Browse AMR Genes

The study identifies fmtA as a methicillin-resistance factor in Staphylococcus aureus, regulated by the global regulator SarA. SarA binds to the fmtA promoter and enhances its transcription, contributing to methicillin resistance.

Gene Information

Gene Name: fmtA
Allele: fmtA
Encodes: low-affinity penicillin binding protein
Source Database: Reslit
Confers Resistance To: Methicillin
Organisms Tested In: • Staphylococcus aureus
Validation Method: binding studies and transcription assays

Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries.

PMID 27531908 · 2016

The study identifies several intrinsic resistance factors in Staphylococcus aureus, including ndh, fmtA, mprF, graRS/vraFG, dltA, SAOUHSC_01025, and SAOUHSC_01050, which contribute to resistance against multiple antibiotics.

Gene Information

Gene Name: fmtA
Allele: fmtA
Encodes: cell surface protein
Source Database: Reslit
Confers Resistance To: DaptomycinVancomycin
Organisms Tested In: • Staphylococcus aureus
Validation Method: Tn-Seq and spot dilution assay

Whole genome sequence and comparative genomics analysis of multidrug-resistant Staphylococcus xylosus NM36 isolated from a cow with mastitis in Basrah city.

PMID 38060084 · 2023

The study identifies multiple antimicrobial resistance genes in Staphylococcus xylosus NM36, including those conferring resistance to quinolones, teicoplanin, bicyclomycin, chloramphenicol, methicillin, fosfomycin, and others. The genome analysis reveals the presence of efflux pumps, regulatory proteins, and other resistance mechanisms contributing to multidrug resistance.

Gene Information

Gene Name: fmtA
Allele: FmtA
Encodes: FmtA protein
Source Database: Reslit
Mechanism: unknown
Confers Resistance To: Methicillin
Organisms Tested In: • Staphylococcus xylosus
Geographic Location: Basrah city
Validation Method: genome annotation
Sequence Accession: GenBank JARUHN000000000.1

Gallium Resistance in Staphylococcus aureus: Polymorphisms and Morphology Impacting Growth in Metals, Antibiotics and Polyfluorinated Compounds.

PMID 40893415 · 2025

This study identified several genes and mutations associated with gallium resistance in Staphylococcus aureus, including sfaA/sfaD, fmtA, KQ76_RS01520, and KQ76_RS08360, which were validated through whole-genome sequencing.

Gene Information

Gene Name: fmtA
Allele: fmtA
Encodes: Teichoic acid D-Ala esterase
Source Database: Reslit
Organisms Tested In: • Staphylococcus aureus
Validation Method: whole-genome sequencing