Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
FosB family fosfomycin resistance bacillithiol transferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| fosB | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 80 | FOSFOMYCIN, fosfomycin | Staphylococcus epidermidis BCM-HMP0060 +47 | Belgium, Australia, Kuwait, Russia, Germany|Egypt|Brazil|Chile|Vietnam|Russia|Belarus|Thailand, London, UK, global, Germany, Brazil, Nigeria, Hungary, Pacific region|Hawaii, Canada|United States, North America|Asia|Europe|Australia|South America, South Africa|Nigeria, United States, North America|South America|Europe|Asia|Africa|Oceania, Europe, Algeria, Novosibirsk, Russia, Northern Ghana, Sudan, Europe|United States|Asia, Saudi Arabia, France, Eastern Spain, Malaysia, China|USA|Canada|Germany|Brazil|France|Japan|Ecuador|India|Australia|Taiwan|Hungary|Caribbean|South Africa, China, Benin, International Space Station, Rio de Janeiro, Basrah city, USA, Vermont, Portugal, South Africa, Europe|Spain, Brandenburg, Germany, Bangladesh, Japan, Canterbury, New Zealand, Denmark, Thailand, Southeast Nigeria|Nigeria, East Africa | 1991, 2001, 2004, 2013, 2014, 2015, 2016, 2017, 2018, 2019, 2020, 2021, 2022, 2023, 2024, 2025 | ACHE01000077.1 | EES57597.1 |
| FosBx1 | Card DatabaseReference Gene CatalogReslit | 6 | FOSFOMYCIN, PHOSPHONIC ACID ANTIBIOTIC +1 | Bacillus thuringiensis BMB171 +4 | Egypt, Europe | 2024, 2025 | CP001903.1 | ADH06626.1 |
| Saur_FosB | Card Database | 1 | FOSFOMYCIN, PHOSPHONIC ACID ANTIBIOTIC | Staphylococcus aureus subsp. aureus IS-88 | - | - | AHLO01000073.1 | EHS19134.1 |
| FosB2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | FOSFOMYCIN, fosfomycin | Bacillus anthracis str. Ames +1 | - | 2003, 2020 | AE016879.1 | AAP27834.1 |
| fosB2 | ResFinder Database | 1 | FOSFOMYCIN | Bacillus anthracis str. Ames | - | 2003 | AE016879 | - |
| FosB | Card DatabaseReference Gene CatalogResFinder Database | 3 | FOSFOMYCIN, PHOSPHONIC ACID ANTIBIOTIC | Staphylococcus epidermidis +1 | - | 1991 | X54227.1 | CAA38136.1 |
| fosB1 | ResFinder Database | 1 | FOSFOMYCIN | Bacillus thuringiensis BMB171 | - | 2010 | CP001903 | - |
| FosB3 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 5 | fosfomycin, FOSFOMYCIN | Enterococcus faecium +2 | China, Brazil | 2013, 2021 | HQ219726|PRJNA206216 | ADX95999.1 |
| fosB3 | ResFinder Database | 1 | FOSFOMYCIN | Enterococcus faecium | - | 2013 | HQ219726 | - |
| FosB4 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | fosfomycin, FOSFOMYCIN | Staphylococcus aureus | Shanghai | 2016 | KR870311|KT032253|KR870314 | ALM24139.1 |
| FosB5 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | fosfomycin, FOSFOMYCIN | Staphylococcus aureus | Shanghai | 2016 | KR870311|KT032253|KR870314 | ALN12426.1 |
| FosB6 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 4 | fosfomycin, FOSFOMYCIN | Staphylococcus aureus | Shanghai | 2016 | KR870311|KT032253|KR870314 | ALM24145.1 |
| FosB1 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | FOSFOMYCIN, PHOSPHONIC ACID ANTIBIOTIC +1 | Staphylococcus aureus +8 | Swiss Canton Tessin|various herds|Switzerland, Kuwait, India | 2016, 2023, 2024 | KP795112.1 | AKS12232.1 |
| fosB5 | ResFinder Database | 1 | FOSFOMYCIN | Staphylococcus aureus | - | 2016 | KT032253 | - |
| fosB6 | ResFinder Database | 1 | FOSFOMYCIN | Staphylococcus aureus | - | 2016 | KR870314 | - |
| fosB4 | ResFinder Database | 1 | FOSFOMYCIN | Staphylococcus aureus | - | 2016 | KR870311 | - |
| fosB-Saur | Reslit | 4 | fosfomycin | Staphylococcus aureus +3 | Norway, Paraguay, East China, Europe | 2022, 2024, 2025 | PRJEB53532 | - |
| fosB-sau | Reslit | 1 | fosfomycin | Staphylococcus aureus | Norway | 2022 | PRJEB53532 | - |
| fosB/fosD | Reslit | 1 | fosfomycin | Staphylococcus equorum | Spain | 2023 | NC_005243.1 | - |
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
The study identifies fosB as a gene encoding a fosfomycin resistance protein in Bacillus subtilis, regulated by sigma(W). Expression of fosB in E. coli confers fosfomycin resistance.
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
FosB, a cysteine-dependent fosfomycin resistance protein under the control of sigma(W), an extracytoplasmic-function sigma factor in Bacillus subtilis.
The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.
The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.
The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.
The genome sequence of Bacillus anthracis Ames and comparison to closely related bacteria.
Complete genomes of two clinical Staphylococcus aureus strains: evidence for the rapid evolution of virulence and drug resistance.
The study identified resistance genes such as blaZ, mecA, and far1 in Staphylococcus aureus strains, highlighting the role of mobile genetic elements in the spread of drug resistance.
IS231-MIC231 elements from Bacillus cereus sensu lato are modular.
IS231-MIC231 elements from Bacillus cereus sensu lato are modular.
Anaerobic degradation of 3-hydroxybenzoate by a newly isolated nitrate-reducing bacterium.
Anaerobic degradation of 3-hydroxybenzoate by a newly isolated nitrate-reducing bacterium.
Anaerobic degradation of 3-hydroxybenzoate by a newly isolated nitrate-reducing bacterium., Plasmid-encoded fosfomycin resistance in bacteria isolated from the urinary tract in a multicentre survey., IS231-MIC231 elements from Bacillus cereus sensu lato are modular.
Complete genome sequence of Bacillus thuringiensis mutant strain BMB171.
Mechanistic studies of FosB: a divalent-metal-dependent bacillithiol-S-transferase that mediates fosfomycin resistance in Staphylococcus aureus.
FosB is a divalent-metal-dependent bacillithiol-S-transferase that confers fosfomycin resistance in Staphylococcus aureus. Disruption of BSH biosynthesis increases sensitivity to fosfomycin.
Structural and chemical aspects of resistance to the antibiotic fosfomycin conferred by FosB from Bacillus cereus.
FosB from Bacillus cereus is a Mn2+-dependent bacillithiol-S-transferase that confers resistance to fosfomycin by catalyzing the nucleophilic addition of bacillithiol or L-cysteine to the antibiotic, rendering it inactive.
The fosfomycin resistance gene fosB3 is located on a transferable, extrachromosomal circular intermediate in clinical Enterococcus faecium isolates.
The study identified the fosB3 gene as a novel fosfomycin resistance gene in Enterococcus faecium, which is located on a transferable, extrachromosomal circular intermediate and can mediate high-level fosfomycin resistance in both Gram-positive and Gram-negative bacteria.
The fosfomycin resistance gene fosB3 is located on a transferable, extrachromosomal circular intermediate in clinical Enterococcus faecium isolates.
The fosfomycin resistance gene fosB3 is located on a transferable, extrachromosomal circular intermediate in clinical Enterococcus faecium isolates.
The fosfomycin resistance gene fosB3 is located on a transferable, extrachromosomal circular intermediate in clinical Enterococcus faecium isolates.
The fosfomycin resistance gene fosB3 is located on a transferable, extrachromosomal circular intermediate in clinical Enterococcus faecium isolates.
Structure and function of the genomically encoded fosfomycin resistance enzyme, FosB, from Staphylococcus aureus.
The study identified FosB as a primary fosfomycin-modifying pathway in Staphylococcus aureus and established its role in resistance through experimental validation.
Epidemiology and molecular characterization of methicillin-resistant Staphylococcus aureus nasal carriage isolates from bovines.
The study identified multiple AMR genes in MRSA isolates from bovines, including blaZ, blaI, blaR, tetM, ermC, aacA-aphD, aadD, aphA3, cat, sdrM, and fosB, which confer resistance to penicillin, tetracycline, erythromycin, gentamicin, kanamycin, chloramphenicol, and fosfomycin.
Comparative genomics of non-pseudomonal bacterial species colonising paediatric cystic fibrosis patients.
The study analyzed non-pseudomonal bacterial species from pediatric cystic fibrosis patients, identifying several AMR genes and mutations. Key findings include the presence of beta-lactamase genes (blaZ, blaI, blaRI) in Staphylococcus aureus, fosfomycin resistance gene fosB, fusidic acid resistance gene fusC, and efflux pumps smeZ, smeJ, and smeK in Stenotrophomonas maltophilia. Additionally, Enterobacter cloacae isolates carried resistance genes qacE delta 1, sul1, and dfrA5.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
The study identifies three novel fosB subtypes (fosB4, fosB5, and fosB6) in methicillin-resistant Staphylococcus aureus isolates that confer fosfomycin resistance.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
The study identifies three novel fosB subtypes (fosB4, fosB5, and fosB6) in methicillin-resistant Staphylococcus aureus isolates that confer fosfomycin resistance.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
The study identifies three novel fosB subtypes (fosB4, fosB5, and fosB6) in methicillin-resistant Staphylococcus aureus isolates that confer fosfomycin resistance.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Characterization of Fosfomycin Resistance Gene, fosB, in Methicillin-Resistant Staphylococcus aureus Isolates.
Complete Genome Sequence of a Novel Bacillus sp. VT 712 Strain Isolated from the Duodenum of a Patient with Intestinal Cancer.
The complete genome sequence of Bacillus sp. VT 712 reveals several antibiotic resistance genes, including those encoding resistance to vancomycin (vanZ, vanB, vanW), tetracycline (tet(A)), fosfomycin (fosB), multidrug resistance efflux pumps (including acrB), beta-lactamases, and the quaternary ammonium compound resistance protein sugE.
Shifts in the Clonal Distribution of Methicillin-Resistant Staphylococcus aureus in Kuwait Hospitals: 1992-2010.
The study identified various AMR genes in MRSA isolates from Kuwait hospitals, including aphA3, aacA-aphD, ermA, ermC, mupA, tetK, tetM, fusC, far1, msrA, mphC, sat, qacA, qacC, merA, merB, dfrS1, aadD, fosB, cat, sdrM, icaA, icaC, and icaD, which conferred resistance to multiple antibiotics.
Complete Circular Genome Sequence of Successful ST8/SCCmecIV Community-Associated Methicillin-Resistant Staphylococcus aureus (OC8) in Russia: One-Megabase Genomic Inversion, IS256's Spread, and Evolution of Russia ST8-IV.
The study identified specific mutations in gyrA and grlA genes contributing to levofloxacin resistance, as well as the fosB gene associated with fosfomycin resistance in the ST8/SCC mec IVc MRSA strain OC8.
Variety of Antimicrobial Resistances and Virulence Factors in Staphylococcus aureus Isolates from Meat Products Legally and Illegally Introduced to Germany.
The study identified multiple antimicrobial resistance genes and mutations in Staphylococcus aureus isolates from meat products, including resistance to β-lactams, macrolides, aminoglycosides, tetracyclines, and others.
Fosfomycin: Mechanism and Resistance.
The paper discusses the mechanisms of fosfomycin resistance, including the identification of fosfomycin-modifying enzymes such as FosA, FosB, FosX, and FosA3, which inactivate fosfomycin and contribute to resistance in various bacterial species.
Genome-Wide Identification of Antimicrobial Intrinsic Resistance Determinants in Staphylococcus aureus.
The study identifies multiple intrinsic resistance determinants in Staphylococcus aureus, including genes such as atpA, rpsT, vraG, and mecA, which contribute to resistance against various antimicrobial agents. These findings highlight potential targets for developing antimicrobial potentiators.
Genome-wide mutant profiling predicts the mechanism of a Lipid II binding antibiotic.
The study identifies several AMR genes involved in resistance to various antibiotics, including murA, murJ, fabI, norA, lmrB2/3, emrA, yhgE, lmrB2, fosB, uppP, vraRS, and mprF, through Tn-seq data and upregulation signatures.
Whole Genome Sequence and Comparative Genomics Analysis of Multi-drug Resistant Environmental Staphylococcus epidermidis ST59.
The study identifies several antibiotic resistance genes in the multidrug-resistant S. epidermidis strain G6_2, including aac(6')-aph(2"), blaZ, mecA, fosB, mphC, msrA, tetK, and qacC, which confer resistance to various antibiotics. Additionally, point mutations in ileS and fusA are associated with resistance to mupirocin and fusidic acid.
Antimicrobial Resistance in Staphylococci of Animal Origin
The paper discusses various antimicrobial resistance genes and mutations in staphylococci of animal origin, highlighting their roles in resistance to multiple antibiotics such as macrolides, lincosamides, streptogramins, oxazolidinones, and others. Key genes include erm, msr, mph, ere, lnu, vga, cfr, optrA, dfr, fus, ileS2, blaZ, aadD, ble, fosD, fosB, czrC, and qac genes, which confer resistance to specific antibiotics and are prevalent in different staphylococcal species.
Taxonomic Distribution of FosB in Human-Microbiota and Activity Comparison of Fosfomycin Resistance.
This study elucidated the taxonomic distribution and resistance capabilities of FosB in the human microbiota, highlighting its role in conferring resistance to fosfomycin.
Antibiotics resistance and toxin profiles of Bacillus cereus-group isolates from fresh vegetables from German retail markets.
The study identified several AMR genes in Bacillus cereus-group isolates from fresh vegetables, including fosB, ykkC, lsaB, and tet(45). These genes were found to confer resistance to various antibiotics such as fosfomycin, tetracycline, and erythromycin.
Milk microbial composition of Brazilian dairy cows entering the dry period and genomic comparison between Staphylococcus aureus strains susceptible to the bacteriophage vB_SauM-UFV_DC4.
The study identified the presence of the beta-lactamase gene blaZ in Staphylococcus aureus strains, which conferred resistance to ampicillin. The MIC assay showed higher resistance levels in the strains compared to the resistance breakpoints.
Antimicrobial Resistance and Virulence of Methicillin-Resistant Staphylococcus aureus from Human, Chicken and Environmental Samples within Live Bird Markets in Three Nigerian Cities.
The study identified various antimicrobial resistance genes in MRSA isolates from human, chicken, and environmental samples in Nigerian live bird markets, highlighting the presence of multidrug-resistant strains and the potential public health risks associated with their dissemination.
Benchmarking hybrid assembly approaches for genomic analyses of bacterial pathogens using Illumina and Oxford Nanopore sequencing.
The study compared hybrid assembly approaches for bacterial pathogen genomes and identified AMR genes such as blaZ, msr(A), and tet(K) in Staphylococcus aureus.
Exploring antibiotic resistance in environmental integron-cassettes through intI-attC amplicons deep sequencing.
The study identified several antibiotic resistance genes (ARGs) in environmental integron-cassettes from the Velhas River, including clinically relevant genes such as blaGES-5, aacA7, dfrA21, qacH, emrE, fosB3, and novA. These genes were associated with various resistance mechanisms, primarily efflux pumps and inactivation.
Whole genome sequencing of coagulase positive staphylococci from a dog-and-owner screening survey.
The study identified several AMR genes in Staphylococcus aureus isolates, including blaZ, tet(K), norA, lmrS, mepR, and fosB, which confer resistance to penicillin, tetracycline, fluoroquinolones, and fosfomycin. No resistance genes were found in S. pseudintermedius isolates.
A Longitudinal Evaluation of the Bacterial Pathogens Colonizing Chronic Non-Healing Wound Sites at a United States Military Treatment Facility in the Pacific Region.
The study identified multiple antimicrobial resistance genes in bacterial isolates from chronic non-healing wounds, including beta-lactamases, aminoglycoside modifying enzymes, macrolide resistance genes, and others. These genes were found in various bacterial species such as E. coli, S. aureus, P. aeruginosa, and others.
Full pathogen characterisation: species identification including the detection of virulence factors and antibiotic resistance genes via multiplex DNA-assays.
The study presents a DNA microarray-based assay for the simultaneous detection of 44 sepsis-relevant bacterial pathogens, 360 virulence factors, and 409 antibiotic resistance genes. The assay was evaluated with 14 multidrug-resistant strains, including all ESKAPE pathogens.
Phenotypic and Genomic Profiling of Staphylococcus argenteus in Canada and the United States and Recommendations for Clinical Result Reporting.
The study characterizes the antimicrobial resistance genes and mutations in Staphylococcus argenteus isolates from North America, highlighting the presence of mecA, mgrA, arlR, mepR, blaZ, fosB, lmrS, and aac(6')-Ie-APH(2')-Ia, which confer resistance to various antibiotics.
A platform for detecting cross-resistance in antibacterial drug discovery.
The study presents a cross-resistance platform (CRP) consisting of 28 Staphylococcus aureus strains with defined resistance genotypes, designed to detect cross-resistance between established and novel antibacterial agents. The CRP includes various AMR genes and mutations that confer resistance to multiple antibiotic classes.
Genomic diversity and molecular epidemiology of Pasteurella multocida.
This study identified several antimicrobial resistance genes in Pasteurella multocida, including aminoglycoside, beta-lactam, tetracycline, macrolide, and sulfonamide resistance genes, highlighting the diverse resistance mechanisms present in this pathogen.
Analysis of Genome Sequences of Coagulase-Negative Staphylococci Isolates from South Africa and Nigeria Highlighted Environmentally Driven Heterogeneity.
The study identified several AMR genes in coagulase-negative staphylococci isolates from South Africa and Nigeria, highlighting environmentally driven heterogeneity. Notably, the tetM gene was found in South African isolates but not in Nigerian ones, while cadmium resistance genes were present in Nigerian isolates. Other genes like blaZ, FosB, mecA, FusF, dfrG, ErmA, ErmB, Erm(43), and mphC were also characterized.
Analysis of Virulence and Antimicrobial Resistance Gene Carriage in Staphylococcus aureus Infections in Equids Using Whole-Genome Sequencing.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from equids, including blaZ, mupA, lnuA, tetK, tetL, tetM, norA, dfrC, dfrG, dfrK, ermA, ermC, msrA, mphC, qacA/B, qacC, and fosB. An isolate (17-021) was found to carry the lnuA gene and mupA plasmid, conferring resistance to clindamycin and mupirocin. A mutation in the prs gene was associated with phenotypic susceptibility to β-lactam drugs in a mecA-positive isolate.
The roles of antimicrobial resistance, phage diversity, isolation source and selection in shaping the genomic architecture of Bacillus anthracis.
The study identifies ten AMR genes in B. anthracis, highlighting their distribution across global isolates and their association with population genomic structure. Key genes include mph L, bla 1, fos B, bla 2, vml R, bcII, tem -116, cfr C, dfr G, and oxa -59, each with distinct resistance mechanisms and geographic prevalence.
First Report of the Plasmid-mediated fosB Gene in Enterococcus faecalis from Pigs.
The study reports the first plasmid-mediated fosB gene in Enterococcus faecalis from pigs, highlighting its role in fosfomycin resistance and the co-occurrence with optrA, posing a public health threat.
First Report of CC5-MRSA-IV-SCCfus "Maltese Clone" in Bat Guano.
The study reports the first isolation of CC5-MRSA-IV-SCCfus 'Maltese Clone' from bat guano in Algeria, highlighting the presence of fusidic acid resistance element fusC, fosfomycin resistance gene fosB, and penicillinase gene blaZ in the MRSA isolates.
Antibiotic Resistance and Pathogenomics of Staphylococci Circulating in Novosibirsk, Russia.
The study identified several AMR genes in Staphylococcus isolates from Novosibirsk, Russia, including mecA, blaZ, aac(6')-Ie-aph(2'')-Ia, ant(4')-Ia, aph(3')-IIIa, ermA, ermC, msrA, norA, dfrC, fosB, and mphC, which confer resistance to beta-lactams, aminoglycosides, macrolides, quinolones, and other antibiotics.
Comparative Analysis of Bacillus cereus Group Isolates' Resistance Using Disk Diffusion and Broth Microdilution and the Correlation between Antimicrobial Resistance Phenotypes and Genotypes.
The study identified several antimicrobial resistance genes in Bacillus cereus group isolates, including beta-lactamase-encoding genes (bla1, blaZ, blaTEM), mph for erythromycin resistance, rph for rifampicin resistance, and fosB for fosfomycin resistance. These genes were detected using ABRIcate and MEGARes 2.0 database, and their association with resistance phenotypes was analyzed.
Antimicrobial resistance and genomic analysis of staphylococi isolated from livestock and farm attendants in Northern Ghana.
The study identified several AMR genes in staphylococci from livestock and farm attendants in Northern Ghana, including mecA1, mecA, tet(K), tet(L), tet(M), cat(pC221), sal(A), aadD, dfrK, dfrG, erm(B), fosB, aac(6')-aph(2''), and blaZ, which confer resistance to various antibiotics such as beta-lactams, tetracyclines, chloramphenicol, aminoglycosides, and macrolides.
Whole-Genome Sequence of Multidrug-Resistant Methicillin-Resistant Staphylococcus epidermidis Carrying Biofilm-Associated Genes and a Unique Composite of SCCmec.
The study identified multiple antimicrobial resistance genes in multidrug-resistant methicillin-resistant Staphylococcus epidermidis isolates, including mecA, blaZ, fusB, fosB, aadD, aac(6')-aph(2"), tet(K), dfrG, msr(A), and qacA. These genes contribute to resistance against various antibiotics such as methicillin, penicillin, fusidic acid, fosfomycin, aminoglycosides, tetracycline, trimethoprim, macrolides, and chlorhexidine.
Molecular Mechanisms of Drug Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of drug resistance in Staphylococcus aureus, focusing on beta-lactam, glycopeptide, oxazolidinone, MLS-B, aminoglycoside, and other resistance mechanisms. Key genes identified include blaZ, mecA, mecC, vanA, cfr, ermA, ermC, aac(6')-Ib, aph(3')-IIIa, and aadD. Mutations in pbp2 and pbp2a were also found to contribute to resistance.
Methicillin Resistant Staphylococci Isolated from Goats and Their Farm Environments in Saudi Arabia Genotypically Linked to Known Human Clinical Isolates: a Pilot Study.
The study identified several AMR genes in methicillin-resistant staphylococci isolates from goats and their farm environments in Saudi Arabia, including mecA, blaZ, norA, lmrS, mepA, mepR, arlR, arlS, tet(38), mecR1, dfrC, fusC, fosB, fexA, tetM, msrA, mphC, fusB, APH(3′)-IIIa, tetK, and dfrG. These genes confer resistance to various antibiotics such as penicillins, fluoroquinolones, aminoglycosides, macrolides, phenicols, diaminopyrimidines, oxazolidinones, tetracyclines, and fosfomycin.
Antibiotic resistance in plant growth promoting bacteria: A comprehensive review and future perspectives to mitigate potential gene invasion risks.
This review highlights the prevalence of antibiotic resistance genes (ARGs) in plant growth-promoting bacteria (PGPB) and emphasizes the potential risks of ARG dissemination through biofertilizers. Key findings include the identification of various ARGs such as bacA, fosB, ermD, bl2a, vanSA, cat, acrD, mexF, mexD, mexW, mexE, mexY, mexX, mexZ, mexR, mexA, mexB, mexC, mexD, mexE, and mexF, which confer resistance to multiple antibiotics.
Molecular Basis of Non-β-Lactam Antibiotics Resistance in Staphylococcus aureus.
The paper discusses the molecular mechanisms of resistance to non-beta-lactam antibiotics in Staphylococcus aureus, highlighting the roles of various genes and mutations in conferring resistance to macrolides, lincosamides, aminoglycosides, glycopeptides, oxazolidinones, lipopeptides, fluoroquinolones, and other antibiotics.
Phenotypic and genomic assessment of the potential threat of human spaceflight-relevant Staphylococcus capitis isolates under stress conditions.
All four Staphylococcus capitis strains were found to be resistant to fosfomycin, with no significant differences in antibiotic susceptibility among the strains.
Phenotypic and Genotypic Virulence Characterisation of Staphylococcus pettenkoferi Strains Isolated from Human Bloodstream and Diabetic Foot Infections.
The study characterizes several AMR genes and mutations in Staphylococcus pettenkoferi strains, including blaZ, mecA, ant(9)-Ia, tet(K), ermA, vgaA, and fosB, as well as mutations in rpoB, gyrA, glrA, and grlB.
ggMOB: Elucidation of genomic conjugative features and associated cargo genes across bacterial genera using genus-genus mobilization networks.
The study identifies various conjugative features and associated cargo genes, highlighting the significant role of conjugation in the spread of antimicrobial resistance (AMR) across bacterial genera. Key AMR genes such as Tn916, CTn341, SXT, ICEEc2, ICEclc, Tn1549, and Tn4555 were found to be prevalent in conjugative genomes, demonstrating their involvement in the dissemination of resistance traits.
A culture-, amplification-independent, and rapid method for identification of pathogens and antibiotic resistance profile in bovine mastitis milk.
The study identified AMR genes such as tet(38), fosB-Saur, and blaZ in bovine mastitis milk using a rapid, culture-independent method involving MinION nanopore sequencing and optimized DNA isolation protocols.
A culture-, amplification-independent, and rapid method for identification of pathogens and antibiotic resistance profile in bovine mastitis milk.
The study identified AMR genes such as tet(38), fosB-Saur, and blaZ in bovine mastitis milk using a rapid, culture-independent method involving MinION nanopore sequencing and optimized DNA isolation protocols.
Genomic Characterization of Staphylococcus aureus in Wildlife.
The study identified several AMR genes in S. aureus isolates from wildlife in Eastern Spain, including blaZ, mecA, mecC, and fosB, which confer resistance to penicillin, methicillin, and fosfomycin. These findings highlight the potential of wildlife as a reservoir for clinically relevant AMR strains.
Complete Genome Sequence and Analysis of a ST573 Multidrug-Resistant Methicillin-Resistant Staphylococcus aureus SauR3 Clinical Isolate from Terengganu, Malaysia.
The study identifies multiple antimicrobial resistance genes in the multidrug-resistant S. aureus isolate SauR3, including blaZ, mecA, norA, norC, sdrM, ermC, lmrS, msrA, mphC, aph(3′)-IIIa, aadE, aac(6′)Ie-aph(2″)Ia, fosB, and SAT-4, contributing to resistance against various antibiotics.
Prevalence and Molecular Characterization of Methicillin-Resistant Staphylococcaceae (MRS) and Mammaliicocci (MRM) in Dromedary Camels from Algeria: First Detection of SCCmec-mecC Hybrid in Methicillin-Resistant Mammaliicoccus lentus.
The study identified methicillin-resistant Staphylococcus and Mammaliicoccus species in dromedary camels in Algeria, including the first detection of a SCCmec-mecC hybrid in Mammaliicoccus lentus. Key resistance genes identified include mecA, mecC, blaZ, aadD, dfrG, ermB, ermA, msrA, mphC, fosB, fusB, and tet(K).
Fosfomycin Resistance in Bacteria Isolated from Companion Animals (Dogs and Cats).
The study identifies fosA, fosA3, fosB, murA, and glpT as genes conferring fosfomycin resistance in bacteria isolated from companion animals. These genes were experimentally validated in various bacterial species, highlighting the spread of fosfomycin resistance among multidrug-resistant bacteria in pets.
Occurrence, Antibiotic Susceptibility, Biofilm Formation and Molecular Characterization of Staphylococcus aureus Isolated from Raw Shrimp in China.
The study identified multiple antibiotic resistance genes in Staphylococcus aureus isolates from raw shrimp in China, including mecA, mecR1, blaZ, aph(3')-IIIa, aad(6), ANT(4')-Ib, tet(K), mph(C), lnu(A), ermB, ermC, dfrC, dfrG, fosB, SAT-4, rpoB, msr(A), mepA, mepR, norA, mgrA, tet(38), sav1866, arlR, and arlS, which confer resistance to various antibiotics such as beta-lactams, aminoglycosides, tetracyclines, macrolides, lincosamides, streptogramins, trimethoprim, fosfomycin, and others.
Antibiotic Resistance/Susceptibility Profiles of Staphylococcus equorum Strains from Cheese, and Genome Analysis for Antibiotic Resistance Genes.
The study identified several antibiotic resistance genes in Staphylococcus equorum strains from cheese, including blaR1-blaZI, bla, mph(C), msr(A), norA, fosB/fosD, and cat, which confer resistance to various antibiotics such as beta-lactams, macrolides, fluoroquinolones, fosfomycin, and chloramphenicol.
Elucidation of the Bovine Intramammary Bacteriome and Resistome from healthy cows of Swiss dairy farms in the Canton Tessin.
The study identified the presence of the tetracycline resistance gene tetK in Mammaliicoccus sciuri isolates, which was associated with tetracycline resistance. The gene was found on small plasmids, suggesting a potential mechanism for horizontal gene transfer.
Whole-Genome Sequencing-Based Screening of MRSA in Patients and Healthcare Workers in Public Hospitals in Benin.
The study identified multiple AMR genes and mutations in MRSA isolates from Benin, including mecA, aac(6')-Ie/aph(2")-Ia, aph(3')-IIIa, blaI, blaR1, blaZ, mecI, mecR1, fosB, erm(C), mph(C), msr(A), qacC, dfrG, and dfrS1, along with mutations in glpT, murA, gyrA, and parC associated with resistance to various antibiotics.
Antibiotic Resistance Mediated by Escherichia coli in Kuwait Marine Environment as Revealed through Genomic Analysis.
The study identified various antibiotic resistance genes in Escherichia coli isolates from Kuwait's marine environment, including beta-lactamases, aminoglycoside-modifying enzymes, fluoroquinolone resistance genes, sulfonamide resistance genes, tetracycline resistance genes, and macrolide resistance genes. Additionally, the MFS-type drug efflux gene mdfA was commonly found in E. coli isolates.
Phylogenomics, phenotypic, and functional traits of five novel (Earth-derived) bacterial species isolated from the International Space Station and their prevalence in metagenomes.
Five novel bacterial species were isolated from the International Space Station (ISS) and characterized. These species, Arthrobacter burdickii, Leifsonia virtsii, Leifsonia williamsii, Paenibacillus vandeheii, and Sporosarcina highlanderae, were identified through phylogenomic, phenotypic, and functional analyses. Their genomes were sequenced, and they were distinguished from known species using ANI and dDDH values, as well as gyrB gene sequence similarities.
Antimicrobial Resistance Genes in Staphylococcus Species Isolated from Diabetic Foot Ulcers and Healthy Skin
The study identified various antimicrobial resistance genes in Staphylococcus species isolated from diabetic foot ulcers and healthy skin, highlighting the prevalence of resistance to beta-lactams, aminoglycosides, macrolides, tetracyclines, fusidic acid, trimethoprim-sulfamethoxazole, fosfomycin, kanamycin, neomycin, and quaternary ammonium compounds.
Investigation of antimicrobial susceptibility and genetic diversity among Staphylococcus pseudintermedius isolated from dogs in Rio de Janeiro.
The study identified 21 resistance determinants in MRSP and MSSP strains of Staphylococcus pseudintermedius, including genes such as blaZ, sdrM, norA, fosB, ykkcd, sepA, aac(6')-aph(2''), dfrG, aph(3')-III, ant(6)-Ia, sat4, erm(B), aad(6), tet(M), cat(pC221), qacG, tet(K), and qacJ, which confer resistance to various antimicrobials.
Whole genome sequence and comparative genomics analysis of multidrug-resistant Staphylococcus xylosus NM36 isolated from a cow with mastitis in Basrah city.
The study identifies multiple antimicrobial resistance genes in Staphylococcus xylosus NM36, including those conferring resistance to quinolones, teicoplanin, bicyclomycin, chloramphenicol, methicillin, fosfomycin, and others. The genome analysis reveals the presence of efflux pumps, regulatory proteins, and other resistance mechanisms contributing to multidrug resistance.
Characterization of the resistome and predominant genetic lineages of Gram-positive bacteria causing keratitis.
The study characterizes the resistome of Gram-positive bacteria causing keratitis, identifying several AMR genes and mutations associated with resistance to antibiotics such as macrolides, aminoglycosides, tetracyclines, and fluoroquinolones. Key findings include the prevalence of ermA, ermB, ermC, mphC, msrA, msrD, mecA, ant(9)-Ia, ant(4′)-Ib, aac(6′)-aph(2″), aph(3′)-III, fosB, tetK, tetM, dfrG, dfrC, and dfrE genes, along with mutations in gyrA and parC contributing to fluoroquinolone resistance.
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolates from acne patients in Egypt, including blaZ, mecA, tet(K), erm(C), lnuA, vgaA, dfrC, fusB, fosBx1, norA, and vanT. These genes were found to be located on plasmids and chromosomes, indicating a multidrug-resistant profile.
Resistome, mobilome, and virulome explored in clinical isolates derived from acne patients in Egypt: unveiling unique traits of an emerging coagulase-negative Staphylococcus pathogen.
The study identified multiple antibiotic resistance genes in coagulase-negative staphylococci (CoNS) isolates from acne patients in Egypt, including blaZ, mecA, tet(K), erm(C), lnuA, vgaA, dfrC, fusB, fosBx1, norA, and vanT. These genes were found to be located on plasmids and chromosomes, indicating a multidrug-resistant profile.
Genomic epidemiology of the primary methicillin-resistant Staphylococcus aureus clones causing invasive infections in Paraguayan children.
The study identified several AMR genes in MRSA isolates causing invasive infections in Paraguayan children, including mecA, blaZ, ermC, aac(6')-aph(2"), tet(38), cat(pC221), fos-B-Saur, and rphC, which confer resistance to various antibiotics such as methicillin, penicillin, erythromycin, clindamycin, gentamicin, tetracycline, chloramphenicol, and rifampin.
Hybrid Illumina-Nanopore assembly improves identification of multilocus sequence types and antimicrobial resistance genes of Staphylococcus aureus isolated from Vermont dairy farms: comparison to Illumina-only and R9.4.1 nanopore-only assemblies.
The study identified various antimicrobial resistance genes in Staphylococcus aureus isolates from Vermont dairy farms, including beta-lactam resistance genes (blaZ, blaI, blaR), tetracycline resistance genes (tet(K), tet(38)), erythromycin resistance genes (erm(T), erm(A)), lincomycin resistance gene (lnu(G)), aminoglycoside resistance genes (aaC3, ant(9)-la), multidrug resistance efflux pumps (lmrS, mepA, mepR, mepB, norA, norB, arlS, arlR, mgrA), and fosfomycin resistance gene (fosB).
Methicillin-resistant Staphylococcus aureus and coagulase-negative Staphylococcus produce antimicrobial substances against members of the skin microbiota in children with atopic dermatitis.
The study identified two bacteriocin gene clusters, aureocin 4181 in MRSA 23ad and epidermicin NI01 in S. epidermidis 84ad, which are involved in the production of antimicrobial substances that inhibit the growth of other staphylococcal species.
Genetic Complexity of CC5 Staphylococcus aureus Isolates Associated with Sternal Bursitis in Chickens: Antimicrobial Resistance, Virulence, Plasmids, and Biofilm Formation.
The study identified multiple antimicrobial resistance genes in S. aureus isolates from sternal bursitis in chickens, including aph(3')-IIIa, tetK, tet38, ermC, parC, and fosB, which confer resistance to aminoglycosides, tetracyclines, macrolides, fluoroquinolones, and fosfomycin.
Genome analysis of multidrug resistant Enterococcus faecium and Enterococcus faecalis circulating among hospitalized patients in uMgungundlovu District, KwaZulu-Natal, South Africa.
The study identified multiple AMR genes including VanC-1, VanG, Vex2, Vex3, emeA, Isa, ermB, TetM, fosB, ParC, ParE, gyrA, gyrB, MATE, MFS, and pmrA in multidrug-resistant Enterococcus faecium and Enterococcus faecalis. These genes conferred resistance to various antibiotics such as vancomycin, tetracycline, erythromycin, clindamycin, ciprofloxacin, and moxifloxacin.
Genomic analysis of Staphylococcus aureus isolates from bacteremia reveals genetic features associated with the COVID-19 pandemic.
The study identifies several antibiotic resistance genes and mutations in Staphylococcus aureus isolates associated with increased resistance to methicillin, macrolides, and other antibiotics during the COVID-19 pandemic.
High toxinogenic potential of Staphylococcus aureus from wild ungulates in Brandenburg, Germany with a low level of antibiotic resistance.
The study identified the blaZ gene conferring resistance to penicillin and cefoxitin in a Staphylococcus aureus isolate, and the fosB gene associated with fosfomycin resistance in four isolates.
Emergence of Staphylococcus argenteus in pediatrics: Molecular insights from a hospital in East China.
The study identified six antibiotic-resistance genes in the S. argenteus strain 22WJ8192, including blaZ, blaI_of_Z, blaR1, aph(3')-IIIa, tet(38), and fosB-Saur, which conferred resistance to penicillin, amikacin, tetracycline, and fosfomycin. These genes were found to be more prevalent in human-origin strains compared to nonhuman-origin strains.
Antimicrobial Susceptibility and Genomic Profiles of Multidrug-Resistant Staphylococcus aureus from Nasopharynx of Asymptomatic Children in Dhaka, Bangladesh.
The study identified multidrug-resistant Staphylococcus aureus isolates, including MRSA-ST80, carrying various AMR genes such as mecA, blaI, blaZ, ermC, aph-S-tph, dha1, norA, tet38, mepA, lmrS, and fosB. Mutations in gyrA and parC were associated with fluoroquinolone resistance.
Whole-genome sequencing of bacteria accountable for lactational mastitis in humans combined with an examination of their antibiotic resistance profiles.
The study identified antibiotic resistance genes such as fosB1, cat86, mdf(A), and erm(D) in bacteria associated with lactational mastitis, highlighting the challenge of antibiotic resistance in these pathogens.
Desiccation tolerance and reduced antibiotic resistance: Key drivers in ST239-III to ST22-IV MRSA clonal replacement at a Malaysian teaching hospital.
The study identifies AMR genes and mutations associated with the clonal replacement of MRSA strains in a Malaysian hospital, highlighting the role of desiccation tolerance and reduced antibiotic resistance.
Genomic insight on Klebsiella variicola isolated from wastewater treatment plant has uncovered a novel bacteriophage.
The study identified the beta-lactamase gene bla LEN and the fosfomycin resistance gene fosB in Klebsiella variicola isolated from a wastewater treatment plant. These genes were found to confer resistance to beta-lactam and fosfomycin antibiotics, respectively.
Detection and genetic characterization of multidrug-resistant staphylococci isolated from public areas in an international airport.
The study identified multiple multidrug-resistant staphylococci, including methicillin-resistant S. haemolyticus, S. epidermidis, and a livestock-associated MRSA (LA-MRSA) strain, carrying various resistance genes such as mecA, blaZ, erm(C), aac(6')-aph(2''), and others, highlighting the presence of AMR in public environments.
Zoonotic transmission of asymptomatic carriage Staphylococcus aureus on dairy farms in Canterbury, New Zealand.
The study identified a bovine isolate carrying the extended-spectrum beta-lactamase gene blaTEM-116, highlighting concerns about antimicrobial resistance in dairy farm environments. Multiple antimicrobial resistance genes were detected in both bovine and human isolates, including genes conferring resistance to tetracyclines, penicillins, fosfomycin, and aminoglycosides.
Mapping Antimicrobial Resistance in Staphylococcus epidermidis Isolates from Subclinical Mastitis in Danish Dairy Cows.
The study identified several antimicrobial resistance genes in Staphylococcus epidermidis isolates from subclinical mastitis in Danish dairy cows, including blaZ for penicillin resistance, fosB for fosfomycin resistance, msr(A) and mph(C) for erythromycin resistance, and tet(K) for tetracycline resistance.
Phylogenomic associations among methicillin-resistant Staphylococcus aureus isolates derived from pets, dairies, and humans.
The study identified several AMR genes in methicillin-resistant Staphylococcus aureus (MRSA) isolates from pets, dairies, and humans, including mecA, tet(M), tet(K), erm(C), erm(A), mph(C), msr(A), blaR1, blaZ, blaI_of_Z, blaPC1, vga(A), fosB-Saur, sat4, bleO, ant(9)-Ia, aph(2'')-Ih, aph(3')-IIIa, and ant(4')-Ia. These genes confer resistance to various antibiotics such as methicillin, tetracycline, erythromycin, macrolides, lincomycin, fosfomycin, streptothricin, bleomycin, spectinomycin, amikacin, gentamicin, kanamycin, tobramycin, and others.
Identification of Novel Staphylococcus aureus Core and Accessory Virulence Patterns in Chronic Rhinosinusitis.
The study identifies various antimicrobial resistance genes in Staphylococcus aureus isolates from patients with chronic rhinosinusitis, including blaI, blaZ, blaPC1, blaR1, erm(T), erm(A), tet(38), mepA, fosB, and ermC, which confer resistance to penicillin, macrolides, lincosamides, streptogramins, tetracycline, and fosfomycin.
A decade of genomic and phenotypic adaptation of carbapenem-resistant Acinetobacter baumannii.
The study identifies various AMR genes and mutations in carbapenem-resistant Acinetobacter baumannii isolates, including blaOXA-23, blaOXA-51-like, and several aminoglycoside resistance genes, contributing to extensive drug resistance.
Comprehensive genomic analysis reveals virulence and antibiotic resistance genes in a multidrug-resistant Bacillus cereus isolated from hospital wastewater in Bangladesh.
The study identified several AMR genes in a multidrug-resistant Bacillus cereus strain isolated from hospital wastewater, including beta-lactamases (BcII, BcIII, BcI), glycopeptide resistance genes (vanW, vanY, vanT), tetracycline resistance gene (tetB(P)), fosfomycin resistance gene (fosB), and efflux pump genes (bcrA, bcrB, ykkCD, qacJ).
Prevalence and antimicrobial resistance of methicillin-resistant and methicillin-susceptible Staphylococcus in small- to medium-scale and large-scale dairy farms in Thailand.
The study identified several AMR genes and mutations in Staphylococcus isolates from small- to medium-scale and large-scale dairy farms in Thailand, highlighting differences in resistance profiles between farm types.
Molecular Epidemiology, Antimicrobial Resistance, and Virulence Profiles of Staphylococcus aureus from Fish, Aquatic Environments, and Fish Handlers in Southeast Nigeria.
The study identified 19 antimicrobial resistance genes in Staphylococcus aureus isolates from fish, aquatic environments, and fish handlers in Southeast Nigeria, highlighting the presence of multidrug-resistant strains with various resistance mechanisms.
Antimicrobial Resistance in Staphylococcus aureus at the Human-Animal-Environment Interface in East Africa: A Systematic Review and Meta-Analysis
The study identified key resistance genes including mecA, blaZ, tet(K), and erm(C) in Staphylococcus aureus isolates from East Africa, highlighting the prevalence of methicillin-resistant and multidrug-resistant strains.
Whole-genome analysis of Lysinibacillus boronitolerans MSR1: A dairy-isolated multidrug-resistant and non-pathogenic strain.
The study identifies several antimicrobial resistance (AMR) genes in Lysinibacillus boronitolerans MSR1, including qacJ, vanW, vanT, and FosBx1, which confer resistance to disinfectants, vancomycin, and fosfomycin.
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