pBD146 was associated with resistance to trimethoprim-sulfamethoxazole, and the presence of dfr6 gene in pBD146 was linked to this resistance.
Pan-Genome Analysis of Delftia tsuruhatensis Reveals Important Traits Concerning the Genetic Diversity, Pathogenicity, and Biotechnological Properties of the Species.
The study identifies multiple antimicrobial resistance genes in Delftia tsuruhatensis, including aminoglycoside, sulfonamide, trimethoprim, tetracycline, and phenicol resistance genes, indicating the potential for multidrug resistance in this species.
Genetic Diversity of Antimicrobial Resistance and Key Virulence Features in Two Extensively Drug-Resistant Acinetobacter baumannii Isolates.
The study identified various AMR genes in two extensively drug-resistant A. baumannii isolates, including aminoglycoside resistance genes, sulfonamide resistance genes, beta-lactamase genes, and efflux pump genes, highlighting the complexity of their resistance mechanisms.
A Metagenomic Approach for Characterizing Antibiotic Resistance Genes in Specific Bacterial Populations: Demonstration with Escherichia coli in Cattle Manure.
The study identified multiple antibiotic resistance genes in E. coli populations from cattle manure, including genes conferring resistance to tetracycline, aminoglycosides, chloramphenicol, sulfonamides, and glycopeptides. These genes were found to be associated with mobile genetic elements, highlighting the potential for horizontal gene transfer.
Emergence of Carbapenem-Resistant ST244, ST292, and ST2446 Pseudomonas aeruginosa Clones in Burn Patients in Yunnan Province.
Genomics of human and chicken Salmonella isolates in Senegal: Broilers as a source of antimicrobial resistance and potentially invasive nontyphoidal salmonellosis infections.
The study identified multiple antimicrobial resistance genes and mutations in Salmonella isolates from Senegal, highlighting the prevalence of resistance to fluoroquinolones, sulfamethoxazole-trimethoprim, tetracycline, and erythromycin. Key genes included aac(3)-Id, aadA7, blaTEM-1b, blaDHA-1, blaOXA-10, blaCMY-2, dfrA1, dfrA14, floR, fosA, qnrB19, qnrB7, sul2, tetA, tetB, aph(3')-Ib, aph(3")-Ib, and aph(6)-Id. Mutations in parC and gyrA were also associated with fluoroquinolone resistance.
Establishment of Epidemiological Cut-Off Values and the Distribution of Resistance Genes in Aeromonas hydrophila and Aeromonas veronii Isolated from Aquatic Animals.
The study identified several tetracycline resistance genes (tetA, tetB, tetD, tetE), florfenicol resistance gene (floR), chloramphenicol resistance gene (cat), quinolone resistance gene (qnrS), and aminoglycoside resistance genes (aac(6')-1b, strA-strB) in Aeromonas hydrophila and Aeromonas veronii isolates from aquatic animals.
Invited Review: Antimicrobial Use and Antimicrobial Resistance in Pathogens Associated with Diarrhea and Pneumonia in Dairy Calves.
The review identified several AMR genes in pathogens associated with calf diarrhea and pneumonia, including beta-lactamases (blaCMY, blaCTX-M, blaTEM), tetracycline resistance genes (tetA, tetB, tetM, tetO), aminoglycoside resistance genes (strA, strB, aadA), sulfonamide resistance genes (sul1, sul2), phenicol resistance genes (cat, floR), and macrolide/lincosamide resistance genes (cfr, ermB).
Whole-genome sequencing and gene sharing network analysis powered by machine learning identifies antibiotic resistance sharing between animals, humans and environment in livestock farming.
The study identified 361 genes associated with antimicrobial resistance in E. coli isolates from poultry farms and slaughterhouses, highlighting extensive gene sharing and multidrug resistance profiles across hosts and environments.
Whole Genome Sequence Analysis of Multidrug Resistant Escherichia coli and Klebsiella pneumoniae Strains in Kuwait.
The study identified multiple AMR genes in multidrug-resistant E. coli and K. pneumoniae isolates from Kuwait, including beta-lactamases (blaKPC-2, blaCTX-M-15, blaOXA-1, blaCMY-4, blaTEM), aminoglycoside-modifying enzymes (aac(3)-IIa, aph(6)-Id, aadA5), sulfonamide resistance genes (sul1, sul2), quinolone resistance genes (gyrA_D87N, qnrB1), and others. Colistin resistance was linked to the pmrB_R256G mutation.
Genomic Profiling of Antibiotic-Resistant Escherichia coli Isolates from Surface Water of Agricultural Drainage in North-Western Mexico: Detection of the International High-Risk Lineages ST410 and ST617.
The study identified multidrug-resistant Escherichia coli isolates from surface water in north-western Mexico, including international high-risk lineages ST410 and ST617. These isolates carried various AMR genes such as blaTEM-1B, blaCTX-M-15, aadA1, aadA2, aadA5, aac(3)-IIa, aac(3)-IId, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, floR, cmlA1, lnu(F), mdf(A), sul2, sul3, tet(A), tet(B), dfrA12, and dfrA17. Additionally, mutations in gyrA (S83L, D87N), parC (S80I), and parE (S458A) were found to contribute to fluoroquinolone resistance.
Use of genomics to explore AMR persistence in an outdoor pig farm with low antimicrobial usage.
The study identified various AMR genes in E. coli isolates from a low antimicrobial usage pig farm, highlighting the persistence of multidrug-resistant strains despite minimal selective pressure.
Genetic Diversity, Distribution, and Genomic Characterization of Antibiotic Resistance and Virulence of Clinical Pseudomonas aeruginosa Strains in Kenya.
The study identified multiple AMR genes and mutations in P. aeruginosa isolates from Kenya, including carbapenemases (blaNDM-1, blaVIM-6), fluoroquinolone resistance genes (qnrVC1, crpP), aminoglycoside resistance genes (aac(3)-IId, aph(3')-Ib, ant(3'')-Ia), tetracycline resistance genes (tetA, tetG), phenicol resistance genes (floR, cmlA), sulfonamide resistance gene (sul), trimethoprim resistance gene (dfrB), glycopeptide resistance gene (ble), and macrolide resistance gene (EreA). Additionally, mutations in gyrA and parC were associated with fluoroquinolone resistance.
Analysis of Antimicrobial Resistance in Non-typhoidal Salmonella Collected From Pork Retail Outlets and Slaughterhouses in Vietnam Using Whole Genome Sequencing.
The study identified several AMR genes in non-typhoidal Salmonella isolates from pork retail outlets and slaughterhouses in Vietnam, including blaTEM-1, blaTEM-150, blaLAP-2, blaCTX-M-55, dfrA12, dfrA14, floR, cmlA1, tetA, tetB, tetM, mcr-1, mcr-3, qnrS1, mphA, aadA1, aadA2, aac(6')-laa, aac(6')-ly, sul1, sul2, sul3, aph(3")-lb, and aph6-ld. These genes conferred resistance to various antibiotics such as ampicillin, penicillins, first-generation cephalosporins, quinolones, trimethoprim, chloramphenicol, tetracycline, colistin, macrolides, gentamicin, sulfonamides, and others.
Antimicrobial resistance and genetic background of non-typhoidal Salmonella enterica strains isolated from human infections in São Paulo, Brazil (2000-2019).
The study identifies several AMR genes, including blaTEM-1, dfrA1, tetA, sul1, floR, aac(6')-laa, qnrE1, aadA1, and aac(6')-ly, in non-typhoidal Salmonella enterica strains. It also reports mutations in mgrB, pmrB, and pmrC associated with colistin resistance.
Antimicrobial Resistance and Transconjugants Characteristics of sul3 Positive Escherichia coli Isolated from Animals in Nanning, Guangxi Province.
The study identified sul3-positive E. coli strains with multiple antibiotic resistance genes, including sul3, sul2, tetA, floR, oqxA, and mcr-1, highlighting the potential for horizontal gene transfer and the need for long-term monitoring of antimicrobial resistance in Nanning.
Urban Wildlife Crisis: Australian Silver Gull Is a Bystander Host to Widespread Clinical Antibiotic Resistance.
The study identifies multiple antibiotic resistance genes, including bla_IMP-4, bla_SHV-12, sul1, sul2, mphA, and floR, in Escherichia coli isolates from Australian silver gulls, highlighting the role of wildlife in the spread of clinical antibiotic resistance.
Multidrug Resistance Genes Carried by a Novel Transposon Tn7376 and a Genomic Island Named MMGI-4 in a Pathogenic Morganella morganii Isolate.
The study identifies a novel transposon Tn7376 and a genomic island MMGI-4 in a multidrug-resistant Morganella morganii isolate, carrying multiple antimicrobial resistance genes including dfrA24, mph(A), aadA1, sul1, floR, catA2, cmlA1, aph(3')-Ia, aac(6')-Ib-cr, tet(A), tet(B), arr-3, blaTEM-1B, blaDHA-17, blaCARB-2, blaOXA-1, blaCTX-M-3, and fosA3.
Analysis of Salmonella enterica Isolated from a Mixed-Use Watershed in Georgia, USA: Antimicrobial Resistance, Serotype Diversity, and Genetic Relatedness to Human Isolates.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from a mixed-use watershed in Georgia, USA, including bla CMY-2, aadA2, strA, strB, sul1, sul2, tetA, tetC, floR, and dfrA12, which conferred resistance to various antibiotics such as ceftiofur, ceftriaxone, streptomycin, sulfisoxazole, tetracycline, chloramphenicol, and trimethoprim.
Prevalence, Characteristics, and Clonal Distribution of Escherichia coli Carrying Mobilized Colistin Resistance Gene mcr-1.1 in Swine Farms and Their Differences According to Swine Production Stages.
The study identified the mobilized colistin resistance gene mcr-1.1 in Escherichia coli isolates from swine farms, highlighting its prevalence and association with multidrug resistance.
Outbreak of Imported Seventh Pandemic Vibrio cholerae O1 El Tor, Algeria, 2018.
The 2018 cholera outbreak in Algeria involved Vibrio cholerae O1 El Tor isolates with resistance to streptomycin, sulfamethoxazole, trimethoprim, and sulfamethoxazole/trimethoprim, decreased susceptibility to ciprofloxacin, and intermediate resistance to chloramphenicol and nitrofurantoin. Mutations in gyrA (S83I), parC (S85L), nfsA (R169C), nfsB (Q5Stop), and vprA (D89N) were identified as contributing to the resistance profiles.
Antimicrobial Resistance in Acinetobacter spp. Isolated from Pet Reptiles
The study identified various AMR genes in Acinetobacter spp. isolated from pet reptiles, including tetracycline, sulfonamide, and aminoglycoside resistance genes, highlighting the presence of multidrug-resistant strains in these animals.
Antimicrobial Resistance and Virulence Characteristics of Klebsiella pneumoniae Isolates in Kenya by Whole-Genome Sequencing.
The study identified several AMR genes in K. pneumoniae isolates from Kenya, including blaCTX-M-15, blaTEM-181, blaOXA-181, blaNDM-1, mcr-8, armA, rmtF, aac(6')-Ib-cr, aph(3")-ib, aph(6)-id, dfrA, sul2, qnrB, tetA, and catII, which confer resistance to various antibiotics such as beta-lactams, carbapenems, aminoglycosides, fluoroquinolones, tetracyclines, and chloramphenicol.
Evaluating the potential of third generation metagenomic sequencing for the detection of BRD pathogens and genetic determinants of antimicrobial resistance in chronically ill feedlot cattle.
The study identified various antimicrobial resistance genes (ARGs) in metagenomic sequencing data from chronically ill feedlot cattle, including genes conferring resistance to beta-lactams, aminoglycosides, macrolides, phenicols, tetracyclines, and trimethoprim. Notably, tetH was the most frequently detected resistance gene, and several ARGs were found to be associated with integrative and conjugative elements (ICEs).
Characterization of metal(loid)s and antibiotic resistance in bacteria of human gut microbiota from chronic kidney disease subjects.
The study identified several antibiotic and metal(loid) resistance genes in gut microbiota from chronic kidney disease (CKD) subjects, including genes encoding beta-lactamases, quinolone resistance proteins, macrolide phosphotransferases, and efflux pumps. Additionally, genes conferring resistance to arsenicals and heavy metals were detected.
Occurrence of bla(NDM-1)-Positive Providencia spp. in a Pig Farm of China.
Four bla NDM-1-positive Providencia strains were identified in a pig farm in China, showing multidrug resistance and carrying additional resistance genes such as bla OXA-10, bla TEM-116, and others.
Genomic Analysis of Two MDR Isolates of Salmonella enterica Serovar Infantis from a Spanish Hospital Bearing the bla(CTX-M-65) Gene with or without fosA3 in pESI-like Plasmids.
The study reports two multidrug-resistant (MDR) isolates of Salmonella enterica serovar Infantis from Spain carrying the blaCTX-M-65 gene on pESI-like plasmids, along with other resistance genes such as floR, aac(3)-IVa, aph(3′)-Ia, aph(4)-Ia, aadA1, tet(A), sul1, dfrA14, and fosA3. Mutations in gyrA and parC were associated with fluoroquinolone resistance, while truncations in nsfA and nsfB were linked to nitrofurantoin resistance.
Genomic Analysis of a Highly Virulent NDM-1-Producing Escherichia coli ST162 Infecting a Pygmy Sperm Whale (Kogia breviceps) in South America.
The study identifies a multidrug-resistant NDM-1-producing E. coli ST162 strain isolated from a pygmy sperm whale, highlighting the presence of various AMR genes including blaNDM-1, blaTEM-1C, blaOXA-1, and others, as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Prediction of Antibiotic Susceptibility Profiles of Vibrio cholerae Isolates From Whole Genome Illumina and Nanopore Sequencing Data: CholerAegon.
The study presents CholerAegon, a bioinformatics pipeline for predicting antimicrobial resistance profiles from whole genome sequencing data of Vibrio cholerae. It identifies AMR genes such as dfrA1, sul2, catB9, and floR, and detects mutations like D476N in parE that contribute to fluoroquinolone resistance.
Characterization of NDM-5 Carbapenemase-Encoding Gene (bla (NDM-5)) - Positive Multidrug Resistant Commensal Escherichia coli from Diarrheal Patients.
The study characterizes the bla NDM-5 gene in multidrug-resistant commensal E. coli from diarrheal patients, highlighting its resistance to various antibiotics and its potential for horizontal transfer.
Genomic Investigation of Proteus mirabilis Isolates Recovered From Pig Farms in Zhejiang Province, China.
The study identified 91 antimicrobial resistance genes in 30 Proteus mirabilis isolates from pig farms in Zhejiang, China, including genes encoding resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, and fluoroquinolones.
Distribution of ESBL/AmpC-Escherichia coli on a Dairy Farm.
The study identified ESBL/AmpC-producing E. coli on a dairy farm, with a high prevalence in calves. Key resistance genes included blaCTX-M-1, blaCTX-M-15, floR, strA, strB, catA, aadA, dfrA, tetA, tetR, tetY, mph(A), and TEM-105.
Molecular characterization of extended spectrum cephalosporin resistant Escherichia coli isolated from livestock and in-contact humans in Southeast Nigeria.
The study identified four variants of bla CTX-M (CTX-M-15, CTX-M-55, CTX-M-64, and CTX-M-65) in extended-spectrum cephalosporin-resistant Escherichia coli from livestock and in-contact humans in Southeast Nigeria. Other AMR genes such as bla TEM-1b, aac 3-IId, qnr S1, and sul 2 were also characterized.
Serotype Diversity and Antimicrobial Resistance Profile of Salmonella enterica Isolates From Freshwater Turtles Sold for Human Consumption in Wet Markets in Hong Kong.
The study identifies the multidrug-resistance gene cfr for the first time in Salmonella, highlighting the expansion of the cfr reservoir and potential horizontal spread to other bacteria. It also detects various AMR genes such as floR, sul2, aph(3')-Ia, aph(3”)-Ib, aph(6)-Id, aac(6')-Ib-cr, bla CMY−2, bla TEM−1, qnrS1, erm(B), mph(E), msr(E), qepA8, arr-3, sul1, dfrA12, dfrA27, tet(A), tet(D), catB3, aadA16, aac(3)-IV, aph(4)-Ia, aadA2, and fosA7.
Emergence of plasmid-mediated tigecycline, β-lactam and florfenicol resistance genes tet(X), bla(OXA-347) and floR in Riemerella anatipestifer isolated in China.
The study identifies the plasmid pRCAD0416RA-1 carrying tet(X), bla(OXA-347), and floR genes in Riemerella anatipestifer, which confer resistance to tigecycline, β-lactams, florfenicol, and chloramphenicol.
Large-Scale Studies on Antimicrobial Resistance and Molecular Characterization of Escherichia coli from Food Animals in Developed Areas of Eastern China.
The study identified mcr-1, tet(X4), and blaNDM-5 genes in Escherichia coli from food animals in eastern China, highlighting their role in resistance to colistin, tigecycline, and meropenem, respectively. These genes were found to be transferable via plasmids, emphasizing the potential for spread of antimicrobial resistance.
Emergence of a Novel NDM-5-Producing Sequence Type 4523 Klebsiella pneumoniae Strain Causing Bloodstream Infection in China.
The study identifies a novel sequence type 4523 Klebsiella pneumoniae strain, ST4523, which is resistant to multiple antibiotics, including carbapenems, and carries the bla NDM-5 gene on a plasmid. The strain also possesses various other resistance genes on plasmids pSHX180-1 and pSHX180-NDM5.
Genomic surveillance of Salmonella spp. in the Philippines during 2013-2014.
The study characterized various AMR genes and mutations in Salmonella isolates from the Philippines, highlighting the presence of ESBL genes, plasmid-mediated quinolone resistance genes, and mutations in gyrA and parC associated with fluoroquinolone resistance.
Emergence, Dissemination and Antimicrobial Resistance of the Main Poultry-Associated Salmonella Serovars in Brazil.
The study characterizes antimicrobial resistance (AMR) genes and mutations in various Salmonella serovars associated with poultry in Brazil, emphasizing the emergence of multidrug-resistant (MDR) strains. Key findings include the identification of AMR genes such as blaCTX-M-2, blaTEM-1B, aac(3)-lla, aac(3)-lld, aadA1, aadA2, aph(6)-ld, dfrA1, floR, mrc-1, strA, strB, sul1, sul2, tet(A), tet(B), and others, which confer resistance to multiple antibiotics.
Tigecycline-resistant Escherichia coli ST761 carrying tet(X4) in a pig farm, China.
The study identifies tet(X4) as a major cause of tigecycline resistance in E. coli ST761 isolates from a pig farm in China. The gene is located on a hybrid plasmid and is part of a multidrug resistance region that includes other resistance genes such as blaTEM-1, tet(A), tet(M), floR, qnrS1, sul3, dfrA5, and mef(B).
A Trade-Off for Maintenance of Multidrug-Resistant IncHI2 Plasmids in Salmonella enterica Serovar Typhimurium through Adaptive Evolution.
The study identifies the stability of clinically relevant ARGs carried by evolved plasmids, showing that their stability depends on antibiotic treatment conditions. Key genes include mcr-1, bla CTX-M-14, oqxAB, floR, and fosA3, which were consistently detected in evolved clones and correlate with resistance phenotypes.
Genomic insight into the integrative conjugative elements from ICEHpa1 family.
The study identifies four novel ICEHpa1 variants (ICE Gpa1818, ICE Gpa1808, ICE Gpa1807, and ICE Gpa1815) carrying diverse resistance genes, including tetracycline, streptomycin, gentamicin, sulfamethoxazole/trimethoprim, florfenicol, and amoxicillin resistance genes.
Genomic characteristics of clinical multidrug-resistant Proteus isolates from a tertiary care hospital in southwest China.
The study identifies multiple AMR genes in clinical multidrug-resistant Proteus isolates, including bla CTX-M-65, bla OXA-1, bla KPC-2, bla NDM-1, and others, highlighting the genetic diversity of mobile genetic elements carrying resistance genes.
WGS-Based Lineage and Antimicrobial Resistance Pattern of Salmonella Typhimurium Isolated during 2000-2017 in Peru.
The study identifies 63 different AMR genes in 90 S. Typhimurium isolates from Peru, including beta-lactamases (blaTEM-181, blaSHV-12, blaSHV-134, blaCTX-M-15), quinolone resistance genes (qnrB5, qnrB19, qnrE2), tetracycline resistance genes (tetA, tetD, tetR), sulfonamide resistance genes (sul3), dihydrofolate reductase (dfrA1, dfrA12), florfenicol resistance gene (floR), lincomycin resistance gene (linG), aminoglycoside resistance genes (aph(3″)-Ib, aph(6)-Id, aadA2), colistin resistance gene (mcr-1), and fosfomycin resistance gene (fosA3).
Identification of a Novel IncHI1B Plasmid in MDR Klebsiella pneumoniae 200 from Swine in China.
The study identifies a novel IncHI1B plasmid, pYhe2001, in MDR Klebsiella pneumoniae 200 from swine, along with several resistance genes including blaCTX-M-27, aadA16, dfrA27, arr-6, aac(6')-Ib-cr, sul1, qnrB2, tetA, and floR. These genes contribute to resistance against multiple antibiotics.
Occurrence of Antimicrobial-Resistant Escherichia coli in Marine Mammals of the North and Baltic Seas: Sentinels for Human Health.
The study identified antimicrobial-resistant Escherichia coli in marine mammals from the North and Baltic Seas, highlighting the presence of resistance genes such as blaTEM, strA, strB, aadA1, sul1, sul2, tet(A), tet(B), tet(D), qnrS, floR, catA1, blaOXA-1-like, blaSHV, and blaCMY-2.
Comparative Genomic Analysis of Antimicrobial-Resistant Escherichia coli from South American Camelids in Central Germany.
The study identified various antimicrobial resistance genes in Escherichia coli isolates from South American camelids in Germany, highlighting the presence of multidrug-resistant strains and the importance of monitoring AMR in these animals.
Genomic Analysis of Carbapenem-Resistant Acinetobacter baumannii Strains Recovered from Chilean Hospitals Reveals Lineages Specific to South America and Multiple Routes for Acquisition of Antibiotic Resistance Genes.
The study identifies various AMR genes in carbapenem-resistant Acinetobacter baumannii strains from Chile, including blaTEM, aacC2, aphA6, sul1, sul2, catA1, tetA(A), aadA1, dfrA1, strAB, cmlB1, floR, oxa58, and oxa23, highlighting the diversity of resistance mechanisms and the role of mobile genetic elements in their dissemination.
Antimicrobial resistance of Salmonella Indiana from retail chickens in China and emergence of an mcr-1-harboring isolate with concurrent resistance to ciprofloxacin, cefotaxime, and colistin.
The study identified multiple AMR genes in Salmonella Indiana isolates, including bla CTX-M-65, bla CTX-M-14, bla CTX-M-27, bla CTX-M-28, bla CTX-M-79, aac(6')-Ib-cr, oqxAB, and mcr-1, which contribute to resistance against various antibiotics.
Resistance and virulence features of hypermucoviscous Klebsiella pneumoniae from bloodstream infections: Results of a nationwide Italian surveillance study.
The study identified various AMR genes in hypermucoviscous Klebsiella pneumoniae isolates, including bla KPC-3, bla KPC-2, CMY-16, CTX-M-15, bla SHV-2, bla DHA-1, bla CTX-M-65, qnr, aadA1, aac(6')-Ib, sul1, dfrA1, mph(A), erm(B), floR, and fosA3. These genes conferred resistance to multiple antibiotics, including carbapenems, cephalosporins, fluoroquinolones, aminoglycosides, sulfonamides, trimethoprim, macrolides, and fosfomycin.
Responses of microbial community and antibiotic resistance genes to co-existence of chloramphenicol and salinity.
The study identified the efflux pump genes floR, cmlA, and tetC as responsible for chloramphenicol resistance in microbial communities under the co-existence of chloramphenicol and salinity.
Characterization of a genomic Island carrying the tet(X4) gene in porcine Acinetobacter towneri co-harboring plasmid-borne bla (NDM-1) and bla (OXA-58) genes.
The study identifies the coexistence of tet(X4), bla(NDM-1), and bla(OXA-58) in a porcine Acinetobacter towneri isolate, highlighting the complex resistance mechanisms involving tigecycline and carbapenem resistance.
The resistomes of Mycobacteroides abscessus complex and their possible acquisition from horizontal gene transfer.
The study identifies numerous AMR genes in Mycobacteroides abscessus complex, highlighting the widespread presence of resistance to multiple antibiotic classes, including beta-lactams, aminoglycosides, glycopeptides, and others. Key findings include the detection of beta-lactamases like blaLAP-1 and blaTLA-2, 23S rRNA methyltransferases such as erm(33), erm(43), and erm(44), and various aminoglycoside modifying enzymes. Additionally, vancomycin resistance genes like vanA, vanB, and vanC were identified, along with efflux pump genes contributing to multidrug resistance.
Genome-associations of extended-spectrum ß-lactamase producing (ESBL) or AmpC producing E. coli in small and medium pig farms from Khon Kaen province, Thailand.
The study identifies various AMR genes in ESBL and/or AmpC-producing E. coli from small and medium pig farms in Thailand, highlighting the co-occurrence of resistance genes conferring resistance to critically important antimicrobials.
Emergence of a floR-carrying plasmid in extended spectrum β-lactamase (ESBL) producing Pasteurella aerogenes, isolated from an avian species in China.
The study identifies the first occurrence of the blaVEB gene in Pasteurellaceae and confirms its function as an ESBL. Additionally, a plasmid carrying the floR gene, which confers florfenicol resistance, was isolated from P. aerogenes.
Salmonella Derby from pig production chain over a 10-year period: antimicrobial resistance, biofilm formation, and genetic relatedness.
The study identified resistance genes blaTEM, aadA, tetA, and floR in Salmonella Derby isolates, which conferred resistance to ampicillin, streptomycin/spectinomycin, tetracycline, and florfenicol, respectively.
Multiplexed Target Enrichment Enables Efficient and In-Depth Analysis of Antimicrobial Resistome in Metagenomes.
The study developed a multiplex PCR-based amplicon sequencing method for efficient and in-depth analysis of the antimicrobial resistome in metagenomes, demonstrating improved recovery of low-abundance antibiotic resistance genes (ARGs) compared to traditional metagenomic shotgun sequencing.
The first outbreak of citrobacteriosis caused by Citrobacter gillenii in reared Russian sturgeon (Acipenser gueldenstaedtii) in Turkiye.
Citrobacter gillenii was identified as the causative agent of a fatal bacterial disease in Russian sturgeon. Resistance genes ampC, sul1, and floR were detected, conferring resistance to penicillin, trimethoprim/sulfamethoxazole, and florfenicol, respectively.
Florfenicol and oxazolidone resistance status in livestock farms revealed by short- and long-read metagenomic sequencing.
The study identified several florfenicol and oxazolidinone resistance genes, including floR, fexA, cfr, optrA, and poxtA, in livestock farms in China. These genes were found to be prevalent in fecal samples from pigs and chickens, highlighting the risk of their spread through mobile genetic elements.
Multistate reptile- and amphibian-associated salmonellosis outbreaks in humans, United States, 2009-2018.
The study identified various AMR genes and mutations in Salmonella isolates from multistate reptile- and amphibian-associated salmonellosis outbreaks in the United States, including bla CMY-2, qnrB19, qnrS1, bla TEM-116, bla TEM-1C, bla TEM-1B, aadA1, aadA2, aph(3")-Ib, aph(6)-Id, dfrA12, sul1, sul3, floR, tet(A), and sul2, which conferred resistance to multiple antibiotics such as ciprofloxacin, ceftriaxone, ampicillin, amoxicillin-clavulanic acid, trimethoprim-sulfamethoxazole, chloramphenicol, and tetracycline.
Whole-Genome Sequencing-Based Species Classification, Multilocus Sequence Typing, and Antimicrobial Resistance Mechanism Analysis of the Enterobacter cloacae Complex in Southern China.
The study identified 80 antibiotic resistance genes in 172 Enterobacter cloacae complex isolates, with a focus on beta-lactamases, aminoglycosides, and fluoroquinolones. Key genes included blaACT-2, blaACT-3, blaACT-6, blaACT-9, blaACT-12, blaTEM-1D, blaCTX-M-3, blaSHV-12, blaNDM-1, blaNDM-5, blaIMP-1, blaIMP-4, blaIMP-26, blaKPC-2, qnrS2, qnrE1, aac(6')-Ib, aac(6')-IIc, aph(3')-Ib, aph(6)-Id, aadA, sul2, dfrA12, tetA, ereA, floR, catA2, mcr-10, arr-6, and fosA3.
Detection and characterization of ESBL-producing Escherichia coli and additional co-existence with mcr genes from river water in northern Thailand.
The study identified ESBL-producing E. coli in river water in northern Thailand, with bla CTX-M-15, bla CTX-M-55, bla CTX-M-14, and bla CTX-M-27 being the most prevalent beta-lactamase genes. Additionally, mcr-1.1 and mcr-3.4 genes were found to confer resistance to colistin. Various other resistance genes were also characterized, including aac(3)-IId, aadA5, ant(3″)-Ia, aph(3″)-Ib, aph(6)-Id, aac(6′)-Ib-cr, qnrS1, mdf(A), erm(B), mph(A), floR, sul2, sul3, tet(A), tet(X), tet(M), dfrA12, dfrA14, dfrA17, cmlA1, catA2, lnu(F), and erm(42).
Antimicrobial resistance and genomic characterization of Salmonella enterica serovar Senftenberg isolates in production animals from the United States.
The study characterized antimicrobial resistance genes and mutations in Salmonella enterica serovar Senftenberg isolates from production animals in the United States, identifying genes such as aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, blaTEM-1B, blaCMY-2, blaSHV-12, floR, catA2, qnrB2, aac(6')-Ib-cr, aadA1, aadA2, sul1, sul2, tetA, and mcr-9.1, along with mutations in gyrA and parC genes contributing to resistance against various antibiotics.
The hazard of carbapenemase (OXA-181)-producing Escherichia coli spreading in pig and veal calf holdings in Italy in the genomics era: Risk of spill over and spill back between humans and animals.
The study identifies multiple AMR genes, including bla OXA-181, bla TEM-1B, aac (3)-IId, aad A2, cml A1, dfr A12, mef (B), sul 3, tet (A), tet (M), incX3, incX1, incFII, qnr S1, aph (3″)-Ib, aph (6)-Id, flo R, lnu (F), sul 2, sul 3, tet (B), mph (A), mph (G), qnr B4, rmt B, and fos A3, in OXA-181-producing E. coli isolates from pigs and bovines in Italy. These genes confer resistance to various antibiotics, including carbapenems, cephalosporins, penicillins, aminoglycosides, trimethoprim, macrolides, sulfonamides, tetracyclines, fluoroquinolones, and fosfomycin.
Coexistence of Multidrug Resistance and Virulence in a Single Conjugative Plasmid from a Hypervirulent Klebsiella pneumoniae Isolate of Sequence Type 25.
The study identifies a conjugative plasmid pCY814036-iucA carrying multidrug resistance genes and virulence factors, and another plasmid pCY814036-KPC2 harboring bla KPC-2 and rmtB, contributing to carbapenem resistance and hypervirulence in a Klebsiella pneumoniae isolate.
Molecular Characterization of Salmonella spp. Isolates from Wild Colombian Babilla (Caiman crocodilus fuscus) Isolated In Situ.
The study identified multiple antibiotic resistance genes in Salmonella isolates from wild Colombian babilla, including blaTEM, strB, sul1, blaCMY2, blaCTX-M, sul2, dfrA1, floR, and qnrD, indicating the potential of these reptiles as carriers of multidrug-resistant bacteria.
Molecular Epidemiology of Antimicrobial Resistance and Virulence Profiles of Escherichia coli, Salmonella spp., and Vibrio spp. Isolated from Coastal Seawater for Aquaculture.
The study identified several AMR genes, including blaTEM, tetA, qnrS, strA, and floR, in Escherichia coli, Salmonella spp., and Vibrio spp. isolates from coastal seawater in Thailand. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, streptomycin, and chloramphenicol.
In Vitro Assessment of Antimicrobial Activity of Phytobiotics Composition towards of Avian Pathogenic Escherichia coli (APEC) and Other E. coli Strains Isolated from Broiler Chickens.
The study identifies several AMR genes in E. coli strains, including aadA, strA/strB, aphA1, aphA2, tetA, tetB, sul1, sul2, sul3, dfrA1, dfrA10, dfrA12, floR, and blaSHV, which confer resistance to various antibiotics such as streptomycin, neomycin, tetracycline, sulfonamides, trimethoprim, chloramphenicol, and cephalosporins.
Antibiotic resistance of Riemerella anatipestifer and comparative analysis of antibiotic-resistance gene detection methods.
The study identified several antibiotic resistance genes in Riemerella anatipestifer, including OXA-209, erm(F), floR, aadS, tet(X), tet(X4), RanA, RanB, and ErmF, which confer resistance to various antibiotics such as beta-lactams, macrolides, fluoroquinolones, aminoglycosides, and tetracyclines.
Genomic Characterization of ESBL/AmpC-Producing Escherichia coli in Stray Dogs Sheltered in Yangzhou, China.
The study identified several beta-lactamase genes, including bla CTX-M-15, bla CTX-M-55, and others, along with additional resistance genes such as tet(A), qnrS1, and oqxAB, contributing to multidrug resistance in ESBL/AmpC-producing E. coli isolated from stray dogs in Yangzhou, China.
Molecular and Clinical Characteristics of Carbapenem-Resistant Klebsiella pneumoniae Isolates at a Tertiary Hospital in Wuhan, China.
The study identified multiple carbapenem-resistant Klebsiella pneumoniae (CRKP) isolates carrying various resistance genes, including blaKPC-1, blaCTX-M-65, blaTEM-1, blaSHV-182, rmtB, aadA2, APH(3')-Ia, sul1, sul2, QnrS1, mphA, FosA6, floR, and tet(A). These genes confer resistance to carbapenems, beta-lactams, aminoglycosides, sulfonamides, fluoroquinolones, macrolides, fosfomycin, chloramphenicol, and tetracyclines.
A Cross-Validated Feature Selection (CVFS) approach for extracting the most parsimonious feature sets and discovering potential antimicrobial resistance (AMR) biomarkers.
The study presents a Cross-Validated Feature Selection (CVFS) approach for identifying the most parsimonious gene sets for predicting antimicrobial resistance (AMR) from bacterial pan-genomes. The CVFS approach was able to extract both known and novel AMR genes, demonstrating its effectiveness in selecting relevant features for AMR prediction.
Hospital-acquired and zoonotic bacteria from a veterinary hospital and their associated antimicrobial-susceptibility profiles: A systematic review.
The study identified several antimicrobial resistance genes, including mecA, blaCMY-2, vanA, and flo, associated with hospital-acquired and zoonotic bacteria in veterinary settings.
Molluscs-A ticking microbial bomb.
The paper discusses the presence of antibiotic resistance genes (ARGs) in bivalve molluscs, highlighting the spread of resistance to various antibiotics such as colistin, beta-lactams, fluoroquinolones, and tetracyclines. It emphasizes the role of bivalve aquacultures in the dissemination of ARGs and the potential risks to human health through the food chain.
Combining analytical epidemiology and genomic surveillance to identify risk factors associated with the spread of antimicrobial resistance in Salmonella enterica subsp. enterica serovar Heidelberg.
The study identified multiple AMR genes in Salmonella enterica subsp. enterica serovar Heidelberg, including bla CMY-2, bla TEM-1A, bla TEM-1B, bla TEM-214, mcr -9, and others, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, and other antimicrobial agents.
Characterization of small plasmids carrying florfenicol resistance gene floR in Actinobacillus pleuropneumoniae and Pasteurella multocida isolates from swine in China.
The study identified the florfenicol resistance gene floR in Actinobacillus pleuropneumoniae and Pasteurella multocida isolates from swine in China, along with three plasmids (pFA11, pMAF5, and pMAF6) carrying the gene.
Metagenomic analysis reveals patterns and hosts of antibiotic resistance in different pig farms.
The study identified various antibiotic resistance genes (ARGs) in pig manure samples from different regions of Shanxi, China, highlighting the prevalence of tetracycline, aminoglycoside, macrolide, and phenicol resistance genes. Key ARGs included tet(W), tet(40), tet(Q), erm(B), erm(F), mef(A), aph(3')-III, ant(6)-Ia, cfr(C), floR, blaACI-1, optrA, cat, cfxA4, cfxA5, blaCTX-M-105, blaCTX-M-65, fexB, erm(T), mdf(A), and ole(B).
Genetic Organization of Acquired Antimicrobial Resistance Genes and Detection of Resistance-Mediating Mutations in a Gallibacterium anatis Isolate from a Calf Suffering from a Respiratory Tract Infection.
The study identified multiple acquired antimicrobial resistance genes and resistance-mediating mutations in a Gallibacterium anatis isolate from a calf with a respiratory tract infection, highlighting the potential for this bacterium to serve as a reservoir for antimicrobial resistance genes.
Characterization of Extensively Drug-Resistant Salmonella enterica Serovar Kentucky Sequence Type 198 Isolates from Chicken Meat Products in Xuancheng, China.
Extensively drug-resistant Salmonella enterica serovar Kentucky ST198 isolates from chicken meat products in Xuancheng, China, were characterized. These isolates carried multiple resistance genes, including bla CTX-M-55, bla TEM-1B, aac(3)-IId, aadA17, rmtB, tet(A), floR, lnu(F), arr-2, qnrS1, sul1, mph(A), and fosA3, and mutations in gyrA (S83F, D87N) and parC (S80I), leading to resistance against several antimicrobial agents.
Emergence of colistin resistance and characterization of antimicrobial resistance and virulence factors of Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia cage culture.
The study identified several AMR genes in Aeromonas hydrophila, Salmonella spp., and Vibrio cholerae isolated from hybrid red tilapia. Notably, mcr-3 was found in A. hydrophila, and qnrS, tetA, blaTEM, and floR were prevalent in Salmonella spp. No colistin resistance genes were detected in V. cholerae.
Antimicrobial resistance profiles of Campylobacter jejuni and Salmonella spp. isolated from enteritis patients in Japan.
The study identified several AMR genes including blaCMY-2, aac(6')-Iaa, ant(3")-Ib, aph(6)-Id, floR, qnrB19, sul2, and tet(A) in cefotaxime-resistant Salmonella isolates. Additionally, mutations in the gyrA gene, specifically Thr86Ile, were found in ciprofloxacin-resistant C. jejuni isolates.
Epidemiological characteristics, virulence potential, antimicrobial resistance profiles, and phylogenetic analysis of Aeromonas caviae isolated from extra-intestinal infections.
The study identified multiple antimicrobial resistance genes in Aeromonas caviae isolates from extra-intestinal infections, including blaMOX, blaPER-3, blaOXA, blaNDM, blaCphA, qnrS2, qnrVC, aac(6')-Ib-cr, tet(A), tet(E), tet(31), dfrA1, dfrA12, dfrA14, dfrA15b, floR, catB3, catII, and catI, which confer resistance to various antibiotics such as cephalosporins, carbapenems, fluoroquinolones, tetracyclines, trimethoprim, and chloramphenicol.
Association of ISVsa3 with Multidrug Resistance in Salmonella enterica Isolates from Cattle (Bos taurus).
The study found that multidrug resistance (MDR) in Salmonella enterica isolates from cattle is strongly associated with the presence of IS Vsa3, an IS91-like transposase. The MDR genes, including floR, tet(A), aph(6)-Id, aph(3"-Ib, sul2, and bla CMY-2, were often located on IncC plasmids carrying IS Vsa3.
Prevalence and Characterization of Salmonella Isolated from Chickens in Anhui, China.
The study identified several AMR genes in Salmonella isolates from chickens in Anhui, China, including blaTEM, blaCMY-2, aadA, strA, aph(3')-IIa, aac(6')-Ib-cr, qnrB, qnrS, sul1, sul2, tetA, tetB, cat1, and floR. These genes were associated with resistance to various antibiotics such as ampicillin, cephalosporins, streptomycin, gentamicin, amikacin, fluoroquinolones, sulfamethoxazole, tetracycline, chloramphenicol, and florfenicol.
Mobile genetic elements drive the multidrug resistance and spread of Salmonella serotypes along a poultry meat production line.
The study identifies multiple antimicrobial resistance genes in Salmonella isolates from a poultry production line, highlighting the role of mobile genetic elements in the spread of multidrug resistance.
The temporal dynamics of antimicrobial-resistant Salmonella enterica and predominant serovars in China.
The study identifies multiple antimicrobial resistance genes in Salmonella enterica isolates from China, highlighting the increasing prevalence of resistance to beta-lactams, quinolones, tetracyclines, and sulfonamides. Key genes include blaTEM-1B, blaCTX-M-14, aac(3)-IV, and mcr-1.
Prevalence and Genomic Characteristics of mcr-Positive Escherichia coli Strains Isolated from Humans, Pigs, and Foods in China.
The study identified mcr-1 as a major gene conferring colistin resistance in Escherichia coli isolates from humans, pigs, and foods in China. Additionally, several other resistance genes such as tet(A), floR, sul2, aadA1, strA, strB, blaCTX-M-14, fosA, lnu(F), and arr-3 were found to confer resistance to various antibiotics.
Dissemination of Pseudomonas aeruginosa bla(NDM-1)-Positive ST308 Clone in Singapore.
The study identifies multiple antibiotic resistance genes (ARGs) in bla NDM-1 -positive P. aeruginosa ST308 isolates, including aac(3)-Id, aac(6′)-Il, aph(3′)-Iib, bla OXA-488, bla NDM-1, bla PDC-19a, catB7, crpP, fosA, msr(E), qnrVC1, sul2, dfrB5, floR, aadA6, aadA11, and aph(3″)-Ib. These genes confer resistance to various antibiotics such as aminoglycosides, beta-lactams, carbapenems, cephalosporins, chloramphenicol, fluoroquinolones, fosfomycin, macrolides, quinolones, sulfonamides, trimethoprim, and streptomycin.
Antimicrobial resistance and genomic characterization of Salmonella enterica isolates from chicken meat.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from chicken meat, including aminoglycoside, beta-lactam, quinolone, tetracycline, sulfonamide, and phenicol resistance genes. These genes were detected using whole genome sequencing and correlated with phenotypic resistance profiles.
Brevundimonas brasiliensis sp. nov.: a New Multidrug-Resistant Species Isolated from a Patient in Brazil.
The study characterizes Brevundimonas brasiliensis sp. nov., a novel species isolated from a neonatal intensive care unit, and identifies several antimicrobial resistance genes and mutations associated with resistance to β-lactams, aminoglycosides, fluoroquinolones, and colistin.
Antibiotic-Resistant Vibrio cholerae O1 and Its SXT Elements Associated with Two Cholera Epidemics in Kenya in 2007 to 2010 and 2015 to 2016.
The study identified antibiotic resistance genes dfrA1, sul2, strA, strB, and floR in Vibrio cholerae O1 strains from two cholera epidemics in Kenya. Chromosomal mutations in gyrA (Ser83Ile) and parC (Ser85Leu) were associated with nalidixic acid resistance.
Virotyping and genetic antimicrobial susceptibility testing of porcine ETEC/STEC strains and associated plasmid types.
The study identified several AMR genes and mutations in porcine ETEC/STEC strains, including beta-lactamases (blaTEM-1A, blaTEM-1B, blaTEM-106), polymyxin resistance genes (mcr-1.1, mcr-2.1, mcr-5.1), aminoglycoside resistance genes (aac(3)-IId, aac(3)-IV, aac(3)-IVa, aph(3')-Ia, aadA1, aadA10, aadA12), florfenicol resistance gene (floR), tetracycline resistance genes (tet(A), tet(B)), quinolone resistance gene (qnrS1), and trimethoprim-sulfamethoxazole resistance genes (dfrA1, dfrA5, dfrA12, dfrA14, dfrA36).
Epidemiological investigation and drug resistance characteristics of Riemerella anatipestifer strains from large-scale duck farms in Shandong Province, China from March 2020 to March 2022.
The study identified multiple drug resistance genes in R. anatipestifer strains, including high prevalence of tetracycline resistance gene tet X (95.9%), macrolide resistance gene ermF (77%), and others. The strains exhibited multidrug resistance, with the highest resistance to gentamicin (77%) and enrofloxacin (73%).
Antimicrobial resistance and virulence genes of invasive Salmonella enterica from children with bacteremia in north-central Nigeria.
The study identified multiple antimicrobial resistance genes in invasive Salmonella enterica isolates from children with bacteremia in north-central Nigeria, including bla TEM, flo R, qnr A, tet A, tet B, and tet G. These genes conferred resistance to various antibiotics such as ampicillin, trimethoprim-sulfamethoxazole, chloramphenicol, tetracycline, and ciprofloxacin.
Multidrug-resistant non-typhoidal Salmonella of public health significance recovered from migratory birds in Bangladesh.
The study identified multidrug-resistant non-typhoidal Salmonella in migratory birds in Bangladesh, highlighting the presence of various AMR genes such as blaCARB-2, floR, sul1, tet(G), dfrA1, and mutations in gyrA and parC associated with quinolone resistance.
Molecular epidemiology and characterization of antimicrobial-resistant Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China.
The study identified several antimicrobial resistance genes in Staphylococcus haemolyticus strains isolated from dairy cattle milk in Northwest, China, including mphC, ermB, floR, aadD, sul1, and gyrA, which confer resistance to erythromycin, florfenicol, gentamicin, trimethoprim-sulfamethoxazole, and ciprofloxacin.
Prevalence of Salmonella Typhimurium and Salmonella Enteritidis isolated from poultry meat: virulence and antimicrobial-resistant genes.
The study identified several antimicrobial resistance genes in Salmonella typhimurium isolates from poultry meat, including tetA, tetB, tetC, tetG, sul1, sul2, floR, cat2, and cmlA, which confer resistance to tetracycline, sulfonamides, and chloramphenicol.
Whole-genome sequencing and phylogenetic analysis capture the emergence of a multi-drug resistant Salmonella enterica serovar Infantis clone from diagnostic animal samples in the United States.
The study identifies a multidrug-resistant Salmonella infantis clone harboring a pESI-like megaplasmid with the blaCTX-M-65 gene, which confers resistance to ceftriaxone and ampicillin. Several other AMR genes, including aac(3)-IVa, aadA1, aph(4)-Ia, sul1, tetA, floR, dfrA14, and fosA, were also characterized.
Antimicrobial resistance in bacteria isolated from peridomestic Rattus species: A scoping literature review.
This scoping review identifies various antimicrobial resistance (AMR) genes in bacteria isolated from peridomestic Rattus species, including beta-lactamases (bla TEM, bla CTX-M, bla SHV, bla VIM, bla IMP, bla NDM-1), aminoglycoside resistance genes (strA, strB, aadA, aphA), sulfonamide resistance genes (sul1, sul2, sul3), tetracycline resistance genes (tetA, tetB, tet34), trimethoprim resistance genes (dfrA1, dfrA17, dfr14), quinolone resistance genes (qnrB1), and others.
Genomic Characterization of Fecal Escherichia coli Isolates with Reduced Susceptibility to Beta-Lactam Antimicrobials from Wild Hogs and Coyotes.
The study identified beta-lactamase genes (blaCMY-2, blaCTX-M-55, blaCTX-M-27), tetracycline resistance genes (tetA, tetB, tetC), aminoglycoside resistance genes (aac(3)-IId, aadA5, ant(3")-Ia, aph(3')-Ia, aph(3")-lb, aph(6)-ld), sulfonamide resistance genes (sul1, sul2, sul3), amphenicol resistance gene (floR), trimethoprim resistance genes (dfrA1, dfrA17), and MLS resistance genes (Inu(F), erm(B), mph(A)) in E. coli isolates from coyotes and wild hogs. Additionally, chromosomal mutations in ampC, gyrA, parC, and parE were found to confer resistance to beta-lactam and quinolone antibiotics.
The emergence of multi-drug resistant and virulence gene carrying Escherichia coli strains in the dairy environment: a rising threat to the environment, animal, and public health.
The study identified multidrug-resistant Escherichia coli strains carrying various antibiotic resistance genes (ARGs) and virulence-associated genes (VAGs) in the dairy environment, highlighting the potential threat to human, animal, and environmental health.
Extended-spectrum β-lactamase-producing E. coli from retail meat and workers: genetic diversity, virulotyping, pathotyping and the antimicrobial effect of silver nanoparticles.
The study identified multiple AMR genes in ESBL-producing E. coli from retail meat and workers, including bla IMP, bla TEM, bla CTX-M-1, bla VIM, bla NDM, tetA (A), tetA (B), sul, flo R, and mcr-1. These genes conferred resistance to various antibiotics such as β-lactams, tetracycline, sulfonamides, fluoroquinolones, and colistin.
Genomic and functional portrait of multidrug-resistant, hydrogen sulfide (H(2)S)-producing variants of Escherichia coli.
The study identified multidrug-resistant, hydrogen sulfide-producing variants of Escherichia coli from Bangladesh, highlighting the presence of various AMR genes such as bla TEM1B, bla CTX-M-55, bla CTX-M-65, bla CTX-M-123, aadA1, aadA2, aph (3')-Ia, aph (3'')-Ib, aph (6)-Id, tet(A), tet(M), sul3, sul2, dfrA12, mph(A), floR, cmlA1, qacL, and qnrS1.
High rate of multidrug resistance and integrons in Escherichia coli isolates from diseased ducks in select regions of China.
The study identified a high rate of multidrug resistance in E. coli isolates from diseased ducks in China, with several AMR genes such as bla TEM, bla CTX-M, qnrS, aadA1, sul1, sul2, tet A, floR, mcr-1, intI1, and intI2 being characterized.
Genomic traits of multidrug resistant enterotoxigenic Escherichia coli isolates from diarrheic pigs.
The study identified 53 resistance genes and 13 categories of 195 virulence factors in multidrug-resistant ETEC isolates from diarrheic pigs, including tet(A), floR, aph(3')-Ia, aadA2, bleO, sul3, dfrA12, QnrS1, and tet(X4).
Poultry production as the main reservoir of ciprofloxacin- and tigecycline-resistant extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198.2-2 causing human infections in China.
The study identifies several AMR genes and mutations in Salmonella enterica serovar Kentucky ST198.2-2, including blaCTX-M-14b, blaCTX-M-55, blaTEM-1B, aadA7, aph(3')-Ia, aac(3)-IId, rmtB, tet(A), sul1, dfrA14, floR, lnu(F), mph(A), arr-2, and fosA3, which confer resistance to various antibiotics. Mutations in gyrA and parC also contribute to fluoroquinolone resistance.
Isolation and characterization of multidrug resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens.
The study identified 25 different antimicrobial resistance genes in multidrug-resistant Gallibacterium anatis biovar haemolytica strains from Polish geese and hens, including tetB, blaTEM-1, blaROB-1, floR, sul2, sul3, dfrK, aadA1, aadA2, aph(3)-la, aph(3)-lb, aph(6)-ld, sat2, dfrA14, dfrA32, merC, merP, merR, merT, qacL, and cmlA1.
Prevalence and molecular characterization of cefotaxime-resistant Salmonella strains recovered from retail meat samples in Shenzhen, China, during 2014-2017.
The study identified several beta-lactamase genes, including bla CTX-M-14, bla CTX-M-55, bla CTX-M-65, bla CTX-M-130, bla CTX-M-27, and bla CMY-2, as well as other resistance genes such as qnrS1, qnrB6, mph(A), oqxAB, mcr-1.1, tet(A), tet(B), sul1, sul2, sul3, aac(6')-Ib, aph(3")-Ib, floR, drfA14, drfA1, and Inu(F), which contribute to cefotaxime resistance in Salmonella strains isolated from retail meat samples in Shenzhen, China.
Multidrug-Resistant and Extensively Drug-Resistant Acinetobacter baumannii Causing Nosocomial Meningitis in the Neurological Intensive Care Unit.
The study identified various AMR genes in 37 A. baumannii strains causing nosocomial meningitis, including beta-lactamases, aminoglycoside modifying enzymes, tetracycline resistance genes, macrolide resistance genes, phenicol resistance genes, sulfonamide resistance genes, rifamycin resistance genes, and antiseptic resistance genes.
Whole Genome Sequencing and Pan-Genomic Analysis of Multidrug-Resistant Vibrio cholerae VC01 Isolated from a Clinical Sample.
The study identified multiple AMR genes in the multidrug-resistant V. cholerae VC01 strain, including catB9, floR, tet(34), sul2, and dfrA1, which confer resistance to chloramphenicol, florfenicol, oxytetracycline, sulfonamide, and trimethoprim, respectively.
Antimicrobial resistance and molecular typing of Staphylococcus aureus isolates from raw milk in Hunan Province.
The study identified multiple antimicrobial resistance genes in Staphylococcus aureus isolates from raw milk in Hunan Province, including femB, ermB, aacA-aphD, tetM, flor, and mecA, which conferred resistance to various antibiotics such as penicillin, erythromycin, gentamicin, doxycycline, florfenicol, and others.
Co-integrate Col3m bla (NDM-1)-harboring plasmids in clinical Providencia rettgeri isolates from Argentina.
The study characterizes bla NDM-1-harboring plasmids in clinical Providencia rettgeri isolates from Argentina, highlighting the presence of various resistance genes such as bla NDM-1, aac(6')-Ib-cr5, aph(3')-Ia, aph(3')-VI, bla PER-2, qnr D1, sul1, sul2, arr3, catB3, floR, mph(E), msr(E), and tet(A).
Phenotypic and genotypic antimicrobial resistance correlation and plasmid characterization in Salmonella spp. isolates from Italy reveal high heterogeneity among serovars.
The study identified several antimicrobial resistance genes including blaTEM-1B, sul1, sul2, tetA, tetB, and others in Salmonella isolates from Italy, highlighting the diversity of resistance mechanisms among different serovars.
The origin and evolution of IncF33 plasmids based on large-scale data sets.
The study identifies several clinically important antibiotic resistance genes carried by IncF33 plasmids, including bla CTX-M-55, bla CTX-M-65, fosA3, rmtB, aph(3'')-Ib, aph(6)-Id, aph(3')-IIa, floR, oqxAB, tet(A), and sul2. These genes contribute to multidrug resistance in Enterobacterales, particularly in Escherichia coli, Salmonella, and Klebsiella pneumoniae.
First Detection and Molecular Characterization of Pseudomonas aeruginosa bla(NDM-1) ST308 in Greece.
The study reports the first detection of blaNDM-1-positive Pseudomonas aeruginosa ST308 in Greece, highlighting the presence of multiple resistance genes including blaNDM-1, blaPAO, blaOXA-10, blaOXA-488, and others, indicating multidrug resistance.
Prioritization of Critical Factors for Surveillance of the Dissemination of Antibiotic Resistance in Pseudomonas aeruginosa: A Systematic Review.
The study identifies 25 critical mobile antibiotic resistance genes (ARGs) in Pseudomonas aeruginosa, including genes such as sul1, qacEΔ1, aac(6′)-Ib, bla VIM-1, and others, which are associated with various antibiotic classes and are linked to mobile genetic elements (MGEs).
Characterization of Salmonella enterica serovar Isangi from South Africa, 2020-2021.
The study identified multiple AMR genes in Salmonella Isangi isolates, including ESBL genes like bla CTX-M-15, bla CTX-M-22, bla CTX-M-3, and others, as well as plasmid-mediated AmpC genes like bla DHA-1 and bla NDM-1. Resistance to multiple antibiotics was observed, highlighting the need for continued monitoring of AMR in this serovar.
Genomic Diversity, Antimicrobial Resistance, Plasmidome, and Virulence Profiles of Salmonella Isolated from Small Specialty Crop Farms Revealed by Whole-Genome Sequencing.
Genomic characterization of tigecycline-resistant Escherichia coli and Klebsiella pneumoniae isolates from hospital sewage.
The study identifies tet(X4) and tmexCD1-toprJ1 as key genes contributing to tigecycline resistance in E. coli and K. pneumoniae isolates from hospital sewage, highlighting the role of plasmid-mediated resistance and efflux pump overexpression.
Molecular epidemiology and pathogenomics of extended-spectrum beta-lactamase producing- Escherichia coli and - Klebsiella pneumoniae isolates from bulk tank milk in Tennessee, USA.
The study identified multiple AMR genes and mutations in ESBL-producing E. coli and K. pneumoniae isolates from bulk tank milk, highlighting the presence of multidrug-resistant strains with resistance to beta-lactams, fluoroquinolones, aminoglycosides, and tetracyclines.
Genetic characterization of a multidrug-resistant Salmonella enterica serovar Agona isolated from a dietary supplement in Germany.
The study identifies 23 antibiotic resistance genes (ARGs) in a multidrug-resistant Salmonella enterica serovar Agona isolate from a dietary supplement in Germany, conferring resistance to 12 different antibiotic classes. Key genes include blaSHV-12, aac(3)-Iig, aac(6')-Iic, aadA2, aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, dfrA19, qacEΔ1, ere(A), sul1, sul2, tet(D), mcr-9.1, catA2, arr, qnrS1, blaTEM-1, aac(3)-IIe, and floR.
Tulathromycin metaphylaxis increases nasopharyngeal isolation of multidrug resistant Mannheimia haemolytica in stocker heifers.
The study found that tulathromycin metaphylaxis increased the isolation of multidrug-resistant (MDR) Mannheimia haemolytica (MH) in stocker heifers. MDR MH isolates were associated with integrative conjugative elements (ICE) carrying antimicrobial resistance genes.
Antimicrobial resistance and genomic characteristics of Salmonella from broilers in Shandong Province.
The study identified multiple antimicrobial resistance genes in Salmonella isolates from broilers in Shandong Province, including tet(A), floR, cmlE, blaTEM, aph(4)-Ia, qnrS1, and mcr-1, highlighting the prevalence of multidrug-resistant strains.
Genomic characterization of Salmonella isolated from retail chicken and humans with diarrhea in Qingdao, China.
The study identified 79 antimicrobial resistance genes (ARGs) in Salmonella isolates from retail chicken and humans with diarrhea in Qingdao, China, including aac(6')-Iaa, bla TEM-1B, tet(A), aph(6)-Id, aph(3")-Ib, sul2, floR, qnrS1, bla NDM-1, mcr-1.1, and mcr-9.1. These genes conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, tetracyclines, sulfonamides, chloramphenicol, fluoroquinolones, carbapenems, and colistin.
Characteristics of antimicrobial resistance in Escherichia coli isolated from retail meat products in North Carolina.
The study identified several AMR genes in E. coli isolates from retail meat products in North Carolina, including aac(3)-IV, aadA1, aph(3'')-lb, blaTEM-1, tetB, and others, highlighting the prevalence of multidrug-resistant E. coli in ground turkey.
Convergence of resistance and evolutionary responses in Escherichia coli and Salmonella enterica co-inhabiting chicken farms in China.
The study identifies several clinically relevant AMR genes, including bla CTX-M, APH(3), floR, mphA, and qnrS1, which are associated with resistance to various antibiotics in E. coli and S. enterica isolates from chicken farms in China.
Emergence of multidrug resistant, ctx negative seventh pandemic Vibrio cholerae O1 El Tor sequence type (ST) 69 in coastal water of Kerala, India.
The study identifies multidrug-resistant Vibrio cholerae O1 El Tor sequence type 69 in coastal waters of Kerala, India, which lacks the ctx gene but contains several antimicrobial resistance genes including sul2, dfrA1, strA, strB, parC, parE, catB9, and floR.
Genomic insights into ESBL-producing Escherichia coli isolated from non-human primates in the Peruvian Amazon.
The study identified three bla CTX-M variants (bla CTX-M-15, bla CTX-M-55, and bla CTX-M-65) and a broad resistome in ESBL-producing E. coli strains isolated from non-human primates in the Peruvian Amazon.
Phenotypic and genetic characterization of antimicrobial resistance in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain from 2006 to 2021.
The study identified various antimicrobial resistance genes and mutations in Salmonella enterica serovar Choleraesuis isolates from humans and animals in Spain, highlighting the presence of multidrug-resistant strains and the role of plasmids in the dissemination of resistance mechanisms.
Impact of florfenicol dosing regimen on the phenotypic and genotypic resistance of enteric bacteria in steers.
The study identified the presence of florfenicol resistance genes floR and fexA in enteric bacteria, which conferred resistance to phenicols. These genes were detected through metagenomic sequencing.
Isolation, Identification, Antimicrobial Resistance, Genotyping, and Whole-Genome Sequencing Analysis of Salmonella Enteritidis Isolated from a Food-Poisoning Incident.
The study identified multiple antimicrobial resistance genes in Salmonella Enteritidis strain 21A, including aac(6')-Iaa, blaTEM-1, qnrB, floR, tetA, sul1, and sul2, which conferred resistance to various antibiotics such as aminoglycosides, beta-lactams, quinolones, tetracyclines, and sulfonamides.
Whole-genome sequencing-based antimicrobial resistance and shedding dynamics of Escherichia coli isolated from calves before and after antimicrobial group treatments.
The study identified several AMR genes and mutations in E. coli isolates from calves, including tetracycline resistance genes (Tet(A), Tet(B), Tet(C), Tet(M)), β-lactamases (TEM-1, TEM-35, OXA-1), florfenicol resistance gene FloR, and macrolide phosphotransferase Mph(B). Mutations in GyrA (D87N, D87Y, S83L) and ParC (S80I) were also associated with quinolone resistance.
Occurrence and molecular characteristics of antimicrobial resistance, virulence factors, and extended-spectrum β-lactamase (ESBL) producing Salmonella enterica and Escherichia coli isolated from the retail produce commodities in Bangkok, Thailand.
The study identified several AMR genes and mutations in Salmonella enterica and Escherichia coli isolated from retail produce in Bangkok, Thailand. Key findings include the presence of bla TEM, qnrS, tetA, tetB, strA, and strB genes, as well as gyrA and parC mutations associated with ciprofloxacin resistance.
Aminoglycoside resistance genes in early members of the Acinetobacter baumannii ST78A (SMAL, Italian clone) reside in an IS26-bounded island in the chromosome.
The study identifies three aminoglycoside resistance genes (aadB, aphA1, and aac(6')-Ian) in the early ST78A isolate SMAL2002, along with sul2 and floR, located in an IS26-bounded chromosomal resistance island.
Multilocus sequence typing and antibiotic resistance of Aeromonas isolated from freshwater fish in Hebei Province.
The study identified several AMR genes in Aeromonas isolates from freshwater fish in Hebei Province, including TEM, tetA, floR, sul2, Ant(3")-I, and qacEΔ1, which confer resistance to various antibiotics such as penicillin, tetracycline, chloramphenicol, sulfonamide, aminoglycoside, and quinolone.
Unseen Weapons: Bacterial Extracellular Vesicles and the Spread of Antibiotic Resistance in Aquatic Environments.
The paper discusses the role of bacterial extracellular vesicles (BEVs) in the spread of antibiotic resistance in aquatic environments, highlighting specific genes such as blaCTX-M, tetA, floR, and sul/I that confer resistance to beta-lactam, tetracycline, florfenicol, and sulfonamide antibiotics, respectively.
Antibiotic susceptibility and resistance genes profiles of Vagococcus salmoninarum in a rainbow trout (Oncorhyncus mykiss, Walbaum) farm.
The study identified several antibiotic resistance genes in Vagococcus salmoninarum isolates from a rainbow trout farm, including tetA, sul1, sul2, sul3, dhfr1, ereB, and floR, which confer resistance to tetracycline, sulfonamides, trimethoprim/sulfamethoxazole, erythromycin, lincomycin, pristinamycin, tylosin, and florfenicol.
Genomic analysis of Salmonella isolated from canal water in Bangkok, Thailand.
The study identified 35 AMR genes and 30 chromosomal-mediated gene mutations in Salmonella strains from Bangkok canal water, highlighting the presence of multidrug-resistant strains with resistance to various antimicrobial classes.
Comparison of genotypic and phenotypic antimicrobial resistance profiles of Salmonella enterica isolates from poultry diagnostic specimens.
The study identified 31 AMR genes in 97 Salmonella enterica isolates from poultry, including aac(3)-IId, aac(3)-IVa, aac(3)-VIa, aac(6′)-Ib4, ant(2′′)-Ia, grdA, aph(3′)-Ia, aph(3′)-IIa, aadA1, aadA2, aadA7, aadA13, aph(3′)-Ib, aph(6)-Ic, aph(6)-Id, aph(4)-Ia, blaCMY-2, blaCTX-M-1, blaHER-3, blaTEM-1, floR, tetA, tetB, tetC, dfrA12, sul1, sul2, fosA7, qnrB19, ble, and mcr-9.
Global transmission of extended-spectrum cephalosporin resistance in Escherichia coli driven by epidemic plasmids.
The study identifies several epidemic plasmid subtypes carrying extended-spectrum cephalosporin resistance (ESC-R) genes, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, and bla CMY-2, which are responsible for the global dissemination of ESC-R in Escherichia coli.
Persistent Colonization of Ciprofloxacin-Resistant and Extended-Spectrum β-Lactamase (ESBL)-Producing Salmonella enterica Serovar Kentucky ST198 in a Patient with Inflammatory Bowel Disease.
The study characterizes three ciprofloxacin-resistant and extended-spectrum β-lactamase (ESBL)-producing Salmonella enterica serovar Kentucky ST198 strains from a single patient with inflammatory bowel disease, highlighting their multidrug-resistant profile and potential epidemiological links to strains from chicken meat.
Prevalence and genomic-based antimicrobial resistance analysis of Avibacterium paragallinarum isolates in Guangdong Province, China.
The study identified multiple antimicrobial resistance genes in Avibacterium paragallinarum isolates from Guangdong, China, including tet(B), aph(3')-Ia, aph(3'')-Ib, aph(6)-Id, aad-A, sul2, sul3, catP, floR, blaOXA-1, blaCTX-M-14, erm(X), mef(B), and fosA3. These genes were associated with resistance to tetracycline, streptomycin, kanamycin, trimethoprim-sulfamethoxazole, chloramphenicol, ampicillin, erythromycin, and fosfomycin.
Identification and florfenicol-treatment of pseudomonas putida infection in gilthead seabream (Sparus aurata) fed on tilapia-trash-feed.
The study identified Pseudomonas putida as the causative agent of high mortality in gilthead seabream and found that all isolates were resistant to ampicillin and sulfamethoxazole-trimethoprim but sensitive to florfenicol.
Antimicrobial Resistance Genes in Respiratory Bacteria from Weaned Dairy Heifers.
The study identified 26 AMR genes in respiratory bacteria from weaned dairy heifers, with high prevalence of tetracycline, aminoglycoside, sulfonamide, beta-lactam, phenicol, and macrolide resistance genes.
Antimicrobial susceptibility and resistome of Actinobacillus pleuropneumoniae in Taiwan: a next-generation sequencing analysis.
The study identified multiple antimicrobial resistance genes in Actinobacillus pleuropneumoniae isolates from Taiwan, including aminoglycoside, tetracycline, beta-lactam, macrolide, and phenicol resistance genes, highlighting the prevalence of multidrug resistance.
Antimicrobial resistance and population genomics of emerging multidrug-resistant Salmonella 4,[5],12:i:- in Guangdong, China.
The study identified multiple AMR genes and mutations in Salmonella 4,[5],12:i:- isolates from Guangdong, China, including gyrA mutations, PMQR genes, and various beta-lactamase genes, contributing to multidrug resistance.
Multidrug-resistant Escherichia coli causing canine pyometra and urinary tract infections are genetically related but distinct from those causing prostatic abscesses.
The study identifies multiple AMR genes and mutations in multidrug-resistant E. coli strains causing infections in dogs and cats, including bla CTX-M-14, bla CTX-M-15, bla CTX-M-27, bla CTX-M-55, bla CMY-2, bla CMY-148, aac(6')-Ib-cr, qnrS1, qnrB6, aadA2, aadA5, aadA16, ant(3′′)-Ia, aph(3′)-Ia, aph(3′′)-Ib, aph(6)-Id, rmtB, floR, cmlA, catA, sul1, sul2, sul3, dfrA12, dfrA14, dfr17, dfrA27, tet(A), tet(B), tet(M), mph(A), erm(B), lnu(F), and arr-3, as well as the gyrA:p.S83L mutation.
Prevalence and Antimicrobial Resistance Diversity of Salmonella Isolates in Jiaxing City, China.
The study identified several AMR genes and mutations in Salmonella isolates from Jiaxing City, China, including blaTEM-1B, blaOXA-10, blaCTX-M-65, floR, sul2, qnrS1, and tet(B), as well as mutations in gyrA and parC contributing to fluoroquinolone resistance.
Antimicrobial susceptibility profile and molecular characterization of Vibrio parahaemolyticus strains isolated from imported shrimps.
The study identified several AMR genes in V. parahaemolyticus isolates from imported shrimps, including aph(3"-Ib, aph(6)-Id, sul2, tet(59), floR, bla CARB-26, bla CARB-31, bla CARB-41, bla OXA-SHE, and qnrA5, which confer resistance to various antibiotics such as streptomycin, trimethoprim-sulfamethoxazole, tetracycline, chloramphenicol, and others.
Molecular and clinical epidemiology of carbapenem resistant Acinetobacter baumannii, Pseudomonas aeruginosa and Enterobacterales in Fiji: a multicentre prospective observational study.
The study identified several carbapenem-resistant genes, including bla OXA-23, bla OXA-66, bla NDM-1, bla OXA-50, bla OXA-395, bla NDM-7, and bla NDM-5, in various bacterial species in Fiji.
Genomic characterisation of Escherichia coli isolated from poultry at retail through Sink Surveillance in Dhaka, Bangladesh reveals high levels of multi-drug resistance.
The study identified multiple AMR genes in E. coli isolates from poultry in Bangladesh, including genes conferring resistance to various antibiotics such as tetracycline, ciprofloxacin, azithromycin, colistin, and others. High levels of multidrug resistance were observed, with specific genes like mcr1.1, bla CTX-M-65, and tet(A) playing significant roles.
The IncC and IncX1 resistance plasmids present in multi-drug resistant Escherichia coli strains isolated from poultry manure in Poland.
The study identifies three resistance plasmids (pECmdr13.2, pECmdr13.3, pECmdr14.1) in multi-drug resistant E. coli strains from poultry manure in Poland, each carrying various AMR genes including tetracycline, aminoglycoside, beta-lactam, sulfonamide, fluoroquinolone, and phenicol resistance genes.
Molecular Characterization and Antibacterial Resistance Determination of Escherichia coli Isolated from Fresh Raw Mussels and Ready-to-Eat Stuffed Mussels: A Major Public Health Concern.
The study identified several AMR genes in E. coli isolates from mussels, including tetB, sul1, sul2, floR, qnrA, and qnrB, which confer resistance to tetracycline, sulfonamides, chloramphenicol, and fluoroquinolones.
Genomic Evaluation of Multidrug-Resistant Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli from Irrigation Water and Fresh Produce in South Africa: A Cross-Sectional Analysis.
The study identified several AMR genes in multidrug-resistant ESBL-producing E. coli isolates from irrigation water and fresh produce in South Africa, including bla CTX-M-1, bla CTX-M-14, bla CTX-M-15, aph(6)-Id, ant(3″)-Ia, aadA2, aph(3″)-Ib, sul2, sul3, dfrA1, fosA3, cmlA1, and floR.
Antimicrobial resistance profiles and genome characteristics of Klebsiella isolated from the faeces of neonates in the neonatal intensive care unit.
The study identified multiple antimicrobial resistance genes in Klebsiella isolates from neonates in the NICU, including bla NDM-1, bla CTX-M-15, bla SHV-67, aac(6')-Ib-cr, aadA16, aph(3'')-Ib, and others. These genes confer resistance to various antibiotics such as carbapenems, cephalosporins, aminoglycosides, and fluoroquinolones. Additionally, the study found a multidrug-resistant Klebsiella pneumoniae strain carrying several resistance genes and plasmids.
Carriage Rate of Enterobacterales Resistant to Extended-Spectrum Cephalosporins in the Tunisian Population.
The study identified bla CTX-M-15 and bla DHA-1 as the primary genes conferring resistance to extended-spectrum cephalosporins in Enterobacterales isolated from healthy Tunisian individuals. Additional resistance mechanisms included aminoglycoside, sulfonamide, tetracycline, and quinolone resistance genes.
Genomic profiling of pan-drug resistant proteus mirabilis Isolates reveals antimicrobial resistance and virulence gene landscape.
The study identified multiple antimicrobial resistance genes in pan-drug resistant Proteus mirabilis isolates, including genes conferring resistance to aminoglycosides, beta-lactams, tetracyclines, sulfonamides, and others. These genes were found on the chromosome and contributed to the isolates' resistance to various antibiotic classes.
The ISVsa3-ORF2-abh-tet(X4) circular intermediate-mediated transmission of tigecycline resistance in Escherichia coli isolates from duck farms.
The study identifies the tet(X4) gene in E. coli isolates from duck farms, demonstrating its presence in a circular intermediate and its ability to transfer via conjugation, highlighting the potential for widespread tigecycline resistance.
Florfenicol-resistant Brevundimonas sanguinis sp. nov., a novel bacterium isolated from patient blood in South Korea.
The study identifies a novel bacterium, Brevundimonas sanguinis sp. nov., isolated from a patient's blood in South Korea, which exhibits resistance to florfenicol due to the presence of the floR gene.
Surveillance of travel-associated isolates elucidates the diversity of non-pandemic Vibrio cholerae.
The study identified various AMR genes in travel-associated V. cholerae isolates, including catB9, floR, sul2, and tetA, which confer resistance to chloramphenicol, sulfonamide, and tetracycline. These genes were detected in both 7PET and non-7PET lineages.
Molecular mechanisms of re-emerging chloramphenicol susceptibility in extended-spectrum beta-lactamase-producing Enterobacterales.
The study identifies catA1, catA2, catB3, catB4, cmlA1, and floR as functional chloramphenicol resistance genes, while catB4 is a non-functional variant due to IS 26-mediated truncation. IS 5 insertion into the catA1 promoter and IS 26-mediated deletion of catB3 lead to reduced or absent chloramphenicol resistance.
Evolution and maintenance of a large multidrug-resistant plasmid in a Salmonella enterica Typhimurium host under differing antibiotic selection pressures.
The study characterizes the evolution of a large multidrug-resistant plasmid (pJXP9) in Salmonella enterica Typhimurium under varying antibiotic selection pressures, identifying several AMR genes and mutations that contribute to resistance and plasmid maintenance.
Molecular characterization of the tet (M)-carrying transposon Tn7124 and plasmids in Escherichia coli isolates recovered from swine.
The study identifies the tet(M)-carrying transposon Tn7124 and plasmids pTA2 and pTA7 in E. coli isolates from swine, highlighting the presence of multiple antibiotic resistance genes such as tet(M), tet(A), floR, aadA1, cmlA1, aadA2, sul3, qnrS1, bleO, and oqxAB.
Combatting extensively drug-resistant Salmonella: a global perspective on outbreaks, impacts, and control strategies.
The paper discusses the emergence and global spread of extensively drug-resistant (XDR) Salmonella, highlighting the resistance mechanisms involving genes such as blaCTX-M-15, floR, cat1, cat2, strA, strB, aacC(3), aadA, ant(3")-Ia, aph(3)-IIa, tet(A), tet(B), tet(D), tet(G), tet(H), dfrA10, dhfrXII, sul1, sul2, sul3, mphA, and ermB.
Microplastic diversity increases the abundance of antibiotic resistance genes in soil.
The study shows that increasing microplastic diversity in soil leads to a significant increase in the abundance of antibiotic resistance genes (ARGs), including those conferring resistance to aminoglycosides, macrolide-lincosamide-streptogramin, florfenicol, and tetracycline.
Florfenicol administration in piglets co-selects for multiple antimicrobial resistance genes.
Florfenicol administration in piglets leads to the selection of multiple antimicrobial resistance genes, including those conferring resistance to phenicols, aminoglycosides, beta-lactams, sulfonamides, and oxazolidinones.
Comparative genomics analysis of Salmonella Enteritidis isolated from clinical cases associated with chicken.
Five Salmonella Enteritidis isolates were analyzed, revealing multiple antimicrobial resistance genes and chromosomal mutations. Key resistance genes included bla CTX−M−55, bla TEM−141, bla TEM−1B, aac(6')-Iaa, aph(3’)-IIa, aph(3’’)-Ib, aph(6)-Id, tet(A), floR, fosA3, and sul2. Chromosomal mutations in gyrA (D87G/D87Y) and acrB (F28L/L40P) were also identified, contributing to fluoroquinolone and multidrug resistance.
Antimicrobial resistance, virulence factors and phylogenetic profiles of Vibrio parahaemolyticus in the eastern coast of Shenzhen.
The study identified several antimicrobial resistance genes in Vibrio parahaemolyticus isolates from Shenzhen, including blaCARB, tet(34), tet(35), qnrVC6, sul2, aph(6)-Id, floR, cat, and blaCTX-M-14. These genes conferred resistance to various antibiotics such as ampicillin, tetracycline, fluoroquinolones, sulfonamides, aminoglycosides, chloramphenicol, and beta-lactams.
First Detection of High-Level Aminoglycoside-Resistant Klebsiella pneumoniae and Enterobacter cloacae Isolates Due to 16S rRNA Methyltransferases with and Without bla(NDM) in Uruguay.
The study identifies the first detection of high-level aminoglycoside-resistant Klebsiella pneumoniae and Enterobacter cloacae isolates in Uruguay, carrying 16S rRNA methyltransferases (rmtB, rmtC, rmtD) along with carbapenemase genes (bla NDM-5, bla NDM-1).
Versatile and Portable Cas12a-mediated Detection of Antibiotic Resistance Markers.
The study developed C12a, a CRISPR/Cas12a-based molecular toolbox for detecting antibiotic resistance genes (ARGs) such as blaCTX-M-15 and floR, which confer resistance to beta-lactams and amphenicols, respectively. The system demonstrated high sensitivity and specificity in detecting these genes in E. coli isolates.
Prevalence, detection of virulence genes and antimicrobial susceptibility of Escherichia coli isolated from arbor acres broilers feeding cycle in China.
The study identified several antibiotic resistance genes in E. coli isolates from broiler chickens, including floR, qnrS, mcr-1, aadE-Sat4-aphA-3, blaNDM, and aac(6')-lb. These genes were associated with resistance to various antibiotics such as florfenicol, ciprofloxacin, colistin, kanamycin, gentamicin, ampicillin, ceftiofur, and meropenem.
Exploring the genomic and antimicrobial resistance tapestry: comparative insights into Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama in Latin American surface waters.
The study identifies several AMR genes, including fosA7.2, qnrB19, aadA1, floR, sat2, tet(B), and tet(A), in Salmonella enterica serotypes Agona, Braenderup, Muenchen, and Panama from Latin American surface waters, highlighting the prevalence of multidrug resistance in these isolates.
Characterizing Methicillin-Resistant Staphylococcus spp. and Extended-Spectrum Cephalosporin-Resistant Escherichia coli in Cattle.
The study identified several AMR genes in E. coli and MRSA isolates from cattle in Austria, including bla CTX-M-1/15, bla CTX-M-9, bla TEM, tet (A), tet (B), dfrA1, dfrA5, dfrA14, dfrA17, sul2, sul3, aadA1, aadA2, floR, cmlA, aphA, and bla ACT. Additionally, the MRSA isolate carried the mecA gene, indicating methicillin resistance.
Loop-mediated isothermal amplification assays for the detection of antimicrobial resistance elements in Vibrio cholera.
The study presents LAMP assays targeting AMR genes in Vibrio cholerae, including aph(6), varG, floR, qnrVC5, and almG, which confer resistance to aminoglycosides, penicillins/carbapenems, phenicol antibiotics, fluoroquinolones, and polymyxins, respectively.
Genomic insights into the dynamic antibiotic resistance landscape of Vibrio cholerae during the Cholera outbreak 2022 in Odisha, India.
Antibiotic Resistance in Mammalian Wild Game: A Meta-Analysis
The study presents a comprehensive meta-analysis of antibiotic resistance in bacteria isolated from mammalian wild game, highlighting the prevalence of various AMR genes and mutations across different bacterial species.
Whole-genome sequencing-based characterization of Salmonella enterica Serovar Enteritidis and Kentucky isolated from laying hens in northwest of Iran, 2022-2023.
The study identified the presence of a multidrug-resistant (MDR) Salmonella enterica serovar Kentucky ST198 clone with high-level ciprofloxacin resistance due to double mutations in gyrA (S83F, D87N) and parC (T57S, S80I) genes. The aminoglycoside resistance gene aac(6′)-Iaa was the most frequently detected gene, but it did not confer resistance to aminoglycosides. Other resistance genes included tetA, floR, sul1, dfrA1, and aph(3′)-Ia.
Detection of antimicrobial resistance in Glaesserella parasuis in South China using whole-genome sequencing.
The study identified several AMR genes and mutations in Glaesserella parasuis isolates from South China, including bla ROB–1, catA3, floR, erm(T), tet(B), and tet(H) for resistance to amoxicillin, chloramphenicol, florfenicol, erythromycin, and tetracycline, as well as mutations in gyrA, parC, and parE for enrofloxacin resistance.
Pandemic one health clones of Escherichia coli and Klebsiella pneumoniae producing CTX-M-14, CTX-M-27, CTX-M-55 and CTX-M-65 ESβLs among companion animals in northern Ecuador.
The study identifies CTX-M-55, CTX-M-65, CTX-M-27, and CTX-M-14 ESβL-producing E. coli and K. pneumoniae in companion animals in Ecuador, highlighting their global One Health significance and the need for surveillance programs.
Phenotypic and genotypic characterization of antimicrobial resistance and virulence profiles of Salmonella enterica serotypes isolated from necropsied horses in Kentucky.
The study identified several AMR genes in Salmonella enterica isolates from necropsied horses, including beta-lactamase genes (blaTEM, blaCTX-M, blaSHV2, blaOXA-9), aminoglycoside resistance gene (aacA[3]), sulfonamide resistance gene (sul2), amphenicol resistance gene (floR), tetracycline resistance gene (tetB), streptomycin resistance gene (strA), macrolide resistance gene (ermB2), and quinolone resistance gene (qnrB2). These genes were associated with resistance to multiple antibiotics, highlighting the presence of multidrug-resistant Salmonella strains.
Molecular Epidemiology and In-Depth Characterization of Klebsiella pneumoniae Clinical Isolates from Armenia.
The study identifies multiple AMR genes and mutations in K. pneumoniae isolates from Armenia, highlighting the presence of XDR and MDR strains with resistance to various antibiotics, including carbapenems, aminoglycosides, and quinolones.
Potential links between human bloodstream infection by Salmonella enterica serovar Typhimurium and international transmission to Colombia.
The study identified qnrB19 and floR as key AMR genes in Colombian S. Typhimurium isolates, contributing to quinolone and chloramphenicol resistance, respectively.
Genomic and resistome analysis of Salmonella enterica isolates from retail markets in Yichun city, China.
The study identified multiple antimicrobial resistance genes in Salmonella enterica isolates from retail markets in Yichun city, China, including genes conferring resistance to various antibiotics such as chloramphenicol, tetracycline, trimethoprim, and extended-spectrum beta-lactamases.
Genotypic and phenotypic characterization of antimicrobial resistance in Salmonella strains isolated from both No-Antibiotics-Ever (NAE) and conventional broiler complexes.
The study identified several AMR genes in Salmonella strains from both NAE and conventional broiler complexes, including aac(6')-Iaa, aph(3")-Ib, aph(6)-Id, tet(B), blaCARB-2, floR, gyrA, and parC. These genes conferred resistance to various antibiotics such as tetracycline, sulfisoxazole, ampicillin, chloramphenicol, nalidixic acid, and ciprofloxacin.
Retrospective analysis of antimicrobial resistance associated with bovine respiratory disease.
The study identified several clinically relevant antimicrobial resistance genes (ARGs) in bovine respiratory disease (BRD) pathogens, including estT, floR, mphE, erm(42), msrE, aadA, ANT(2''-Ia), APH(3''-Ib), APH(3'-Ia), APH(6)-Id, sul2, tet(H), ROB-1, and OXA-2. Additionally, mutations in gyrA and parC were found to confer resistance to fluoroquinolones in Mannheimia haemolytica.
Genomic epidemiology and antimicrobial resistance of Morganella clinical isolates between 2016 and 2023.
The study identified several AMR genes in Morganella clinical isolates, including tet(B), sul1, catA2, sul2, floR, aadA1, and others, contributing to resistance against various antibiotics.
Antimicrobial Resistance in Pasteurella multocida Isolates from Bovine Mastitis Can Be Associated with Multidrug-Resistance-Mediating Integrative and Conjugative Elements (ICEs).
Serovar and multilocus sequence typing analysis of Pasteurella multocida from diseased pigs in Taiwan.
The study identified the floR gene as a significant contributor to florfenicol resistance in Pasteurella multocida isolates from diseased pigs in Taiwan.
Unveiling the silent threat: A comprehensive review of Riemerella anatipestifer - From pathogenesis to drug resistance.
This review highlights the pathogenesis, virulence factors, and antibiotic resistance genes of Riemerella anatipestifer, emphasizing its significance in poultry farming and the need for further research on its resistance mechanisms.
Epidemic trend of Salmonella from swines and broilers in China from 2014 to 2023 and genetic evolution analysis of ESBLs-producing strains.
The study identified several AMR genes in ESBL-producing Salmonella strains from swines and broilers in China, including blaCTX-M-14, blaTEM-1B, blaCTX-M-65, aac(6')-Iaa, floR, sul2, tet(B), arr-2, fosA3, dfrA12, mph(A), lnu(F), blaCTX-M-55, blaOXA-1, sul1, tet(A), catB3, qnrS1, and mcr-1.1. These genes conferred resistance to various antibiotics such as beta-lactams, aminoglycosides, sulfonamides, tetracyclines, rifampicin, fosfomycin, trimethoprim, macrolides, lincomycin, quinolones, and colistin.
Integrative and conjugative elements associated with antimicrobial resistance in multidrug resistant Pasteurella multocida isolates from bovine respiratory disease (BRD)-affected animals in Spanish feedlots.
The study identified multiple antimicrobial resistance genes and mutations in multidrug-resistant Pasteurella multocida isolates from bovine respiratory disease-affected animals in Spanish feedlots, highlighting the role of mobile genetic elements in the spread of resistance.
Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinical Aeromonas complex.
The study identified multiple beta-lactamase genes, including bla NDM-1, bla PER-3, and bla OXA-1, along with other resistance genes such as aac(6′)-Ib-cr6, aph(3″)-Ib, and floR, which contribute to resistance against various antibiotics in Aeromonas isolates.
Broiler litter moisture and trace metals contribute to the persistence of Salmonella strains that harbor large plasmids carrying siderophores.
The study identified several antimicrobial resistance genes in Salmonella strains isolated from broiler litter, including aadA1, aac(3)-IV, aph(3′)-Ia, aph(4)-Ia, dfrA14, floR, sul1, tetA, sul2, merRTPCA, qacE, aph(3″)-Ib, aph(6)-Id, pcoABCDRE, silP, and silE. These genes were found on various plasmids and contributed to resistance against multiple antibiotics such as streptomycin, chloramphenicol, sulfamethoxazole, tetracycline, mercury, quaternary ammonium compounds, copper, and silver.
Isolation, Identification, and Characteristics of Aeromonas salmonicida subsp. masoucida from Diseased Starry Flounder (Platichthys stellatus).
The study identified 11 antimicrobial resistance genes in Aeromonas salmonicida subsp. masoucida strains isolated from diseased starry flounders, including genes conferring resistance to beta-lactams, tetracyclines, sulfonamides, chloramphenicol, and biocides.
Strict relationship between phenotypic and plasmid-associated genotypic of multidrug-resistant Escherichia coli isolated from Taihe Black-Boned Silky Fowl farms.
The study identified multiple AMR genes in multidrug-resistant E. coli isolates from Taihe Black-Boned Silky Fowl farms, including blaTEM, blaOXA-10, tetA, tetR, floR, cmlA, qnrS, strA, strB, aadA, aac(3)-IId, sul, and dfrA. These genes were associated with resistance to beta-lactams, tetracyclines, chloramphenicol, fluoroquinolones, aminoglycosides, and sulfonamides.
Comprehensive genomic epidemiology and antimicrobial resistance profiles of clinical Klebsiella pneumoniae species complex isolates from a tertiary hospital in Wenzhou, China (2019-2021).
The study identified a variety of antimicrobial resistance genes in clinical Klebsiella pneumoniae species complex isolates, including bla KPC−2, bla CTX−M, bla SHV, aac(6')-Ib, aadA1, aadA2, aph(3')-Ia, oqxAB, qnrB19, qnrS1, tet(A), tet(D), sul1, sul2, sul3, cmlA1, floR, fosA, and fosA3. These genes confer resistance to multiple classes of antibiotics, highlighting the complexity of antimicrobial resistance in these isolates.
Genomic features, antimicrobial resistance and pathogenicity assessment of Escherichia coli serotype O177:H51 strain JS01 isolated from a diseased chicken.
The study identified 64 AMR genes and 177 virulence factor genes in the E. coli strain JS01, highlighting its multidrug resistance and high pathogenicity.
High prevalence of plasmid-mediated Fosfomycin resistance in waterfowl-derived Escherichia coli strains: insights into genetic context and transmission dynamics in China.
The study identifies fosA3 as a prevalent plasmid-mediated fosfomycin resistance gene in waterfowl-derived E. coli strains, along with other resistance genes such as blaCTX-M-55, blaNDM-5, mcr-1.1, tetA, floR, qnrS, sul2, and aphA1. These genes contribute to multidrug resistance and highlight the importance of monitoring their spread.
Inhibitory effects of benzyl isothiocyanate on widespread mcr-1-harbouring IncX4 plasmid transfer.
The study characterizes the presence of mcr-1.1, mcr-3.5, blaCTX-M-55, and tet(X4) genes in clinical isolates of Enterobacterales from Thailand, highlighting their role in multidrug resistance and the potential for horizontal gene transfer.
Intestinal and Extraintestinal Pathotypes of Escherichia coli Are Prevalent in Food Prepared and Marketed on the Streets from the Central Zone of Mexico and Exhibit a Differential Phenotype of Resistance Against Antibiotics.
The study identifies multiple antibiotic resistance genes in E. coli isolates from street-prepared food in Mexico, including strA, sul1, catA1, floR, qnrS, and tetA, which confer resistance to streptomycin, sulfonamides, chloramphenicol, quinolones, and tetracycline.
Genome-Based Molecular Diversity of Extended-Spectrum β-Lactamase-Producing Escherichia coli From Pigeons in China.
The study identifies multiple extended-spectrum β-lactamase (ESBL) genes, including bla CTX-M, bla TEM, bla OXA, bla LAP, and bla CMY, as well as other antibiotic resistance genes such as mcr-1, mcr-1.1, tet(X4), aadA1, aadA2, aph(6)-Id, aph(3")-Ib, aph(3')-Ia, aph(3')-IIa, aac(3)-IVa, aph(4)-Ia, tet(A), tet(M), sul2, sul3, dfrA14, qnrS1, arr-2, fosA3, cmlA5, floR, mph(A), and lnu(F) in ESBL-producing E. coli isolates from pigeons in China.
Plasmid-Mediated Co-Occurrence of mcr-1.1 in Extended-Spectrum β-Lactamase (ESBL)-Producing Escherichia coli Isolated From the Indigenous Seminomadic Community in Malaysia.
The study identifies the presence of mcr-1.1, bla TEM, bla CTX-M−15, bla CTX-M−55, and other resistance genes in ESBL-producing E. coli isolates from the Jehai community in Malaysia, highlighting the co-occurrence of multiple antibiotic resistance mechanisms.
The First Case of Antimicrobial-Resistant Salmonella Stanley ST29 Diagnosed Secondary to Acute Cholecystitis.
The study identifies multiple antimicrobial resistance genes in Salmonella Stanley ST29, including beta-lactamases, quinolone resistance genes, macrolide resistance genes, and others, contributing to resistance against various antibiotics.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaOXA-51-like, and several aminoglycoside resistance genes, contributing to extensive drug resistance.
Antimicrobial Resistance in Nigeria: A Comprehensive Review of Environmental, Food, and Clinical Impacts
The study identifies several AMR genes, including bla CTX-M-15, floR, and various tetracycline and sulfonamide resistance genes, highlighting the spread of multidrug-resistant bacteria in Nigeria's environment, food supply chain, and clinical settings.
The pet café is a neglected site for transmission of antimicrobial-resistant Escherichia coli in urban life.
The study identifies multiple antimicrobial resistance genes (ARGs) in Escherichia coli isolates from pet cafés, highlighting the role of plasmids in the transmission of these genes. Key ARGs include tet(X4), sul2, sul3, strA, strB, dfrA14, qnrS1, qnrS2, oqxB, blaCTX-M-15, blaCTX-M-14, blaCTX-M-65, floR, and tet(A).
Genomic Insights of Antibiotic-Resistant Escherichia coli Isolated from Intensive Pig Farming in South Africa Using 'Farm-to-Fork' Approach.
The study identified multiple antibiotic resistance genes and mutations in E. coli isolates from intensive pig farming in South Africa, highlighting the spread of resistance across the pork production continuum.
A Multidrug-Resistant Escherichia coli Caused the Death of the Chinese Soft-Shelled Turtle (Pelodiscus sinensis).
The study identifies a multidrug-resistant E. coli strain (HD-593) isolated from diseased Chinese soft-shelled turtles, which exhibits resistance to 14 antibiotics and carries several resistance genes including quinolone, aminoglycoside, beta-lactam, and acylaminol resistance genes.
Emergence and characteristics of multidrug-resistant Salmonella enterica subspecies enterica serovar Infantis harboring the pESI plasmid in chicken slaughterhouses in South Korea.
The study identifies multidrug-resistant Salmonella enterica subsp. enterica serovar Infantis isolates harboring the pESI plasmid, which carries genes such as bla CTX-M-65, aadA1, dfrA14, sul1, tetA, and floR, leading to resistance against multiple antibiotics including third-generation cephalosporins.
Dogs fed raw meat-based diets are vectors of drug-resistant Salmonella infection in humans.
Genomic insights into antibiotic-resistant non-typhoidal Salmonella isolates from outpatients in Minhang District in Shanghai.
The study identifies multiple antibiotic resistance genes and mutations in non-typhoidal Salmonella isolates from Minhang District, Shanghai, highlighting the prevalence of multidrug-resistant strains and the role of specific genetic elements in resistance mechanisms.
Multidrug-resistant Klebsiella pneumoniae ST70 harboring bla(NDM) in a migratory Penguin.
The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Klebsiella pneumoniae ST70 isolate from a Magellanic Penguin, highlighting the potential of migratory penguins as vectors of antimicrobial-resistant microorganisms.
Genomic insights into multidrug - resistant Salmonella enterica isolates from pet dogs and cats.
The study identified multiple AMR genes in multidrug-resistant Salmonella enterica isolates from pet dogs and cats, including aac(6')-Iaa, aadA1, aadA2, blaTEM-1B, qacL, sul3, tet(A), qnrS1, fosA7, dfrA12, cmlA1, aph(3')-Ib, aph(6)-Id, blaCTX-M-55, blaTEM-215, and floR, which confer resistance to various antibiotics such as ampicillin, tetracycline, sulfamethoxazole, ciprofloxacin, and chloramphenicol.
Emergence of highly virulent Aeromonas dhakensis in channel catfish aquaculture: Genomic insights into pathogenicity and antimicrobial resistance.
The study identified 60 antibiotic resistance genes in the highly virulent Aeromonas dhakensis strain CWH5, including genes conferring resistance to multiple drug classes such as beta-lactams, tetracyclines, sulfonamides, and macrolides.
Human-wildlife ecological interactions shape Escherichia coli population and resistome in two sloth species from Costa Rica.
The study identified several AMR genes in E. coli isolates from two sloth species in Costa Rica, including blaTEM-1B, aph(3')-Id, aph(6)-Id, tet(A), tet(B), sul2, qnrS1, floR, and dfrA8, which were associated with resistance to various antibiotics.
Prevalence and antimicrobial resistance of Salmonella enterica isolated from cattle farms in Inner Mongolia.
The study identified several AMR genes in Salmonella enterica isolates from Inner Mongolia, including bla TEM-1, cmlA, tetA, tetB, tetM, aadA2, aph(3')-IIa, aacC4, aac(3)-IIa, sul1, sul3, oqxA, and oqxB, which confer resistance to beta-lactams, chloramphenicol, tetracyclines, aminoglycosides, sulfonamides, and quinolones.
Taxonomic and phenotypic characterization of a novel Providencia species: Providencia lanzhouensis sp. nov.
The study identifies Providencia lanzhouensis sp. nov., a novel species with multiple antimicrobial resistance genes, including aadA1, aadA2, aph(6)-Id, aph(3'')-Ib, aph(3')-Ia, sat2, sul2, ere(A), dfrA32, floR, tetC, and qnrD1, which confer resistance to aminoglycosides, streptomycin, sulfonamides, macrolides, trimethoprim, phenicols, tetracyclines, and quinolones.
Antimicrobial resistance and virulence gene profiles of Escherichia coli isolated from poultry farms using One Health perspective in Abeokuta, Nigeria.
The study identified 30 different resistance determinants in 14 whole genome sequenced E. coli isolates from poultry farms in Abeokuta, Nigeria. These included genes such as blaTEM-1B, blaCARB-2, aph(3'')-Ib, aph(6)-Id, floR, sul1, sul2, tet(A), and tet(B), among others, which conferred resistance to various antimicrobial classes.
Clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars detected in poultry retail meat in North Carolina, USA.
The study identifies the clonal spread of bla(CTX-M-65) producing Salmonella enterica serovars in poultry retail meat in North Carolina, USA. It characterizes the resistance profiles of these isolates, including the presence of bla(CTX-M-65), aac(3)-Iva, aadA1, aph(4)-Ia, floR, mdsA, mdsB, sul1, tet(A), dfrA14, aph(3')-Ia, sul2, aph(3'')-Ib, and fosA3.
Population Structure, Genomic Features, and Antibiotic Resistance of Avian Pathogenic Escherichia coli in Shandong Province and Adjacent Regions, China (2008-2023).
The study identified multiple antibiotic resistance genes and mutations in Avian Pathogenic Escherichia coli (APEC) isolates from Shandong Province and adjacent regions in China, highlighting the high prevalence of multidrug resistance and the presence of specific resistance mechanisms such as beta-lactamases, tetracycline resistance genes, and fluoroquinolone resistance mutations.
Co-resistance and plasmid-mediated co-dissemination of florfenicol and azithromycin resistance in non-O157 Shiga toxin-producing Escherichia coli from cattle in Xinjiang, China.
The study identified the florfenicol resistance gene floR and the azithromycin resistance gene mph(A) in non-O157 STEC strains from cattle in Xinjiang, China. These genes were found on plasmids capable of horizontal transfer, contributing to the co-resistance and dissemination of resistance to florfenicol and azithromycin.
Genomic characterization and global relatedness of multidrug-resistant Salmonella Goldcoast ST2529.
The study identifies the bla NDM-1 gene in a multidrug-resistant Salmonella Goldcoast ST2529 strain, which confers resistance to multiple beta-lactam antibiotics, chloramphenicol, tetracycline, and fluoroquinolones. The gene is located on an IncFII-type plasmid and was successfully transferred via conjugation.
Unveiling the Genetic Diversity and Antimicrobial Resistance Profiles of Salmonella Population From 2016 to 2020 in Thai Canal Water.
The study identified 50 acquired resistance genes and seven chromosomal-mediated gene mutations in Salmonella populations from Thai canal water, highlighting the prevalence of multidrug-resistant strains and the diversity of resistance mechanisms.
Ecological connectivity of genomic markers of antimicrobial resistance in Escherichia coli in Hong Kong.
The study identifies various antimicrobial resistance genes in E. coli isolates from Hong Kong, including blaTEM-1, floR, tet(A), aph(3')-Ia, blaNDM, tet(X4), and mcr, which confer resistance to multiple antibiotics.
Unraveling the role of mobile genetic elements in antibiotic resistance transmission and defense strategies in bacteria.
The study characterizes several AMR genes, including blaIPM-4, blaOXA-1, blaOXA-10, aacA4, blaOXA-101, aadA11, aadA9, qacEΔ1, sat2-aadA1, and others, highlighting their role in conferring resistance to various antibiotics in different bacterial species.
CapSeq for Surveillance in Environmental Samples
The study demonstrates the effectiveness of CapSeq in detecting and genotyping bacterial pathogens and antibiotic resistance genes in bovine respiratory disease (BRD) samples, highlighting the presence of various resistance genes such as bla-TEM, bla-ROB, tetM, tetQ, tetS, tetH, tetX, floR, rrs, and rrl.
Antimicrobial Resistance of Salmonella and Characterization of Two Mcr-1-Harboring Isolates from Pork Products in Guangdong, China.
Two mcr-1-harboring Salmonella Kentucky ST198 isolates were identified, showing resistance to multiple antibiotics including colistin, tetracycline, and fluoroquinolones. The study highlights the presence of complex resistance determinants such as the multidrug resistance region (MRR) and SGI1-KI.
Evidence of ESBL plasmid transfer and selective persistence of multiple host-associated Escherichia coli isolates in a chicken cecal fermentation model.
The study identifies multiple ESBL-producing E. coli isolates and characterizes their resistance genes, highlighting the transfer of bla CTX-M-1 plasmids among isolates in a chicken cecal fermentation model.
Molecular epidemiology of pESI-carrying Salmonella Infantis in Korea: insights from a one health framework.
The study identifies multiple antimicrobial resistance genes and a quinolone resistance mutation in pESI-carrying Salmonella Infantis isolates from the Korean poultry production chain, highlighting the potential for zoonotic transmission.
Global phylogeography and genomic characterization of bla(NDM-1)-positive clinical Proteus mirabilis isolates from China.
The study identifies blaNDM-1 as a key determinant of carbapenem resistance in Proteus mirabilis isolates from China, along with other resistance genes such as blaCTX-M-14, blaCTX-M-65, and blaTEM-1. It also characterizes the genomic context of blaNDM-1, including its integration into SGI1 and plasmid-borne elements.
Detection and characterization of heteroresistance to chloramphenicol in Klebsiella pneumoniae isolates.
The study identifies cat1 and floR genes as pivotal in chloramphenicol heteroresistance in Klebsiella pneumoniae isolates.
Antibiotic resistance and novel Sequence Types of Klebsiella spp. in human, animal, and food sources: a One Health perspective from Northern Nigeria.
The study identified various AMR genes in Klebsiella spp. isolates from human, animal, and food sources, including strB, qnrS1, sul2, tetA, dfrA14, blaTEM-1, and blaSHV-11, which conferred resistance to multiple antibiotics.
Antimicrobial Resistance and Genomic Characterization of an Escherichia coli Strain Harboring p0111 and an IncX1-Type Plasmid, Isolated from the Brain of an Ostrich.
The study identifies multiple antimicrobial resistance genes in an Escherichia coli strain isolated from an ostrich, including bla CTX-M-55, rmtB, sul1, APH(6)-Id, tet(A), AAC(3)-IIc, aadA2, bla TEM-1B, and floR, which confer resistance to various antibiotics such as cephalosporins, aminoglycosides, sulfonamides, tetracyclines, and chloramphenicol.
Genetic diversity, virulence genes, antimicrobial resistance, and biofilm formation of Klebsiella pneumoniae isolated from bovine mastitis milk in South Korea.
The study identified several AMR genes in K. pneumoniae isolates from bovine mastitis milk in South Korea, including blaSHV, strA, strB, sulI, sulII, tetA, tetB, tetC, floR, dfrXII, blaTEM, blaCTX-M, and blaOXA, which confer resistance to various antibiotics such as ampicillin, gentamicin, trimethoprim/sulfamethoxazole, tetracycline, chloramphenicol, and others.
Molecular characterization of drug-resistance genes and dynamics of multidrug-resistant Salmonella spp. in waterfowl: a pre- and post-antibiotic ban surveillance in Guangdong, China from 2013 to 2023.
The study identified several AMR genes in Salmonella isolates from waterfowl in Guangdong, China, including bla CTX-M, bla TEM, bla OXA, aad A1, aad A2, aac C2, aac (3)-IV, aph (3’)-I, qnr A, qnr S, clm A, flo R, tet (A), and Sul II. These genes were associated with resistance to various antibiotics such as β-lactams, aminoglycosides, quinolones, chloramphenicol, tetracyclines, and sulfonamides.
Community gut colonization by tet(X4)-positive multidrug-resistant Escherichia coli in healthy individuals from urban residents in Shenzhen, China.
The study identifies tet(X4)-positive multidrug-resistant E. coli in healthy individuals from urban areas in Shenzhen, China, highlighting the presence of tigecycline resistance and other resistance genes in the community gut microbiota.
Genomic insights into Shigella species isolated from small ruminants and manure in the North West Province, South Africa.
The study identified multiple antibiotic resistance genes in Shigella species isolated from small ruminants and manure in South Africa, highlighting the presence of multidrug-resistant strains and the diversity of resistance mechanisms.
Global genomic survey of Salmonella Kentucky: discovery of a chromosomeborne bla(NDM-5) and the emergence of ST314, an MDR clone mediated by the IncR plasmid.
The study discovered a chromosome-borne bla(NDM-5) gene in Salmonella Kentucky and identified the IncR plasmid as a key mediator of antimicrobial resistance in the MDR clone ST314.
Emerging threat of antimicrobial resistance determinants and plasmid replicon types acquisition by Escherichia coli of poultry and other food-producing animal origin in China: local findings with global implications.
The study identifies multiple antimicrobial resistance genes in Escherichia coli from poultry and other food-producing animals in China, highlighting the prevalence of beta-lactamases, tetracycline resistance genes, aminoglycoside modifying enzymes, quinolone resistance genes, and sulfonamide resistance genes.
Analysis of avian pathogenic Escherichia Coli (APEC) and its antimicrobial resistance risk characteristics and critical control points in laying hens.
The study identified several AMR genes in APEC isolates, including tet(A), floR, sul2, aph(3')-Ib, aph(6)-Id, bla TEM-1B, qnrS1, bla CTX-M-55, dfrA14, and mph(A), which contribute to resistance against tetracyclines, florfenicol, sulfonamides, aminoglycosides, beta-lactams, fluoroquinolones, and macrolides.
Global geographic and genomic epidemiology analysis of carbapenem-resistant Escherichia coli carrying bla(NDM-9).
The study characterizes bla NDM-9 -carrying carbapenem-resistant Escherichia coli (CREC) and identifies various antibiotic resistance genes (ARGs) contributing to multidrug resistance. It highlights the role of mobile genetic elements in the dissemination of bla NDM-9 and emphasizes the importance of surveillance for these high-risk clones.
Genomic characterisation of multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from various sources in Algeria, North Africa.
The study identified multiple AMR genes and chromosomal mutations in multidrug-resistant Salmonella enterica serovar Kentucky ST198 isolates from Algeria, including bla TEM-1B, bla CTX-M-15, aac(3)-Id, aadA7, sul1, tet(A), mph(A), qnrB19, cmlA1, and floR, along with mutations in gyrA and parC genes that confer resistance to ciprofloxacin.
Genetic insights into antimicrobial resistance and virulence characteristics of Salmonella enterica isolated from Nile tilapia sourced from retail markets in Thailand.
The study identified multiple antimicrobial resistance (AMR) genes in Salmonella enterica isolates from Nile tilapia, including beta-lactamases (bla TEM−1B, bla CTX−M−55, bla CTX−M−14, bla LAP−2), quinolone resistance genes (qnrS1, qnrS13), tetracycline resistance genes (tet(A), tet(B), tet(M)), aminoglycoside resistance genes (aadA2, aph(3’’)-Ib, aph(6)-Id, aac(6’)-Ia), sulfonamide resistance genes (sul1, sul2, sul3), florfenicol resistance gene (floR), and efflux pump systems (mdsABC, mdtK).
Comprehensive analysis of Escherichia coli in bovine urinary tract infections: serotypes, antibiotic resistance, and virulence gene profiles.
The study identified multiple antimicrobial resistance genes in E. coli isolates from bovine urinary tract infections, including tetA, gyrA, blaSHV, floR, and aac(3)-IV, highlighting the prevalence of multidrug resistance.
Diversity of Multi-Drug Resistance Genes in Escherichia coli Isolated from Poultry in Southern Togo.
The study identified multiple AMR genes in E. coli isolates from poultry in southern Togo, including blaCTX-M-55, sul2, tet(A), floR, aph(6)-Id, aph(3")-Ib, gyrA, gyrB, parC, parE, pmrA, pmrB, folp, 23S, 16S-rrsB, 16S-rrsC, 16S-rrsH, ampC-promoter, rpoB, and mcr-1.1. These genes confer resistance to various antibiotics, highlighting the prevalence of multidrug resistance in poultry-associated E. coli.
Research of antimicrobial resistance and its associated genes distribution in Escherichia coli from diarrheic calves in the Ulagai region of China.
The study identified several antimicrobial resistance genes in E. coli isolates from diarrheic calves in the Ulagai region of China, including sul2, TEM-1, tetR, strB, QacH, floR, and CTXM-55, which were associated with resistance to various antibiotics.
PanARGMiner (Pan-Genomic Antimicrobial Resistance Gene Miner): An advanced feature selection framework for extracting key resistance genes from pan-genomic datasets.
PanARGMiner effectively identifies key resistance genes from pan-genomic datasets, including both known and novel AMR genes, across multiple bacterial species.
Genomic analysis of multidrug-resistant Salmonellaenterica Serovar Montevideo isolates in China.
The study identified multiple AMR genes in Chinese S. Montevideo isolates, including beta-lactamases (bla TEM−1B, bla OXA−1, bla LAP−2, bla CTX−M−55, bla CTX−M−65, bla DHA−1), quinolone resistance genes (qnrS2, qnrS1, qnrA1, qnrB6, qnrB4, qepA1), macrolide resistance genes (mphA, mphE, msrE, mphB), tetracycline resistance genes (tetA, tetD, tetB), sulfonamide resistance genes (sul1, sul2, dfrA14, dfrA12, dfrA27, sul3), and chloramphenicol resistance genes (floR, catA2, catB3).
Precise species identification and whole-genome sequencing analysis of Enterobacter cloacae complex causing bloodstream infections in China.
The study identified various AMR genes in Enterobacter cloacae complex (ECC) isolates, including bla ACT, bla NDM, and mcr-10, which confer resistance to beta-lactams, carbapenems, and polymyxins, respectively. It also found that E. roggenkampii was the most common species among carbapenem-resistant isolates and showed high resistance to both carbapenems and colistin.
A Monitoring Method to Evaluate the Accumulation of Antimicrobial-Resistance Genes in Gram-Negative Bacteria Distributed in Environmental Water.
The study identified multiple antimicrobial resistance genes (ARGs) in Gram-negative bacteria isolated from environmental water samples, including bla NDM-5, bla CTX-M-27, bla DHA-1, and others, indicating the presence of carbapenem-resistant and extended-spectrum beta-lactamase-producing bacteria in the Vietnamese VAC ecosystem.
Prevalence and genetic basis of extended-spectrum β-lactamase-producing Escherichia coli carriage in broiler farms in the United Arab Emirates.
The study identified bla TEM and bla CTX-M as the most common β-lactam resistance genes in ESBL-producing E. coli isolates from broiler farms in the UAE, with bla CTX-M-55 and bla CTX-M-15 being the prevalent variants. Additionally, the mcr-1.1 gene was detected in 10.3% of isolates, indicating colistin resistance.
Molecular characterization of mcr-1.1-harboring multidrug-resistant Escherichia coli isolates from chicken in the United Arab Emirates: implications for one health surveillance.
The study identified mcr-1.1-harboring multidrug-resistant E. coli isolates from chicken in the UAE, highlighting the presence of various AMR genes and mutations contributing to resistance against multiple antibiotics, including colistin, beta-lactams, quinolones, and aminoglycosides.
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