fosB
fosfomycin resistance protein
NCBI Pathogen Isolates
Bacterial genomes carrying this gene
NCBI Reference Gene Catalog
Known alleles and reference sequences
UniProt
Protein entries specific to fosB
AMR Rules
Browse AMR rules for fosB
Validation StatusCandidate
Overview
- Validation Method
- expression in E. coli and MIC testing
- Drug Classes
- fosfomycin
- Organisms
- Bacillus subtilis, Escherichia coli, Staphylococcus aureus
- Papers
- 2
- Databases
- Reslit
Papers2
1
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
The study identifies fosB as a gene encoding a fosfomycin resistance protein in Bacillus subtilis, regulated by sigma(W). Expression of fosB in E. coli confers fosfomycin resistance.
Gene Information
- Gene Name
- fosB
- Allele
- fosB
- Encodes
- fosfomycin resistance protein
- Source Database
- Reslit
- Confers Resistance To
- fosfomycin
- Organisms Tested In
- • Bacillus subtilis• Escherichia coli
- Validation Method
- expression in E. coli and MIC testing
2
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
The study identified resistance genes such as blaZ, mecA, and far1 in Staphylococcus aureus strains, highlighting the role of mobile genetic elements in the spread of drug resistance.
Gene Information
- Gene Name
- fosB
- Allele
- fosB
- Encodes
- fosfomycin resistance protein
- Source Database
- Reslit
- Confers Resistance To
- fosfomycin
- Organisms Tested In
- • Staphylococcus aureus
- Validation Method
- sequencing
- Sequence Accession
- NC_002950|NC_003923|BX571856|BX571857|BX571858
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