florr

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fluoroquinolone resistance protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to florr

AMR Rules

Browse AMR rules for florr

Validation StatusCandidate

Overview

Mechanism: efflux
Validation Method: whole genome sequencing
Drug Classes: phenicols
Organisms: Salmonella enterica serovar Senftenberg, Escherichia coli
Geographic Location: India, South America
Papers: 2
Databases: Reslit

Papers2

Extensive drug resistant Salmonella enterica serovar Senftenberg carrying blaNDM encoding plasmid p5558 (IncA/C) from India.

PMID 30722761 · 2019

The study identifies multiple antimicrobial resistance genes in a multidrug-resistant Salmonella enterica serovar Senftenberg isolate, including blaNDM-1, blaTEM-1, blaOXA-9, blaCMY-2, aac(6')-Ia, aac(6')-Ib, aph(3')-Ib, aph(6')-Ib, ant(3'')-Ia, sul-1, sul-2, and florR. Additionally, mutations in gyrA (S83Y, D87G) and parC (S80I) were associated with fluoroquinolone resistance.

Gene Information

Gene Name: florr
Allele: florR
Encodes: fluoroquinolone resistance protein
Source Database: Reslit
Confers Resistance To: phenicols
Organisms Tested In: • Salmonella enterica serovar Senftenberg
Geographic Location: India
Validation Method: whole genome sequencing
Sequence Accession: PRJNA483094

CTX-M-producing Escherichia coli ST602 carrying a wide resistome in South American wild birds: Another pandemic clone of One Health concern.

PMID 37415721 · 2023

The study identifies two CTX-M-producing E. coli ST602 strains, UNB7 and GP188, from wild birds in Brazil and Chile, carrying a wide resistome against antibiotics, heavy metals, disinfectants, and herbicides.