fnr

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Regulator, mediates aerobic to anaerobic transition

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Validation StatusCandidate

Overview

Mechanism: regulation
Validation Method: gene knockout and CRISPRi experiments
Drug Classes: ciprofloxacin, trimethoprim
Organisms: Escherichia coli
Papers: 1
Databases: Reslit

Papers1

Potentiating antibiotic efficacy via perturbation of non-essential gene expression.

PMID 34741116 · 2021

The study identifies genes such as acrA, tolC, recA, and fnr that, when knocked out or inhibited, potentiate the efficacy of antibiotics like ampicillin, erythromycin, tetracycline, ciprofloxacin, and trimethoprim in E. coli and Salmonella enterica.

Gene Information

Gene Name: fnr
Allele: fnr
Encodes: Regulator, mediates aerobic to anaerobic transition
Source Database: Reslit
Mechanism: regulation
Confers Resistance To: ciprofloxacintrimethoprim
Organisms Tested In: • Escherichia coli
Validation Method: gene knockout and CRISPRi experiments
Sequence Accession: WWEV00000000.1|MSDR00000000.1|WWEX00000000.1|WWEY00000000.1

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fnr

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fnr

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