fosA12

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glutathione S-transferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to fosA12

AMR Rules

Browse AMR rules for fosA12

Validation StatusConfirmed2+ DBs

Overview

Validation Method: whole genome sequencing and MIC testing
Drug Classes: fosfomycin, FOSFOMYCIN
Organisms: Klebsiella pneumoniae, Proteus terrae subsp. cibarius
Geographic Location: India
Papers: 2
Databases: Reference Gene CatalogReslit

Papers2

Multiple mutations in lipid-A modification pathway & novel fosA variants in colistin-resistant Klebsiella pneumoniae.

PMID 30112189 · 2018

The study identifies novel and rare mutations in the arnT and eptA genes involved in lipid A modification pathways, along with novel fosA variants, contributing to colistin resistance in Klebsiella pneumoniae.

Gene Information

Gene Name: fosA12
Allele: FosA12
Encodes: glutathione S-transferase
Source Database: Reslit
Confers Resistance To: fosfomycin
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: India
Validation Method: whole genome sequencing and MIC testing
Sequence Accession: MNPB00000000|MNPC00000000|MNPD00000000|MNPG00000000|MNPH00000000|MNPF00000000|MNPE00000000|MNPA00000000

Identification and characteristics of a novel fosfomycin glutathione transferase, FosA12, from an MDR clinical isolate of Proteus vulgaris.

PMID 41984079 · 2026

Gene Information

Gene Name: fosA12
Allele: FosA12
Encodes: fosfomycin resistance glutathione transferase FosA12
Source Database: Reference Gene Catalog
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Proteus terrae subsp. cibarius
Sequence Accession: PQ518868.1
Protein Accession: XKC16833.1

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fosA12

View on PubMed

glutathione S-transferase

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

UniProt

Protein entries specific to fosA12

AMR Rules

Browse AMR rules for fosA12

Validation StatusConfirmed2+ DBs

Overview

Validation Method: whole genome sequencing and MIC testing
Drug Classes: fosfomycin, FOSFOMYCIN
Organisms: Klebsiella pneumoniae, Proteus terrae subsp. cibarius
Geographic Location: India
Papers: 2
Databases: Reference Gene CatalogReslit

Papers2

Multiple mutations in lipid-A modification pathway & novel fosA variants in colistin-resistant Klebsiella pneumoniae.

PMID 30112189 · 2018

Gene Information

Gene Name: fosA12
Allele: FosA12
Encodes: glutathione S-transferase
Source Database: Reslit
Confers Resistance To: fosfomycin
Organisms Tested In: • Klebsiella pneumoniae
Geographic Location: India
Validation Method: whole genome sequencing and MIC testing
Sequence Accession: MNPB00000000|MNPC00000000|MNPD00000000|MNPG00000000|MNPH00000000|MNPF00000000|MNPE00000000|MNPA00000000

Identification and characteristics of a novel fosfomycin glutathione transferase, FosA12, from an MDR clinical isolate of Proteus vulgaris.

PMID 41984079 · 2026

Gene Information

Gene Name: fosA12
Allele: FosA12
Encodes: fosfomycin resistance glutathione transferase FosA12
Source Database: Reference Gene Catalog
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Proteus terrae subsp. cibarius
Sequence Accession: PQ518868.1
Protein Accession: XKC16833.1

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No comments yet. Be the first to comment!

fosA12

Gene Information

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fosA12

Gene Information

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