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fosK

fosfomycin resistance protein

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to fosK

Browse AMR rules for fosK

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic inactivation
Validation Method: cloning in E. coli DH10B and measurement of MIC
Drug Classes: Fosfomycin, FOSFOMYCIN
Organisms: Acinetobacter soli HK001, Escherichia coli DH10B, Acinetobacter soli
Alleles: 2
Papers: 1
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants2

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
FosK	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	4	Fosfomycin, FOSFOMYCIN	Acinetobacter soli HK001 +2	-	2014

Papers1

1

Novel integron-mediated fosfomycin resistance gene fosK.

PMID 24841262 · 2014

The study identifies a novel fosfomycin resistance gene, fosK, mediated by a class 1 integron in Acinetobacter soli HK001. The gene was cloned and shown to significantly increase fosfomycin resistance in E. coli DH10B.

Gene Information

Gene Name: fosK
Allele: FosK
Encodes: fosfomycin resistance protein
Source Database: Reslit
Confers Resistance To: Fosfomycin
Organisms Tested In: • Acinetobacter soli HK001
• Escherichia coli DH10B
Validation Method: cloning in E. coli DH10B and measurement of MIC
Sequence Accession: AB917040

2

Novel integron-mediated fosfomycin resistance gene fosK.

PMID 24841262 · 2014

Gene Information

Gene Name: fosK
Allele: FosK
Encodes: fosfomycin resistance glutathione transferase FosK
Source Database: Reference Gene Catalog
Mechanism: Enzymatic inactivation
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Acinetobacter soli
Sequence Accession: AB917040.2
Protein Accession: BAO79518.1
Notes: ARO:3003207

3

Novel integron-mediated fosfomycin resistance gene fosK.

PMID 24841262 · 2014

Gene Information

Gene Name: fosK
Allele: FosK
Encodes: fosfomycin resistance glutathione transferase FosK
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Acinetobacter soli
Sequence Accession: AB917040.2
Protein Accession: BAO79518.1
Notes: ARO:3003207

4

Novel integron-mediated fosfomycin resistance gene fosK.

PMID 24841262 · 2014

Gene Information

Gene Name: fosK
Allele: FosK
Encodes: fosfomycin resistance glutathione transferase FosK, fosfomycin thiol transferase
Source Database: Card Database
Mechanism: Enzymatic inactivation, antibiotic inactivation
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Acinetobacter soli
Sequence Accession: AB917040.2
Protein Accession: BAO79518.1
Notes: ARO:3003207

5

Novel integron-mediated fosfomycin resistance gene fosK.

PMID 24841262 · 2014

Gene Information

Gene Name: fosK
Allele: fosK
Source Database: ResFinder Database
Mechanism: Enzymatic inactivation
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Acinetobacter soli
Sequence Accession: AB917040