fosL

fosfomycin resistance glutathione transferase FosL2

NCBI Pathogen Isolates

Bacterial genomes carrying this gene

NCBI Reference Gene Catalog

Known alleles and reference sequences

Protein entries specific to fosL

Browse AMR rules for fosL

Validation StatusConfirmed2+ DBs

Overview

Mechanism: Enzymatic modification
Validation Method: cloning in E. coli + disk diffusion
Drug Classes: FOSFOMYCIN, fosfomycin
Organisms: Salmonella enterica, Escherichia coli, Salmonella enterica serovar Typhimurium DT104, Klebsiella pneumoniae
Geographic Location: Switzerland|France|Lebanon|Unknown|Nepal|South Africa|China|Egypt|Kuwait, Switzerland|United States
Alleles: 3
Papers: 3
Databases: Card DatabaseReference Gene CatalogResFinder DatabaseReslit

Allele Variants3

Allele	Database	Papers	Drug Classes	Organisms	Countries	Years	Sequence Accession	Protein Accession
FosL2	Reference Gene Catalog	1	FOSFOMYCIN	Salmonella enterica	-	-	AADAGT010000018.1	EAO1661882.1
FosL1	Card DatabaseReference Gene CatalogResFinder DatabaseReslit	6	fosfomycin, FOSFOMYCIN	Escherichia coli +2	Switzerland\|United States, Switzerland\|France\|Lebanon\|Unknown\|Nepal\|South Africa\|China\|Egypt\|Kuwait	2020, 2022, 2023	MN464149\|PRJNA596098\|WTUN00000000\|SAMN13612190	QHR93773.1
fosL1	ResFinder Database	1	FOSFOMYCIN	Escherichia coli	-	2020	MN464149	-

Papers3

1

Gene Information

Gene Name: fosL
Allele: FosL2
Encodes: fosfomycin resistance glutathione transferase FosL2
Source Database: Reference Gene Catalog
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Salmonella enterica
Sequence Accession: AADAGT010000018.1
Protein Accession: EAO1661882.1

2

Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli.

PMID 31932373 · 2020

The study identifies fosL1, a novel plasmid-mediated fosfomycin resistance gene in Escherichia coli, which encodes a putative glutathione S-transferase enzyme conferring high-level resistance to fosfomycin.

Gene Information

Gene Name: fosL
Allele: FosL1
Encodes: putative glutathione S-transferase enzyme
Source Database: Reslit
Confers Resistance To: fosfomycin
Organisms Tested In: • Escherichia coli
• Salmonella enterica serovar Typhimurium DT104
Geographic Location: Switzerland|United States
Validation Method: cloning in E. coli + disk diffusion
Sequence Accession: MN464149|PRJNA596098|WTUN00000000|SAMN13612190

3

Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli.

PMID 31932373 · 2020

Gene Information

Gene Name: fosL
Allele: FosL1
Encodes: fosfomycin resistance glutathione transferase FosL1
Source Database: Reference Gene Catalog
Mechanism: Enzymatic modification
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Escherichia coli
Sequence Accession: MN464149.1
Protein Accession: QHR93773.1
Notes: ARO:3005024

4

Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli.

PMID 31932373 · 2020

Gene Information

Gene Name: fosL
Allele: FosL1
Encodes: fosfomycin resistance glutathione transferase FosL1
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Escherichia coli
Sequence Accession: MN464149.1
Protein Accession: QHR93773.1
Notes: ARO:3005024

5

Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli.

PMID 31932373 · 2020

Gene Information

Gene Name: fosL
Allele: FosL1
Encodes: fosfomycin resistance glutathione transferase FosL1, fosfomycin thiol transferase
Source Database: Card Database
Mechanism: Enzymatic modification, antibiotic inactivation
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Escherichia coli
Sequence Accession: MN464149.1
Protein Accession: QHR93773.1
Notes: ARO:3005024

6

Characterization of FosL1, a Plasmid-Encoded Fosfomycin Resistance Protein Identified in Escherichia coli.

PMID 31932373 · 2020

Gene Information

Gene Name: fosL
Allele: fosL1
Source Database: ResFinder Database
Mechanism: Enzymatic modification
Confers Resistance To: FOSFOMYCIN
Organisms Tested In: • Escherichia coli
Sequence Accession: MN464149

7

Selective Culture Medium for Screening of Fosfomycin Resistance in Enterobacterales.

PMID 34669459 · 2022

The study developed a selective culture medium called SuperFOS for screening fosfomycin-resistant Enterobacterales. It successfully detected fosfomycin resistance in various strains, including those harboring plasmid-mediated resistance genes such as fosA3, fosA4, fosA8, and fosL1.

Gene Information

Gene Name: fosL
Allele: FosL1
Encodes: plasmid-mediated fosfomycin resistance gene
Source Database: Reslit
Confers Resistance To: fosfomycin
Organisms Tested In: • Escherichia coli
• Klebsiella pneumoniae
Geographic Location: Switzerland|France|Lebanon|Unknown|Nepal|South Africa|China|Egypt|Kuwait
Validation Method: PCR and sequencing

8

Uropathogenic Escherichia coli (UPEC)-Associated Urinary Tract Infections: The Molecular Basis for Challenges to Effective Treatment.

PMID 37764013 · 2023

This review discusses the molecular basis of challenges to effective treatment of UPEC-associated urinary tract infections, focusing on virulence factors and antibiotic resistance mechanisms.

Gene Information

Gene Name: fosL
Allele: FosL1
Encodes: fosfomycin resistance protein
Source Database: Reslit
Confers Resistance To: fosfomycin
Organisms Tested In: • Escherichia coli
Validation Method: plasmid analysis

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