Browse AMR Genes
Explore antimicrobial resistance genes from the literature
Explore antimicrobial resistance genes from the literature
glutathione S-transferase
Overview
| Allele | Database | Papers | Drug Classes | Organisms | Countries | Years | Sequence Accession | Protein Accession |
|---|---|---|---|---|---|---|---|---|
| fosC2 | Card DatabaseReference Gene CatalogResFinder DatabaseReslit | 7 | Fosfomycin, FOSFOMYCIN | Escherichia coli +3 | Japan, China|Russia, Egypt, China | 2010, 2022, 2023, 2025 |
| AB522970|AB522969 |
| BAJ10053.1 |
| FosC2 | Card Database | 1 | - | Escherichia coli | - | - | AB522969.1 | BAJ10053.1 |
Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes.
The study identified two novel plasmid-mediated fosfomycin-modifying enzymes, FosA3 and FosC2, which inactivate fosfomycin through glutathione S-transferase activity.
Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes.
Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes.
Prevalence of fosfomycin resistance among CTX-M-producing Escherichia coli clinical isolates in Japan and identification of novel plasmid-mediated fosfomycin-modifying enzymes.
Aliidiomarina shirensis as Possible Source of the Integron- and Plasmid-Mediated Fosfomycin Resistance Gene fosC2.
The study identifies Aliidiomarina shirensis as a possible natural reservoir of the fosC2 gene, which confers fosfomycin resistance. The fosC2 gene was found in the chromosome of A. shirensis and in integron structures of other species. Functional characterization showed that the FosC2 enzyme from A. shirensis exhibits higher catalytic efficiency compared to the acquired FosC2 enzyme.
High incidence of fosfomycin-resistant uropathogenic E. coli among children.
The study identified several plasmid-mediated fosfomycin-resistant genes, including fosA, fosA3, fosA4, fosA5, and fosC2, in fosfomycin-resistant uropathogenic E. coli isolates from children. These genes were found to confer resistance to fosfomycin.
Whole-genome sequencing-based species classification, multilocus sequence typing, and antibiotic resistance mechanisms of the clinical Aeromonas complex.
The study identified multiple beta-lactamase genes, including bla NDM-1, bla PER-3, and bla OXA-1, along with other resistance genes such as aac(6′)-Ib-cr6, aph(3″)-Ib, and floR, which contribute to resistance against various antibiotics in Aeromonas isolates.
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