Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
dihydropteroate synthase
Overview
| Protein Change | Nucleotide Change | Mechanism | Organism | Resistance To | Database | Validation Status |
|---|---|---|---|---|---|---|
| F17L | Primary mutation that is directly associated with sulfonamide resistance, dihydropteroate synthase FolP | Staphylococcus aureus | sulfamethoxazolesulfonamides | Reference Gene CatalogReslit | Confirmed | |
| T184A | - | - | Elizabethkingia anophelis | trimethoprim sulfamethoxazole | Reslit | Candidate |
| L186F | - | - | Campylobacter jejuni | sulfonamides | Reslit | Candidate |
| D238N | - | - | Campylobacter jejuni | sulfonamides | Reslit | Candidate |
| N245K | - | - | Campylobacter jejuni | sulfonamides | Reslit | Candidate |
| F246Y | - | - | Campylobacter jejuni | sulfonamides | Reslit | Candidate |
| R171P | - | single resistance variant, dihydropteroate synthase FolP | Salmonella Gallinarum, Salmonella enterica | sulfonamides | Card DatabaseReference Gene CatalogReslit | Confirmed |
| F28L | - | dihydropteroate synthase FolP | Salmonella Gallinarum, Escherichia coli, Salmonella enterica | sulfonamidessulfamethoxazole | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| F28I | - | dihydropteroate synthase FolP | Salmonella Gallinarum, Escherichia coli, Salmonella enterica | sulfonamidessulfamethoxazole | Reference Gene CatalogResFinder DatabaseReslit | Confirmed |
| L10I | - | - | Elizabethkingia anophelis | trimethoprim sulfamethoxazole | Reslit | Candidate |
| T52A | - | - | Elizabethkingia anophelis | trimethoprim sulfamethoxazole | Reslit | Candidate |
| N171D | - | - | Elizabethkingia anophelis | trimethoprim sulfamethoxazole | Reslit | Candidate |
| L174I | - | - | Elizabethkingia anophelis | trimethoprim sulfamethoxazole | Reslit | Candidate |
| S18L | - | Primary mutation that is directly associated with sulfonamide resistance, dihydropteroate synthase FolP | Staphylococcus aureus | sulfonamides | Reference Gene CatalogReslit | Confirmed |
| T51M | - | Primary mutation that is directly associated with sulfonamide resistance, dihydropteroate synthase FolP | Staphylococcus aureus | sulfonamides | Reference Gene CatalogReslit | Confirmed |
| E208K | - | Secondary mutation that is only found in the presence of the primary mutations, dihydropteroate synthase FolP | Staphylococcus aureus | sulfonamides | Reference Gene CatalogReslit | Confirmed |
| I100L | - | - | Streptococcus suis | sulfonamides | Reslit | Candidate |
| E20D | - | - | Streptococcus suis | sulfonamides | Reslit | Candidate |
| F31L | - | dihydropteroate synthase FolP | Neisseria gonorrhoeae, Neisseria meningitidis | sulfonamides | Reference Gene CatalogReslit | Confirmed |
| G194C | - | dihydropteroate synthase FolP | Neisseria gonorrhoeae, Neisseria meningitidis | sulfonamides | Reference Gene CatalogReslit | Confirmed |
| R228S | single resistance variant, dihydropteroate synthase FolP | Neisseria gonorrhoeae, Neisseria meningitidis | sulfonamides | Card DatabaseReference Gene CatalogReslit | Confirmed | |
| F211L | - | - | Brucella melitensis | sulfamethoxazole | Reslit | Candidate |
| F4Y | - | - | Escherichia coli | sulfonamides | Reslit | Candidate |
| A247T | - | - | Escherichia coli | sulfonamides | Reslit | Candidate |
| P64S | - | single resistance variant, dihydropteroate synthase FolP | Escherichia coli | sulfamethoxazolesulfonamides | Card DatabaseReference Gene CatalogResFinder Database | Confirmed |
| P64H | - | single resistance variant, dihydropteroate synthase FolP | Escherichia coli | sulfonamides | Card DatabaseReference Gene Catalog | Confirmed |
| P64L | - | single resistance variant, dihydropteroate synthase FolP | Escherichia coli | sulfonamides | Card DatabaseReference Gene Catalog | Confirmed |
| P64R | - | single resistance variant, dihydropteroate synthase FolP | Escherichia coli | sulfonamides | Card DatabaseReference Gene Catalog | Confirmed |
| P64A | - | single resistance variant, dihydropteroate synthase FolP | Escherichia coli | sulfonamides | Card DatabaseReference Gene Catalog | Confirmed |
| V48F | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| V48G | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| R54G | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| P55A | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| P55H | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| P55L | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| T53I | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| T53A | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| P55R | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| P55S | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| T53P | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| T53N | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| P55T | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| V48A | - | single resistance variant | Mycobacterium leprae | dapsone | Card Database | Established |
| F25I | - | single resistance variant, dihydropteroate synthase FolP | Streptococcus pyogenes | sulfonamides | Card DatabaseReference Gene Catalog | Confirmed |
| P64PSFLY | - | dihydropteroate synthase FolP | Haemophilus influenzae | sulfonamides | Reference Gene Catalog | Established |
| G189C | - | dihydropteroate synthase FolP | Haemophilus influenzae | sulfonamides | Reference Gene Catalog | Established |
| G194GSG | - | dihydropteroate synthase FolP | Neisseria gonorrhoeae, Neisseria meningitidis | sulfonamides | Reference Gene Catalog | Established |
| P68A | - | dihydropteroate synthase FolP | Neisseria meningitidis | sulfonamides | Reference Gene Catalog | Established |
| P68L | - | dihydropteroate synthase FolP | Neisseria meningitidis | sulfonamides | Reference Gene Catalog | Established |
| P68S | - | dihydropteroate synthase FolP | Neisseria meningitidis | sulfonamides | Reference Gene Catalog | Established |
| R228T | - | dihydropteroate synthase FolP | Neisseria meningitidis | sulfonamides | Reference Gene Catalog | Established |
| A184V | - | dihydropteroate synthase FolP | Staphylococcus aureus | sulfonamides | Reference Gene Catalog | Established |
| E258EKE | - | dihydropteroate synthase FolP | Staphylococcus aureus | sulfonamides | Reference Gene Catalog | Established |
| R213G | - | dihydropteroate synthase FolP | Streptococcus pyogenes | sulfonamides | Reference Gene Catalog | Established |
| - | - | Streptococcus pneumoniae | trimethoprim sulfamethoxazole | Reslit | Candidate | |
| T66M | - | - | sulfonamides | Reslit | Candidate | |
| - | - | Neisseria meningitidis | sulfonamides | Reslit | Candidate | |
| - | - | - | sulfonamides | Reslit | Candidate |
Integrative Analysis of Whole Genome Sequencing and Phenotypic Resistance Toward Prediction of Trimethoprim-Sulfamethoxazole Resistance in Staphylococcus aureus.
Research Article
mutations in chromosomal gene folP are responsible for SMZ resistance
Elizabethkingia Intra-Abdominal Infection and Related Trimethoprim-Sulfamethoxazole Resistance: A Clinical-Genomic Study.
Research Article
The T184A mutation was significantly associated with TMP/SMX resistance.
Sulfonamide Resistance in Clinical Isolates of Campylobacter jejuni: Mutational Changes in the Chromosomal Dihydropteroate Synthase
Research Article
Four amino acid residues associated with sulfonamide resistance in C. jejuni
Analysis of random mutations in Salmonella Gallinarum dihydropteroate synthase conferring sulfonamide resistance.
Research Article
Mutations in folP confer sulfonamide resistance
Salmonella gallinarum folP with mutation conferring resistance to sulfonamides; CARD accession: CARD:3007749
folP
Whole-genome sequence and resistance determinants of four Elizabethkingia anophelis clinical isolates collected in Hanoi, Vietnam.
Research Article
Multiple mutations in folP gene affecting sulfonamide resistance.
The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Staphylococcus aureus Dihydropteroate Synthase.
Research Article
Mutations were identified in the folP gene encoding dihydropteroate synthase (DHPS) and were associated with sulfonamide resistance.
folP
How Streptococcus suis escapes antibiotic treatments.
Review
Mutations in folP lead to sulfonamide resistance in streptococci.
Continuing genomic evolution of the Neisseria meningitidis cc11.2 urethritis clade, NmUC: a narrative review.
Review
Whole-genome sequencing and antimicrobial resistance in Brucella melitensis from a Norwegian perspective.
Research Article
Mutation in folP was not associated with sulfamethoxazole resistance as determined by phenotypic testing.
Whole Genome Sequencing and Characterization of Multidrug-Resistant (MDR) Bacterial Strains Isolated From a Norwegian University Campus Pond.
Research Article
The novel 2024 WHO Neisseria gonorrhoeae reference strains for global quality assurance of laboratory investigations and superseded WHO N. gonorrhoeae reference strains-phenotypic, genetic and reference genome characterization.
Research Article
carried R228S mutation leading to sulfonamide resistance
Cloning, sequencing, and enhanced expression of the dihydropteroate synthase gene of Escherichia coli MC4100.
Research Article
Sulfonamide resistance in Neisseria meningitidis as defined by site-directed mutagenesis could have its origin in other species.
Research Article
folP
Characterization of mutations contributing to sulfathiazole resistance in Escherichia coli.
Research Article
Escherichia coli folP with mutation conferring resistance to sulfonamides; CARD accession: CARD:3003386
Mutation analysis of the Mycobacterium leprae folP1 gene and dapsone resistance.
Research Article
Mycobacterium leprae folP with mutation conferring resistance to dapsone; CARD accession: CARD:3003389
Multidrug resistant Mycobacterium leprae from patients with leprosy.
Research Article
Mycobacterium leprae folP with mutation conferring resistance to dapsone; CARD accession: CARD:3003389
Mutations in genes related to drug resistance in Mycobacterium leprae isolates from leprosy patients in Korea.
Research Article
Mycobacterium leprae folP with mutation conferring resistance to dapsone; CARD accession: CARD:3003389
The impact of antimicrobials on gonococcal evolution.
Research Article
Neisseria gonorrhoeae folP with mutation conferring resistance to sulfonamides; CARD accession: CARD:3004873
Sulfonamide resistance in Streptococcus pyogenes is associated with differences in the amino acid sequence of its chromosomal dihydropteroate synthase.
Research Article
Streptococcus pyogenes folP with mutation conferring resistance to sulfonamides; CARD accession: CARD:3003387
folP
Multiple interspecies recombination events documented by whole-genome sequencing in multidrug-resistant Haemophilus influenzae clinical isolates.
Research Article
folP
Assessment of trimethoprim-sulfamethoxazole susceptibility testing methods for fastidious Haemophilus spp.
Research Article
folP
Mutations in folP associated with elevated sulfonamide MICs for Neisseria meningitidis clinical isolates from five continents.
Research Article
folP
mutations in folP associated with elevated sulfonamide MICs
Progression of antibiotic resistance in Neisseria meningitidis.
Review
folP
Clinical significance of Aeromonas species isolated from patients with diarrhea.
Research Article
folP
Resistance to antibacterial antifolates in multidrug-resistant Staphylococcus aureus: prevalence estimates and genetic basis.
Research Article
folP
Mutations and horizontal transmission have contributed to sulfonamide resistance in Streptococcus pyogenes.
Research Article
folP
Oxygen-induced mitochondrial damage and aging.
Review
folP
Antimicrobial resistance determinants and susceptibility profiles of pneumococcal isolates recovered in Trinidad and Tobago.
Research Article
One to two codon insertions within the folP gene result in an intermediate phenotype (MIC 1–2 mg/L) against SXT; when combined with the folA substitution I100L, they result in a resistant phenotype (MIC ≥ 4 mg/L).
Antimicrobial Resistance Profiling and Phylogenetic Analysis of Neisseria gonorrhoeae Clinical Isolates From Kenya in a Resource-Limited Setting.
Research Article
Methicillin-resistant Staphylococcus aureus outbreak in a Dutch equine referral clinic.
Research Article
Evidence for soft selective sweeps in the evolution of pneumococcal multidrug resistance and vaccine escape.
Research Article
insertion shortly after S61 in folP leads to sulfonamide resistance